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  1. AU="Ostermann, Philipp"
  2. AU="Qiu, Y Z"
  3. AU="Luo, Yue-Jia"
  4. AU="Tamandl, Dietmar" AU="Tamandl, Dietmar"
  5. AU="Holzer, Timothy R"
  6. AU="Zhou, C L"
  7. AU="Lomax, Tony"

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  1. Buch ; Dissertation / Habilitation: Charakterisierung von niedrig aviden T-Zellen im transgenen Mausmodell

    Ostermann, Philipp

    2009  

    Verfasserangabe vorgelegt von Philipp Ostermann
    Sprache Deutsch
    Umfang [5], 83 Bl., Ill., graph. Darst., 30 cm
    Erscheinungsland Deutschland
    Dokumenttyp Buch ; Dissertation / Habilitation
    Dissertation / Habilitation Hannover, Med. Hochsch., Diss., 2009
    HBZ-ID HT016095523
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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    SignaturLeihstatusStandort
    2009 E 2414 bestellbar zur Ausleihe Magazin

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  2. Artikel ; Online: Human brain organoids to explore SARS-CoV-2-induced effects on the central nervous system.

    Ostermann, Philipp Niklas / Schaal, Heiner

    Reviews in medical virology

    2023  Band 33, Heft 2, Seite(n) e2430

    Abstract: Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19). In less than three years, an estimated 600 million infections with SARS-CoV-2 occurred worldwide, resulting in a pandemic ... ...

    Abstract Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19). In less than three years, an estimated 600 million infections with SARS-CoV-2 occurred worldwide, resulting in a pandemic with tremendous impact especially on economic and health sectors. Initially considered a respiratory disease, COVID-19, along with its long-term sequelae (long-COVID) rather is a systemic disease. Neurological symptoms like dementia or encephalopathy were reported early during the pandemic as concomitants of the acute phase and as characteristics of long-COVID. An excessive inflammatory immune response is hypothesized to play a major role in this context. However, direct infection of neural cells may also contribute to the neurological aspects of (long)-COVID-19. To mainly explore such direct effects of SARS-CoV-2 on the central nervous system, human brain organoids provide a useful platform. Infecting these three-dimensional tissue cultures allows the study of viral neurotropism as well as of virus-induced effects on single cells or even the complex cellular network within the organoid. In this review, we summarize the experimental studies that used SARS-CoV-2-infected human brain organoids to unravel the complex nature of (long)-COVID-19-related neurological manifestations.
    Mesh-Begriff(e) Humans ; SARS-CoV-2/physiology ; COVID-19 ; Post-Acute COVID-19 Syndrome ; Central Nervous System ; Brain ; Organoids
    Sprache Englisch
    Erscheinungsdatum 2023-02-15
    Erscheinungsland England
    Dokumenttyp Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1086043-5
    ISSN 1099-1654 ; 1052-9276
    ISSN (online) 1099-1654
    ISSN 1052-9276
    DOI 10.1002/rmv.2430
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Cellular rejuvenation to combat HIV-1-related neurocognitive impairment.

    Ostermann, Philipp N / Evering, Teresa H

    Trends in microbiology

    2023  Band 32, Heft 1, Seite(n) 13–16

    Abstract: HIV-1-related neurocognitive impairment affects a significant proportion of people living with HIV, and accelerated brain aging has been implicated in its pathogenesis. This forum explores the application of cellular rejuvenation strategies to target ... ...

    Abstract HIV-1-related neurocognitive impairment affects a significant proportion of people living with HIV, and accelerated brain aging has been implicated in its pathogenesis. This forum explores the application of cellular rejuvenation strategies to target molecular mechanisms of brain aging, promote neuronal health, and combat cognitive decline.
    Mesh-Begriff(e) Humans ; HIV Infections/complications ; HIV Infections/therapy ; HIV-1 ; Rejuvenation ; Aging/pathology ; Aging/psychology ; Brain
    Sprache Englisch
    Erscheinungsdatum 2023-10-14
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1158963-2
    ISSN 1878-4380 ; 0966-842X
    ISSN (online) 1878-4380
    ISSN 0966-842X
    DOI 10.1016/j.tim.2023.09.011
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  4. Artikel ; Online: Immunoadsorption as a method of antibody donation during the COVID-19 pandemic.

    Rothenburg, Jannik / Rink-Baron, Silke / Müller, Lisa / Ostermann, Philipp Niklas / Fischer, Johannes C / Hermsen, Derik / Stegbauer, Johannes / Moldenhauer, Anja

    Vox sanguinis

    2024  

    Abstract: Background and objectives: Initial therapeutic efforts to treat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) included the use of plasma from convalescent donors containing anti-SARS-CoV-2 antibodies. High-neutralizing antibody titres are ...

