Artikel ; Online: Short- and long-term outcomes of laparoscopic liver resection for non-alcoholic fatty liver disease-associated hepatocellular carcinoma: a retrospective cohort study.
HPB : the official journal of the International Hepato Pancreato Biliary Association
2023 Band 25, Heft 12, Seite(n) 1573–1586
Abstract: Background: We compared the recurrence-free survival (RFS), overall survival (OS), and safety of laparoscopic liver resection (LLR) between non-alcoholic fatty liver disease (NAFLD) and non-NAFLD hepatocellular carcinoma (HCC) patients.: Methods: ... ...
| Abstract | Background: We compared the recurrence-free survival (RFS), overall survival (OS), and safety of laparoscopic liver resection (LLR) between non-alcoholic fatty liver disease (NAFLD) and non-NAFLD hepatocellular carcinoma (HCC) patients. Methods: Patients with HCC (n = 349) were divided into four groups based on the HCC etiology (NAFLD [n = 71], hepatitis B [n = 27], hepatitis C [n = 187], alcohol/autoimmune hepatitis [AIH] [n = 64]). RFS and OS were assessed by multivariate analysis after adjustment for clinicopathological variables. A subgroup analysis was performed based on the presence (n = 248) or absence (n = 101) of cirrhosis. Results: Compared with the NAFLD group, the hazard ratios (95% confidence intervals) for RFS in the hepatitis B, hepatitis C, and alcohol/AIH groups were 0.49 (0.22-1.09), 0.90 (0.54-1.48), and 1.08 (0.60-1.94), respectively. For OS, the values were 0.28 (0.09-0.84), 0.52 (0.28-0.95), and 0.59 (0.27-1.30), respectively. With cirrhosis, NAFLD was associated with worse OS than hepatitis C (P = 0.010). Without cirrhosis, NAFLD had significantly more complications (P = 0.034), but comparable survival than others. Discussion: Patients with NAFLD-HCC have some disadvantages after LLR. In patients with cirrhosis, LLR is safe, but survival is poor. In patients without cirrhosis, the complication risk is high. |
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| Mesh-Begriff(e) | Humans ; Carcinoma, Hepatocellular ; Non-alcoholic Fatty Liver Disease/surgery ; Liver Neoplasms ; Retrospective Studies ; Liver Cirrhosis/surgery ; Hepatitis C/complications ; Hepatitis B/complications ; Laparoscopy/adverse effects | |||||
| Sprache | Englisch | |||||
| Erscheinungsdatum | 2023-09-14 | |||||
| Erscheinungsland | England | |||||
| Dokumenttyp | Journal Article | |||||
| ZDB-ID | 2131251-5 | |||||
| ISSN | 1477-2574 ; 1365-182X | |||||
| ISSN (online) | 1477-2574 | |||||
| ISSN | 1365-182X | |||||
| DOI | 10.1016/j.hpb.2023.09.002 | |||||
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| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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