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Article ; Online: Acrodermatitis continua of Hallopeau in an elderly patient successfully and rapidly treated with risankizumab: a case report.

Orsini, Diego / Iacovelli, Paolo / Frascione, Pasquale / Pacifico, Alessia

2023 Volume 34, Issue 1, Page(s) 2229468

MeSH term(s)	Aged ; Humans ; Acrodermatitis/drug therapy ; Antibodies, Monoclonal/therapeutic use ; Exanthema ; Psoriasis/drug therapy ; Skin Diseases, Vesiculobullous
Chemical Substances	risankizumab (90ZX3Q3FR7) ; Antibodies, Monoclonal
Language	English
Publishing date	2023-06-28
Publishing country	England
Document type	Case Reports ; Letter
ZDB-ID	1036299-x
ISSN	1471-1753 ; 0954-6634
ISSN (online)	1471-1753
ISSN	0954-6634
DOI	10.1080/09546634.2023.2229468
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Article: Analysing the COVID-19 epidemic in Italy through the Reed-Frost model: A methodology to delimit epidemic waves over time.

Di Pilla, Andrea / Federico, Bruno / Orsini, Diego / Damiani, Gianfranco / Specchia, Maria Lucia

Epidemiologia e prevenzione

2023 Volume 47, Issue 1-2, Page(s) 26–33

Abstract: Objectives: to set out a method based on the Reed Frost model to delimit over time COVID-19 epidemic waves in Italy.: Design: the available national epidemic reports published by the Protezione Civile (Italian civil defence) from 24.02.2020 to 16 ... ...

Title translation	Analisi dell’epidemia di COVID-19 in Italia attraverso il modello Reed-Frost: una metodologia per delimitare nel tempo le ondate epidemiche.
Abstract	Objectives: to set out a method based on the Reed Frost model to delimit over time COVID-19 epidemic waves in Italy. Design: the available national epidemic reports published by the Protezione Civile (Italian civil defence) from 24.02.2020 to 16.022022 were used to collect data on COVID-19 epidemic in Italy. Then, the Reed-Frost model was applied to develop a methodology based on the calculation of the effective contact probability, i.e., the probability of contact. Setting and participants: in Italy, a daily report related to the epidemic was immediately available, including main epidemiological data (point and periodic infection prevalence, mortality, etc), which made it possible for researchers from different institutions to perform analyses about the epidemic. Results: an iterative methodology was developed resulting in the identification of the start-of-wave, end-of-wave, and inter-wave periods and of the starting and ending days of the COVID-19 epidemic waves in Italy (first wave: from 26±2 February 2020 to 28±2 June 2020). Conclusions: this study led to the development of an accessible and reproducible method to determine the start-of-wave and end-of-wave dates of an epidemic, starting only from the number of cases and susceptible people. The main implications of the method mainly consist in allowing benchmarking and forecasting analyses of the epidemic trend to be carried out to support policy and decision-making processes.
MeSH term(s)	Humans ; COVID-19/epidemiology ; Epidemics ; Italy/epidemiology ; Prevalence ; SARS-CoV-2 ; Forecasting
Language	English
Publishing date	2023-03-21
Publishing country	Italy
Document type	Journal Article
ZDB-ID	1038112-0
ISSN	1120-9763
ISSN	1120-9763
DOI	10.19191/EP23.1.A479.001
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Article: Rapidly and successful improvement of nail psoriasis with risankizumab.

Orsini, Diego / Pacifico, Alessia / Iacovelli, Paolo / Frascione, Pasquale / De Simone, Paola / Assorgi, Chiara / Pigliacelli, Flavia

Clinical case reports

2023 Volume 11, Issue 10, Page(s) e8035

Abstract: This clinical case demonstrates quick resolution of nail psoriasis in a patient treated with risankizumab, highlighting the role of IL-23 in the pathogenesis of nail psoriasis. ...

Abstract	This clinical case demonstrates quick resolution of nail psoriasis in a patient treated with risankizumab, highlighting the role of IL-23 in the pathogenesis of nail psoriasis.
Language	English
Publishing date	2023-10-09
Publishing country	England
Document type	Case Reports
ZDB-ID	2740234-4
ISSN	2050-0904
ISSN	2050-0904
DOI	10.1002/ccr3.8035
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Article ; Online: Long-term management of pediatric psoriasis with ixekizumab: a case report.

