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  1. Article ; Online: Eosinophil: An innate immune cell with anti-filarial vaccine and biomarker potential.

    Kwarteng, Alexander / Mensah, Caleb / Osei-Poku, Priscilla

    Health science reports

    2023  Volume 6, Issue 6, Page(s) e1320

    Abstract: Background: Filarial infections continue to pose a great challenge in endemic countries. One of the central goals in the fight against human filarial infections is the development of strategies that will lead to the inhibition of microfilariae (mf) ... ...

    Abstract Background: Filarial infections continue to pose a great challenge in endemic countries. One of the central goals in the fight against human filarial infections is the development of strategies that will lead to the inhibition of microfilariae (mf) transmission. Keeping mf under a certain threshold within endemic populations will stop transmission and eliminate the infection.
    Method: A narrative review was carried out to identify the possibilities and limitations of exploring the use of eosinophil responses as an anti-filarial vaccine, and biomarker for the detection of filarial infections. An extensive literature search was performed in online scientific databases including PubMed Central, PubMed, BioMed Central, with the use of predefined search terms.
    Results: A better understanding of the parasite-host interactions will lead to the development of improved and better treatment or vaccine strategies that could eliminate filariasis as soon as possible. Highlighted in this review is the explorative use of eosinophil-producing CLC/Galectin-10 as a potential biomarker for filarial infections. Also discussed are some genes, and pathways involved in eosinophil recruitments that could be explored for anti-filarial vaccine development.
    Conclusion: In this short communication, we discuss how eosinophil-regulated genes, pathways, and networks could be critical in providing more information on how reliably a front-line immune player could be exploited for anti-filarial vaccine development and early infection biomarker.
    Language English
    Publishing date 2023-06-05
    Publishing country United States
    Document type Journal Article
    ISSN 2398-8835
    ISSN (online) 2398-8835
    DOI 10.1002/hsr2.1320
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Use of medicinal plants as a remedy against lymphatic filariasis: Current status and future prospect.

    Fordjour, Fatima A / Osei-Poku, Priscilla / Genfi, Afua K A / Ainooson, Kwaw G / Amponsah, Kingsley / Arthur, Patrick K / Stephenson, G Richard / Kwarteng, Alexander

    Health science reports

    2023  Volume 6, Issue 5, Page(s) e1295

    Abstract: Despite the successes achieved so far with the Global Programme to Eliminate Lymphatic Filariasis, there is still an appreciable number of lymphatic filarial patients who need alternative treatment and morbidity management strategies. The ... ...

    Abstract Despite the successes achieved so far with the Global Programme to Eliminate Lymphatic Filariasis, there is still an appreciable number of lymphatic filarial patients who need alternative treatment and morbidity management strategies. The unresponsiveness of some cohorts to the drugs used in the mass drug administration program is currently raising a lot of questions and this needs urgent attention. Natural medicinal plants have a long-standing history of being effective against most disease conditions. Countries such as India have been able to integrate their natural plant remedies into the treatment of lymphatic filarial conditions, and the results are overwhelmingly positive. Components of
    Language English
    Publishing date 2023-05-27
    Publishing country United States
    Document type Journal Article
    ISSN 2398-8835
    ISSN (online) 2398-8835
    DOI 10.1002/hsr2.1295
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Inter-library loan at ZB MED

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  3. Article ; Online: Knowledge and perceptions of lymphatic filariasis patients in selected hotspot endemic communities in southern Ghana.

    Kwarteng, Alexander / Kenyon, Kristi Heather / Opoku Asiedu, Samuel / Garcia, Regiane / Kini, Priscilla / Osei-Poku, Priscilla / Kwarteng, Efiba Senkyire / Amewu, Emmanuel Kobla Atsu

    PLOS global public health

    2023  Volume 3, Issue 10, Page(s) e0002476

    Abstract: Lymphatic filariasis (LF) is a mosquito-borne neglected tropical disease that is one of the leading global causes of permanent disability. To date, LF interventions have been largely biomedical, focusing on drug treatments to disrupt parasite ... ...

