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Article ; Online: Phytochemical Screening by LC-ESI-MS/MS and Effect of the Ethyl Acetate Fraction from Leaves and Stems of Jatropha macrantha Müll Arg. on Ketamine-Induced Erectile Dysfunction in Rats

Johnny Aldo Tinco-Jayo / Enrique Javier Aguilar-Felices / Edwin Carlos Enciso-Roca / Jorge Luis Arroyo-Acevedo / Oscar Herrera-Calderon

Molecules, Vol 27, Iss 115, p

2022 Volume 115

Abstract: Jatropha macrantha Müll Arg. L is also known as “huanarpo macho” and used in the Peruvian traditional medicine as an aphrodisiac and erectile dysfunction (ED). The aim of this study was to determine the phytochemical constituents in leaves and stems ... ...

Abstract	Jatropha macrantha Müll Arg. L is also known as “huanarpo macho” and used in the Peruvian traditional medicine as an aphrodisiac and erectile dysfunction (ED). The aim of this study was to determine the phytochemical constituents in leaves and stems ethyl acetate fraction (LEAF and SEAF) of J. macrantha and to compare the antioxidant activity and the ameliorative effect on ketamine-induced erectile dysfunction in rats. The phytochemical constituents were determined by LC-ESI-MS/MS, the total phenolic compounds and total flavonoids (TPC and TF) by Folin-Ciocalteu and aluminum chloride, respectively. The antioxidant activity was determined by DPPH, ABTS, and FRAP assays. Experimental groups were divided as follows: I: negative control; II: positive control (ketamine at 50 mg/ kg/d); III: sildenafil 5 mg/kg; IV, V, VI: LEAF at 25, 50 and 100 mg/kg, respectively, and VII, VIII, IX: SEAF at 25, 50, and 100 mg/kg, respectively. The phytochemical analysis revealed the presence mainly of coumarins, flavonoids, phenolic acids, and terpenes. TPC of LEAF and SEAF were 359 ± 5.21 mg GAE/g and 306 ± 1.93 mg GAE/g, respectively; TF in LEAF and SEAF were 23.7 ± 0.80 mg EQ/g, and 101 ± 1.42 mg EQ/g, respectively. The DPPH, ABTS, FRAP in SEAF were 647 ± 3.27; 668 ± 2.30; and 575 ± 2.86 μmol TE/g, respectively, whilst LEAF showed 796 ± 3.15; 679 ± 0.85; and 806 ± 3.42 μmol TE/g, respectively. Regarding sexual behavior, LEAF showed a better effect in mount frequency, intromission frequency, ejaculation frequency, mount latency, intromission latency, ejaculatory latency, and post ejaculatory latency than SEAF. As conclusion, LEAF of J. macrantha at 50 mg/kg showed a better effect on sexual behavior in male rats with erectile dysfunction than SEAF but not higher than sildenafil.
Keywords	antioxidant agent ; aphrodisiac ; liquid chromatography ; huanarpo ; sexual behavior ; experimental model ; Organic chemistry ; QD241-441
Subject code	590
Language	English
Publishing date	2022-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Histopathological evaluation of Senecio rhizomatus Rusby in 7,12-dimethylbenz(α) anthracene-induced breast cancer in female rats

Jorge Luis Arroyo-Acevedo / Oscar Herrera-Calderon / Juan Pedro Rojas-Armas / Roberto Chávez-Asmat / James Calva / Tapan Behl

Veterinary World, Vol 14, Iss 3, Pp 569-

2021 Volume 577

Abstract: Background and Aim: Senecio rhizomatus Rusby (SrR) is a medicinal plant of the Asteraceae family and traditionally consumed as infusion in the Andean region from Peru for inflammatory disorders. This study aimed to determine the histopathological changes ...

