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Article: How to reduce uncommon but severe transcatheter aortic valve implantation complications: stroke, thrombosis, endocarditis, cognitive decline?

Saia, Francesco / Orzalkiewicz, Mateusz

European heart journal supplements : journal of the European Society of Cardiology

2021 Volume 23, Issue Suppl E, Page(s) E142–E146

Abstract: Transcatheter aortic valve implantation has become a valid alternative to surgical aortic valve replacement for patients with symptomatic severe aortic stenosis, regardless of baseline surgical risk. The incidence of periprocedural complications has ... ...

Abstract	Transcatheter aortic valve implantation has become a valid alternative to surgical aortic valve replacement for patients with symptomatic severe aortic stenosis, regardless of baseline surgical risk. The incidence of periprocedural complications has steadily declined over the years, thanks to technical advancement of transcatheter heart valves, delivery systems, and increased operators' experience. Beyond the most common periprocedural complications, there are a few uncommon but potentially severe complications that more often occur during follow-up, although they may also arise in the periprocedural phase. Stroke, infective endocarditis, valve thrombosis, and cognitive decline are among them. In this brief review, we describe the incidence, predictive factors, and potential preventive measures for those events.
Language	English
Publishing date	2021-10-08
Publishing country	England
Document type	Journal Article
ZDB-ID	1463769-8
ISSN	1554-2815 ; 1520-765X
ISSN (online)	1554-2815
ISSN	1520-765X
DOI	10.1093/eurheartj/suab110
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Article ; Online: Gestione della coronaropatia asintomatica nei pazienti candidati ad impianto transcatetere di valvola aortica.

Orzalkiewicz, Mateusz / Saia, Francesco

Giornale italiano di cardiologia (2006)

2021 Volume 22, Issue 1, Page(s) 53–61

Abstract: Coronary artery disease (CAD) and severe aortic stenosis (AS) often coexist. When significant coronary lesions were found in patients undergoing surgical aortic valve replacement, combined coronary artery bypass grafting was the gold standard of ... ...

Title translation	Management of asymptomatic coronary artery disease in patients undergoing transcatheter aortic valve implantation.
Abstract	Coronary artery disease (CAD) and severe aortic stenosis (AS) often coexist. When significant coronary lesions were found in patients undergoing surgical aortic valve replacement, combined coronary artery bypass grafting was the gold standard of treatment. Differently, the management of concomitant CAD in patients who are candidates for transcatheter aortic valve implantation (TAVI) is a matter of debate. In this review, we discuss the evidence and present the current viewpoints regarding the definition and prognostic implications of CAD in patients undergoing TAVI and the potential role and limitations of invasive functional coronary stenosis assessment in severe AS. We present the challenges of percutaneous coronary intervention (PCI) in this setting, including timing of intervention, completeness of revascularization in the context of the complexity of the disease and the risk associated with the PCI procedure itself. Finally, we mention ongoing trials that should provide some long-awaited answers in this field.
MeSH term(s)	Aortic Valve/surgery ; Aortic Valve Stenosis/surgery ; Coronary Artery Bypass ; Coronary Artery Disease/surgery ; Humans ; Percutaneous Coronary Intervention ; Transcatheter Aortic Valve Replacement/adverse effects ; Treatment Outcome
Language	Italian
Publishing date	2021-02-24
Publishing country	Italy
Document type	Journal Article ; Review
ZDB-ID	2272414-X
ISSN	1972-6481 ; 1827-6806
ISSN (online)	1972-6481
ISSN	1827-6806
DOI	10.1714/3502.34883
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Zs.A 6738: Show issues

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Article ; Online: A novel high-risk aortic root anatomy for right coronary artery occlusion during TAVI.

Orzalkiewicz, Mateusz / Bruno, Antonio G / Saia, Francesco / Palmerini, Tullio

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions

2023 Volume 102, Issue 7, Page(s) 1389–1392

Abstract: Acute coronary occlusion during transcatheter aortic valve implantation (TAVI) is a rare but potentially lethal complication. Main mechanisms are sinus insufficiency or sinus sequestration with well-described risk factors. We present two cases of acute ... ...