    Abstract Lymphatic filariasis (LF) is a mosquito-borne neglected tropical disease that is one of the leading global causes of permanent disability. To date, LF interventions have been largely biomedical, focusing on drug treatments to disrupt parasite transmission and manage disease morbidity. Although important, these Mass Drug Administration (MDA) programs neglect the significance of socio-economic burden to the health of LF patients, which are compounded by social stigmatization, discrimination and associated depressive illnesses. The MDA program also typically fails to engage with local community beliefs and perceptions of LF, which may differ markedly from biomedical explanations and may have fueled non-compliance to treatments which is one of the major challenges of the Mass Drug Administration program. LF is not only a biomedical issue but also a social issue and LF interventions need to understand people's world views and the contexts through which they interpret bodily maladies. Hence, an effective LF intervention must bring together both the biomedical and the social components. The goal of this exploratory study was to assist in refining a large qualitative study (currently underway) that seeks to integrate culturally appropriate LF interventions into current LF control programs in Ghana. In this paper, we discuss the findings of a pre-intervention, exploratory study aimed at gaining a baseline grasp of a local culturally informed understanding of lymphatic filariasis and the knowledge gaps looking at three endemic Ghanaian communities in the Ahanta West District. A structured questionnaire was employed to assess the wellbeing, social inclusion, and cultural understanding of LF with a geographic focus within LF-endemic areas in Ghana. Interestingly, 45.8% of the 72 participants reported to have received information about LF from health care providers and the MDA program but only 5 out of the 72 (6.9%) respondents believed that LF was transmitted by mosquitos. This baseline study revealed several alternative interpretations and misconceptions about the disease, as well as the social and economic impacts, and importantly, the need to integrate qualitative research to develop culturally appropriate interventions and increase engagement with existing control programs.
    Language English
    Publishing date 2023-10-31
    Publishing country United States
    Document type Journal Article
    ISSN 2767-3375
    ISSN (online) 2767-3375
    DOI 10.1371/journal.pgph.0002476
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Antibiotic resistance and

    Kini, Priscilla / Wireko, Solomon / Osei-Poku, Priscilla / Asiedu, Samuel O / Amewu, Emmanuel K A / Asiedu, Ebenezer / Amanor, Ernest / Mensah, Caleb / Wilson, Mary B / Larbi, Amma / Boahen, Kennedy G / Sylverken, Augustina A / Amato, Katherine R / Kwarteng, Alexander

    Health science reports

    2023  Volume 6, Issue 2, Page(s) e1104

    Abstract: Background and aim: Filarial infections affect over 150 million people in the tropics. One of the major forms of filarial pathologies is lymphedema; a condition where the immune response is significantly altered, resulting in changes in the normal flora. ...

    Abstract Background and aim: Filarial infections affect over 150 million people in the tropics. One of the major forms of filarial pathologies is lymphedema; a condition where the immune response is significantly altered, resulting in changes in the normal flora.
    Method: We recruited 160 individuals with stages I-VII lymphedema, in a cross-sectional study in the Ahanta West District of the Western Region of Ghana. Swabs from lymphedematous limb ulcers, pus, and cutaneous surfaces were cultured using standard culture-based techniques. The culture isolates were subjected to Matrix-Assisted Laser Desorption/Ionization Time of Flight (MALDI-TOF) mass spectrometry for bacterial identification. Antimicrobial susceptibility testing (AST) was performed using the Kirby-Bauer method.
    Results: In all, 112
    Conclusion: This study indicates a heightened level of methicillin-resistant
    Language English
    Publishing date 2023-02-07
    Publishing country United States
    Document type Journal Article
    ISSN 2398-8835
    ISSN (online) 2398-8835
    DOI 10.1002/hsr2.1104
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Order via subito

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