Abstract	Background and Aim: Senecio rhizomatus Rusby (SrR) is a medicinal plant of the Asteraceae family and traditionally consumed as infusion in the Andean region from Peru for inflammatory disorders. This study aimed to determine the histopathological changes afforded by SrR in 7, 12-dimethylbenz[α]anthracene (DMBA)-induced breast cancer (BC) in rats. Materials and Methods: An ethanolic extract of SrR aerial parts was prepared by maceration with 96% ethanol, and the chemical components were identified by gas chromatography coupled to mass spectrometry; the antioxidant activity was determined by 1,1-diphenyl-2-picril-hidrazil (DPPH) assay; and the acute toxicity was assessed according to the OCED 423 guidelines. In a pharmacological study, 30 female Holztman rats were distributed randomly into five groups, as follows. Group I: Negative control (physiological serum, 2 mL/kg); Group II. DMBA (80 mg/Kg body weight); and Groups III, IV, and V: DMBA + ethanol extract of SrR at doses of 10, 100, and 200 mg/kg, respectively. Results: The antioxidant activity of the SrR extract against DPPH was 92.50% at 200 μg/mL. The oral administration of SrR at doses of 50, 300, 2000, and 5000 mg/kg did not show any clinical evidence of toxicity or occurrence of death. The groups that received SrR presented a lower frequency of tumors and a cumulative tumor volume compared with the DMBA group (p<0.05); the DMBA group exhibited a higher incidence of necrosis and moderate mitosis, up to 66.67% and 100.00%, respectively. Finally, infiltrating carcinoma with extensive tumor necrosis was evidenced. Conclusion: In experimental conditions, the ethanolic extract of SrR had a protective effect in DMBA-induced BC in female rats. Furthermore, the antioxidant activity of its main phytochemicals could be responsible for the effect observed, and SrR seems to be a safe extract in the preclinical phase.
Keywords	breast cancer ; carcinogenic ; experimental pharmacology ; phytotherapy ; senecio rhizomatus ; Animal culture ; SF1-1100 ; Veterinary medicine ; SF600-1100
Subject code	616
Language	English
Publishing date	2021-03-01T00:00:00Z
Publisher	Veterinary World
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A bibliometric analysis of the scientific production related to “zero hunger” as a sustainable development goal

Oscar Herrera-Calderon / Ricardo Ángel Yuli-Posadas / Gilmar Peña-Rojas / Vidalina Andía-Ayme / Renán Dilton Hañari-Quispe / Orlando Gregorio-Chaviano

Agriculture & Food Security, Vol 10, Iss 1, Pp 1-

trends of the pacific alliance towards 2030

2021 Volume 15

Abstract: Abstract Background In 2015, The United Nations (UN) established 17 Sustainable Development Goals (SDGs) by 2030. In Latin America, the Pacific Alliance is integrated by Chile, Colombia, Peru, and Mexico, which the scientific activity is focused on the ... ...

Abstract	Abstract Background In 2015, The United Nations (UN) established 17 Sustainable Development Goals (SDGs) by 2030. In Latin America, the Pacific Alliance is integrated by Chile, Colombia, Peru, and Mexico, which the scientific activity is focused on the scientific production from research and academic institutions. In this study, the main goal was to analyze the scientific production (2015–2019) in the Pacific Alliance related to “zero hunger” as SDG. The bibliometric analysis of the scientific literature was carried out using the Scopus database with search terms related to zero hunger and validated by Elsevier. We analyzed the annual production of original articles, productive journals, leading institutions, funding agencies, authors, and the most influential original. Results Our results showed that the Pacific Alliance produced 2215 (81.0%) original articles, which is the fraction of non-excluded outputs with an annual growth rate of 12.62%, Mexico was the leading country, Nutrición Hospitalaria was the most active journal, and The Universidad Autónoma de Mexico was the leading institution and CONACYT as the leading funding institution. Conclusion As conclusion, the scientific production of the Pacific Alliance is showing positive substantial changes, which reflects the main research themes related to zero hunger, such as food security, sustainable agriculture, and malnutrition to achieve this SDG by 2030.
Keywords	VOSviewer ; Bibliometric indicators ; Science mapping analysis ; Scientometric ; Zero hunger ; Sustainable development ; Agriculture ; S ; Nutrition. Foods and food supply ; TX341-641
Subject code	001
Language	English
Publishing date	2021-09-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Investigating Potential Inhibitory Effect of Uncaria tomentosa (Cat’s Claw) against the Main Protease 3CLpro of SARS-CoV-2 by Molecular Modeling

Andres F. Yepes-Pérez / Oscar Herrera-Calderon / José-Emilio Sánchez-Aparicio / Laura Tiessler-Sala / Jean-Didier Maréchal / Wilson Cardona-G

Evidence-Based Complementary and Alternative Medicine, Vol

2020 Volume 2020

Abstract: COVID-19 is a disease caused by severe acute respiratory syndrome coronavirus 2. Presently, there is no effective treatment for COVID-19. As part of the worldwide efforts to find efficient therapies and preventions, it has been reported the crystalline ... ...

