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Article: Early Implant Failure: A Meta-Analysis of 7 Years of Experience.

Grigoras, Radu Ionut / Cosarca, Adina / Ormenișan, Alina

2024 Volume 13, Issue 7

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2024-03-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm13071887
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Article ; Online: Resemblances and differences between osteoradionecrosis of the jaw and medication-related osteonecrosis of the jaw.

Golu, Mihai Vlad / Paşcanu, Ionela / Petrovan, Cecilia / Mocan, Simona / Cosarcă, Adina / Temistocle, Despina Bereczki / Ormenişan, Alina

Medicine and pharmacy reports

2024 Volume 97, Issue 1, Page(s) 76–83

Abstract: Aim: The aim of this retrospective study was to identify the clinical, radiological, and histological characteristics of patients diagnosed with osteonecrosis of the jaw (ONJ) and treated at the Oral and Maxillo-Facial Surgery Clinic of the Emergency ... ...

Abstract	Aim: The aim of this retrospective study was to identify the clinical, radiological, and histological characteristics of patients diagnosed with osteonecrosis of the jaw (ONJ) and treated at the Oral and Maxillo-Facial Surgery Clinic of the Emergency Clinical County Hospital of Targu Mures between 2017 and 2022. The study aimed to analyze correlations between patient characteristics, particularly their history of bone modifying agent use or local radiotherapy during cancer treatment, in order to identify specific patient profiles that could aid in evaluating treatment response and guide individualized treatment strategies. Methods: Fifty-two patients diagnosed with ONJ were included in the study. The patients were divided into two groups based on their medical history: the bone modifying agent use group and the radiotherapy group. Clinical, radiological, and histological data were collected and analyzed. Statistical analysis, including p-values, was performed to compare patient characteristics between the two groups. Results: Patients in the radiotherapy group were significantly older than those in the bone modifying agent use group (66 years vs. 56.9 years, p=0.001). There was a higher proportion of males in the radiotherapy group compared to the bone modifying agent use group (90% vs. 22%, p<0.001). Jaw involvement was more prevalent in the radiotherapy group compared to the bone modifying agent use group (95% vs. 66%, p=0.018). Histological analysis showed a similar frequency of Actinomyces species in both groups (50% vs. 34%, p=0.264). Conclusions: The findings of this study suggest the existence of two distinct patient profiles based on their treatment history (bone modifying agent use vs. radiotherapy) in ONJ. Patients in the radiotherapy group were older, predominantly male, and exhibited a higher prevalence of jaw involvement. Histological analysis revealed no significant differences in Actinomyces species frequency between the two groups. These distinct patient profiles may indicate different responses to treatment, emphasizing the need for individualized treatment strategies tailored to specific patient characteristics. Further research is warranted to validate these findings and develop personalized approaches for managing ONJ.
Language	English
Publishing date	2024-01-29
Publishing country	Romania
Document type	Journal Article
ZDB-ID	2974425-8
ISSN	2668-0572 ; 2602-0807
ISSN (online)	2668-0572
ISSN	2602-0807
DOI	10.15386/mpr-2610
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Article ; Online: Recurrent submandibular fistula after Sunitinib treatment in a patient with renal cell carcinoma: a case report.

Golu, Mihai Vlad / Paşcanu, Ionela / Petrovan, Cecilia / Cosarca, Adina / Bereczki, Despina Temistocle / Ormenisan, Alina

Medicine and pharmacy reports

2023 Volume 96, Issue 3, Page(s) 323–327

Abstract: Sunitinib is commonly used in the treatment of patients with renal cell carcinoma and is associated with serious side-effects. We present the first report of a recurrent submandibular fistula in a patient treated with sunitinib. A 68-year-old man was ... ...

Abstract	Sunitinib is commonly used in the treatment of patients with renal cell carcinoma and is associated with serious side-effects. We present the first report of a recurrent submandibular fistula in a patient treated with sunitinib. A 68-year-old man was referred to our clinic for a cutaneous fistula situated on the right side of his lower jaw. The patient had been diagnosed with bone metastases from a renal carcinoma 2 years ago and had received a single 4 mg dose of zoledronic acid and subsequent treatment with sunitinib 37.5 mg once daily for the past 4 weeks. The patient was treated surgically by a perilesional incision and primary closure with sutures, advised on meticulous oral hygiene and was kept on an antimicrobial agent in the form of clindamycin. After reinitiating his oncological treatment with sunitinib the cutaneous fistula re-appeared and bone abnormalities were also detected on his X-ray. After 18 months a contralateral cutaneous fistula was observed along with a spontaneous avulsion of the patient's left molar. Repeat surgical treatment and sequestrectomy was performed with the subsequent histopathological examination revealing a suspicion of osteonecrosis of the jaw and an associated Actinomyces infection.
Language	English
Publishing date	2023-07-27
Publishing country	Romania
Document type	Case Reports
ZDB-ID	2974425-8
ISSN	2668-0572 ; 2602-0807
ISSN (online)	2668-0572
ISSN	2602-0807
DOI	10.15386/mpr-2502
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Article ; Online: HPV disrupt the cytoskeleton in oral squamous cell carcinomas from non-oropharyngeal sites via the E-cadherin/Mena/SMA pathway.

