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  1. Book ; Online ; E-Book: Prosthetic biomechanics in engineering

    Abu Osman, N. A.

    2022  

    Abstract: Prosthetic Biomechanics in Engineering is about the recent advances in prosthetic engineering research. The scope of the book is focused on the design, development and evaluation of a prosthetic systems that are being used in biomechanical applications"- ...

    Author's details edited by N. A. Abu Osman
    Abstract "Prosthetic Biomechanics in Engineering is about the recent advances in prosthetic engineering research. The scope of the book is focused on the design, development and evaluation of a prosthetic systems that are being used in biomechanical applications"--
    Keywords Biomedical materials/Biodegradation ; Prosthesis/Complications
    Subject code 610.28
    Language English
    Size 1 online resource (257 pages)
    Publisher CRC Press, Taylor & Francis Group
    Publishing place Boca Raton, FL
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 1-00-319673-X ; 1-000-51494-3 ; 1-000-51497-8 ; 1-003-19673-X ; 1-03-205241-4 ; 978-1-00-319673-0 ; 978-1-000-51494-0 ; 978-1-000-51497-1 ; 978-1-003-19673-0 ; 978-1-03-205241-0
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book: Composites in Biomedical Applications

    Sapuan, S M / Nukman, Y. / Abu Osman, N a / Ilyas, R A

    2020  

    Abstract: Composites in Biomedical Applications presents a comprehensive overview on recent developments in composites and their use in biomedical applications. It features cutting-edge developments to encourage further advances in the field of composite research. ...

    Author's details S. M. Sapuan, Y. Nukman, N.A. Abu Osman, R.A. Ilyas
    Abstract Composites in Biomedical Applications presents a comprehensive overview on recent developments in composites and their use in biomedical applications. It features cutting-edge developments to encourage further advances in the field of composite research. -- -- Highlights a completely new research theme in polymer-based composite materials -- -- Outlines a broad range of different research fields, including polymer and natural fiber reinforcement used in the development of composites for bio...
    Keywords Biocomposites ; Biomaterials ; Bionanocomposites ; Nanocomposites ; Polymeric composites ; Regenerative medicine ; Tissue engineering ; Biocomposite Materials ; Morphological Chart ; PLLA Composite ; PBS Buffer Solution ; Magnesium Composite ; TCP ; Drug Delivery Reservoir ; Neat PLA ; Metal Matrix Composites ; tissue regeneration or replacement ; Femoral Prosthesis ; polymer-based composite materials ; Cementless Prosthesis ; ergonomics design application ; Waste Rubber ; biomedical applications ; Buttock Popliteal Length ; fatigue behavior ; Popliteal Height ; Socket Prosthesis ; PLA Matrix ; Culture Chamber ; PBS Buffer ; Polymerization Shrinkage ; Bone Tissue Repair ; Bamboo Fibers ; Biomedical Nanocomposites ; Chitosan Nanocomposite ; MFI ; Human Body Tissues
    Language English
    Size 302 p.
    Edition 1
    Publisher Taylor & Francis Ltd
    Document type Book
    Note PDA Manuell_6
    Format 156 x 234 x 19
    ISBN 9780367271688 ; 0367271680
    Database PDA

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  3. Article ; Online: Pathways to professional mental care in the Swiss young adult community: a case-control study.

    Osman, N / Michel, C / Schimmelmann, B G / Schilbach, L / Meisenzahl, E / Schultze-Lutter, F

    European archives of psychiatry and clinical neuroscience

    2024  

    Abstract: Treatment success for mental health (MH) problems depends, among others, on the timeliness of help-seeking. Therefore, we studied the effect of symptoms and reasons for help-seeking on the point-of-contact and the most intensive professional treatment in ...

