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Book ; Thesis: Powikłania ogólnochirurgiczne i urologiczne występujące po przeszczepieniu nerek oraz sposoby zapobiegania i leczenia w oparciu o własny materiał operacyjny

Ostrowski, Marek

= Surgical and urologic complications following renal transplantation, their prevention and management in 420 recipients

(Annales Academiae Medicae Stetinensis : Suplement ; 42)

1998

Title variant	Surgical and urologic complications following renal transplantation, their prevention and management in 420 recipients
Author's details	Marek Ostrowski
Series title	Annales Academiae Medicae Stetinensis : Suplement ; 42 Annales Academiae Medicae Stetinensis Annales Academiae Medicae Stetinensis ; Suplement
Collection	Annales Academiae Medicae Stetinensis Annales Academiae Medicae Stetinensis ; Suplement
Language	Polish
Size	90 S. : Ill., graph. Darst.
Publisher	Pomorska Akademia Medyczna
Publishing place	Szczecin
Publishing country	Poland
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Habil.-Schr
HBZ-ID	HT011172995
ISBN	83-86342-48-X ; 978-83-86342-48-8
Database	Catalogue ZB MED Medicine, Health

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Article ; Online: Evaluating the Influence of Visual Attentional Tracking on Pointing Movement Precision.

Styrkowiec, Piotr / Ostrowski, Maciej

Journal of motor behavior

2021 Volume 54, Issue 2, Page(s) 237–255

Abstract: Multiple object tracking (MOT) and goal-directed movements are both based on attentional processes. This study focused on the instant effect of attentive tracking with respect to pointing performance. We measured the precision of pointing to the targets ... ...

Abstract	Multiple object tracking (MOT) and goal-directed movements are both based on attentional processes. This study focused on the instant effect of attentive tracking with respect to pointing performance. We measured the precision of pointing to the targets of an MOT task immediately after the tracking period when all the objects were still in motion, and to the precision of pointing to moving objects in the task without attentional tracking. The results demonstrated that an increase in the attentional tracking load was the primary factor that decreased pointing precision, although visual load may also contribute to this influence. We also manipulated the relationship between the number of targets and the density of the MOT display (the total number of objects displayed), which affected the MOT accuracy but not the pointing precision.
MeSH term(s)	Attention ; Humans ; Motion Perception ; Movement ; Psychomotor Performance
Language	English
Publishing date	2021-07-12
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2066611-1
ISSN	1940-1027 ; 0022-2895
ISSN (online)	1940-1027
ISSN	0022-2895
DOI	10.1080/00222895.2021.1944972
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Article: Pea GH3 acyl acid amidosynthetase conjugates IAA to proteins in immature seeds of Pisum sativum L. – A new perspective on formation of high-molecular weight conjugates of auxin

Ostrowski, Maciej / Ciarkowska, Anna

Journal of plant physiology. 2021 Jan., v. 256

2021

Abstract: Gretchen Hagen 3 (GH3) acyl acid amidosynthetases are encoded by early auxin-responsive genes and catalyze an ATP-dependent biosynthesis of IAA-amino acid conjugates. An amide conjugate of IAA, indole-3-acetyl-aspartate (IAA-aspartate, IAA-Asp), is a ... ...

Abstract	Gretchen Hagen 3 (GH3) acyl acid amidosynthetases are encoded by early auxin-responsive genes and catalyze an ATP-dependent biosynthesis of IAA-amino acid conjugates. An amide conjugate of IAA, indole-3-acetyl-aspartate (IAA-aspartate, IAA-Asp), is a predominant form of bound auxin in immature seeds of pea. However, there is some evidence that IAA is also able to form high molecular weight amide conjugates with proteins in pea and other plant species. In this short study we report that recombinant PsGH3 IAA-amino acid synthetase, which exhibits a preference for the formation of IAA-Asp, can also conjugate IAA with the protein fraction from immature seeds of pea (S-10 fraction). We studied [¹⁴C]IAA incorporation to the S-10 protein fraction by two assays: TLC method and protein precipitation by trichloroacetic acid (TCA). In both cases, radioactivity of [¹⁴C]IAA in the protein fraction increases in comparison to the control (without PsGH3), about 9.3- and 3.17-fold, respectively. l-Asp, as a preferred substrate in the IAA conjugation catalyzed by PsGH3, down-regulates [¹⁴C]IAA conjugation to the proteins as shown by the TLC assay (∼2.8-fold decrease) and the TCA precipitation variant (∼2-fold decrease). Moreover, l-Trp that competes with Asp for the catalytic site of PsGH3 and inhibits activity of the enzyme, diminished radioactivity of [¹⁴C]IAA-proteins about 1.2- and 2.8-fold, respectively. Taking into account that amino group of an amino acid or a protein acts as an acceptor of the indole-3-acetyl moiety from IAA-AMP intermediate during GH3-dependent conjugation, we masked amine groups (α- and ε-NH₂) of the S-10 protein fraction from pea seeds by reductive alkylation. The alkylated proteins revealed about 3- and 2.8-fold lower radioactivity of [¹⁴C]IAA than non-alkylated fraction for TLC and TCA precipitation variant, respectively. This is a first study demonstrating that formation of high molecular weight IAA conjugates with proteins is catalyzed by a GH3 acyl acid amidosynthetase.
Keywords	Pisum sativum ; active sites ; alkylation ; amino acids ; biosynthesis ; enzyme activity ; moieties ; molecular weight ; peas ; plant physiology ; radioactivity ; trichloroacetic acid ; trichloroacetic acid precipitation
Language	English
Dates of publication	2021-01
Publishing place	Elsevier GmbH
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	283647-6
ISSN	1618-1328 ; 0176-1617
ISSN (online)	1618-1328
ISSN	0176-1617
DOI	10.1016/j.jplph.2020.153312
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Article ; Online: The Arterial Anastomosis Between Deep Inferior Epigastric Artery and Small Polar Renal Artery in Kidney Transplantation: A Case Report.

