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  1. AU="Orobello, Nicklas C"
  2. AU=Kim Chang H.
  3. AU="Livingston, Abel"
  4. AU="DeKoven, Mitchell P"
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  1. Article ; Online: A Nearly Obstructive Intratracheal Mass in a Pediatric Patient.

    Hakimi, Amir A / Orobello, Nicklas C / Mudd, Pamela A

    JAMA otolaryngology-- head & neck surgery

    2023  Volume 149, Issue 4, Page(s) 368–369

    MeSH term(s) Child ; Humans ; Trachea/pathology
    Language English
    Publishing date 2023-02-02
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2701825-8
    ISSN 2168-619X ; 2168-6181
    ISSN (online) 2168-619X
    ISSN 2168-6181
    DOI 10.1001/jamaoto.2022.4908
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    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Fourth branchial cleft sinus with foreign material within thyroid gland.

    Orobello, Nicklas C / Insalaco, Louis F / Roby, Brianne B

    International journal of pediatric otorhinolaryngology

    2020  Volume 132, Page(s) 109948

    Abstract: Fourth branchial cleft anomalies are rare lesions that present diagnostic dilemmas to otolaryngologists. The report presented is a case of a 17-year-old female with food matter and abscess within the thyroid gland that were associated with a 4th ... ...

    Abstract Fourth branchial cleft anomalies are rare lesions that present diagnostic dilemmas to otolaryngologists. The report presented is a case of a 17-year-old female with food matter and abscess within the thyroid gland that were associated with a 4th branchial cleft sinus. A thyroid ultrasound revealed a 3.0 x 1.5 x 2.5-cm lesion with abnormal echogenicity that was concerning for early abscess. The patient subsequently underwent direct laryngoscopy and right thyroid lobectomy. Her symptoms resolved after surgery. This case demonstrates an unusual presentation in which food passed through the tract to the thyroid gland itself.
    MeSH term(s) Abscess/etiology ; Abscess/surgery ; Adolescent ; Branchial Region/abnormalities ; Craniofacial Abnormalities/complications ; Female ; Foreign Bodies/etiology ; Foreign Bodies/surgery ; Humans ; Laryngoscopy ; Pharyngeal Diseases/complications ; Thyroid Diseases/etiology ; Thyroid Diseases/surgery ; Thyroid Gland ; Thyroidectomy
    Language English
    Publishing date 2020-02-13
    Publishing country Ireland
    Document type Case Reports ; Journal Article
    ZDB-ID 754501-0
    ISSN 1872-8464 ; 0165-5876
    ISSN (online) 1872-8464
    ISSN 0165-5876
    DOI 10.1016/j.ijporl.2020.109948
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 134: Show issues

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  3. Article ; Online: Predicting failure of detection of peritonsillar abscess with ultrasound in pediatric populations.

    Orobello, Nicklas C / Crowder, Hannah R / Riley, Phoebe E / Michel, Margaret / Behzadpour, Hengameh K / Rana, Md Sohel / Sanchez-Jacob, Ramon / Reilly, Brian K

    American journal of otolaryngology

    2023  Volume 45, Issue 1, Page(s) 104021

    Abstract: Purpose: Some patients require additional imaging following ultrasound (US) to definitively diagnose a peritonsillar abscess (PTA), delaying intervention and disease resolution. We seek to evaluate patient characteristics which may predispose to a ... ...

