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  1. Article ; Online: Safety of Testosterone-Replacement Therapy in Older Men.

    Orwoll, Eric

    The New England journal of medicine

    2023  Volume 389, Issue 2, Page(s) 177–178

    MeSH term(s) Aged ; Humans ; Male ; Testosterone/adverse effects ; Testosterone/therapeutic use ; Hormone Replacement Therapy/adverse effects ; Hormone Replacement Therapy/methods
    Chemical Substances Testosterone (3XMK78S47O)
    Language English
    Publishing date 2023-07-12
    Publishing country United States
    Document type Editorial
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMe2305946
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.34: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Book ; Audio / Video: Atlas of osteoporosis

    Orwoll, Eric S.

    2009  

    Author's details ed.: Eric S. Orwoll
    Keywords Osteoporosis
    Language English
    Size 1 -CD-ROM, 12 cm
    Edition 3. ed.
    Publisher Springer u.a.
    Publishing place New York, N.Y
    Publishing country United States
    Document type Book ; Audio / Video
    HBZ-ID HT015928286
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2009 MO 265 order for loan Magazin

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  3. Book: Atlas of osteoporosis

    Orwoll, Eric S.

    2009  

    Author's details ed.: Eric S. Orwoll
    Keywords Osteoporosis
    Language English
    Size VII, 215 S. : Ill., graph. Darst., 31cm
    Edition 3. ed.
    Publisher Springer u.a.
    Publishing place New York, N.Y
    Publishing country United States
    Document type Book
    Note Includes bibliographical references and index. - Previous ed.: 2003
    HBZ-ID HT015928199
    ISBN 978-1-573-40296-5 ; 978-1-57340-296-5 ; 1-57340-296-6 ; 1-573-40296-6
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    2009 C 38 order for loan Magazin

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  4. Article ; Online: Current and Developing Pharmacologic Agents for Improving Skeletal Health in Adults with Osteogenesis Imperfecta.

    Liu, Winnie / Nicol, Lindsey / Orwoll, Eric

    Calcified tissue international

    2024  

    Abstract: Osteogenesis imperfecta (OI) is a genetic disorder characterized by increased bone fragility largely caused by defects in structure, synthesis, or post-translational processing of type I collagen. Drugs currently used to improve skeletal health in OI ... ...

    Abstract Osteogenesis imperfecta (OI) is a genetic disorder characterized by increased bone fragility largely caused by defects in structure, synthesis, or post-translational processing of type I collagen. Drugs currently used to improve skeletal health in OI were initially developed to treat osteoporosis and clinical trials are ongoing to study their effectiveness in OI adults. Additionally, novel bone-protective agents are in preclinical studies and various phases of OI clinical trials. This review summarizes current knowledge on available pharmacologic agents and current drug trials involving OI participants. A PubMed online database search of all study types published in the English language using the terms "osteogenesis imperfecta," "OI," and "brittle bone disease" was performed in August 2022. Articles screened were restricted to adults. A ClinicalTrials.gov database search of all studies involving "osteogenesis imperfecta" was performed in August 2023. Although clinical trial data are limited, bisphosphonates and teriparatide may be useful in improving bone mineral density. As of yet, no clinical trials are available that adequately evaluate the usefulness of current therapies in reducing fracture risk. Several therapeutics, including teriparatide, setrusumab, anti-TGF-β antibodies, and allogeneic stem cells, are being studied in clinical trials. Preclinical studies involving Dickkopf-1 antagonists present promising data in non-OI bone disease, and could be useful in OI. Research is ongoing to improve therapeutic options for adults with OI and clinical trials involving gene-editing may be possible in the coming decade.
    Language English
    Publishing date 2024-03-12
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 304266-2
    ISSN 1432-0827 ; 0944-0747 ; 0008-0594 ; 0171-967X
    ISSN (online) 1432-0827
    ISSN 0944-0747 ; 0008-0594 ; 0171-967X
    DOI 10.1007/s00223-024-01188-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 317: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  5. Book: Osteoporosis

    Orwoll, Eric S.

    pathophysiology and clinical management

    (Contemporary endocrinology)

    2003  

    Author's details ed. by Eric S. Orwoll
    Series title Contemporary endocrinology
    Keywords Osteoporosis / physiopathology ; Osteoporosis / therapy
    Language English
    Size XI, 614 S. : Ill., graph. Darst.
    Publisher Humana Press
    Publishing place Totowa, NJ
    Publishing country United States
    Document type Book
    HBZ-ID HT013456665
    ISBN 0-89603-933-1 ; 978-0-89603-933-9
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2003 A 798 order for loan Magazin

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  6. Article ; Online: Further Elucidation of the Potential Benefits of Testosterone Therapy in Older Men.