    Abstract Background and objectives: Initial therapeutic efforts to treat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) included the use of plasma from convalescent donors containing anti-SARS-CoV-2 antibodies. High-neutralizing antibody titres are required for therapeutic efficacy. This study aims to show that immunoadsorption followed by tangential flow filtration can be used to obtain antibody concentrates with high-neutralizing capacities.
    Materials and methods: Eligible donors (n = 10, five males and three females) underwent immunoadsorption using adsorber columns specific for human antibodies. Glycine-washed out eluates of 1.5 L volume were further concentrated by tangential flow filtration using 30 kDa ultrafiltration membranes. The same membranes were applied for diafiltrations to exchange residual glycine for 0.9% normal saline.
    Results: Antibody concentrates were obtained within 8 h from the start of donation and had 4.58 ± 1.95, 3.28 ± 1.28 and 2.02 ± 0.92 times higher total IgG, IgA and IgM concentrations, 3.29 ± 1.62 and 3.74 ± 0.6 times higher SARS-CoV-2 N and S antibody concentrations and 3.85 ± 1.71 times higher SARS-CoV-2 S-specific IgG concentrations compared to the donors' peripheral blood. The specific SARS-CoV-2 virus neutralization capacities increased in all but one concentrate. All antibody concentrates (50-70 mL final volume) passed microbiological tests, were free of hazardous glycine levels and could be stored at -80°C and 4°C for 1 year with 20 ± 3% antibody loss.
    Conclusion: Immunoadsorption followed by tangential flow filtration is a feasible procedure to collect IgG, IgA and IgM as well as SARS-CoV-2 N- and S-specific antibody concentrates of low volume, free of albumin and coagulation factors. Whether these concentrates can be used as passive immunisation in infected patients remains to be elucidated.
    Sprache Englisch
    Erscheinungsdatum 2024-05-13
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 80313-3
    ISSN 1423-0410 ; 0042-9007
    ISSN (online) 1423-0410
    ISSN 0042-9007
    DOI 10.1111/vox.13647
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Buch ; Online ; Dissertation / Habilitation: Investigating the capacity of locked nucleic acid mixmer antisense oligonucleotides to inhibit viral replication

    Ostermann, Philipp [Verfasser] / Schaal, Heiner [Gutachter] / Feldbrügge, Michael [Gutachter]

    2022  

    Verfasserangabe Philipp Niklas Ostermann ; Gutachter: Heiner Schaal, Michael Feldbrügge
    Schlagwörter Biowissenschaften, Biologie ; Life Science, Biology
    Thema/Rubrik (Code) sg570
    Sprache Englisch
    Verlag Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf
    Erscheinungsort Düsseldorf
    Dokumenttyp Buch ; Online ; Dissertation / Habilitation
    Datenquelle Digitale Dissertationen im Internet

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  6. Artikel ; Online: Let It Go: HIV-1

    Ostermann, Philipp Niklas / Ritchie, Anastasia / Ptok, Johannes / Schaal, Heiner

    Journal of virology

    2021  Band 95, Heft 15, Seite(n) e0034221

    Abstract: After human immunodeficiency virus type 1 (HIV-1) was identified in the early 1980s, intensive work began to understand the molecular basis of HIV-1 gene expression. Subgenomic HIV-1 RNA regions, spread throughout the viral genome, were described to have ...

    Abstract After human immunodeficiency virus type 1 (HIV-1) was identified in the early 1980s, intensive work began to understand the molecular basis of HIV-1 gene expression. Subgenomic HIV-1 RNA regions, spread throughout the viral genome, were described to have a negative impact on the nuclear export of some viral transcripts. Those studies revealed an intrinsic RNA code as a new form of nuclear export regulation. Since such regulatory regions were later also identified in other viruses, as well as in cellular genes, it can be assumed that, during evolution, viruses took advantage of them to achieve more sophisticated replication mechanisms. Here, we review HIV-1
    Mesh-Begriff(e) Acquired Immunodeficiency Syndrome/pathology ; Acquired Immunodeficiency Syndrome/virology ; Active Transport, Cell Nucleus/genetics ; Algorithms ; Computational Biology/methods ; Gene Expression Regulation, Viral/genetics ; Genome, Viral/genetics ; HIV-1/genetics ; HIV-1/growth & development ; Humans ; RNA, Viral/genetics ; Virus Replication/genetics ; env Gene Products, Human Immunodeficiency Virus/genetics ; gag Gene Products, Human Immunodeficiency Virus/genetics ; pol Gene Products, Human Immunodeficiency Virus/genetics
    Chemische Substanzen RNA, Viral ; env Gene Products, Human Immunodeficiency Virus ; gag Gene Products, Human Immunodeficiency Virus ; pol Gene Products, Human Immunodeficiency Virus
    Sprache Englisch
    Erscheinungsdatum 2021-07-12
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 80174-4
    ISSN 1098-5514 ; 0022-538X
    ISSN (online) 1098-5514
    ISSN 0022-538X
    DOI 10.1128/JVI.00342-21
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel: RT-PCR Testing of Organ Culture Medium for Corneal Storage Fails to Detect SARS-CoV-2 Infection Due to Lack of Viral Replication