Abstract	Acute coronary occlusion during transcatheter aortic valve implantation (TAVI) is a rare but potentially lethal complication. Main mechanisms are sinus insufficiency or sinus sequestration with well-described risk factors. We present two cases of acute right coronary artery occlusion during TAVI with a self-expanding valve in the absence of classical risk factors and propose a novel mechanism.
MeSH term(s)	Humans ; Transcatheter Aortic Valve Replacement/adverse effects ; Aortic Valve/diagnostic imaging ; Aortic Valve/surgery ; Coronary Occlusion/diagnostic imaging ; Coronary Occlusion/etiology ; Coronary Occlusion/therapy ; Aortic Valve Stenosis/diagnostic imaging ; Aortic Valve Stenosis/surgery ; Aortic Valve Stenosis/complications ; Aorta, Thoracic ; Coronary Vessels ; Treatment Outcome
Language	English
Publishing date	2023-10-27
Publishing country	United States
Document type	Case Reports
ZDB-ID	1459995-8
ISSN	1522-726X ; 1522-1946
ISSN (online)	1522-726X
ISSN	1522-1946
DOI	10.1002/ccd.30883
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Article ; Online: Overinflation of balloon-expandable valves for transcatheter treatment of pure noncalcified native aortic regurgitation: How much oversizing is needed and achievable?

Orzalkiewicz, Mateusz / Taglieri, Nevio / Palmerini, Tullio / Saia, Francesco

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions

2022

Abstract: Transcatheter aortic valve implantation (TAVI) in noncalcified pure aortic valve regurgitation is challenging as dedicated valves are not widely available. We present a case series of four inoperable patients who underwent compassionate TAVI for this ... ...

Abstract	Transcatheter aortic valve implantation (TAVI) in noncalcified pure aortic valve regurgitation is challenging as dedicated valves are not widely available. We present a case series of four inoperable patients who underwent compassionate TAVI for this indication at our institution with a balloon-expandable valve. In this context, we analyzed the relevant technical aspects such as the need for larger oversizing of the transcatheter prosthesis and the safety and limits of valve overexpansion.
Language	English
Publishing date	2022-12-21
Publishing country	United States
Document type	Case Reports
ZDB-ID	1459995-8
ISSN	1522-726X ; 1522-1946
ISSN (online)	1522-726X
ISSN	1522-1946
DOI	10.1002/ccd.30529
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Article ; Online: Off-label Use of Balloon-Expandable Transcatheter Valves to Treat Pure Aortic Regurgitation.

Orzalkiewicz, Mateusz / Foroni, Marco / Chietera, Francesco / Bendandi, Francesco / Mazzapicchi, Alessandro / Bruno, Antonio Giulio / Ghetti, Gabriele / Taglieri, Nevio / Marrozzini, Cinzia / Galiè, Nazzareno / Palmerini, Tullio / Saia, Francesco

The American journal of cardiology

2024

Abstract: Transcatheter aortic valve implantation (TAVI) in native pure aortic regurgitation (AR) with off-label use of balloon expandable valves (BEV) has been reported. However, there are scant data regarding optimal oversizing and its safety and our study ... ...

Abstract	Transcatheter aortic valve implantation (TAVI) in native pure aortic regurgitation (AR) with off-label use of balloon expandable valves (BEV) has been reported. However, there are scant data regarding optimal oversizing and its safety and our study assessed BEV oversizing and outcomes of TAVI. Thirteen consecutive tricuspid aortic valve patients undergoing transfemoral TAVIs for pure AR with Sapien BEV at our centre between 2019 and 2023 (69.2% males, mean age 80.8 years, STS 4.0%) were divided into small annulus group (≤618mm
Language	English
Publishing date	2024-04-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	80014-4
ISSN	1879-1913 ; 0002-9149
ISSN (online)	1879-1913
ISSN	0002-9149
DOI	10.1016/j.amjcard.2024.04.030
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Article ; Online: Reply: Can We State That Placing a Stent Is Sufficient?

Palmerini, Tullio / Saia, Francesco / Bruno, Antonio G / Orzalkiewicz, Mateusz / Bartorelli, Antonio L

JACC. Cardiovascular interventions

2020 Volume 13, Issue 11, Page(s) 1382–1383

MeSH term(s)	Coronary Occlusion ; Humans ; Registries ; Stents ; Transcatheter Aortic Valve Replacement ; Treatment Outcome
Language	English
Publishing date	2020-06-01
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	2452157-7
ISSN	1876-7605 ; 1936-8798
ISSN (online)	1876-7605
ISSN	1936-8798
DOI	10.1016/j.jcin.2020.04.024
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Zs.A 6669: Show issues

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Article ; Online: Predictors of bail-out stenting in patients with small vessel disease treated with drug-coated balloon percutaneous coronary intervention.

