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  1. Article ; Online: Identification and Characterization of an HtrA Sheddase Produced by

    Osman, Ikram Omar / Caputo, Aurelia / Pinault, Lucile / Mege, Jean-Louis / Levasseur, Anthony / Devaux, Christian A

    International journal of molecular sciences

    2023  Volume 24, Issue 13

    Abstract: Having previously shown that soluble E-cadherin (sE-cad) is found in sera of Q fever patients and that infection of BeWo cells ... ...

    Abstract Having previously shown that soluble E-cadherin (sE-cad) is found in sera of Q fever patients and that infection of BeWo cells by
    MeSH term(s) Humans ; Coxiella burnetii/enzymology ; Coxiella burnetii/genetics ; Coxiella burnetii/pathogenicity ; Interleukin-10/metabolism ; Macrophages/microbiology ; Q Fever/microbiology ; Q Fever/physiopathology ; THP-1 Cells/microbiology ; Cadherins/metabolism ; Genome, Bacterial/genetics ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Gene Expression Regulation, Bacterial ; Recombinant Proteins/genetics ; Host Microbial Interactions ; Serine Endopeptidases/genetics ; Serine Endopeptidases/metabolism ; Escherichia coli/genetics
    Chemical Substances Interleukin-10 (130068-27-8) ; DegP protease (EC 3.4.21.-) ; Cadherins ; Bacterial Proteins ; Recombinant Proteins ; Serine Endopeptidases (EC 3.4.21.-)
    Language English
    Publishing date 2023-06-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241310904
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Can ACE2 Receptor Polymorphism Predict Species Susceptibility to SARS-CoV-2?

    Devaux, Christian A / Pinault, Lucile / Osman, Ikram Omar / Raoult, Didier

    Frontiers in public health

    2021  Volume 8, Page(s) 608765

    Abstract: A novel severe acute respiratory syndrome coronavirus, SARS-CoV-2, emerged in China in December 2019 and spread worldwide, causing more than 1.3 million deaths in 11 months. Similar to the human SARS-CoV, SARS-CoV-2 shares strong sequence homologies with ...

    Abstract A novel severe acute respiratory syndrome coronavirus, SARS-CoV-2, emerged in China in December 2019 and spread worldwide, causing more than 1.3 million deaths in 11 months. Similar to the human SARS-CoV, SARS-CoV-2 shares strong sequence homologies with a sarbecovirus circulating in
    MeSH term(s) Animals ; COVID-19/immunology ; COVID-19/pathology ; China ; Chiroptera/virology ; Genetic Predisposition to Disease ; Host Specificity/genetics ; Humans ; Ophiophagus hannah/virology ; Pandemics ; Pangolins/virology ; Polymorphism, Single Nucleotide ; Receptors, Angiotensin/genetics ; Replication Origin ; SARS-CoV-2/genetics ; SARS-CoV-2/pathogenicity
    Chemical Substances Receptors, Angiotensin
    Language English
    Publishing date 2021-02-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2020.608765
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Preferential apical infection of intestinal cell monolayers by SARS-CoV-2 is associated with damage to cellular barrier integrity: Implications for the physiopathology of COVID-19

    Garrec, Clémence / Arrindell, Jeffrey / Andrieu, Jonatane / Desnues, Benoit / Mege, Jean-Louis / Osman, Ikram Omar / Devaux, Christian A.

    bioRxiv

    Abstract: SARS-CoV-2 can infect different organs, including the intestine. In Caco-2 intestinal cell line, SARS-CoV-2 modulates the ACE2 receptor expression and affects the expression of molecules involved in intercellular junctions. To further explore the ... ...