Abstract	COVID-19 is a disease caused by severe acute respiratory syndrome coronavirus 2. Presently, there is no effective treatment for COVID-19. As part of the worldwide efforts to find efficient therapies and preventions, it has been reported the crystalline structure of the SARS-CoV-2 main protease Mpro (also called 3CLpro) bound to a synthetic inhibitor, which represents a major druggable target. The druggability of Mpro could be used for discovering drugs to treat COVID-19. A multilevel computational study was carried out to evaluate the potential antiviral properties of the components of the medicinal herb Uncaria tomentosa (Cat’s claw), focusing on the inhibition of Mpro. The in silico approach starts with protein-ligand docking of 26 Cat’s claw key components, followed by ligand pathway calculations, molecular dynamics simulations, and MM-GBSA calculation of the free energy of binding for the best docked candidates. The structural bioinformatics approaches led to identification of three bioactive compounds of Uncaria tomentosa (speciophylline, cadambine, and proanthocyanidin B2) with potential therapeutic effects by strong interaction with 3CLpro. Additionally, in silico drug-likeness indices for these components were calculated and showed good predicted therapeutic profiles of these phytochemicals. Our findings suggest the potential effectiveness of Cat’s claw as complementary and/or alternative medicine for COVID-19 treatment.
Keywords	Other systems of medicine ; RZ201-999 ; covid19
Subject code	540
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: GC-MS Profile, Antioxidant Activity, and In Silico Study of the Essential Oil from Schinus molle L. Leaves in the Presence of Mosquito Juvenile Hormone-Binding Protein (mJHBP) from Aedes aegypti

Oscar Herrera-Calderon / Haydee Chavez / Edwin Carlos Enciso-Roca / Pablo Williams Común-Ventura / Renan Dilton Hañari-Quispe / Linder Figueroa-Salvador / Eddie Loyola Loyola-Gonzales / Josefa Bertha Pari-Olarte / Nada H. Aljarba / Saad Alkahtani / Gaber El-Saber Batiha

BioMed Research International, Vol

2022 Volume 2022

Abstract: Schinus molle is a medicinal plant used as an anti-inflammatory and for rheumatic pain in the traditional medicine of Peru. On the other hand, Aedes aegypti is the main vector of several tropical diseases and the transmitter of yellow fever, chikungunya, ...

Abstract	Schinus molle is a medicinal plant used as an anti-inflammatory and for rheumatic pain in the traditional medicine of Peru. On the other hand, Aedes aegypti is the main vector of several tropical diseases and the transmitter of yellow fever, chikungunya, malaria, dengue, and Zika virus. In this study, the aim was to investigate the antioxidant activity in vitro and the insecticidal activity in silico, in the presence of the mosquito juvenile hormone-binding protein (mJHBP) from Aedes aegypti, of the essential oil from S. molle leaves. The volatile phytochemicals were analyzed by gas chromatography-mass spectrometry (GC-MS), and the profile antioxidants were examined by DPPH, ABTS, and FRAP assays. The evaluation in silico was carried out on mJHBP (PDB: 5V13) with an insecticidal approach. The results revealed that EO presented as the main volatile components to alpha-phellandrene (32.68%), D-limonene (12.59%), and beta-phellandrene (12.24%). The antioxidant activity showed values for DPPH=11.42±0.08 μmol ET/g, ABTS=134.88±4.37 μmol ET/g, and FRAP=65.16±1.46 μmol ET/g. Regarding the insecticidal approach in silico, alpha-muurolene and gamma-cadinene had the best biding energy on mJHBP (ΔG=−9.7 kcal/mol), followed by beta-cadinene (ΔG=−9.5 kcal/mol). Additionally, the volatile components did not reveal antioxidant activity, and its potential insecticidal effect would be acting on mJHBP from A. aegypti.
Keywords	Medicine ; R
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The Hydroalcoholic Extract of Uncaria tomentosa (Cat’s Claw) Inhibits the Infection of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) In Vitro