Bereczki-Temistocle, Despina / Jung, Ioan / Gurzu, Simona / Kovacs, Zsolt / Chiciudean, Rebeca / Ormenisan, Alina / Banias, Laura

Pathology, research and practice

2023 Volume 249, Page(s) 154723

Abstract: In this paper, we aimed to evaluate the mechanism of actin cytoskeleton disruption, in oral squamous cell carcinoma (OSCC). A total of 43 patients with surgically resected OSCCs located in non-oropharyngeal regions were randomly selected. The expression ... ...

Abstract	In this paper, we aimed to evaluate the mechanism of actin cytoskeleton disruption, in oral squamous cell carcinoma (OSCC). A total of 43 patients with surgically resected OSCCs located in non-oropharyngeal regions were randomly selected. The expression of E-cadherin, β-catenin, smooth muscle actin (SMA), Mena, maspin, V-set and immunoglobulin domain containing 1 (VSIG1), β human chorionic gonadotropin (βhCG), and angiotensin-converting enzyme (ACE) was assessed via immunohistochemistry (IHC) and evaluated in association with the prevalence of high-risk human papillomavirus (HPV). Mena positivity (n = 30; 69.77%) was more frequent in poorly differentiated OSCC of the tongue and lips with high-risk HPV viral DNA and a lymph node ratio (LNR) ≤ 2.5. Loss of E-cadherin was more prevalent among poorly differentiated stage pT4N1 tumors with an LNR ≤ 2.5 and perineural invasion. These cases were classified as SMA-high tumors. Independent negative prognostic factors included high Mena expression, loss of E-cadherin, high SMA expression, and the presence of high-risk HPV. No VSIG1 positivity was observed. In conclusion, in non-oropharyngeal OSCC, cytoskeleton activity might be driven by the Mena/E-cadherin/SMA axis, reflecting active epithelial-mesenchymal interaction. High Mena intensity is an indicator of poorly differentiated carcinomas with high-risk HPV and unfavorable prognosis.
MeSH term(s)	Humans ; Mouth Neoplasms/pathology ; Squamous Cell Carcinoma of Head and Neck ; Carcinoma, Squamous Cell/pathology ; Papillomavirus Infections ; Cadherins/metabolism ; Prognosis ; Head and Neck Neoplasms ; Cytoskeleton/metabolism ; Cytoskeleton/pathology
Chemical Substances	Cadherins
Language	English
Publishing date	2023-07-27
Publishing country	Germany
Document type	Journal Article
ZDB-ID	391889-0
ISSN	1618-0631 ; 0344-0338
ISSN (online)	1618-0631
ISSN	0344-0338
DOI	10.1016/j.prp.2023.154723
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Article ; Online: Evaluation of Three Esthetic Restorative Materials Used for Carious or Noncarious Cervical Lesion Restoration

Beresescu Gabriela / Tegla Emanuela / Temistocle Despina / Ormenisan Alina / Baldean Alina

Journal of Interdisciplinary Medicine, Vol 4, Iss 1, Pp 19-

2019 Volume 24

Abstract: Background: Cervical lesions appear on the cervical surface of the lingual or buccal side of the tooth and are classified into carious and non-carious lesions. ...

Abstract	Background: Cervical lesions appear on the cervical surface of the lingual or buccal side of the tooth and are classified into carious and non-carious lesions.
Keywords	carious ; non-carious ; cervical lesions ; restoration materials ; retention rates ; Medicine ; R
Language	English
Publishing date	2019-03-01T00:00:00Z
Publisher	Sciendo
Document type	Article ; Online
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Article: Successful Closure of an Oro-Antral Communication, after Three Previously Failed Attempts, Using Bichat Fat Pad Flap: A Case Report.