    Abstract Treatment success for mental health (MH) problems depends, among others, on the timeliness of help-seeking. Therefore, we studied the effect of symptoms and reasons for help-seeking on the point-of-contact and the most intensive professional treatment in a community sample. Participants were recruited as part of the 'Bern Epidemiological At-Risk' (BEAR) study on 16-40-year-old community persons of the Swiss canton Bern. Of the 2,683 participants, 615 (22.9%) reported at least one instance of help-seeking for MH problems and were selected for the presented analyses. Help-seeking behavior was assessed by a modified version of the 'WHO pathway-to-care questionnaire', from which the outcome 'most intensive MH professional contact' was generated. The effect of symptoms and reasons for help-seeking were analyzed in separate models using path analyses. Most help-seeking persons sought MH professional help (n = 405; 65.9%) with a high number of medical pre-contacts (n = 233; 37.9%). The 'most intensive MH professional contact' was provided after an average of 1.47 contacts. Both models showed negative associations between non-MH professional pre-contacts and the most intensive, likely most adequate MH treatment. In the symptom model, 'substance misuse' and 'central-vegetative problems' increased the general likelihood of MH professional contact. Our findings highlight the importance of the first point-of-contact in pathways to adequate MH care and, when seeking help from non-MH professional, of quick referrals to MH professionals. Awareness campaigns or training of health professionals, such as general practitioners, may support timely contact with MH professionals to improve diagnosis, prognosis, and outcome.
    Language English
    Publishing date 2024-03-01
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1045583-8
    ISSN 1433-8491 ; 0175-758X ; 0940-1334
    ISSN (online) 1433-8491
    ISSN 0175-758X ; 0940-1334
    DOI 10.1007/s00406-024-01757-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Placental transport of Erythromycin and its effect on placental inflammatory factors.

    Elbiss, Hassan / Osman, Nawal

    Pakistan journal of medical sciences

    2023  Volume 39, Issue 1, Page(s) 75–79

    Abstract: Objective: Erythromycin is used for prevention and control of infectious perinatal morbidity. It has been hypothesised that erythromycin crosses the placenta and has an effect on the production of placental inflammatory factors. We evaluated the ... ...

    Abstract Objective: Erythromycin is used for prevention and control of infectious perinatal morbidity. It has been hypothesised that erythromycin crosses the placenta and has an effect on the production of placental inflammatory factors. We evaluated the transport of erythromycin in an ex-vivo closed perfusion system of the placenta and determined its effect on the production of placenta inflammatory markers.
    Methods: In 2013, a prospective basic science study was conducted at the placental laboratory of College of Medicine and Health Sciences, United Arab Emirates. Six term placentas from uncomplicated pregnancies were studied using the ex-vivo dual closed-loop human placental cotyledon perfusion technique. Erythromycin was added to the perfusate in the maternal compartment. Samples were obtained from the maternal and fetal up to 240 minutes.
    Results: The reference antipyrine was detected in the fetal circulation in the first 15 minutes after addition of the drug. At this point the mean antipyrine was 49.90±2.10μg/ml in the maternal perfusate and 7.1±1.56μg/ml in fetal perfusate. The fetal and maternal concentration became similar at 120 minutes. The transfer of antipyrine from maternal to fetal compartment was 98.66%. The differences between perfusion groups were non-significant that indicates the perfusion of placentas was comparable. After media exchange in both sides, erythromycin was added to the maternal perfusate. The experimental period of four hours was continued with medium circulation on both maternal and fetal circulation. The concentration of erythromycin decreased in the maternal circuit by 36.4% and increased in the fetal circuit by 65%. The concentration of IL-6 in the maternal circuit was normal.
    Conclusion: Erythromycin crossed the placenta and did not inhibit the production of IL-6. Future studies are needed concerning neonatal adverse effects and the development of antibiotic resistance.
    Language English
    Publishing date 2023-01-24
    Publishing country Pakistan
    Document type Journal Article
    ZDB-ID 2032827-8
    ISSN 1681-715X ; 1682-024X ; 1017-4699
    ISSN (online) 1681-715X
    ISSN 1682-024X ; 1017-4699
    DOI 10.12669/pjms.39.1.6683
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Activation of Nrf2 pathway as a protective mechanism against oxidative stress-induced diseases: Potential of astaxanthin.

    Kanwugu, Osman N / Glukhareva, Tatiana V

    Archives of biochemistry and biophysics

    2023  Volume 741, Page(s) 109601

    Abstract: Astaxanthin, a red-orange liposoluble carotenoid, has been the centre of considerable attention in recent years for its numerous biological activities, notably its potent antioxidant activity. It is reported that astaxanthin elicits these biological ... ...