    Abstract Purpose: Some patients require additional imaging following ultrasound (US) to definitively diagnose a peritonsillar abscess (PTA), delaying intervention and disease resolution. We seek to evaluate patient characteristics which may predispose to a secondary imaging requirement to diagnose PTA, in order to better understand ultrasound limitations and predict who will require additional studies.
    Materials and methods: Retrospective chart review of patients with an US for suspected PTA between July 2017 and July 2020. Patient age, weight, and clinical characteristics, such as pain, trismus, and reduced neck range of motion (ROM) were collected. The need for additional imaging, subsequent surgical intervention, and hospital length of stay (LOS) were also recorded.
    Results: Of 411 qualifying patients, 73 underwent additional imaging. Patients who required additional imaging were younger (9.8 vs 11.3 years, p = 0.026) and more likely to have decreased neck ROM (17.8 vs 5.3 %, p = 0.001). Surgical intervention was performed more commonly (27.4 vs 14.8 %, p = 0.015) and hospital LOS was longer (24.0 vs 5.0 h, p < 0.001) in those with secondary imaging.
    Conclusions: Specific patient characteristics, such as younger age and decreased neck range of motion, are associated with a higher need for additional imaging. Additionally, the need for additional imaging is associated with a longer hospital LOS and increased likelihood of surgical intervention. Nearly 18 % of patients who underwent US evaluation of PTA required secondary imaging. Although transcervical US remains an excellent tool for diagnosing PTA, this data supports the utility of secondary imaging in certain instances.
    MeSH term(s) Humans ; Child ; Peritonsillar Abscess/diagnostic imaging ; Peritonsillar Abscess/surgery ; Retrospective Studies ; Ultrasonography ; Length of Stay ; Neck/diagnostic imaging ; Drainage/methods
    Language English
    Publishing date 2023-08-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604541-8
    ISSN 1532-818X ; 0196-0709
    ISSN (online) 1532-818X
    ISSN 0196-0709
    DOI 10.1016/j.amjoto.2023.104021
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1637: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Evaluation of Cochlear Implantation in Children With Cochlear Nerve Absence or Deficiency.

    Shakhtour, Leyn B / Song, Sophia / Orobello, Nicklas C / Garrett, Samuel / Ambrose, Tracey / Behzadpour, Hengameh K / Vezina, Gilbert / Preciado, Diego A / Reilly, Brian K

    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery

    2024  

    Abstract: Objective: To identify associations between cochleovestibular anatomy findings and hearing outcomes found in children with imaging evidence of an absent or hypoplastic cochlear nerve treated with cochlear implantation (CI).: Study design: ... ...

    Abstract Objective: To identify associations between cochleovestibular anatomy findings and hearing outcomes found in children with imaging evidence of an absent or hypoplastic cochlear nerve treated with cochlear implantation (CI).
    Study design: retrospective review.
    Setting: Cochlear implant program at tertiary care center.
    Methods: A retrospective review was performed to identify children with imaging evidence of cochlear nerve absence or deficiency who underwent CI evaluation. High-resolution 3-dimensional T2-weighted magnetic resonance imaging in the oblique sagittal and axial planes were reviewed by a neuroradiologist to identify cochleovestibular anatomy. Hearing was assessed pre and postoperatively with Speech Perception Category scores.
    Results: Seven CI recipients were identified (n = 10 ears) who had bilateral severe to profound sensorineural hearing loss with lack of auditory development with binaural hearing aid trial and imaging evidence of cochlear nerve aplasia/hypoplasia. All ears had 2 nerves in the cerebellopontine angle (100%, n = 10), half of the ears had evidence of 2 or less nerves in the internal auditory canal (IAC). All children showed large improvement in speech perception after CI.
    Conclusion: Our experience with CIs for children with absent or hypoplastic cochlear nerves demonstrates that CI can be a viable option in select patients who satisfy preoperative audiological criteria. Radiological identification of a hypoplastic or aplastic cochlear nerve does not preclude auditory innervation of the cochlea. CI recipients in this subgroup must be counseled on difficulty in predicting postimplantation language and speech outcomes, and cautioned about facial nerve stimulation.
    Language English
    Publishing date 2024-05-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 392085-9
    ISSN 1097-6817 ; 0161-6439 ; 0194-5998
    ISSN (online) 1097-6817
    ISSN 0161-6439 ; 0194-5998
    DOI 10.1002/ohn.827
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  5. Article: Efficacy of common reagents for killing ticks in the ear canal.

    Orobello, Nicklas C / Dirain, Carolyn O / Kaufman, Phillip E / Antonelli, Patrick J

    Laryngoscope investigative otolaryngology

    2018  Volume 3, Issue 6, Page(s) 492–495

    Abstract: Objective: To determine if widely available solutions can effectively kill ticks that may be found in the human ear canal.: Methods: This study was prospective, controlled and blinded animal study. Lone star ticks (: Results: Acetone killed ticks ... ...