Bereczki-Temistocle, Despina Luciana / Gurzu, Simona / Ioan, Ioan / Vlad, Golu Mihai / Beresescu, Gabriela / Ormenisan, Alina

World journal of plastic surgery

2021 Volume 12, Issue 1, Page(s) 90–94

Abstract: An oro-antral communication represents an abnormal connection between the oral cavity and the maxillary sinus. It occurs most often after tooth extractions, improper implant placement or incorrect management of the sinus lifts. Surgical repair is ... ...

Abstract	An oro-antral communication represents an abnormal connection between the oral cavity and the maxillary sinus. It occurs most often after tooth extractions, improper implant placement or incorrect management of the sinus lifts. Surgical repair is challenging and most practitioners usually choose the buccal advancement flap, the palatal flap and in some cases the buccal fat pad flap to close the defect. We present a 43 year-old female of a large oro-antral communication and associated chronic sinusitis which was succesfully manged by surgery. Previous interventions including 2 buccal advancement flaps, and a double layer closure using Collagen membrane and buccal advancement flap were unsuccesful. The stepwise intervention consisted on the complete cleaning of the sinus, using the Caldwell Luc technique, followed by the closure of the oro-antral communication using Bichat fat pad flap. The particular aspect was the proper integration of the buccal fat pad flap, after 3 failed attempts, without dehiscence or any other complications. The buccal fat pad flap can be succesfully used for closure of lage oro-antral communications, even when previous methods have failed and local tissue is of poor quality.
Language	English
Publishing date	2021-02-11
Publishing country	Iran
Document type	Case Reports
ZDB-ID	2781494-4
ISSN	2252-0724 ; 2228-7914
ISSN (online)	2252-0724
ISSN	2228-7914
DOI	10.52547/wjps.12.1.90
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Article ; Online: Selecting the Best Surgical Treatment Methods in Oro-Antral Communications.

Bereczki-Temistocle, Despina Luciana / Gurzu, Simona / Jung, Ioan / Cosarca, Adina / Beresescu, Gabriela / Golu, Vlad / Petrovan, Cecilia / Ormenisan, Alina

International journal of environmental research and public health

2022 Volume 19, Issue 21

Abstract: Introduction: an oro-antral communication is defined as a permanent pathological connection between the maxillary sinus and the septic oral cavity. Several flaps can be used for the closure (buccal flap, palatal flap, combination techniques) but ... ...

Abstract	Introduction: an oro-antral communication is defined as a permanent pathological connection between the maxillary sinus and the septic oral cavity. Several flaps can be used for the closure (buccal flap, palatal flap, combination techniques) but relapses occur often in case of a large defects and underlying general conditions. Bichat fad pad flap is a multipotent pedicled fatty tissue that is easily accessible from the oral cavity that can be used for the closure of medium-sized defects, even in immunocompromised patients due to its stem cell capacity. Materials and methods: the medical information of the patients diagnosed with oro-antral communications who were admitted and treated in the Oral and Maxillo-Facial Clinic Targu Mures, between 2013 and 2020 were analyzed. A database containing general information, reported causes, associated diseases, surgical methods used during admission, and relapses, was created. The information was statistically processed. The written consent and ethical approval were obtained. Results: the study shows that from a total of 140 cases, 72 were treated using buccal advancement flap, 49 using Bichat fat pad flap, and 19 using palatal flaps. The dimensions of the communications ranged between 0.3 cm and 1.5 cm. Several statistically significant results could be found when comparing the surgical methods. Of the 72 patients treated with buccal advancement flaps, 25 presented relapses as opposed to the patients treated with Bichat fat pad flaps who showed no complications, Conclusions: the most frequently used surgical treatment is the buccal flap, which also has the highest relapse rate. Both primary treatment with Bichat fat-pad flap and re-treatment of relapses using this flap have had 100% success rates, even in patients with general associated conditions, in contrast with patients treated by using the buccal flap. The dimensions of the oro-antral communication and general conditions are crucial factors for the success of the surgical treatment.
MeSH term(s)	Humans ; Oroantral Fistula/etiology ; Oroantral Fistula/surgery ; Surgical Flaps ; Adipose Tissue ; Maxillary Sinus ; Recurrence
Language	English
Publishing date	2022-11-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph192114543
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Article: Effects of Laser Application on Alveolar Bone Mesenchymal Stem Cells and Osteoblasts: An In Vitro Study.

Lazăr, Luminița / Manu, Doina Ramona / Dako, Timea / Mârțu, Maria-Alexandra / Suciu, Mircea / Ormenișan, Alina / Păcurar, Mariana / Lazăr, Ana-Petra

Diagnostics (Basel, Switzerland)

2022 Volume 12, Issue 10

Abstract: Mesenchymal stem cells isolated from the bone marrow have a great differentiation potential, being able to produce many cell lines, including osteoblasts. Osteoblasts have an important role in bone remodeling by actively participating in the maturation ... ...