    Abstract Astaxanthin, a red-orange liposoluble carotenoid, has been the centre of considerable attention in recent years for its numerous biological activities, notably its potent antioxidant activity. It is reported that astaxanthin elicits these biological activities via a number of cellular pathways. The Nrf2/Keap1 pathway is a major regulator of the antioxidant defence system of cells; it modulates the expression of a plethora of genes related to redox homeostasis as well as cellular detoxification. The pathway has received lots of attention as a prospective therapeutic target for diseases related to oxidative stress and inflammation. Several reports have shown that the pathway is inducible by many natural compounds. This present work reviews the Nrf2/Keap1 pathway, its regulation and involvement in diseases, provides a brief overview of naturally occurring compounds as activators of the pathway as well as discusses the effect of astaxanthin on the pathway.
    MeSH term(s) Antioxidants/pharmacology ; Antioxidants/metabolism ; Kelch-Like ECH-Associated Protein 1/metabolism ; NF-E2-Related Factor 2/metabolism ; Oxidation-Reduction ; Oxidative Stress ; Humans
    Chemical Substances Antioxidants ; astaxanthine (8XPW32PR7I) ; Kelch-Like ECH-Associated Protein 1 ; NF-E2-Related Factor 2 ; NFE2L2 protein, human
    Language English
    Publishing date 2023-04-20
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 523-x
    ISSN 1096-0384 ; 0003-9861
    ISSN (online) 1096-0384
    ISSN 0003-9861
    DOI 10.1016/j.abb.2023.109601
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book ; Online: Faculty Opinions recommendation of Research and Development on Therapeutic Agents and Vaccines for COVID-19 and Related Human Coronavirus Diseases.

    Osman, Nawal

    Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature

    2020  

    Keywords covid19
    Publisher Faculty Opinions Ltd
    Publishing country uk
    Document type Book ; Online
    DOI 10.3410/f.737557315.793573792
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Book ; Online: Faculty Opinions recommendation of Eosinophil Responses During COVID-19 Infections and Coronavirus Vaccination.

    Osman, Nawal

    Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature

    2020  

    Keywords covid19
    Publisher Faculty Opinions Ltd
    Publishing country uk
    Document type Book ; Online
    DOI 10.3410/f.737841097.793574279
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Book ; Online: Faculty Opinions recommendation of An Analysis of 38 Pregnant Women with COVID-19, Their Newborn Infants, and Maternal-Fetal Transmission of SARS-CoV-2

    Osman, Nawal

    Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature

    Maternal Coronavirus Infections and Pregnancy Outcomes.

    2020  

    Keywords covid19
    Publisher Faculty Opinions Ltd
    Publishing country uk
    Document type Book ; Online
    DOI 10.3410/f.737575754.793573795
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: Traumatic atlantoaxial rotatory subluxation in adults: is cervical fusion the answer?

    Osman, Nebiyu / Kia, Cameron

    Journal of spine surgery (Hong Kong)

    2022  Volume 8, Issue 2, Page(s) 193–195

    Language English
    Publishing date 2022-07-13
    Publishing country China
    Document type Editorial
    ZDB-ID 2874556-5
    ISSN 2414-4630 ; 2414-469X
    ISSN (online) 2414-4630
    ISSN 2414-469X
    DOI 10.21037/jss-22-41
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Book ; Online: A computational framework of human values for ethical AI

    Osman, Nardine / d'Inverno, Mark

    2023  

    Abstract: In the diverse array of work investigating the nature of human values from psychology, philosophy and social sciences, there is a clear consensus that values guide behaviour. More recently, a recognition that values provide a means to engineer ethical AI ...

    Abstract In the diverse array of work investigating the nature of human values from psychology, philosophy and social sciences, there is a clear consensus that values guide behaviour. More recently, a recognition that values provide a means to engineer ethical AI has emerged. Indeed, Stuart Russell proposed shifting AI's focus away from simply ``intelligence'' towards intelligence ``provably aligned with human values''. This challenge -- the value alignment problem -- with others including an AI's learning of human values, aggregating individual values to groups, and designing computational mechanisms to reason over values, has energised a sustained research effort. Despite this, no formal, computational definition of values has yet been proposed. We address this through a formal conceptual framework rooted in the social sciences, that provides a foundation for the systematic, integrated and interdisciplinary investigation into how human values can support designing ethical AI.
    Keywords Computer Science - Artificial Intelligence ; Computer Science - Computers and Society ; Computer Science - Multiagent Systems ; 68T01 ; I.2.0
    Subject code 170
    Publishing date 2023-05-04
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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