Orsini, Diego / Ibba, Luciano / Narcisi, Alessandra / Frascione, Pasquale / Pacifico, Alessia / Valenti, Mario / Costanzo, Antonio / Gargiulo, Luigi

The Journal of dermatological treatment

2023 Volume 34, Issue 1, Page(s) 2198622

Abstract: Psoriasis in pediatric patients is uncommon and the management of moderate-to-severe cases can be challenging. We report the case of a 17-year-old girl who presented with severe plaque psoriasis unresponsive to UVB phototherapy. The Psoriasis Area ... ...

Abstract	Psoriasis in pediatric patients is uncommon and the management of moderate-to-severe cases can be challenging. We report the case of a 17-year-old girl who presented with severe plaque psoriasis unresponsive to UVB phototherapy. The Psoriasis Area Severity Index (PASI) was 18 and the Dermatology Life Quality Index was 24. We decided to prescribe ixekizumab, observing complete skin clearance after only 8 weeks. The patient is still on treatment with no reported adverse events after two years.
MeSH term(s)	Female ; Humans ; Child ; Adolescent ; Antibodies, Monoclonal, Humanized/therapeutic use ; Psoriasis/therapy ; Skin ; Ultraviolet Therapy ; Treatment Outcome ; Severity of Illness Index
Chemical Substances	ixekizumab (BTY153760O) ; Antibodies, Monoclonal, Humanized
Language	English
Publishing date	2023-04-13
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	1036299-x
ISSN	1471-1753 ; 0954-6634
ISSN (online)	1471-1753
ISSN	0954-6634
DOI	10.1080/09546634.2023.2198622
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Article ; Online: SARS-CoV-2: an environmental trigger of Darier's disease?

Orsini, Diego / D'Arino, Andrea / Pigliacelli, Flavia / Iacovelli, Paolo / Pacifico, Alessia / Cota, Carlo / Di Prete, Monia / Maramao, Fabio Stefano

The Journal of dermatological treatment

2023 Volume 34, Issue 1, Page(s) 2242541

MeSH term(s)	Humans ; Darier Disease/etiology ; SARS-CoV-2 ; COVID-19
Language	English
Publishing date	2023-08-02
Publishing country	England
Document type	Journal Article
ZDB-ID	1036299-x
ISSN	1471-1753 ; 0954-6634
ISSN (online)	1471-1753
ISSN	0954-6634
DOI	10.1080/09546634.2023.2242541
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Article ; Online: Stroke pathway performance assessment: a retrospective observational study.

Camporesi, Jacopo / Strumia, Silvia / Di Pilla, Andrea / Paolucci, Matteo / Orsini, Diego / Assorgi, Chiara / Cacciuttolo, Maria Gabriella / Specchia, Maria Lucia

BMC health services research

2023 Volume 23, Issue 1, Page(s) 1391

Abstract: Background and aim: Performance assessment of the Stroke Pathway is a key element in healthcare quality. The aim of this study has been to carry out a retrospective assessment of the Stroke Pathway in a first level Stroke Unit in Italy, analyzing the ... ...

