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Article ; Online: Undergraduate Premedical Student Perceptions of an Emergency Department-Based Social Needs Screening Program.

Vongsachang, Hursuong / Oshima, Sachi / Nguyen, Christine / Gaulocher, Suzanne / Wang, N Ewen

Medical science educator

2020 Volume 30, Issue 2, Page(s) 673–677

Abstract: Background: Medical school admission requirements increasingly encompass competencies beyond the traditional premedical curriculum, such as service orientation and knowledge of "social determinants of health.": Activity: The Stanford Help Desk is an ... ...

Abstract	Background: Medical school admission requirements increasingly encompass competencies beyond the traditional premedical curriculum, such as service orientation and knowledge of "social determinants of health." Activity: The Stanford Help Desk is an undergraduate service-learning program that provides didactic and experiential exposure to the social determinants of health through screening for social and legal needs of emergency department (ED) patients. We assessed student perceptions of program impact through student applications, course evaluations, and an online program survey. Results and discussion: This course strengthened students' understanding of their career aspirations in medicine. Students were resolved to incorporate consideration of social determinants of health in future practice.
Language	English
Publishing date	2020-03-10
Publishing country	United States
Document type	Journal Article
ISSN	2156-8650
ISSN (online)	2156-8650
DOI	10.1007/s40670-020-00936-x
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Article: Identification of miR-199-5p and miR-199-3p Target Genes: Paxillin Facilities Cancer Cell Aggressiveness in Head and Neck Squamous Cell Carcinoma

Tanaka, Nozomi / Minemura, Chikashi / Asai, Shunichi / Kikkawa, Naoko / Kinoshita, Takashi / Oshima, Sachi / Koma, Ayaka / Kasamatsu, Atsushi / Hanazawa, Toyoyuki / Uzawa, Katsuhiro / Seki, Naohiko

Genes. 2021 Nov. 27, v. 12, no. 12

2021

Abstract: Our previous study revealed that the miR-199 family (miR-199a-5p/-3p and miR-199b-5p/-3p) acts as tumor-suppressive miRNAs in head and neck squamous cell carcinoma (HNSCC). Furthermore, recent studies have indicated that the passenger strands of miRNAs ... ...

Abstract	Our previous study revealed that the miR-199 family (miR-199a-5p/-3p and miR-199b-5p/-3p) acts as tumor-suppressive miRNAs in head and neck squamous cell carcinoma (HNSCC). Furthermore, recent studies have indicated that the passenger strands of miRNAs are involved in cancer pathogenesis. The aim of this study was to identify cancer-promoting genes commonly regulated by miR-199-5p and miR-199-3p in HNSCC cells. Our in silico analysis and luciferase reporter assay identified paxillin (PXN) as a direct target of both miR-199-5p and miR-199-3p in HNSCC cells. Analysis of the cancer genome atlas (TCGA) database showed that expression of PXN significantly predicted a worse prognosis (5-year overall survival rate; p = 0.0283). PXN expression was identified as an independent factor predicting patient survival according to multivariate Cox regression analyses (p = 0.0452). Overexpression of PXN was detected in HNSCC clinical specimens by immunostaining. Functional assays in HNSCC cells showed that knockdown of PXN expression attenuated cancer cell migration and invasion, suggesting that aberrant expression of PXN contributed to HNSCC cell aggressiveness. Our miRNA-based approach will provide new insights into the molecular pathogenesis of HNSCC.
Keywords	cell movement ; computer simulation ; databases ; head and neck squamous cell carcinoma ; luciferase ; microRNA ; neoplasm cells ; pathogenesis ; patients ; prognosis ; regression analysis ; survival rate
Language	English
Dates of publication	2021-1127
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2527218-4
ISSN	2073-4425
ISSN	2073-4425
DOI	10.3390/genes12121910
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Molecular Pathogenesis of the Coronin Family:

Kase-Kato, Ikuko / Asai, Shunichi / Minemura, Chikashi / Tsuneizumi, Kenta / Oshima, Sachi / Koma, Ayaka / Kasamatsu, Atsushi / Hanazawa, Toyoyuki / Uzawa, Katsuhiro / Seki, Naohiko

International journal of molecular sciences

2021 Volume 22, Issue 23

Abstract: In humans, the coronin family is composed of seven proteins containing WD-repeat domains that regulate actin-based cellular processes. Some members of the coronin family are closely associated with cancer cell migration and invasion. The Cancer Genome ... ...

