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  1. Book ; Collection: Techniques in aquatic toxicology

    Ostrander, Gary K.

    1996  

    Author's details edited by Gary K. Ostrander
    Keywords Water/Pollution/Toxicology/Measurement ; Water quality bioassay/Technique
    Language English
    Dates of publication 1996-9999
    Publisher CRC
    Publishing place Boca Raton u.a.
    Publishing country United States
    Document type Book ; Collection (display volumes)
    Note Verlagsangabe wechselt
    HBZ-ID HT017443534
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

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  2. Book: Techniques in aquatic toxicology / [1]

    Ostrander, Gary K.

    (Environmental chemistry and toxicology aquatic sciences)

    1996  

    Author's details edited by Gary K. Ostrander
    Series title Environmental chemistry and toxicology aquatic sciences
    Techniques in aquatic toxicology
    Collection Techniques in aquatic toxicology
    Keywords Wasseranalyse
    Subject Wasseruntersuchung ; Wasser
    Language English
    Size 686 S. : Ill., graph. Darst.
    Publisher CRC
    Publishing place Boca Raton u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT007436283
    ISBN 1-566-70149-X ; 978-1-566-70149-5
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Shelf markLoan statusLocation
    978/2985 available for loan (reading room) Freihandmagazin (U1)

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  3. Article ; Online: Castanospermine reduces Zika virus infection-associated seizure by inhibiting both the viral load and inflammation in mouse models.

    Tharappel, Anil M / Cheng, Yichen / Holmes, Eric H / Ostrander, Gary K / Tang, Hengli

    Antiviral research

    2020  Volume 183, Page(s) 104935

    Abstract: Zika virus (ZIKV) outbreaks have been reported worldwide, including a recent occurrence in Brazil where it spread rapidly, and an association with increased cases of microcephaly was observed in addition to neurological issues such as GBS that were ... ...

    Abstract Zika virus (ZIKV) outbreaks have been reported worldwide, including a recent occurrence in Brazil where it spread rapidly, and an association with increased cases of microcephaly was observed in addition to neurological issues such as GBS that were reported during previous outbreaks. Following infection of neuronal tissues, ZIKV can cause inflammation, which may lead to neuronal abnormalities, including seizures and paralysis. Therefore, a drug containing both anti-viral and immunosuppressive properties would be of great importance in combating ZIKV related neurological abnormalities. Castanospermine (CST) is potentially a right candidate drug as it reduced viral load and brain inflammation with the resulting appearance of delayed neuronal disorders, including seizures and paralysis in an Ifnar1
    MeSH term(s) Animals ; Antiviral Agents/therapeutic use ; Cell Line, Tumor ; Chlorocebus aethiops ; Disease Models, Animal ; Female ; Glioblastoma ; Humans ; Immunosuppressive Agents/therapeutic use ; Indolizines/therapeutic use ; Inflammation/drug therapy ; Inflammation/virology ; Male ; Mice ; Seizures/drug therapy ; Seizures/immunology ; Seizures/virology ; Vero Cells ; Viral Load/drug effects ; Zika Virus/drug effects ; Zika Virus Infection/complications ; Zika Virus Infection/drug therapy
    Chemical Substances Antiviral Agents ; Immunosuppressive Agents ; Indolizines ; castanospermine (Q0I3184XM7)
    Keywords covid19
    Language English
    Publishing date 2020-09-16
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 306628-9
    ISSN 1872-9096 ; 0166-3542
    ISSN (online) 1872-9096
    ISSN 0166-3542
    DOI 10.1016/j.antiviral.2020.104935
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1627: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  4. Article: Transmissible Tumors: Breaking the Cancer Paradigm.

    Ostrander, Elaine A / Davis, Brian W / Ostrander, Gary K

    Trends in genetics : TIG

    2015  Volume 32, Issue 1, Page(s) 1–15

    Abstract: Transmissible tumors are those that have transcended the bounds of their incipient hosts by evolving the ability to infect another individual through direct transfer of cancer cells, thus becoming parasitic cancer clones. Coitus, biting, and scratching ... ...