    Müller, Lisa / Ostermann, Philipp Niklas / Schaal, Heiner / Salla, Sabine / Timm, Jörg / Geerling, Gerd / Menzel-Severing, Johannes

    Pathogens. 2022 Jan. 22, v. 11, no. 2

    2022  

    Abstract: Concerns of possible transmission of SARS-CoV-2 from donors to patients by corneal transplantation have caused a decline in corneal transplantations. Graft culture media are routinely tested for infectious risks, but it is unclear whether this ... ...

    Abstract Concerns of possible transmission of SARS-CoV-2 from donors to patients by corneal transplantation have caused a decline in corneal transplantations. Graft culture media are routinely tested for infectious risks, but it is unclear whether this constitutes a viable means to avoid transmitting SARS-CoV-2 via keratoplasty. We found that SARS-CoV-2 RNA was not present in the medium after seven days of organ culture of corneas from donors (n = 4), who were SARS-CoV-2-positive upon tissue procurement. These medium samples showed no presence of viral RNA. To pursue this question under controlled conditions and further exclude the possibility of productive infection in corneal grafts, we inoculated corneoscleral discs from healthy donors (n = 8) with infectious SARS-CoV-2 and performed PCR testing of the culture medium at various time points. After seven days of culture, we also tested for SARS-CoV-2 RNA within the inoculated corneal tissue. The medium from tissue samples inoculated with SARS-CoV-2 showed no increase in viral RNA, which may indicate lack of viral replication in these corneal grafts. SARS-CoV-2-RNA was, however, detected on or in corneal tissue seven days after inoculation. Our data suggest that corneal grafts may not be permissive for replication of SARS-CoV-2 and demonstrates that PCR testing of culture media cannot safely exclude that tissue has been exposed to SARS-CoV-2. It also demonstrates the difficulty to differentiate between virus adherence and virus replication by PCR testing in SARS-CoV-2 exposed tissue.
    Schlagwörter RNA ; Severe acute respiratory syndrome coronavirus 2 ; cornea ; culture media ; organ culture ; virus replication ; viruses
    Sprache Englisch
    Erscheinungsverlauf 2022-0122
    Erscheinungsort Multidisciplinary Digital Publishing Institute
    Dokumenttyp Artikel
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens11020133
    Datenquelle NAL Katalog (AGRICOLA)

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  8. Artikel: RT-PCR Testing of Organ Culture Medium for Corneal Storage Fails to Detect SARS-CoV-2 Infection Due to Lack of Viral Replication.

    Müller, Lisa / Ostermann, Philipp Niklas / Schaal, Heiner / Salla, Sabine / Timm, Jörg / Geerling, Gerd / Menzel-Severing, Johannes

    Pathogens (Basel, Switzerland)

    2022  Band 11, Heft 2

    Abstract: Concerns of possible transmission of SARS-CoV-2 from donors to patients by corneal transplantation have caused a decline in corneal transplantations. Graft culture media are routinely tested for infectious risks, but it is unclear whether this ... ...

    Abstract Concerns of possible transmission of SARS-CoV-2 from donors to patients by corneal transplantation have caused a decline in corneal transplantations. Graft culture media are routinely tested for infectious risks, but it is unclear whether this constitutes a viable means to avoid transmitting SARS-CoV-2 via keratoplasty. We found that SARS-CoV-2 RNA was not present in the medium after seven days of organ culture of corneas from donors (n = 4), who were SARS-CoV-2-positive upon tissue procurement. These medium samples showed no presence of viral RNA. To pursue this question under controlled conditions and further exclude the possibility of productive infection in corneal grafts, we inoculated corneoscleral discs from healthy donors (n = 8) with infectious SARS-CoV-2 and performed PCR testing of the culture medium at various time points. After seven days of culture, we also tested for SARS-CoV-2 RNA within the inoculated corneal tissue. The medium from tissue samples inoculated with SARS-CoV-2 showed no increase in viral RNA, which may indicate lack of viral replication in these corneal grafts. SARS-CoV-2-RNA was, however, detected on or in corneal tissue seven days after inoculation. Our data suggest that corneal grafts may not be permissive for replication of SARS-CoV-2 and demonstrates that PCR testing of culture media cannot safely exclude that tissue has been exposed to SARS-CoV-2. It also demonstrates the difficulty to differentiate between virus adherence and virus replication by PCR testing in SARS-CoV-2 exposed tissue.
    Sprache Englisch
    Erscheinungsdatum 2022-01-22
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens11020133
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  9. Artikel: Modifying splice site usage with