Abstract	In humans, the coronin family is composed of seven proteins containing WD-repeat domains that regulate actin-based cellular processes. Some members of the coronin family are closely associated with cancer cell migration and invasion. The Cancer Genome Atlas (TCGA) analysis revealed that
MeSH term(s)	Apoptosis ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Carcinoma, Squamous Cell/genetics ; Carcinoma, Squamous Cell/metabolism ; Carcinoma, Squamous Cell/pathology ; Cell Movement ; Cell Proliferation ; Gene Expression Regulation, Neoplastic ; Humans ; MicroRNAs/genetics ; Microfilament Proteins/genetics ; Microfilament Proteins/metabolism ; Mouth Neoplasms/genetics ; Mouth Neoplasms/metabolism ; Mouth Neoplasms/pathology ; Neoplasm Invasiveness ; Prognosis ; Survival Rate ; Tumor Cells, Cultured
Chemical Substances	Biomarkers, Tumor ; MicroRNAs ; Microfilament Proteins ; Mirn140 microRNA, human ; coronin proteins (145420-64-0)
Language	English
Publishing date	2021-11-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms222312684
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Article ; Online: Identification of

Tanaka, Nozomi / Minemura, Chikashi / Asai, Shunichi / Kikkawa, Naoko / Kinoshita, Takashi / Oshima, Sachi / Koma, Ayaka / Kasamatsu, Atsushi / Hanazawa, Toyoyuki / Uzawa, Katsuhiro / Seki, Naohiko

Genes

2021 Volume 12, Issue 12

Abstract: Our previous study revealed that ... ...

Abstract	Our previous study revealed that the
MeSH term(s)	Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; Computational Biology/methods ; Databases, Genetic ; Gene Expression Regulation, Neoplastic ; Head and Neck Neoplasms/genetics ; Head and Neck Neoplasms/metabolism ; Head and Neck Neoplasms/pathology ; Humans ; MicroRNAs/genetics ; Neoplasm Grading ; Paxillin/genetics ; Paxillin/metabolism ; Squamous Cell Carcinoma of Head and Neck/genetics ; Squamous Cell Carcinoma of Head and Neck/metabolism ; Squamous Cell Carcinoma of Head and Neck/pathology ; Survival Rate
Chemical Substances	MicroRNAs ; PXN protein, human ; Paxillin ; mirn199 microRNA, human
Language	English
Publishing date	2021-11-27
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2527218-4
ISSN	2073-4425 ; 2073-4425
ISSN (online)	2073-4425
ISSN	2073-4425
DOI	10.3390/genes12121910
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Article ; Online: Impact of Oncogenic Targets by Tumor-Suppressive

Koma, Ayaka / Asai, Shunichi / Minemura, Chikashi / Oshima, Sachi / Kinoshita, Takashi / Kikkawa, Naoko / Koshizuka, Keiichi / Moriya, Shogo / Kasamatsu, Atsushi / Hanazawa, Toyoyuki / Uzawa, Katsuhiro / Seki, Naohiko

International journal of molecular sciences

2021 Volume 22, Issue 18

Abstract: We newly generated an RNA-sequencing-based microRNA (miRNA) expression signature of head and neck squamous cell carcinoma (HNSCC). Analysis of the signature revealed that both strands of some miRNAs, ... ...

Abstract	We newly generated an RNA-sequencing-based microRNA (miRNA) expression signature of head and neck squamous cell carcinoma (HNSCC). Analysis of the signature revealed that both strands of some miRNAs, including
MeSH term(s)	Base Sequence ; Cell Line, Tumor ; Cell Movement/genetics ; Cell Proliferation/genetics ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Head and Neck Neoplasms/genetics ; Head and Neck Neoplasms/pathology ; Humans ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Neoplasm Invasiveness ; Neoplasm Proteins/genetics ; Neoplasm Proteins/metabolism ; Oncogenes ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Signal Transduction/genetics ; Squamous Cell Carcinoma of Head and Neck/genetics ; Squamous Cell Carcinoma of Head and Neck/pathology
Chemical Substances	MIRN139 microRNA, human ; MicroRNAs ; Neoplasm Proteins ; RNA, Messenger
Language	English
Publishing date	2021-09-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms22189947
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Article ; Online: Identification of Tumor Suppressive Genes Regulated by

Oshima, Sachi / Asai, Shunichi / Seki, Naohiko / Minemura, Chikashi / Kinoshita, Takashi / Goto, Yusuke / Kikkawa, Naoko / Moriya, Shogo / Kasamatsu, Atsushi / Hanazawa, Toyoyuki / Uzawa, Katsuhiro

International journal of molecular sciences

2021 Volume 22, Issue 12

Abstract: We identified the microRNA (miRNA) expression signature of head and neck squamous cell carcinoma (HNSCC) tissues by RNA sequencing, in which 168 miRNAs were significantly upregulated, including both strands of ... ...