Andres F. Yepes-Perez / Oscar Herrera-Calderón / Cristian A. Oliveros / Lizdany Flórez-Álvarez / María I. Zapata-Cardona / Lina Yepes / Wbeimar Aguilar-Jimenez / María T. Rugeles / Wildeman Zapata

Evidence-Based Complementary and Alternative Medicine, Vol

2021 Volume 2021

Abstract: The coronavirus disease 2019 (COVID-19) has become a serious problem for public health since it was identified in the province of Wuhan (China) and spread around the world producing high mortality rates and economic losses. Nowadays, the WHO recognizes ... ...

Abstract	The coronavirus disease 2019 (COVID-19) has become a serious problem for public health since it was identified in the province of Wuhan (China) and spread around the world producing high mortality rates and economic losses. Nowadays, the WHO recognizes traditional, complementary, and alternative medicine for treating COVID-19 symptoms. Therefore, we investigated the antiviral potential of the hydroalcoholic extract of Uncaria tomentosa stem bark from Peru against SARS-CoV-2 in vitro. The antiviral activity of U. tomentosa against SARS-CoV-2 in vitro was assessed in Vero E6 cells using cytopathic effect (CPE) and plaque reduction assay. After 48 h of treatment, U. tomentosa showed an inhibition of 92.7% of SARS-CoV-2 at 25.0 μg/mL (p<0.0001) by plaque reduction assay on Vero E6 cells. In addition, U. tomentosa induced a reduction of 98.6% (p=0.02) and 92.7% (p=0.03) in the CPE caused by SARS-CoV-2 on Vero E6 cells at 25 μg/mL and 12.5 μg/mL, respectively. The EC50 calculated for the U. tomentosa extract by plaque reduction assay was 6.6 μg/mL (4.89–8.85 μg/mL) for a selectivity index of 4.1. The EC50 calculated for the U. tomentosa extract by TCID50 assay was 2.57 μg/mL (1.05–3.75 μg/mL) for a selectivity index of 10.54. These results showed that U. tomentosa, known as cat's claw, has an antiviral effect against SARS-CoV-2, which was observed as a reduction in the viral titer and CPE after 48 h of treatment on Vero E6 cells. Therefore, we hypothesized that U. tomentosa stem bark could be promising in the development of new therapeutic strategies against SARS-CoV-2.
Keywords	Other systems of medicine ; RZ201-999
Subject code	570
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Phytochemical Constituents and Ameliorative Effect of the Essential Oil from Annona muricata L. Leaves in a Murine Model of Breast Cancer

Juan Pedro Rojas-Armas / Jorge Luis Arroyo-Acevedo / Miriam Palomino-Pacheco / José Manuel Ortiz-Sánchez / James Calva / Hugo Jesus Justil-Guerrero / Americo Castro-Luna / Norma Ramos-Cevallos / Edwin César Cieza-Macedo / Oscar Herrera-Calderon

Molecules, Vol 27, Iss 1818, p

2022 Volume 1818

Abstract: Annona muricata leaves are traditionally used as an anticancer plant in the world. The aim of this study was to evaluate the ameliorative effect of the essential oil from Annona muricata leaves (EOAm) in an experimental model of breast cancer and to ... ...