Ostrowski, P / Kotowski, M J / Tejchman, K / Szemitko, M / Sieńko, J / Ostrowski, M

Transplantation proceedings

2022 Volume 54, Issue 4, Page(s) 1145–1147

Abstract: The presence of multiple renal arteries is the most common form of vascular anomalies found in donor kidneys. In rare cases, small renal polar arteries may be found. They can be anastomosed with deep inferior epigastric arteries, resulting in vascular ... ...

Abstract	The presence of multiple renal arteries is the most common form of vascular anomalies found in donor kidneys. In rare cases, small renal polar arteries may be found. They can be anastomosed with deep inferior epigastric arteries, resulting in vascular augmentation of transplanted kidneys and contributing to better graft function. Renal perfusion may be increased via 2 types of vascular reconstruction known as "turbocharging" and "supercharging". Turbocharging uses vascular sources within the same organ area, whereas supercharging uses distant vascular sources. Using additional vessels can either complicate the surgery or, contradictorily, ease the way of procedure. This case study presents a kidney transplant during which arterial anastomosis between deep inferior epigastric artery and small polar renal artery was performed.
MeSH term(s)	Anastomosis, Surgical ; Epigastric Arteries/surgery ; Humans ; Kidney/blood supply ; Kidney Transplantation/adverse effects ; Kidney Transplantation/methods ; Renal Artery/diagnostic imaging ; Renal Artery/surgery
Language	English
Publishing date	2022-05-12
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	82046-5
ISSN	1873-2623 ; 0041-1345
ISSN (online)	1873-2623
ISSN	0041-1345
DOI	10.1016/j.transproceed.2022.02.050
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Article ; Online: Outcomes of Kidney Transplant During the SARS-CoV-2 Pandemic at 1 Center in Poland.

Wojas, W / Kotowski, M J / Marczak, I / Ostrowski, P / Ostrowski, M / Sieńko, J

Transplantation proceedings

2022 Volume 54, Issue 4, Page(s) 888–889

Abstract: The SARS-CoV-2 pandemic has significantly affected the number of transplanted organs worldwide. The rules and restrictions related to transplantation activities in Poland are included in the updated guidelines of the Polish Organizational and ... ...

Abstract	The SARS-CoV-2 pandemic has significantly affected the number of transplanted organs worldwide. The rules and restrictions related to transplantation activities in Poland are included in the updated guidelines of the Polish Organizational and Coordination Centre for Transplantation. Our clinic faces the same problems as the rest of the hospitals in the country. Not only are the number of recipients falling, but there are also numerous restrictions concerning, among other things, qualification of donors and recipients and even preparation of centers for long-term care in the event of infection of organ recipients with the SARS-CoV-2 virus. Statistics showed, after an initial fall in the number of kidneys transplanted, a temporary normalization during the summer months, only to record a fall again with an increase in new cases of COVID-19. A total of 29 kidneys were transplanted at our center between March and December 2020. Kidney transplantation is not only linked to the operation itself, but also to the follow-up care of the recipients. Reduced immunity among recipients due to immunosuppressive treatment as well as comorbidities among recipients contribute to this group being at increased risk of symptomatic SARS-CoV-2 infection. The number of cases of SARS-CoV-2 infection among kidney transplant recipients at our center was 7, of which we recorded 2 deaths due to COVID-19 in the period after kidney transplant. Postoperative complications probably related to previous SARS-CoV-2 infection occurred in 1 patient.
MeSH term(s)	COVID-19/epidemiology ; Humans ; Kidney Transplantation/adverse effects ; Pandemics ; Poland/epidemiology ; SARS-CoV-2 ; Transplant Recipients
Language	English
Publishing date	2022-04-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	82046-5
ISSN	1873-2623 ; 0041-1345
ISSN (online)	1873-2623
ISSN	0041-1345
DOI	10.1016/j.transproceed.2022.03.006
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Article: Thermochemistry of the binary system nitrocellulose + dimethyl 4,4´-dinitroheptanedioate

Tomaszewski, W. / Gołofit, T. / Ostrowski, M.