Abstract	We identified the microRNA (miRNA) expression signature of head and neck squamous cell carcinoma (HNSCC) tissues by RNA sequencing, in which 168 miRNAs were significantly upregulated, including both strands of the
MeSH term(s)	Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Cell Proliferation ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Genes, Tumor Suppressor ; Head and Neck Neoplasms/genetics ; Head and Neck Neoplasms/metabolism ; Head and Neck Neoplasms/pathology ; Humans ; MicroRNAs/genetics ; Prognosis ; Squamous Cell Carcinoma of Head and Neck/genetics ; Squamous Cell Carcinoma of Head and Neck/metabolism ; Squamous Cell Carcinoma of Head and Neck/pathology ; Survival Rate ; Tumor Cells, Cultured
Chemical Substances	Biomarkers, Tumor ; MIRN31 microRNA, human ; MicroRNAs
Language	English
Publishing date	2021-06-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms22126199
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Article ; Online: Correction to: Dissatisfaction After Post-Mastectomy Breast Reconstruction: A Mixed-Methods Study.

Shammas, Ronnie L / Fish, Laura J / Sergesketter, Amanda R / Offodile, Anaeze C / Phillips, Brett T / Oshima, Sachi / Lee, Clara N / Hollenbeck, Scott T / Greenup, Rachel A

Annals of surgical oncology

2021 Volume 28, Issue Suppl 3, Page(s) 898

Language	English
Publishing date	2021-09-11
Publishing country	United States
Document type	Published Erratum
ZDB-ID	1200469-8
ISSN	1534-4681 ; 1068-9265
ISSN (online)	1534-4681
ISSN	1068-9265
DOI	10.1245/s10434-021-10796-3
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Article ; Online: Dissatisfaction After Post-Mastectomy Breast Reconstruction: A Mixed-Methods Study.

Shammas, Ronnie L / Fish, Laura J / Sergesketter, Amanda R / Offodile, Anaeze C / Phillips, Brett T / Oshima, Sachi / Lee, Clara N / Hollenbeck, Scott T / Greenup, Rachel A

Annals of surgical oncology

2021 Volume 29, Issue 2, Page(s) 1109–1119

Abstract: Background: Breast reconstruction is associated with improved patient well-being after mastectomy; however, factors that contribute to post-surgical dissatisfaction remain poorly characterized.: Methods: Adult women who underwent post-mastectomy ... ...

Abstract	Background: Breast reconstruction is associated with improved patient well-being after mastectomy; however, factors that contribute to post-surgical dissatisfaction remain poorly characterized. Methods: Adult women who underwent post-mastectomy implant-based or autologous breast reconstruction between 2015 and 2019 were recruited to participate in semi-structured interviews regarding their lived experiences with reconstructive care. Participants completed the BREAST-Q, and tabulated scores were used to dichotomize patient-reported outcomes as satisfied or dissatisfied (high or low) for each BREAST-Q domain. A convergent mixed-methods analysis was used to evaluate interviews for content related to satisfaction or dissatisfaction with breast reconstruction. Results: Overall, we interviewed 21 women and identified 17 subcodes that corresponded with the five BREAST-Q domains. Sources of dissatisfaction were found to be related to the following domains: (a) low breast satisfaction due to asymmetry, cup size, and lack of sensation and physical feeling (n = 8, 38%); (b) poor sexual well-being due to shape, look and feel (n = 7, 78% [of 9 who discussed sexual well-being]); (c) reduced physical well-being of the chest due to persistent pain and weakness (n = 11, 52%); (d) reduced abdominal well-being due to changes in abdominal strength, numbness, and posture (n = 6, 38% [of 16 who underwent abdominally based reconstruction]); and (e) low psychosocial well-being impacted by an unexpected appearance that negatively influenced self-confidence and self-identity (n = 13, 62%). Conclusion: Patients may be unprepared for the physical, sexual, and psychosocial outcomes of breast reconstruction. Targeted strategies to improve preoperative education and shared decision making are needed to mitigate unexpectedness associated with breast reconstruction and related outcomes.
MeSH term(s)	Adult ; Breast Neoplasms/surgery ; Female ; Humans ; Mammaplasty ; Mastectomy ; Patient Satisfaction ; Quality of Life
Language	English
Publishing date	2021-08-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	1200469-8
ISSN	1534-4681 ; 1068-9265
ISSN (online)	1534-4681
ISSN	1068-9265
DOI	10.1245/s10434-021-10720-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 4042: Show issues

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Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Decrease of lysyl hydroxylase 2 activity causes abnormal collagen molecular phenotypes, defective mineralization and compromised mechanical properties of bone.