Abstract	Annona muricata leaves are traditionally used as an anticancer plant in the world. The aim of this study was to evaluate the ameliorative effect of the essential oil from Annona muricata leaves (EOAm) in an experimental model of breast cancer and to determine the volatile constituents with gas chromatography-mass spectrometry (GC-MS). Thirty female rats were assigned to five groups: the control group; the DMBA (7,12-dimethylbenz[α]anthracene) group; and three groups received daily EOAm doses of 50, 100, and 200 mg/kg/day, plus DMBA, respectively. After 13 weeks of treatment, tumors were analyzed pathologically and biochemical markers in serum were noted. As a result, in GC-MS analysis, 40 compounds were identified and 4 of them were abundant: Z-caryophyllene (40.22%), followed by α-selinene (9.94%), β-pinene (8.92%), and β-elemene (7.48%). Furthermore, EOAm in a dose-dependent form produced a reduction in tumor frequency and the accumulated tumor volume was reduced by 50% and 71% with doses of 100 and 200 mg/kg, respectively. Serum levels of reduced glutathione (GSH) increased and malondialdehyde (MDA) decreased significantly compared to the DMBA group. Serum levels of vascular endothelial growth factor (VEGF) decreased significantly from 70.75 ± 7.15 pg/mL in the DMBA group to 46.50 ± 9.00 and 34.13 ± 11.50 pg/mL in groups treated with doses of 100 and 200 mg/kg, respectively. This study concludes that the EOAm leaves showed an ameliorative effect in a murine model of breast cancer.
Keywords	antitumor ; medicinal plant ; volatile oil ; monoterpenes ; sesquiterpenes ; guanábana ; Organic chemistry ; QD241-441
Subject code	571
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Equivalencia terapéutica de tabletas de diazepam dispensadas en la ciudad de Ica, Perú

Oscar Herrera-Calderon / Miguel Grande-Ortiz

Revista Médica Herediana, Vol 23, Iss 3, Pp 154-

2012 Volume 159

Abstract: Objetivos: Determinar la equivalencia terapéutica in vitro de tres formulaciones de diazepam 10 mg tabletas, para establecer su intercambiabilidad con el medicamento de referencia original. Material y métodos: Estudio descriptivo, comparativo, realizado ... ...

Abstract	Objetivos: Determinar la equivalencia terapéutica in vitro de tres formulaciones de diazepam 10 mg tabletas, para establecer su intercambiabilidad con el medicamento de referencia original. Material y métodos: Estudio descriptivo, comparativo, realizado en junio del 2010, utilizando tres medicamentos genéricos dispensados en la ciudad de Ica y el medicamento original de referencia: Diazepam (Valium®) de laboratorios Roche. Se determinaron los perfiles de disolución efectuados en medios similares a pH fisiológicos del organismo según lo señalado por la OMS (Reporte Técnico 937). Para establecer la equivalencia terapéutica se empleó el factor de similitud (f2), considerando que dos formulaciones son equivalentes terapéuticos in vitro si los valores están comprendidos entre 50 y 100. Resultados: Los medicamentos evaluados presentaron a pH 1,2 una disolución muy rápida, sin embargo las tres formulaciones de prueba y el de referencia presentaron a pH 4,5 y pH 6,8 una disolución lenta con valores f2 a pH 4,5: Genérico A (f2 = 76,0); Genérico B (f2 = 68,9); Genérico C (f2 = 30,5); y a pH 6,8: Genérico A (f2 = 60,6); Genérico B (f2 = 78,2); Genérico C (f2 =20,4). Conclusiones: Según los valores f2 encontrados para las tres formulaciones de diazepam el medicamento genérico C (genérico nacional) no es equivalente al medicamento de referencia dado que no se pudo demostrar su intercambiabilidad, la que si se logró establecer para los medicamentos genéricos A y B.
Keywords	Equivalencia terapéutica ; diazepam ; OMS ; Medicine ; R
Language	Spanish
Publishing date	2012-07-01T00:00:00Z
Publisher	Universidad Peruana Cayetano Heredia
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Phytochemical screening, antioxidant activity and analgesic effect of Waltheria ovata Cav. roots in mice

Oscar Herrera-Calderon / Edwin Enciso-Roca / Bertha Pari-Olarte / Jorge Arroyo-Acevedo

Asian Pacific Journal of Tropical Disease, Vol 6, Iss 12, Pp 1000-

2016 Volume 1003

Abstract: Objective: To determine the phytochemical screening, antioxidant activity and analgesic effect of crude ethanol extract of Waltheria ovata (W. ovata) Cav. root in mice. Methods: Phytochemical screening was developed by color or the precipitate formation. ...