Abstract	Mesenchymal stem cells isolated from the bone marrow have a great differentiation potential, being able to produce many cell lines, including osteoblasts. Osteoblasts have an important role in bone remodeling by actively participating in the maturation and mineralization of the extracellular matrix. The aim of this study was to determine the effect of laser application on the viability and proliferation of osteoblasts. Methods: Alveolar bone was harvested from 8 patients and placed into a culture medium to induce proliferation of mesenchymal stem cells. These were differentiated into osteoblasts in special conditions. The cells from each patient were split into two groups, one was treated using a 980 nm laser (1W output power, pulsed mode, 20 s, 50 mm distance) (laser "+") and the other one did not receive laser stimulation (laser "-"). Results: Using the confocal microscope, we determined that the cells from the laser "+" group were more active when compared to the laser "-" group. The number of cells in the laser "+" group was significantly greater compared to the laser "-" group as the ImageJ-NIH software showed ( Conclusions: Laser application increases the proliferation rate of osteoblasts and intensifies their cellular activity.
Language	English
Publishing date	2022-09-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics12102358
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Article: Statistical Study on the Motivation of Patients in the Pediatric Dentistry.

Josan, Lucian / Bucur, Sorana Maria / Păcurar, Mariana / Teodorescu, Elina / Sălcudean, Andreea / Molnar Varlam, Cristina Stanca / Ormenișan, Alina

Children (Basel, Switzerland)

2022 Volume 9, Issue 11

Abstract: Our statistical study included 344 participants selected from the patients of the Pedodontics-Orthodontics Discipline of the Tîrgu-Mureş University of Medicine and Pharmacy. The patients' age was between 6 and 18 years, with an average of 13.70 and a ... ...

Abstract	Our statistical study included 344 participants selected from the patients of the Pedodontics-Orthodontics Discipline of the Tîrgu-Mureş University of Medicine and Pharmacy. The patients' age was between 6 and 18 years, with an average of 13.70 and a standard deviation of 4.62. The study participants were informed and agreed to complete two questionnaires of our conception regarding their health status, oral hygiene, and motivation for pedodontics or orthodontic treatment. The results of the two questionnaires were interpreted according to the gender and age of the patients. Data processing was performed with NCSS/PASS Dawson Edition statistical software, using the CHI2 test, considering a
Language	English
Publishing date	2022-11-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2732685-8
ISSN	2227-9067
ISSN	2227-9067
DOI	10.3390/children9111782
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Article ; Online: Case Report. Practical Advantages of CBCT in the Surgical Treatment of Impacted Lower Third Molar

Ormenișan Alina / Iacob Alina / Szava Daniel / Bogozi Balint / Coșarcă Adina

Acta Medica Marisiensis, Vol 63, Iss 1, Pp 41-

2017 Volume 45

Abstract: Introduction: The imaging method of cone beam is an improved, extremely accurate computed tomography applicable in the whole field of dentistry. Due to its ability to locate the exact position of the impacted teeth, CBCT software has an important role in ...

Abstract	Introduction: The imaging method of cone beam is an improved, extremely accurate computed tomography applicable in the whole field of dentistry. Due to its ability to locate the exact position of the impacted teeth, CBCT software has an important role in the management of difficult cases of impacted third molar. In some situations, the lower third molar is quite near to the inferior alveolar nerve that the surgical extraction can present a high risk of post-operative sensitive impairs of the skin and mucosa of the lower lip and chin on the same side. Presentation of case series: Our study tried to assess the contribution of CBCT in the pre-operative evaluation and further treatment of patients with impacted third molars in mandibular bone with high risk of inferior alveolar nerve injury. The paper presents three clinical cases showing positive signs on standard OPG, which exhibit indicators of a potential contact between the inferior alveolar nerve and the impacted lower third molars. For an improved exploration Dental CT Scan, DICOM image acquisition program, and 3D reconstruction with a special software were used. Conclusions: The study showed that compared with panoramic radiography, CBCT improve the evaluation of the surgical risk and allow a more accurate planning of surgery.
Keywords	impacted third molar ; cbct ; inferior alveolar nerve ; mandibular canal ; Medicine ; R
Subject code	610
Language	English
Publishing date	2017-03-01T00:00:00Z
Publisher	Sciendo
Document type	Article ; Online
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