Saito, Tomoaki / Terajima, Masahiko / Taga, Yuki / Hayashi, Fumihiko / Oshima, Sachi / Kasamatsu, Atsushi / Okubo, Yasuhiko / Ito, Chizuru / Toshimori, Kiyotaka / Sunohara, Masataka / Tanzawa, Hideki / Uzawa, Katsuhiro / Yamauchi, Mitsuo

Bone

2021 Volume 154, Page(s) 116242

Abstract: Lysyl hydroxylase 2 (LH2) is an enzyme that catalyzes the hydroxylation of lysine (Lys) residues in fibrillar collagen telopeptides, a critical post-translational modification for the stability of intermolecular cross-links. Though abnormal LH2 ... ...

Abstract	Lysyl hydroxylase 2 (LH2) is an enzyme that catalyzes the hydroxylation of lysine (Lys) residues in fibrillar collagen telopeptides, a critical post-translational modification for the stability of intermolecular cross-links. Though abnormal LH2 activities have been implicated in various diseases including Bruck syndrome, the molecular basis of the pathologies is still not well understood. Since LH2 null mice die at early embryonic stage, we generated LH2 heterozygous (LH2
MeSH term(s)	Animals ; Collagen/chemistry ; Collagen Type I/genetics ; Mice ; Osteogenesis Imperfecta ; Phenotype ; Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase/chemistry ; Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase/genetics ; Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase/metabolism ; Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase/pharmacokinetics
Chemical Substances	Collagen Type I ; Collagen (9007-34-5) ; Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase (EC 1.14.11.4) ; lysyl hydroxylase 2, mouse (EC 1.14.11.4)
Language	English
Publishing date	2021-10-27
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	632515-4
ISSN	1873-2763 ; 8756-3282
ISSN (online)	1873-2763
ISSN	8756-3282
DOI	10.1016/j.bone.2021.116242
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Zs.A 1571: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Cellphone enabled point-of-care assessment of breast tumor cytology and molecular HER2 expression from fine-needle aspirates.

Joh, Daniel Y / Heggestad, Jacob T / Zhang, Shengwei / Anderson, Gray R / Bhattacharyya, Jayanta / Wardell, Suzanne E / Wall, Simone A / Cheng, Amy B / Albarghouthi, Faris / Liu, Jason / Oshima, Sachi / Hucknall, Angus M / Hyslop, Terry / Hall, Allison H S / Wood, Kris C / Shelley Hwang, E / Strickland, Kyle C / Wei, Qingshan / Chilkoti, Ashutosh

NPJ breast cancer

2021 Volume 7, Issue 1, Page(s) 85

Abstract: Management of breast cancer in limited-resource settings is hindered by a lack of low-cost, logistically sustainable approaches toward molecular and cellular diagnostic pathology services that are needed to guide therapy. To address these limitations, we ...

Abstract	Management of breast cancer in limited-resource settings is hindered by a lack of low-cost, logistically sustainable approaches toward molecular and cellular diagnostic pathology services that are needed to guide therapy. To address these limitations, we have developed a multimodal cellphone-based platform-the EpiView-D4-that can evaluate both cellular morphology and molecular expression of clinically relevant biomarkers directly from fine-needle aspiration (FNA) of breast tissue specimens within 1 h. The EpiView-D4 is comprised of two components: (1) an immunodiagnostic chip built upon a "non-fouling" polymer brush-coating (the "D4") which quantifies expression of protein biomarkers directly from crude cell lysates, and (2) a custom cellphone-based optical microscope ("EpiView") designed for imaging cytology preparations and D4 assay readout. As a proof-of-concept, we used the EpiView-D4 for assessment of human epidermal growth factor receptor-2 (HER2) expression and validated the performance using cancer cell lines, animal models, and human tissue specimens. We found that FNA cytology specimens (prepared in less than 5 min with rapid staining kits) imaged by the EpiView-D4 were adequate for assessment of lesional cellularity and tumor content. We also found our device could reliably distinguish between HER2 expression levels across multiple different cell lines and animal xenografts. In a pilot study with human tissue (n = 19), we were able to accurately categorize HER2-negative and HER2-positve tumors from FNA specimens. Taken together, the EpiView-D4 offers a promising alternative to invasive-and often unavailable-pathology services and may enable the democratization of effective breast cancer management in limited-resource settings.
Language	English
Publishing date	2021-07-02
Publishing country	United States
Document type	Journal Article
ISSN	2374-4677
ISSN	2374-4677
DOI	10.1038/s41523-021-00290-0
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