    Abstract SARS-CoV-2 can infect different organs, including the intestine. In Caco-2 intestinal cell line, SARS-CoV-2 modulates the ACE2 receptor expression and affects the expression of molecules involved in intercellular junctions. To further explore the possibility that the intestinal epithelium serves as an alternative infection route for SARS-CoV-2, we used a model of polarised intestinal cell monolayers grown on the polycarbonate membrane of Transwell inserts, inoculated with the virus either in the upper or lower chamber of culture. In both polarised Caco-2 cell monolayers and co-culture Caco-2/HT29 cell monolayer, apical SARS-CoV-2 inoculation was found to be much more effective in establishing infection than basolateral inoculation. In addition, apical SARS-CoV-2 infection triggers monolayer degeneration, as shown by histological examination, measurement of trans-epithelial electronic resistance, and cell adhesion molecule expression. During this process, the infectious viruses reach the lower chamber, suggesting either a transcytosis mechanism from the apical side to the basolateral side of cells, a paracellular trafficking of the virus after damage to intercellular junctions in the epithelial barrier, or both. Taken together, these data highlight a preferential tropism of SARS-CoV-2 for the apical side of the human intestinal tract and suggests that infection via the intestinal lumen leads to a systemic infection.
    Keywords covid19
    Language English
    Publishing date 2024-01-09
    Publisher Cold Spring Harbor Laboratory
    Document type Article ; Online
    DOI 10.1101/2024.01.08.574642
    Database COVID19

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  4. Article: Coxiella burnetii

    Devaux, Christian A / Osman, Ikram Omar / Million, Matthieu / Raoult, Didier

    Frontiers in veterinary science

    2020  Volume 7, Page(s) 558481

    Abstract: The "One Health" concept recognizes that human health is connected to animal health and to the ecosystems. ...

    Abstract The "One Health" concept recognizes that human health is connected to animal health and to the ecosystems.
    Language English
    Publishing date 2020-11-05
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2834243-4
    ISSN 2297-1769
    ISSN 2297-1769
    DOI 10.3389/fvets.2020.558481
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Angiotensin II Receptor Blockers (ARBs Antihypertensive Agents) Increase Replication of SARS-CoV-2 in Vero E6 Cells.

    Pires de Souza, Gabriel Augusto / Osman, Ikram Omar / Le Bideau, Marion / Baudoin, Jean-Pierre / Jaafar, Rita / Devaux, Christian / La Scola, Bernard

    Frontiers in cellular and infection microbiology

    2021  Volume 11, Page(s) 639177

    Abstract: Several comorbidities, including hypertension, have been associated with an increased risk of developing severe disease during SARS-CoV-2 infection. Angiotensin II receptor blockers (ARBs) are currently some of the most widely-used drugs to control blood ...

    Abstract Several comorbidities, including hypertension, have been associated with an increased risk of developing severe disease during SARS-CoV-2 infection. Angiotensin II receptor blockers (ARBs) are currently some of the most widely-used drugs to control blood pressure by acting on the angiotensin II type 1 receptor (AT1R). ARBs have been reported to trigger the modulation of the angiotensin I converting enzyme 2 (ACE2), the receptor used by the virus to penetrate susceptible cells, raising concern that such treatments may promote virus capture and increase their viral load in patients receiving ARBs therapy. In this
    MeSH term(s) Angiotensin Receptor Antagonists/pharmacology ; Angiotensin-Converting Enzyme Inhibitors/pharmacology ; Antihypertensive Agents/pharmacology ; COVID-19 ; Humans ; Renin-Angiotensin System ; SARS-CoV-2
    Chemical Substances Angiotensin Receptor Antagonists ; Angiotensin-Converting Enzyme Inhibitors ; Antihypertensive Agents
    Language English
    Publishing date 2021-06-11
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2021.639177
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Control of

    Osman, Ikram Omar / Garrec, Clémence / de Souza, Gabriel Augusto Pires / Zarubica, Ana / Belhaouari, Djamal Brahim / Baudoin, Jean-Pierre / Lepidi, Hubert / Mege, Jean-Louis / Malissen, Bernard / Scola, Bernard La / Devaux, Christian Albert

    Frontiers in cellular and infection microbiology

    2022  Volume 12, Page(s) 798767

    Abstract: COVID-19 is the biggest pandemic the world has seen this century. Alongside the respiratory damage observed in patients with severe forms of the disease, gastrointestinal symptoms have been frequently reported. These symptoms (e.g., diarrhoea), sometimes ...