Abstract	Background and aim: Performance assessment of the Stroke Pathway is a key element in healthcare quality. The aim of this study has been to carry out a retrospective assessment of the Stroke Pathway in a first level Stroke Unit in Italy, analyzing the temporal trend of the Stroke Pathway performance and the impact of the COVID-19 pandemic. Methods: A retrospective observational study was carried out analyzing data from 1/01/2010 to 31/12/2020. The following parameters were considered: volume and characteristics of patients with ischemic stroke undergoing intravenous thrombolysis, baseline modified Rankin Scale (mRS) and National Institutes of Health Stroke Scale (NIHSS) scores, Onset-to-Door (OTD), Door-To-Imaging (DTI) and Door-To-Needle (DTN) Times, mRS score 3 months after the ischemic event onset (3 m-mRS) and NIHSS score 24 h after the ischemic event onset (24 h-NIHSS). The study also compared the pre-COVID-19 pandemic period (March-December 2019) with the one immediately following it (March-December 2020). Results: 418 patients were included. Over time, treatment was extended to older patients (mean age from 66.3 to 75.51 years; p = 0.006) and with a higher level of baseline disability (baseline mRS score from 0.22 to 1.22; p = 0.000). A statistically significant reduction over the years was found for DTN, going from 90 min to 61 min (p = 0.000) with also an increase in the number of thrombolysis performed within the "golden hour" - more than 50% in 2019 and more of 60% in 2020. Comparing pre- and during COVID-19 pandemic periods, the number of patients remained almost unchanged, but with a significantly higher baseline disability (mRS = 1.18 vs. 0.72, p = 0.048). The pre-hospital process indicator OTD increased from 88.13 to 118.48 min, although without a statistically significant difference (p = 0.197). Despite the difficulties for hospitals due to pandemic, the hospital process indicators DTI and DTN remained substantially unchanged, as well as the clinical outcome indicators 3 m-mRS, NHISS and 24 h-NHISS. Conclusions: The results of the retrospective assessment of the Stroke Pathway highlighted its positive impact both on hospital processes and patients' outcomes, even during the COVID-19 pandemic, so that the current performance is aligning itself with international goals. Moreover, the analysis showed the need of improvement actions for both hospital and pre-hospital phases. The Stroke Pathway should be improved with the thrombolysis starting in the diagnostic imaging department in order to further reduce the DTN score. Moreover, health education initiatives involving all the stakeholders should be promoted, also by using social media, to increase population awareness on timely recognition of stroke signs and symptoms and emergence medical services usage.
MeSH term(s)	Humans ; Aged ; Fibrinolytic Agents/therapeutic use ; Retrospective Studies ; Brain Ischemia/therapy ; Pandemics ; Thrombolytic Therapy ; Treatment Outcome ; Stroke/diagnosis ; Stroke/epidemiology ; Stroke/drug therapy ; Time-to-Treatment ; COVID-19/epidemiology
Chemical Substances	Fibrinolytic Agents
Language	English
Publishing date	2023-12-11
Publishing country	England
Document type	Observational Study ; Journal Article
ZDB-ID	2050434-2
ISSN	1472-6963 ; 1472-6963
ISSN (online)	1472-6963
ISSN	1472-6963
DOI	10.1186/s12913-023-10343-8
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Article ; Online: Safety of Interleukin Inhibitors in Patients with Plaque Psoriasis and Neoplasm: A Retrospective Study from Two Referral Centers.

Gargiulo, Luigi / Ibba, Luciano / Valenti, Mario / Orsini, Diego / Cristaudo, Antonio / Frascione, Pasquale / Costanzo, Antonio / Narcisi, Alessandra

Clinical drug investigation

2023 Volume 43, Issue 10, Page(s) 807–812

Language	English
Publishing date	2023-09-16
Publishing country	New Zealand
Document type	Letter
ZDB-ID	1220136-4
ISSN	1179-1918 ; 0114-2402 ; 1173-2563
ISSN (online)	1179-1918
ISSN	0114-2402 ; 1173-2563
DOI	10.1007/s40261-023-01306-2
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Article ; Online: Effectiveness of ixekizumab for the treatment of moderate-to-severe plaque psoriasis with involvement of difficult-to-treat areas: A 52-week multicenter retrospective study.

Valenti, Mario / Gargiulo, Luigi / Ibba, Luciano / Cortese, Andrea / Toso, Francesco / Orsini, Diego / Lora, Viviana / Frascione, Pasquale / Sena, Paolo / Carugno, Andrea / Assorgi, Chiara / Costanzo, Antonio / Narcisi, Alessandra

The Journal of dermatology

2024

Abstract: Biological drugs have dramatically changed the approach to treating moderate-to-severe plaque psoriasis, achieving excellent skin clearance and safety outcomes. However, the management of difficult-to-treat areas (e.g., scalp, palms/soles, nails, and ... ...