    Abstract Objective: To determine if widely available solutions can effectively kill ticks that may be found in the human ear canal.
    Methods: This study was prospective, controlled and blinded animal study. Lone star ticks (
    Results: Acetone killed ticks most rapidly (nymph mean time = 185.1 s; adult mean time = 562.9 s). Isopropyl alcohol 70% (nymphs, 328.9 s; adults, 1128.4 s) and ethanol 95% (nymphs, 294 s; adults, 1129.4 s) took longer to kill the ticks. All ticks treated with 4% lidocaine survived. These differences were significant (nymphs,
    Conclusions: Acetone was the fastest acting and most effective reagent, followed by ethanol and isopropyl alcohol. These solutions may prove useful in otoacariasis with an intact tympanic membrane.
    Level of evidence: N/A.
    Language English
    Publishing date 2018-10-29
    Publishing country United States
    Document type Journal Article
    ISSN 2378-8038
    ISSN 2378-8038
    DOI 10.1002/lio2.217
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  6. Article ; Online: Collagen and α-Tubulin of Mouse Tympanic Membrane Fibroblasts Treated with Quinolones and Aminoglycosides.

    Milne-Davies, Bailey A / Antonelli, Patrick J / Orobello, Nicklas C / Dirain, Carolyn O

    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery

    2017  Volume 156, Issue 2, Page(s) 341–349

    Abstract: Objective To assess collagen and α-tubulin levels of mouse tympanic membrane fibroblasts treated with quinolone and aminoglycoside antibiotics at concentrations found in eardrops. Study Design Prospective controlled cell culture study. Setting Academic ... ...

    Abstract Objective To assess collagen and α-tubulin levels of mouse tympanic membrane fibroblasts treated with quinolone and aminoglycoside antibiotics at concentrations found in eardrops. Study Design Prospective controlled cell culture study. Setting Academic tertiary medical center. Subjects Mouse tympanic membrane fibroblasts. Methods In experiment 1, fibroblasts were treated with the following for 24 or 48 hours: phosphate-buffered saline (negative control), dilute hydrochloric acid (positive control), 0.5% gatifloxacin, or commercially available 0.3% ciprofloxacin, 0.3% ciprofloxacin + 0.1% dexamethasone, 0.3% ofloxacin, 0.5% moxifloxacin, 0.3% gentamicin, or 3.5 mg/mL of neomycin + polymyxin B sulfate + hydrocortisone. In experiment 2, cells were treated with the pure form of gatifloxacin, gentamicin, ofloxacin, or ciprofloxacin. Cells were observed with phase-contrast microscope until harvested. Proteins were extracted for Western blotting with antibodies against collagen α1 type I (collagen 1A1) and α-tubulin, and for densitometry to quantify levels. Results Collagen and tubulin levels in fibroblasts treated with ofloxacin, moxifloxacin, gatifloxacin, or gentamicin for 24 hours were not different from the saline control. Fibroblasts treated with neomycin + polymyxin B + hydrocortisone, ciprofloxacin + dexamethasone, or ciprofloxacin for 24 hours had lower collagen 1A1 and α-tubulin levels (all P < .001) than the negative control. After 48 hours, fibroblasts treated with neomycin + polymyxin B sulfate + hydrocortisone, ciprofloxacin + dexamethasone, ciprofloxacin, or moxifloxacin had lower collagen 1A1 ( P ≤ .007) and α-tubulin ( P < .0001; except ciprofloxacin, P = .033) as compared with control. In experiment 2, only cells treated with ciprofloxacin had lower collagen 1A1 and α-tubulin levels and cell viability (all P < .0001) than control. Cytotoxicity assay and phase-contrast images mirrored the protein findings. Conclusion The adverse impact of topical antibiotic exposure on tympanic membrane collagen and tubulin protein levels is drug specific. This may be important for selection of ototopical therapy.
    MeSH term(s) Aminoglycosides/pharmacology ; Animals ; Blotting, Western ; Cells, Cultured ; Collagen/drug effects ; Fibroblasts/drug effects ; Mice ; Mice, Transgenic ; Prospective Studies ; Quinolones/pharmacology ; Tubulin/drug effects ; Tympanic Membrane/cytology
    Chemical Substances Aminoglycosides ; Quinolones ; Tubulin ; Collagen (9007-34-5)
    Language English
    Publishing date 2017-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 392085-9
    ISSN 1097-6817 ; 0161-6439 ; 0194-5998
    ISSN (online) 1097-6817
    ISSN 0161-6439 ; 0194-5998
    DOI 10.1177/0194599816672627
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  7. Article ; Online: Ciprofloxacin Decreases Collagen in Mouse Tympanic Membrane Fibroblasts.