    Abstract COVID-19 is the biggest pandemic the world has seen this century. Alongside the respiratory damage observed in patients with severe forms of the disease, gastrointestinal symptoms have been frequently reported. These symptoms (e.g., diarrhoea), sometimes precede the development of respiratory tract illnesses, as if the digestive tract was a major target during early SARS-CoV-2 dissemination. We hypothesize that in patients carrying intestinal SARS-CoV-2, the virus may trigger epithelial barrier damage through the disruption of E-cadherin (E-cad) adherens junctions, thereby contributing to the overall gastrointestinal symptoms of COVID-19. Here, we use an intestinal Caco-2 cell line of human origin which expresses the viral receptor/co-receptor as well as the membrane anchored cell surface adhesion protein E-cad to investigate the expression of E-cad after exposure to SARS-CoV-2. We found that the expression of
    MeSH term(s) Angiotensin-Converting Enzyme 2/genetics ; Animals ; Antigens, CD/genetics ; COVID-19 ; Caco-2 Cells ; Cadherins/genetics ; Gastrointestinal Diseases ; Gene Expression ; Humans ; Mice ; RNA, Messenger ; Receptors, Virus/genetics ; SARS-CoV-2/genetics
    Chemical Substances Antigens, CD ; CDH1 protein, human ; Cadherins ; RNA, Messenger ; Receptors, Virus ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
    Language English
    Publishing date 2022-05-04
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2022.798767
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Expression of ACE2, Soluble ACE2, Angiotensin I, Angiotensin II and Angiotensin-(1-7) Is Modulated in COVID-19 Patients.

    Osman, Ikram Omar / Melenotte, Cléa / Brouqui, Philippe / Million, Matthieu / Lagier, Jean-Christophe / Parola, Philippe / Stein, Andréas / La Scola, Bernard / Meddeb, Line / Mege, Jean-Louis / Raoult, Didier / Devaux, Christian A

    Frontiers in immunology

    2021  Volume 12, Page(s) 625732

    Abstract: The etiological agent of COVID-19 SARS-CoV-2, is primarily a pulmonary-tropic coronavirus. Infection of alveolar pneumocytes by SARS-CoV-2 requires virus binding to the angiotensin I converting enzyme 2 (ACE2) monocarboxypeptidase. ACE2, present on the ... ...

    Abstract The etiological agent of COVID-19 SARS-CoV-2, is primarily a pulmonary-tropic coronavirus. Infection of alveolar pneumocytes by SARS-CoV-2 requires virus binding to the angiotensin I converting enzyme 2 (ACE2) monocarboxypeptidase. ACE2, present on the surface of many cell types, is known to be a regulator of blood pressure homeostasis through its ability to catalyze the proteolysis of Angiotensin II (Ang II) into Angiotensin-(1-7) [Ang-(1-7)]. We therefore hypothesized that SARS-CoV-2 could trigger variations of ACE2 expression and Ang II plasma concentration in SARS-CoV-2-infected patients. We report here, that circulating blood cells from COVID-19 patients express less ACE2 mRNA than cells from healthy volunteers. At the level of circulating cells, this
    MeSH term(s) Adult ; Angiotensin I/blood ; Angiotensin II/blood ; Angiotensin-Converting Enzyme 2/blood ; Angiotensin-Converting Enzyme 2/genetics ; COVID-19/blood ; COVID-19/virology ; Female ; Gene Expression Profiling ; HLA-DR Antigens ; Humans ; Lipopolysaccharide Receptors ; Male ; Middle Aged ; Monocytes/immunology ; Monocytes/metabolism ; Peptide Fragments/blood ; Pilot Projects ; Prospective Studies ; RNA, Messenger ; Virus Shedding
    Chemical Substances CD14 protein, human ; HLA-DR Antigens ; Lipopolysaccharide Receptors ; Peptide Fragments ; RNA, Messenger ; Angiotensin II (11128-99-7) ; Angiotensin I (9041-90-1) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23) ; angiotensin I (1-7) (IJ3FUK8MOF)
    Language English
    Publishing date 2021-06-14
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.625732
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Whole Genome Sequencing of SARS-CoV-2 Strains in COVID-19 Patients From Djibouti Shows Novel Mutations and Clades Replacing Over Time.

