Article ; Online: Correlation between contrast sensitivity and morphological features obtained by OCT in patients with age-related macular degeneration treated with a loading dose of vascular endothelial growth factor inhibitors.
Archivos de la Sociedad Espanola de Oftalmologia
2023 Volume 98, Issue 7, Page(s) 377–385
Abstract: Objective: To determine the correlation between contrast sensitivity and morphological characteristics obtained by Optical Coherence Tomography (OCT) in patients with Age-Related Macular Degeneration treated with a loading dose of vascular endothelial ... ...
| Abstract | Objective: To determine the correlation between contrast sensitivity and morphological characteristics obtained by Optical Coherence Tomography (OCT) in patients with Age-Related Macular Degeneration treated with a loading dose of vascular endothelial growth factor inhibitors (anti-VEGF). Design: This is an ambispective (prospective + retrospective) observational, cross-sectional, and analytical study. Participants: All patients over 55 years of age with Age-Related Macular Degeneration who attended the Retina service of the Ophthalmology department and met the inclusion criteria between March-May 2022. Methods: Data collection was carried out by reviewing the records of patients diagnosed with Age-Related Macular Degeneration of the neovascular variety treated with the loading dose of anti-VEGF. OCT studies obtained by Optovue® iVue80 prior to the application of intravitreal injections of patients who met the inclusion criteria and were currently in the first month after the last dose of anti-VEGF were analyzed. A total of 33 subjects were included, of which 30 continued follow-ups. The subjects underwent a new ophthalmological evaluation and new retinal measurements of the affected eye. Normality tests (Shapiro‒Wilk) were performed where a nonparametric data distribution was demonstrated. Results: A linear regression analysis was performed comparing the logarithmic values of both visual acuity and contrast sensitivity, obtaining a significant relationship between both values after the application of treatment (P = <.0001***). Likewise, correlation was demonstrated between the decrease in contrast sensitivity values and all the characteristics evaluated in the patients' OCT. Conclusions: Antiangiogenesis strategies can lead to better results in global visual function, positively impacting contrast sensitivity. |
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| MeSH term(s) | Humans ; Angiogenesis Inhibitors/therapeutic use ; Contrast Sensitivity ; Cross-Sectional Studies ; Macular Degeneration/diagnostic imaging ; Macular Degeneration/drug therapy ; Prospective Studies ; Retrospective Studies ; Tomography, Optical Coherence/methods ; Vascular Endothelial Growth Factor A/antagonists & inhibitors |
| Chemical Substances | Angiogenesis Inhibitors ; Vascular Endothelial Growth Factor A |
| Language | English |
| Publishing date | 2023-04-07 |
| Publishing country | Spain |
| Document type | Observational Study ; Journal Article |
| ISSN | 2173-5794 |
| ISSN (online) | 2173-5794 |
| DOI | 10.1016/j.oftale.2023.02.005 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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