    Abstract Transmissible tumors are those that have transcended the bounds of their incipient hosts by evolving the ability to infect another individual through direct transfer of cancer cells, thus becoming parasitic cancer clones. Coitus, biting, and scratching are transfer mechanisms for the two primary species studied, the domestic dog (Canis lupus familiaris) and the Tasmanian devil (Sarcophilus harrisii). Canine transmissible venereal tumors (CTVT) are likely thousands of years old, and have successfully travelled from host to host around the world, while the Tasmanian devil facial tumor disease (DFTD) is much younger and geographically localized. The dog tumor is not necessarily lethal, while the devil tumor has driven the population to near extinction. Transmissible tumors are uniform in that they have complex immunologic profiles, which allow them to escape immune detection by their hosts, sometimes for long periods of time. In this review, we explore how transmissible tumors in CTVT, DFTD, and as well as the soft-shell clam and Syrian hamster, can advance studies of tumor biology.
    MeSH term(s) Animals ; Biological Evolution ; Dog Diseases/transmission ; Dogs ; Facial Neoplasms/veterinary ; Genetic Variation ; Marsupialia ; Mesocricetus ; Mya ; Neoplasms/genetics ; Neoplasms/immunology ; Neoplasms/veterinary ; Venereal Tumors, Veterinary
    Language English
    Publishing date 2015-12-11
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Review
    ZDB-ID 619240-3
    ISSN 1362-4555 ; 0168-9525 ; 0168-9479
    ISSN (online) 1362-4555
    ISSN 0168-9525 ; 0168-9479
    DOI 10.1016/j.tig.2015.10.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2272: Show issues Location:
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  5. Article ; Online: Molecular toxicology of corals: a review.

    Rotchell, Jeanette M / Ostrander, Gary K

    Journal of toxicology and environmental health. Part B, Critical reviews

    2011  Volume 14, Issue 8, Page(s) 571–592

    Abstract: Coral reefs worldwide have become increasingly affected by a phenomenon known as "coral bleaching," the loss of the symbiotic algae from the host corals. The underlying causes and mechanism(s) of coral bleaching are not well known, although several have ... ...

    Abstract Coral reefs worldwide have become increasingly affected by a phenomenon known as "coral bleaching," the loss of the symbiotic algae from the host corals. The underlying causes and mechanism(s) of coral bleaching are not well known, although several have been hypothesized. While coral bleaching has been a primary focus in recent years, corals respond differentially to numerous environmental stresses. The impacts of heat, hydrocarbons, salinity, sewage effluents, biocides, heavy metals, and ultraviolet light have been investigated in both laboratory experiments and field surveys among multiple coral species. Herein what is known regarding the biological impacts of such stresses on corals at the molecular level of organization is summarized. The objective is to focus attention at the early stages of biological effects in order to encourage and facilitate research that provide ways to understand how changes at the molecular level might elucidate processes likely occurring at the population level. This, in turn, should accelerate studies that may elucidate the cellular and physiological changes contributing to coral decline, rather than just document the continued global loss of coral diversity and abundance.
    MeSH term(s) Animals ; Anthozoa/drug effects ; Anthozoa/physiology ; Ecotoxicology/methods ; Environmental Monitoring ; Environmental Pollutants/adverse effects ; Environmental Pollutants/metabolism ; Fishes/genetics ; Molecular Biology ; Pigmentation/drug effects ; Sea Anemones/genetics ; Sequence Analysis, Protein ; Signal Transduction ; Species Specificity ; Urochordata/genetics
    Chemical Substances Environmental Pollutants
    Language English
    Publishing date 2011
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1415246-0
    ISSN 1521-6950 ; 1093-7404
    ISSN (online) 1521-6950
    ISSN 1093-7404
    DOI 10.1080/10937404.2011.615112
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4944: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Book: Techniques in aquatic toxicology