Abstract	Biological drugs have dramatically changed the approach to treating moderate-to-severe plaque psoriasis, achieving excellent skin clearance and safety outcomes. However, the management of difficult-to-treat areas (e.g., scalp, palms/soles, nails, and genitalia) still represents a challenge in psoriasis treatment. Data in the literature on difficult-to-treat sites are limited and, frequently, no specific analysis is performed during clinical trials. We conducted a 52-week, retrospective study to evaluate the effectiveness of ixekizumab in 120 patients with moderate-to-severe plaque psoriasis of at least one difficult-to-treat area (scalp, palmoplantar surfaces, nails, and genitalia). Ninety-nine patients had scalp psoriasis, 35 had involvement of the palms or soles, 27 were affected by genital psoriasis, and 22 patients reported involvement of the nails. After 1 year of treatment, 96% of patients with scalp involvement, 95.6% of patients with palmoplantar psoriasis, 95.2% of patients with genital psoriasis, and 85% of patients with nail involvement achieved a site-specific Physician's Global Assessment of 0 or 1 (clear or almost clear). No serious adverse events were observed during the study. Our study supports the effectiveness of ixekizumab in plaque psoriasis involving difficult-to-treat sites.
Language	English
Publishing date	2024-01-31
Publishing country	England
Document type	Journal Article
ZDB-ID	800103-0
ISSN	1346-8138 ; 0385-2407
ISSN (online)	1346-8138
ISSN	0385-2407
DOI	10.1111/1346-8138.17115
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Article ; Online: Instrumental evaluation of skin barrier function and clinical outcomes during dupilumab treatment for atopic dermatitis: An observational study.

Cristaudo, Antonio / Pigliacelli, Flavia / Sperati, Francesca / Orsini, Diego / Cameli, Norma / Morrone, Aldo / Mariano, Maria

Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)

2021 Volume 27, Issue 5, Page(s) 810–813

Abstract: Background: Atopic dermatitis (AD) is a chronic, inflammatory skin disease characterized by pruritus, xerosis, and skin barrier dysfunction. Skin barrier alteration is associated with an increase in trans-epidermal water loss (TEWL) and reduction in ... ...

Abstract	Background: Atopic dermatitis (AD) is a chronic, inflammatory skin disease characterized by pruritus, xerosis, and skin barrier dysfunction. Skin barrier alteration is associated with an increase in trans-epidermal water loss (TEWL) and reduction in skin hydration. Dupilumab is a monoclonal antibody targeting interleukin-13 modulating pro-inflammatory signal transduction, which has been approved for moderate to severe AD. The aim of this study is to evaluate the effects of Dupilumab on skin barrier functions, using non-invasive instruments and clinical evaluation. Materials and methods: Thirty patients affected by moderate-severe AD, who had been administered dupilumab, were evaluated by clinical examination and through the instrumental measurements of TEWL and corneometry at the baseline (T0) and 8 weeks (T1) on lesional skin. The clinical evaluation was performed using the Eczema Area and Severity Index (EASI) score. Moreover, a Dermatology Life Quality Index (DLQI) and 7-day numeric rating scale (NRS) questionnaires were administered to each patient. Results: The instrumental parameters of skin barrier recovery confirmed the clinical improvement outcomes with a statistically significant reduction of TEWL at T1. Conclusion: Our data confirm the clinical outcomes already reported in the literature and show that there was an inverse proportional correlation between TEWL levels and clinical severity after 8 weeks of treatment with dupilumab.
MeSH term(s)	Antibodies, Monoclonal, Humanized ; Dermatitis, Atopic/drug therapy ; Eczema ; Humans ; Severity of Illness Index ; Treatment Outcome
Chemical Substances	Antibodies, Monoclonal, Humanized ; dupilumab (420K487FSG)
Language	English
Publishing date	2021-03-02
Publishing country	England
Document type	Journal Article ; Observational Study
ZDB-ID	1229160-2
ISSN	1600-0846 ; 0909-752X ; 1397-1344
ISSN (online)	1600-0846
ISSN	0909-752X ; 1397-1344
DOI	10.1111/srt.13025
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Article ; Online: RNA-based COVID-19 vaccine is not a contraindication to phototherapy: Real-life data on minimal erythema dose changes.

Pacifico, Alessia / Pigatto, Paolo D M / Cristaudo, Antonio / Orsini, Diego / Buja, Alessandra / Linder, Dennis / Grada, Ayman / Damiani, Giovanni

Dermatologic therapy

2022 Volume 35, Issue 4, Page(s) e15337

MeSH term(s)	COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; Contraindications ; Erythema/etiology ; Humans ; Phototherapy ; RNA ; Ultraviolet Therapy
Chemical Substances	COVID-19 Vaccines ; RNA (63231-63-0)
Language	English
Publishing date	2022-02-08
Publishing country	United States
Document type	Letter
ZDB-ID	1354801-3
ISSN	1529-8019 ; 1396-0296
ISSN (online)	1529-8019
ISSN	1396-0296
DOI	10.1111/dth.15337
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