    Orobello, Nicklas C / Dirain, Carolyn O / Schultz, Gregory / Milne-Davies, Bailey A / Ng, Maria R A / Antonelli, Patrick J

    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery

    2016  Volume 155, Issue 1, Page(s) 127–132

    Abstract: Objectives: To determine how collagen production by tympanic membrane fibroblasts is affected by ciprofloxacin at levels found in eardrops.: Study design: Prospective, controlled, and blinded cell culture study.: Setting: Academic tertiary medical ...

    Abstract Objectives: To determine how collagen production by tympanic membrane fibroblasts is affected by ciprofloxacin at levels found in eardrops.
    Study design: Prospective, controlled, and blinded cell culture study.
    Setting: Academic tertiary medical center.
    Subjects: Cell culture of mouse fibroblasts.
    Methods: A primary fibroblast culture was established from mouse tympanic membranes. Fibroblasts were cultured until they were 75% confluent, then treated with dilute hydrochloric acid (control) or ciprofloxacin (0.01% or 0.3%) for 24 or 72 hours for Western blotting and for 24 or 48 hours for cytotoxicity assay. Cells were observed with phase-contrast microscope. Western blotting was performed for collagen type 1 α1 (collagen 1A1) and α-tubulin.
    Results: Fibroblasts treated with 0.01% and 0.3% ciprofloxacin for 24 hours had lower levels of collagen 1A1 (P = .0005 and P < .0001, respectively) and α-tubulin (both P < .0001) than control fibroblasts. Collagen 1A1 and α-tubulin levels were lower in fibroblasts treated with 0.3% than with 0.01% ciprofloxacin (P = .02 and P = .014). After 72 hours, 0.3% ciprofloxacin completely eliminated collagen 1A1 and α-tubulin (P < .001). Cells treated with 0.01% ciprofloxacin for 72 hours also had lower collagen 1A1 (P < .0001) and α-tubulin (P = .005) as compared with the control. Seventy-two-hour incubation in 0.01% or 0.3% ciprofloxacin resulted in lower levels of collagen 1A1 (P = .009 and P < .0001, respectively) and α-tubulin (P = .007 and P < .0001, respectively) than 24-hour incubation. Cytotoxicity assay and phase-contrast microscopy mirrored these findings.
    Conclusions: Treatment of tympanic membrane fibroblasts with 0.3% ciprofloxacin, as found in eardrops, reduces fibroblast viability and collagen and α-tubulin protein levels. These findings could explain tympanic membrane healing problems associated with quinolone eardrops.
    MeSH term(s) Animals ; Blotting, Western ; Cells, Cultured ; Ciprofloxacin/toxicity ; Collagen Type I/metabolism ; Fibroblasts/drug effects ; Fibroblasts/metabolism ; Mice ; Prospective Studies ; Tubulin/metabolism ; Tympanic Membrane/drug effects ; Tympanic Membrane/metabolism
    Chemical Substances Collagen Type I ; Tubulin ; collagen type I, alpha 1 chain ; Ciprofloxacin (5E8K9I0O4U)
    Language English
    Publishing date 2016-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 392085-9
    ISSN 1097-6817 ; 0161-6439 ; 0194-5998
    ISSN (online) 1097-6817
    ISSN 0161-6439 ; 0194-5998
    DOI 10.1177/0194599816633671
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