    Orwoll, Eric

    JAMA internal medicine

    2017  Volume 177, Issue 4, Page(s) 459–460

    MeSH term(s) Hormone Replacement Therapy ; Humans ; Hypogonadism ; Male ; Testosterone
    Chemical Substances Testosterone (3XMK78S47O)
    Language English
    Publishing date 2017-02-24
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2699338-7
    ISSN 2168-6114 ; 2168-6106
    ISSN (online) 2168-6114
    ISSN 2168-6106
    DOI 10.1001/jamainternmed.2016.9576
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.119: Show issues Location:
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  7. Book: Osteoporosis in men

    Orwoll, Eric S.

    the effects of gender on skeletal health

    1999  

    Author's details ed. by Eric S. Orwoll
    Language English
    Size XXIV, 582 S. : Ill., graph. Darst.
    Publisher Acad. Press
    Publishing place San Diego u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT010915976
    ISBN 0-12-528640-6 ; 978-0-12-528640-4
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1999 A 5380 order for loan Magazin

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  8. Book: Osteoporosis in men

    Orwoll, Eric S. / Bilezikian, John P. / Vanderschueren, Dirk

    the effects of gender on skeletal health

    2010  

    Author's details Eric S. Orwoll ; John P. Bilezikian ; Dirk Vanderschueren
    Keywords Osteoporosis ; Men ; Sex Factors ; Risk Factors ; Bone and Bones / physiology
    Language English
    Size XV, 741 S., [3] Bl. : Ill., graph. Darst.
    Edition [2. ed.]
    Publisher Elsevier Acad. Press
    Publishing place Amsterdam u.a.
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT016168744
    ISBN 978-0-12-374602-3 ; 0-12-374602-7
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    2009 A 6557 order for loan Magazin

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  9. Article ; Online: Passing the Baton--Harnessing the Full Value of Older Scientists.

    Orwoll, Eric

    The New England journal of medicine

    2016  Volume 374, Issue 26, Page(s) 2514–2517

    MeSH term(s) Age Distribution ; Faculty, Medical/statistics & numerical data ; Financing, Government/trends ; Humans ; National Institutes of Health (U.S.) ; Research Personnel/economics ; Research Personnel/trends ; Research Support as Topic/trends ; Retirement/trends ; United States
    Language English
    Publishing date 2016-06-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMp1603666
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.34: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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  10. Article: BMI and BPH correlate with urinary microbiome diversity and lower urinary tract symptoms in men.

    Bowie, Kate R / Garzotto, Mark / Orwoll, Eric / Karstens, Lisa

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Several studies have identified bacteria and other microbes in the bladder and lower urinary tract in the absence of infection. In women, the urinary microbiome has been associated with lower urinary tract symptoms (LUTS), however, similar studies have ... ...

    Abstract Several studies have identified bacteria and other microbes in the bladder and lower urinary tract in the absence of infection. In women, the urinary microbiome has been associated with lower urinary tract symptoms (LUTS), however, similar studies have not been undertaken in large cohorts of men. Here we examine the urinary microbiome and its association with LUTS in a subset of 500 men aged 65 to 90 years from the Osteoporotic Fractures in Men (MrOS) study. We identified significant associations between benign prostatic hyperplasia (BPH), age, and body mass index (BMI) with several diversity metrics. Our analysis revealed complex relationships between BMI, BPH, LUTS, and alpha diversity which give insight into the intricate dynamics of the urinary microbiome. By beginning to uncover the interrelationships of BPH, BMI, LUTS, and the urinary microbiome, these results can inform future study design to better understand the heterogeneity of the male urinary microbiome.
    Language English
    Publishing date 2023-12-15
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.12.14.571758
    Database MEDical Literature Analysis and Retrieval System OnLINE

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