    Ptok, Johannes / Müller, Lisa / Ostermann, Philipp Niklas / Ritchie, Anastasia / Dilthey, Alexander T / Theiss, Stephan / Schaal, Heiner

    Computational and structural biotechnology journal

    2021  Band 19, Seite(n) 3069–3076

    Abstract: Codon degeneracy of amino acid sequences permits an additional "mRNP code" layer underlying the genetic code that is related to RNA processing. In pre-mRNA splicing, splice site usage is determined by both intrinsic strength and sequence context ... ...

    Abstract Codon degeneracy of amino acid sequences permits an additional "mRNP code" layer underlying the genetic code that is related to RNA processing. In pre-mRNA splicing, splice site usage is determined by both intrinsic strength and sequence context providing RNA binding sites for splicing regulatory proteins. In this study, we systematically examined modification of splicing regulatory properties in the neighborhood of a GT site, i.e. potential splice site, without altering the encoded amino acids. We quantified the splicing regulatory properties of the neighborhood around a potential splice site by its
    Sprache Englisch
    Erscheinungsdatum 2021-05-21
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ISSN 2001-0370
    ISSN 2001-0370
    DOI 10.1016/j.csbj.2021.05.033
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  10. Artikel: COVID-19 antibody donation using immunoadsorption: Report of two cases.

    Rothenburg, Jannik / Rink-Baron, Silke / Mueller, Lisa / Ostermann, Philipp Niklas / Fischer, Johannes / Stegbauer, Johannes / Moldenhauer, Anja

    Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis

    2021  Band 60, Heft 5, Seite(n) 103193

    Abstract: For more than a year the whole world is suffering from the COVID-19 pandemic with no treatment option in sight. Administration of plasma from convalescent donors containing anti-SARS-CoV-2 antibodies, though promising according to case reports, failed to ...

    Abstract For more than a year the whole world is suffering from the COVID-19 pandemic with no treatment option in sight. Administration of plasma from convalescent donors containing anti-SARS-CoV-2 antibodies, though promising according to case reports, failed to show a clear benefit in a greater number of trials. One reason could be varying and low antibody contents in a majority of plasma units hampering standardization and clinical efficacy. Besides, other plasma components unnecessarily transfused like coagulation factors might promote hypercoagulation seen in severe COVID-19 etiopathology. We therefore hypothesized that instead of collecting whole plasma units, convalescent donors could donate solely immunoglobulins by undergoing immunoadsorption, a mode of therapy regularly applied in autoimmune diseases. Here, we report the results of the first two antibody donations performed at the University Hospital Düsseldorf. In both cases, immunoadsorptions were very well tolerated with no side effects. Collected and neutralized eluates were concentrated using tangential flow filtration increasing the concentration of immunoglobulins 10fold as compared to peripheral blood and leading to probably eight times more neutralizing antibodies than in one plasma unit. Therefore, immunoadsorption can be used as a method of antibody donation. Whether these donated antibodies can be used as passive immunization in acutely infected patients remains to be elucidated.
    Mesh-Begriff(e) Antibodies, Neutralizing/blood ; Antibodies, Neutralizing/isolation & purification ; Antibodies, Viral/blood ; Antibodies, Viral/isolation & purification ; COVID-19/immunology ; COVID-19/therapy ; Convalescence ; Humans ; Immunization, Passive/methods ; Immunosorbent Techniques ; SARS-CoV-2/immunology
    Chemische Substanzen Antibodies, Neutralizing ; Antibodies, Viral
    Sprache Englisch
    Erscheinungsdatum 2021-06-15
    Erscheinungsland England
    Dokumenttyp Case Reports ; Journal Article
    ZDB-ID 2046795-3
    ISSN 1878-1683 ; 1473-0502
    ISSN (online) 1878-1683
    ISSN 1473-0502
    DOI 10.1016/j.transci.2021.103193
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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