Ghetti, Gabriele / Bendandi, Francesco / Donati, Francesco / Ciurlanti, Leonardo / Nardi, Elena / Bruno, Antonio Giulio / Orzalkiewicz, Mateusz / Palmerini, Tullio / Saia, Francesco / Marrozzini, Cinzia / Galié, Nazzareno / Taglieri, Nevio

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions

2023 Volume 102, Issue 1, Page(s) 18–24

Abstract: Background: Drug-coated balloons (DCBs) have shown comparable results with drug-eluting stents in small vessel disease (SVD) percutaneous coronary intervention (PCI) in terms of target vessel revascularization and a reduced incidence of myocardial ... ...

Abstract	Background: Drug-coated balloons (DCBs) have shown comparable results with drug-eluting stents in small vessel disease (SVD) percutaneous coronary intervention (PCI) in terms of target vessel revascularization and a reduced incidence of myocardial infarction. However, the relatively high rate of bail-out stenting (BOS) still represents a major drawback of DCB PCI. Aims: The aim of the study was to investigate the clinical, anatomic, and procedural features predictive of BOS after DCB PCI in SVD. Methods: We included all consecutive patients undergoing PCI at our institution between January 2020 and May 2022 who were treated with DCB PCI of a de novo lesion in a coronary vessel with a reference vessel diameter (RVD) between 2.0 and 2.5 mm. Angiographic success was defined as a residual stenosis <30% without flow-limiting dissection. Patients who did not meet these criteria underwent BOS. Results: A total of 168 consecutive patients and 216 coronary stenoses were included. The rate of bail-out stent was 13.9%. On multivariate analysis, DCB/RVD ratio (odds ratio [OR]: 4.39, 95% confidence interval [CI]: 1.71-11.29, p < 0.01), vessel tortuosity (OR: 7.00, 95% CI: 1.66-29.62, p < 0.01), distal vessel disease (OR: 5.66, 95% CI: 2.02-15.83, p < 0.01), and high complexity (Grade C of ACC/AHA classification) coronary stenoses (OR: 6.31, 95% CI: 1.53-26.04, p = 0.01) were independent predictors of BOS. Conclusions: BOS is not an infrequent occurrence in DCB PCI of small vessels and is correlated with vessel tortuosity, distal diffuse vessel disease, higher lesion complexity, and balloon diameter oversizing.
MeSH term(s)	Humans ; Percutaneous Coronary Intervention/adverse effects ; Percutaneous Coronary Intervention/methods ; Coronary Artery Disease/diagnostic imaging ; Coronary Artery Disease/therapy ; Coronary Artery Disease/complications ; Angioplasty, Balloon, Coronary/adverse effects ; Treatment Outcome ; Stents/adverse effects ; Vascular Diseases/complications ; Coronary Stenosis/diagnostic imaging ; Coronary Stenosis/therapy ; Coronary Stenosis/complications ; Coronary Restenosis/etiology ; Coronary Angiography/adverse effects ; Coated Materials, Biocompatible
Chemical Substances	Coated Materials, Biocompatible
Language	English
Publishing date	2023-05-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	1459995-8
ISSN	1522-726X ; 1522-1946
ISSN (online)	1522-726X
ISSN	1522-1946
DOI	10.1002/ccd.30688
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Article ; Online: Coronary ectasia in different scenarios, primarily in myocardial infarction with nonobstructive coronary artery disease.

Ghetti, Gabriele / Chietera, Francesco / Donati, Francesco / Bendandi, Francesco / Minnucci, Matteo / Bruno, Antonio Giulio / Orzalkiewicz, Mateusz / Nardi, Elena / Palmerini, Tullio / Saia, Francesco / Marrozzini, Cinzia / Galié, Nazzareno / Taglieri, Nevio

Journal of cardiovascular medicine (Hagerstown, Md.)

2023 Volume 24, Issue 3, Page(s) 167–171

Abstract: Aims: Several causes have been reported for coronary artery ectasia (CAE), mostly atherosclerosis and tunica media abnormalities. The main aim of the present study was to investigate if CAE extension differs in distinct clinical settings.: Methods: ... ...

