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  1. Article: Epidemiología del hipotiroidismo congénito en México.

    Vela-Amieva, Marcela / Gamboa-Cardiel, Salvador / Pérez-Andrade, Martha E / Ortiz-Cortés, Joel / González-Contreras, Claudia R / Ortega-Velázquez, Venancio

    Salud publica de Mexico

    2004  Volume 46, Issue 2, Page(s) 141–148

    Abstract: Objective: To describe the epidemiological characteristics of congenital hypothyroidism (CH) in newborns (NB) detected by the Ministry of Health of Mexico (SSA).: Material and methods: A cross-sectional study was conducted. Thyroid stimulating ... ...

    Title translation Epidemiology of congenital hypothyroidism in Mexico.
    Abstract Objective: To describe the epidemiological characteristics of congenital hypothyroidism (CH) in newborns (NB) detected by the Ministry of Health of Mexico (SSA).
    Material and methods: A cross-sectional study was conducted. Thyroid stimulating hormone (TSH) was quantified in 1,379,717 blood samples of NB (from umbilical cord or heel prick), collected in Guthrie cards, between January 2001 and December 2002, in medical units of the SSA. The samples with TSH > or = 15 microUI/ml for cord blood and > or = 10 microUI/ml for heel blood were considered suspicious and were submitted for confirmation by thyroid hormone profile and/or scintigraphy. When the results were positive, the case was registered as confirmed CH and the clinical and demographic data were recorded in specific formats. Statistical analysis was performed using descriptive statistics.
    Results: The prevalence of CH was 4.12 x 10,000 NB, with female predominance (66.84%). Regional variations in the prevalence were observed, the highest in Quintana Roo (8.13 x 10,000 NB) and the lowest in Sinaloa (0.62 x 10,000 NB). Abnormalities included 57.46% of ectopic glands, 35.91% of athyrosis, and 6.63% abnormal thyroid function conditions. The main clinical features were umbilical hernia (43.73%) and jaundice (41.58%). A total of 151 (17.12%) suspicious NB were not confirmed because of incomplete or inaccurate identification data, death of the NB, parent refusal, and change of address.
    Conclusions: CH was present in 1:2,426 NB, with a female predominance (2:1); an ectopic thyroid was the most common finding, and its prominent clinical features were umbilical hernia and jaundice.
    MeSH term(s) Congenital Hypothyroidism ; Cross-Sectional Studies ; Female ; Humans ; Hypothyroidism/blood ; Hypothyroidism/epidemiology ; Infant, Newborn ; Male ; Mexico/epidemiology
    Language Spanish
    Publishing date 2004-05-15
    Publishing country Mexico
    Document type English Abstract ; Journal Article
    ZDB-ID 954220-6
    ISSN 0036-3634
    ISSN 0036-3634
    DOI 10.1590/s0036-36342004000200008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Hipertirotropinemia en recién nacidos mexicanos

    Vela-Amieva Marcela / Hernández-Osorio Crescencio / Gamboa-Cardiel Salvador / González-Contreras Claudia R / Pérez-Andrade Martha Elva / Ortiz-Cortés Joel / Aguirre-Vélez Blanca E

    Salud Pública de México, Vol 45, Iss 4, Pp 269-

    2003  Volume 275

    Abstract: OBJETIVO: Comunicar las diferencias encontradas en los niveles de concentración sanguínea de la hormona estimulante de la tiroides y su posible uso como indicador del estado de suficiencia de yodo en una muestra de recién nacidos mexicanos. MATERIAL Y ... ...

    Abstract OBJETIVO: Comunicar las diferencias encontradas en los niveles de concentración sanguínea de la hormona estimulante de la tiroides y su posible uso como indicador del estado de suficiencia de yodo en una muestra de recién nacidos mexicanos. MATERIAL Y MÉTODOS: De septiembre de 1999 a agosto de 2000 se estudiaron 25 427 recién nacidos en unidades asistenciales de la Secretaría de Salud de cinco estados de la República Mexicana. Se analizaron 8 095 muestras de sangre de talón y 17 332 de cordón umbilical. La sangre fue recolectada en papel filtro y procesada mediante ensayo inmunoenzimático. Para el análisis estadístico se emplearon las pruebas U de Mann-Wittney, y de Kruskal-Wallis. RESULTADOS: Se observó que 9.95% de las muestras de talón y 24.27% de las de cordón presentaron hipertirotropinemia (TSH>5 µUI/ml). CONCLUSIONES: El porcentaje de muestras de hipertirotropinemia observado es mayor del esperado para una población con aporte suficiente de yodo. Este hallazgo pudiera deberse a una deficiencia en la ingesta materna de yodo.
    Keywords tamiz neonatal ; tirotropina ; deficiencia de yodo ; hipotiroidismo congénito ; retardo mental ; México ; Public aspects of medicine ; RA1-1270
    Language English
    Publishing date 2003-01-01T00:00:00Z
    Publisher Instituto Nacional de Salud Pública
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Hipertirotropinemia en recién nacidos mexicanos.