Abstract	Objective: To determine the phytochemical screening, antioxidant activity and analgesic effect of crude ethanol extract of Waltheria ovata (W. ovata) Cav. root in mice. Methods: Phytochemical screening was developed by color or the precipitate formation. The evaluation of antioxidant activity and total phenolic content were assessed using 2,2- diphenyl-1-picrylhydrazyl and Folin-Ciocalteu’s reagent, respectively. The analgesic effect was determined by acetic acid and formalin test. Different doses of W. ovata (50, 150, 300 and 500 mg/kg body weight) were administered p.o. to various groups of mice. Results: Phytochemical screening confirmed the presence of phenolic compounds, flavonoids, tannins, saponins, terpenoids and steroids. The antioxidant activity showed 25% for 0.1 µg/ mL and was significantly higher (P < 0.01) than trolox and vitamin C, meanwhile, the total phenolic content (gallic acid equivalent) was 2 200 mg/g of dry extract. W. ovata demonstrated an independent analgesic effect in different experimental models, like, acetic acid (72.51%, P < 0.01) and formalin (first phase: 58.6%, P < 0.01; second phase: 91.5%, P < 0.01, respectively) at dose of 300 mg/kg, similar to diclofenac (5 mg/kg) and morphine (30 mg/kg), respectively. Conclusions: W. ovata root’s crude ethanol extract showed strong antioxidant activity and high phenolic content. The analgesic effect was demonstrated in two experimental models of pain implying that both peripheral and central mechanisms were involved. This might be due to the presence of various phytochemicals in the extract.
Keywords	Waltheria ovata ; Antioxidant ; Writhing test ; Formalin ; Phytochemical screening ; Medicine ; R ; Arctic medicine. Tropical medicine ; RC955-962
Language	English
Publishing date	2016-12-01T00:00:00Z
Publisher	Asian Pacific Journal of Tropical Disease Editorial Office
Document type	Article ; Online
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Article ; Online: Anticonvulsant effect of ethanolic extract of Cyperus articulatus L. leaves on pentylenetetrazol induced seizure in mice

Oscar Herrera-Calderon / Rocio Santiváñez-Acosta / Bertha Pari-Olarte / Edwin Enciso-Roca / Vicente Martin Campos Montes / Jorge Luis Arroyo Acevedo

Journal of Traditional and Complementary Medicine, Vol 8, Iss 1, Pp 95-

2018 Volume 99

Abstract: Cyperus articulatus (CA) rhizomes have demonstrated different properties on nervous system. However, the leaves still have not studied to treat epilepsy. The aim of this study was to determine the effect of CA ethanolic extract on pentylenetetrazol (PTZ) ...

Abstract	Cyperus articulatus (CA) rhizomes have demonstrated different properties on nervous system. However, the leaves still have not studied to treat epilepsy. The aim of this study was to determine the effect of CA ethanolic extract on pentylenetetrazol (PTZ) induced seizures in mice as well as measuring its antioxidant activity in vivo and in vitro. Mice were divided into five groups: (1) control (PTZ 80 mg/kg; i.p.), (2) PTZ-Diazepam (1 mg/kg; i.p.), (3–5) PTZ-CA 50, PTZ-CA 150 and PTZ-CA 300 (50, 150 and 300 mg/kg of CA extract, 30 min prior to each PTZ injection). The PTZ-CA 150 group showed lower seizure scores (P < 0.01), latency (P < 0.01), frequency (P < 0.01) and duration (P < 0.01) than control group. The antioxidant activity of CA extract scavenged DPPH radical showed IC 50 = 16.9 ± 0.1 μg/mL and TEAC = 2.28 ± 0.08, mmol trolox/g of extract, the content of gamma amino butyric acid (GABA) and malondialdehyde (MDA) were significantly high (P < 0.01) at dose of 150 mg/kg (82 ± 1.2 ng/g tissue; 1.0 ± 2.2 mol/g tissue, respectively). The present research demonstrated that CA extract possesses a potential effect to prevent PTZ induced seizures, antioxidant activity in addition to increase GABA levels.
Keywords	Pentylenetetrazol ; Anticonvulsant ; Cyperus articulatus ; Antioxidant ; Medicine ; R
Language	English
Publishing date	2018-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
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