Abstract	Aims: Several causes have been reported for coronary artery ectasia (CAE), mostly atherosclerosis and tunica media abnormalities. The main aim of the present study was to investigate if CAE extension differs in distinct clinical settings. Methods: Three hundred and forty-one patients with diagnosis of CAE were identified among 9659 coronary angiographies and divided into four groups according to the patient's admission diagnosis: stable or unstable angina (S-UA), myocardial infarction (MI), aortic disease, aortic valvular disease (AVD). S-UA and MI were subgrouped according to the presence of obstructive coronary artery disease (OCAD). Multivariable logistic regression was used to investigate the relationship between clinical diagnosis and CAE extension as expressed by Markis classification and number of coronary vessels affected by CAE. Results: No significant differences in CAE extension were found among the four groups, in terms of vessels affected by CAE (P = 0.37) or Markis class (P = 0.33). CAE was not related to the extension of OCAD as assessed by the Gensini score, which was higher in MI and S-UA groups (P < 0.01). However, when ischemic patients were sub-divided on the basis of the presence of OCAD, MI without obstructive coronary artery disease (MINOCA) was associated with a higher extension of CAE in terms of Markis class 1 (OR 5.08, 95% CI 1.61-16.04; P < 0.01). Conclusion: The extension of CAE is comparable in patients referred to coronary angiography for different clinical scenarios, including S-UA, MI, aortic disease, and AVD; however, patients with MINOCA were associated with a higher extension of CAE.Graphical abstract: Difference in coronary artery ectasia extension in terms of Markis class severity, respectively, stratified by clinical presentation and obstructive coronary artery disease presence, http://links.lww.com/JCM/A519.
MeSH term(s)	Humans ; Coronary Artery Disease/diagnostic imaging ; Dilatation, Pathologic ; MINOCA ; Myocardial Infarction/diagnostic imaging ; Myocardial Infarction/etiology ; Coronary Angiography ; Coronary Vessels/diagnostic imaging ; Coronary Aneurysm
Language	English
Publishing date	2023-02-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	2223461-5
ISSN	1558-2035 ; 1558-2027
ISSN (online)	1558-2035
ISSN	1558-2027
DOI	10.2459/JCM.0000000000001445
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Zs.A 5210: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 559: Show issues

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Article ; Online: Transcatheter Aortic Valve Replacement for Pure Aortic Regurgitation in a Large and Noncalcified Annulus.

Orzalkiewicz, Mateusz / Bruno, Antonio Giulio / Taglieri, Nevio / Ghetti, Gabriele / Marrozzini, Cinzia / Galiè, Nazzareno / Palmerini, Tullio / Saia, Francesco

JACC. Cardiovascular interventions

2021 Volume 14, Issue 19, Page(s) e271–e273

MeSH term(s)	Aortic Valve/diagnostic imaging ; Aortic Valve/surgery ; Aortic Valve Insufficiency/diagnostic imaging ; Aortic Valve Insufficiency/etiology ; Aortic Valve Insufficiency/surgery ; Aortic Valve Stenosis/diagnostic imaging ; Aortic Valve Stenosis/surgery ; Heart Valve Prosthesis ; Humans ; Prosthesis Design ; Transcatheter Aortic Valve Replacement/adverse effects ; Treatment Outcome
Language	English
Publishing date	2021-09-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2452157-7
ISSN	1876-7605 ; 1936-8798
ISSN (online)	1876-7605
ISSN	1936-8798
DOI	10.1016/j.jcin.2021.08.010
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Article ; Online: Coronary Stent Infection and Subsequent Abscessualization Causing Dislocation in Extravascular Position.

Bendandi, Francesco / Bruno, Antonio Giulio / Donati, Francesco / Ciurlanti, Leonardo / Orzalkiewicz, Mateusz / Palmerini, Tullio / Marrozzini, Cinzia / Saia, Francesco / Galiè, Nazzareno / Martin Suarez, Sofia / Taglieri, Nevio / Ghetti, Gabriele

JACC. Cardiovascular interventions

2022 Volume 15, Issue 16, Page(s) e189–e191

MeSH term(s)	Coronary Artery Bypass ; Coronary Artery Disease ; Humans ; Percutaneous Coronary Intervention/adverse effects ; Stents ; Treatment Outcome
Language	English
Publishing date	2022-07-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	2452157-7
ISSN	1876-7605 ; 1936-8798
ISSN (online)	1876-7605
ISSN	1936-8798
DOI	10.1016/j.jcin.2022.05.048
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