    Vela-Amieva, Marcela / Hernández-Osorio, Crescencio / Gamboa-Cardiel, Salvador / González-Contreras, Claudia R / Pérez-Andrade, Martha Elva / Ortiz-Cortés, Joel / Aguirre-Vélez, Blanca E

    Salud publica de Mexico

    2003  Volume 45, Issue 4, Page(s) 269–275

    Abstract: Objective: To assess the differences in the blood concentration levels of the thyroid stimulating hormone and their possible use as an indicator of iodine sufficiency, in a sample of Mexican newborns.: Material and methods: A cross-sectional study ... ...

    Title translation Hyperthyrotropinemia in Mexican newborns.
    Abstract Objective: To assess the differences in the blood concentration levels of the thyroid stimulating hormone and their possible use as an indicator of iodine sufficiency, in a sample of Mexican newborns.
    Material and methods: A cross-sectional study was conducted from September 1999 to August 2000, among 25,427 Mexican newborns in the Ministry of Health clinics from 5 states. A total of 8,095 heel-prick and 17,332 umbilical cord blood samples were analyzed. Blood samples were collected in filter paper and processed by enzyme-linked immunosorbent assay. The Mann-Whitney U test and the Kruskal-Wallis test were used for statistical analyses.
    Results: Hyperthyrotropinemia was found in 9.95% of heel samples and in 24.27% of umbilical cord samples (TSH > 5 microUl/ml).
    Conclusions: The percentage of hyperthyrotropinemia observed in this study was higher than that expected in a population with sufficient iodine intake; these findings could be due to poor maternal iodine intake.
    MeSH term(s) Cross-Sectional Studies ; Female ; Humans ; Hypothyroidism/blood ; Hypothyroidism/diagnosis ; Hypothyroidism/prevention & control ; Infant, Newborn ; Male ; Mexico ; Neonatal Screening ; Thyrotropin/blood ; Thyrotropin/deficiency
    Chemical Substances Thyrotropin (9002-71-5)
    Language Spanish
    Publishing date 2003-11-19
    Publishing country Mexico
    Document type Comparative Study ; English Abstract ; Journal Article ; Multicenter Study
    ZDB-ID 954220-6
    ISSN 0036-3634
    ISSN 0036-3634
    DOI 10.1590/s0036-36342003000400005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Short report: neonatal screening pilot study of Toxoplasma gondii congenital infection in Mexico.

    Vela-Amieva, Marcela / Cañedo-Solares, Irma / Gutiérrez-Castrellón, Pedro / Pérez-Andrade, Martha / González-Contreras, Claudia / Ortíz-Cortés, Joel / Ortega-Velázquez, Venancio / Galván-Ramírez, Maria de la Luz / Ruiz-García, Matilde / Saltigeral-Simentel, Patrica / Ordaz-Favila, Juan Carlos / Sánchez, Carmen / Correa, Dolores

    The American journal of tropical medicine and hygiene

    2005  Volume 72, Issue 2, Page(s) 142–144

    Abstract: Congenital toxoplasmosis is an obstetric problem in Mexico, but its actual frequency is unknown. Using a network for screening of non-infectious disorders, we performed a pilot study to determine the frequency of IgM antibodies to Toxoplasma gondii in 1, ... ...

    Abstract Congenital toxoplasmosis is an obstetric problem in Mexico, but its actual frequency is unknown. Using a network for screening of non-infectious disorders, we performed a pilot study to determine the frequency of IgM antibodies to Toxoplasma gondii in 1,003 infants (53.1% male, mean +/- SD age = 18.3 +/- 13.0 days, birth weight = 3.116 +/- 0.453 kg) in Mexico City from March to April 2003. Blood samples embedded in filter paper were assayed for IgM antibodies using a capture enzyme-linked immunosorbent assay and results were confirmed by Western blot. Two asymptomatic newborns, one of them premature, had IgM and IgG antibodies in a serum sample taken from both the infant and the mother and were clinically followed. Our data suggest a frequency of approximately two cases of congenital T. gondii infection per 1,000 newborns in Mexico City.
    MeSH term(s) Adult ; Animals ; Antibodies, Protozoan/blood ; Blotting, Western ; Enzyme-Linked Immunosorbent Assay ; Female ; Humans ; Infant, Newborn ; Infectious Disease Transmission, Vertical/prevention & control ; Male ; Mexico/epidemiology ; Pilot Projects ; Prevalence ; Risk Factors ; Toxoplasma/immunology ; Toxoplasmosis, Congenital/epidemiology ; Toxoplasmosis, Congenital/etiology ; Toxoplasmosis, Congenital/prevention & control ; Toxoplasmosis, Congenital/transmission
    Chemical Substances Antibodies, Protozoan
    Language English
    Publishing date 2005-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2942-7
    ISSN 1476-1645 ; 0002-9637
    ISSN (online) 1476-1645
    ISSN 0002-9637
    Database MEDical Literature Analysis and Retrieval System OnLINE

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