    Ostrander, Gary K

    (A CRC Press book)

    2005  

    Title variant Aquatic toxicology
    Author's details ed. by Gary K. Ostrander
    Series title A CRC Press book
    Language English
    Size XVI, 766 S., zahlr. Ill., graph. Darst., 27cm
    Publisher Taylor & Francis
    Publishing place Boca Raton u.a.
    Document type Book
    Note Includes bibliographical references and index
    ISBN 1566706645 ; 9781566706643
    Database Former special subject collection: coastal and deep sea fishing

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  7. Book: Techniques in aquatic toxicology

    Ostrander, Gary K

    (A CRC Press book)

    2005  

    Title variant Aquatic toxicology
    Author's details ed. by Gary K. Ostrander
    Series title A CRC Press book
    Language English
    Size XVI, 766 S., zahlr. Ill., graph. Darst., 27cm
    Publisher Taylor & Francis
    Publishing place Boca Raton u.a.
    Document type Book
    Note Includes bibliographical references and index
    ISBN 1566706645 ; 9781566706643
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  8. Book: The laboratory fish

    Ostrander, Gary K

    (The handbook of experimental animals)

    2000  

    Author's details ed. by Gary K. Ostrander
    Series title The handbook of experimental animals
    Language English
    Size XVI, 678 S, Ill., graph. Darst
    Publisher Acad. Press
    Publishing place San Diego u.a.
    Document type Book
    Note Literaturangaben
    ISBN 0125296509 ; 9780125296502
    Database Former special subject collection: coastal and deep sea fishing

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  9. Book: The laboratory fish

    Ostrander, Gary K

    (The handbook of experimental animals)

    2000  

    Author's details ed. by Gary K. Ostrander
    Series title The handbook of experimental animals
    Language English
    Size XVI, 678 S, Ill., graph. Darst
    Publisher Acad. Press
    Publishing place San Diego u.a.
    Document type Book
    Note Literaturangaben
    ISBN 0125296509 ; 9780125296502
    Database Special collection on veterinary medicine and general parasitology

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  10. Article ; Online: Genetics of athletic performance.

    Ostrander, Elaine A / Huson, Heather J / Ostrander, Gary K

    Annual review of genomics and human genetics

    2009  Volume 10, Page(s) 407–429

    Abstract: Performance enhancing polymorphisms (PEPs) are examples of natural genetic variation that affect the outcome of athletic challenges. Elite athletes, and what separates them from the average competitor, have been the subjects of discussion and debate for ... ...

    Abstract Performance enhancing polymorphisms (PEPs) are examples of natural genetic variation that affect the outcome of athletic challenges. Elite athletes, and what separates them from the average competitor, have been the subjects of discussion and debate for decades. While training, diet, and mental fitness are all clearly important contributors to achieving athletic success, the fact that individuals reaching the pinnacle of their chosen sports often share both physical and physiological attributes suggests a role for genetics. That multiple members of a family often participate in highly competitive events, such as the Olympics, further supports this argument. In this review, we discuss what is known regarding the genes and gene families, including the mitochondrial genome, that are believed to play a role in human athletic performance. Where possible, we describe the physiological impact of the critical gene variants and consider predictions about other potentially important genes. Finally, we discuss the implications of these findings on the future for competitive athletics.
    MeSH term(s) Athletic Performance ; DNA, Mitochondrial/genetics ; Doping in Sports ; Genetic Variation ; Humans ; Muscle, Skeletal/anatomy & histology ; Muscle, Skeletal/metabolism ; Phenotype ; Sports/physiology
    Chemical Substances DNA, Mitochondrial
    Language English
    Publishing date 2009
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Review
    ZDB-ID 2037670-4
    ISSN 1545-293X ; 1527-8204
    ISSN (online) 1545-293X
    ISSN 1527-8204
    DOI 10.1146/annurev-genom-082908-150058
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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