    Osman, Ikram Omar / Levasseur, Anthony / Brechard, Ludivine / Abdillahi Hassan, Iman / Salah Abdillahi, Idil / Ali Waberi, Zeinab / Delerce, Jeremy / Bedotto, Marielle / Houhamdi, Linda / Fournier, Pierre-Edouard / Colson, Philippe / Aboubaker, Mohamed Houmed / Raoult, Didier / Devaux, Christian A

    Frontiers in medicine

    2021  Volume 8, Page(s) 737602

    Abstract: Since the start of COVID-19 pandemic the Republic of Djibouti, in the horn of Africa, has experienced two epidemic waves of the virus between April and August 2020 and between February and May 2021. By May 2021, COVID-19 had affected 1.18% of the ... ...

    Abstract Since the start of COVID-19 pandemic the Republic of Djibouti, in the horn of Africa, has experienced two epidemic waves of the virus between April and August 2020 and between February and May 2021. By May 2021, COVID-19 had affected 1.18% of the Djiboutian population and caused 152 deaths. Djibouti hosts several foreign military bases which makes it a potential hot-spot for the introduction of different SARS-CoV-2 strains. We genotyped fifty three viruses that have spread during the two epidemic waves. Next, using spike sequencing of twenty-eight strains and whole genome sequencing of thirteen strains, we found that Nexstrain clades 20A and 20B with a typically European D614G substitution in the spike and a frequent P2633L substitution in nsp16 were the dominant viruses during the first epidemic wave, while the clade 20H South African variants spread during the second wave characterized by an increase in the number of severe forms of COVID-19.
    Language English
    Publishing date 2021-09-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2021.737602
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Expression of ACE2 receptor, soluble ACE2, Angiotensin I, Angiotensin II and Angiotensin (1-7), is modulated in COVID-19 patients.

    OSMAN, Ikram Omar / Menelotte, Clea / Brouqui, Philippe / MILLION, Matthieu / LAGIER, Jean-christophe / PAROLA, Phillipe / STEIN, Andreas / LA SCOLA, Bernard / MEDDEB, Line / MEGE, Jean-Louis / RAOULT, Didier / DEVAUX, Christian Albert

    medRxiv

    Abstract: Although SARS-CoV-2 is primarily a pulmonary-tropic virus, it is nonetheless responsible for multi-organ failure in patients with severe forms of COVID-19, particularly those with hypertension or cardiovascular disease. Infection requires virus binding ... ...

    Abstract Although SARS-CoV-2 is primarily a pulmonary-tropic virus, it is nonetheless responsible for multi-organ failure in patients with severe forms of COVID-19, particularly those with hypertension or cardiovascular disease. Infection requires virus binding to the angiotensin I converting enzyme 2 (ACE2) monocarboxypeptidase, a regulator of blood pressure homeostasis through its ability to catalyze the proteolysis of Angiotensin II (AngII) into Ang(1-7). Although assumed, it had not been proven so far whether the SARS-CoV-2 replication in COVID-19 patients could modulate the expression of the ACE2 receptor and/or the AngII plasma levels. We demonstrate here, that in COVID-19 patients the ACE2 mRNA expression is markedly reduced in circulating blood cells. This ACE2 gene dysregulation mainly affects the monocytes which also show a lower expression of membrane ACE2 protein. Moreover, a significant decrease in soluble ACE2 plasma levels is observed in COVID-19 patients, whereas the concentration of sACE2 returns to normal levels in patients recovered from COVID-19. In the plasma of COVID-19 patients, we also found an increase in AngI and AngII. On the other hand, the plasma levels of Ang(1-7) remains almost stable in COVID-19 patients. Despite the Ang(1-7) presence in the plasma of COVID-19 patients it seems insufficient to prevent the effects of massive AngII accumulation. These are the first direct evidence that the SARS-CoV-2 may affect the expression of blood pressure regulators with possible harmful consequences on COVID-19 outcome.
    Keywords covid19
    Language English
    Publishing date 2021-02-10
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2021.02.08.21251001
    Database COVID19

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