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  1. Article ; Online: Assessment of sexual dysfunction in patients with multiple sclerosis: a perspective from neurologist.

    Gaviria-Carrillo, Mariana / Bueno-Florez, Silvia Juliana / Ortiz-Salas, Paola Andrea

    BMC neurology

    2022  Volume 22, Issue 1, Page(s) 372

    Abstract: Background: Sexual dysfunction (SD) is a common comorbidity in people with multiple sclerosis (pwMS). It affects the quality of life and remains an overlooked condition. The objective of this study was to describe how Colombian neurologists assess and ... ...

    Abstract Background: Sexual dysfunction (SD) is a common comorbidity in people with multiple sclerosis (pwMS). It affects the quality of life and remains an overlooked condition. The objective of this study was to describe how Colombian neurologists assess and treat SD and explore the barriers during sexual function evaluation.
    Methods: In this observational cross-sectional study we developed a questionnaire for neurologists with 4 sections (demographic data, evaluation and treatment of SD, and possible reasons for not discussing sexual dysfunction.) It was sent via email to 326 Colombian neurologists. We grouped the answers according to the type of consultation (neurologists from a MS program or no MS program). We described through absolute frequencies and proportions.
    Results: Fifty neurologists answered the survey. 64% stated that they usually study sexual dysfunction in neurological disorders. The main methods employed were private reading (86%) and attending conferences (14%). 5/50 participants have never attend pwMS; the Sect. 2-4 was not answered by them. 29% work in a MS program, all of them asked their patients about sexual function, but 18.75% of physicians working outside an MS program have never asked about it. Main reasons for not talking about sexual dysfunction were lack of knowledge (65.1%), presence of a companion (65.1%) and lack of time (55.8%). 91% of the neurologists reported that their patients usually and frequently ask about sexual function. Neurologists use informal questions to assess sexual function (80%), although 64.4% said that they are aware of SD questionnaires. When sexual dysfunction is detected, 91% of neurologists refer patients to another specialist and 87% do not start any treatment.
    Conclusions: Colombian neurologists are concerned with sexual function in pwMS, however it remains an underdiagnosed an undertreated condition. It is necessary to strengthen knowledge about the diagnosis and treatment of sexual dysfunction in pwMS, for neurologists and patients. It is also imperative to eliminate barriers around the topic and include sexual function evaluation and treatment as the routine care of pwMS.
    MeSH term(s) Humans ; Multiple Sclerosis/complications ; Multiple Sclerosis/epidemiology ; Multiple Sclerosis/therapy ; Neurologists ; Quality of Life ; Sexual Dysfunction, Physiological/diagnosis ; Sexual Dysfunction, Physiological/epidemiology ; Sexual Dysfunction, Physiological/etiology ; Surveys and Questionnaires
    Language English
    Publishing date 2022-09-29
    Publishing country England
    Document type Journal Article ; Observational Study
    ZDB-ID 2041347-6
    ISSN 1471-2377 ; 1471-2377
    ISSN (online) 1471-2377
    ISSN 1471-2377
    DOI 10.1186/s12883-022-02884-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Polycystic ovary syndrome and the new antiepileptic drugs: A systematic review.

    Ortiz Salas, Paola Andrea / Rodríguez, Jesús Hernán / Florez, Silvia Juliana Bueno / Suarez, Fabio Enrique

    Epilepsy research

    2022  Volume 185, Page(s) 106968

    Abstract: Objective: To evaluate the presence of polycystic ovary syndrome (PCOS) in women of reproductive age with the use of antiepileptic drugs.: Methods: A systematic literature review of observational analytical studies (cohort, cross-sectional and case- ... ...

    Abstract Objective: To evaluate the presence of polycystic ovary syndrome (PCOS) in women of reproductive age with the use of antiepileptic drugs.
    Methods: A systematic literature review of observational analytical studies (cohort, cross-sectional and case-control), from January 1966 to January 2021 on PCOS in women of reproductive age with the use of the antiepileptics. The search covered the Cochrane, MEDLINE, Embase and LILACS databases.
    Inclusion criteria: Studies reporting the frequency of PCOS with the antiepileptic drugs in women of reproductive age.
    Exclusion criteria: studies that did not have categorically relevant measurements, those published as abstracts only, and studies of investigational treatment. Data extraction was performed based on the PECOT strategy, considering the method of intervention, methodological quality, and presence of PCOS with the antiepileptic drugs.
    Results: A total of 2043 references were obtained from which 22 articles were selected by title and abstract. Four articles met the inclusion criteria. No articles were found describing the risk of PCOS upon exposure to levetiracetam, felbamate, gabapentin, lacosamide, pregabalin, rufinamide, tiagabine, topiramate, vigabatrin, or zonisamide. Only articles related to oxcarbazepine and lamotrigine were found, in which the frequency of PCOS was like that found in women without epilepsy.
    Conclusions: The anticonvulsants are probably safer, but the risk of developing PCOS associated with the antiepileptics cannot be established, since there are insufficient studies.
    MeSH term(s) Anticonvulsants/adverse effects ; Cross-Sectional Studies ; Female ; Humans ; Lamotrigine ; Levetiracetam ; Polycystic Ovary Syndrome/drug therapy
    Chemical Substances Anticonvulsants ; Levetiracetam (44YRR34555) ; Lamotrigine (U3H27498KS)
    Language English
    Publishing date 2022-06-18
    Publishing country Netherlands
    Document type Journal Article ; Systematic Review
    ZDB-ID 632939-1
    ISSN 1872-6844 ; 0920-1211
    ISSN (online) 1872-6844
    ISSN 0920-1211
    DOI 10.1016/j.eplepsyres.2022.106968
    Database MEDical Literature Analysis and Retrieval System OnLINE

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