Thermochimica acta. 2022 Jan., v. 707

2022

Abstract: The DSC measurements of the binary mixtures of nitrocellulose (NC) and dimethyl 4,4´-dinitroheptanedioate (DNHD), of expected fine plasticizing properties, were carried out. It was concluded that depending on the time interval between measurements, in ... ...

Abstract	The DSC measurements of the binary mixtures of nitrocellulose (NC) and dimethyl 4,4´-dinitroheptanedioate (DNHD), of expected fine plasticizing properties, were carried out. It was concluded that depending on the time interval between measurements, in cases of specifically low DNHD content in NC mixtures DNHD did not crystallize. The course of the melting process during the second and subsequent measurements performed on the same sample indicates that the process was taking place in confined spaces, i.e. pores as well as in unconfined space. The occurrence of two i.e. high-temperature and low-temperature glass transitions as well as β-relaxation was observed, depending on the composition of the samples and time interval between the measurements. The thermochemical properties of the investigated DNHD/NC binary system are complex and allow to conclude that thermal behavior of the samples across a variety of concentration and temperature ranges, reflects limited miscibility of the components used.
Keywords	crystallization ; glass ; temperature ; thermal properties
Language	English
Dates of publication	2022-01
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	1500974-9
ISSN	0040-6031
ISSN	0040-6031
DOI	10.1016/j.tca.2021.179103
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Article ; Online: Pea GH3 acyl acid amidosynthetase conjugates IAA to proteins in immature seeds of Pisum sativum L. - A new perspective on formation of high-molecular weight conjugates of auxin.

Ostrowski, Maciej / Ciarkowska, Anna

Journal of plant physiology

2020 Volume 256, Page(s) 153312

Abstract	Gretchen Hagen 3 (GH3) acyl acid amidosynthetases are encoded by early auxin-responsive genes and catalyze an ATP-dependent biosynthesis of IAA-amino acid conjugates. An amide conjugate of IAA, indole-3-acetyl-aspartate (IAA-aspartate, IAA-Asp), is a predominant form of bound auxin in immature seeds of pea. However, there is some evidence that IAA is also able to form high molecular weight amide conjugates with proteins in pea and other plant species. In this short study we report that recombinant PsGH3 IAA-amino acid synthetase, which exhibits a preference for the formation of IAA-Asp, can also conjugate IAA with the protein fraction from immature seeds of pea (S-10 fraction). We studied [
MeSH term(s)	Gene Expression Regulation, Plant ; Indoleacetic Acids/metabolism ; Ligases/genetics ; Ligases/metabolism ; Molecular Weight ; Pisum sativum/genetics ; Pisum sativum/growth & development ; Pisum sativum/metabolism ; Plant Growth Regulators/metabolism ; Seeds/genetics ; Seeds/metabolism
Chemical Substances	Indoleacetic Acids ; Plant Growth Regulators ; indoleacetic acid (6U1S09C61L) ; Ligases (EC 6.-)
Language	English
Publishing date	2020-11-04
Publishing country	Germany
Document type	Journal Article
ZDB-ID	283647-6
ISSN	1618-1328 ; 0176-1617
ISSN (online)	1618-1328
ISSN	0176-1617
DOI	10.1016/j.jplph.2020.153312
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Article: Correction: McLennan et al. Assessing the Use of Molecular Barcoding and qPCR for Investigating the Ecology of

McLennan, Kate / Ruvindy, Rendy / Ostrowski, Martin / Murray, Shauna

Microorganisms

2022 Volume 10, Issue 10

Abstract: The authors wish to make the following corrections to this paper [ ... ]. ...

Abstract	The authors wish to make the following corrections to this paper [...].
Language	English
Publishing date	2022-09-26
Publishing country	Switzerland
Document type	Published Erratum
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms10101906
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Article ; Online: Biochemical Characterization of Recombinant UDPG-Dependent IAA Glucosyltransferase from Maize (

Ciarkowska, Anna / Ostrowski, Maciej / Kozakiewicz, Anna

International journal of molecular sciences

2021 Volume 22, Issue 7

Abstract: Here, we report a biochemical characterization of recombinant maize indole-3-acetyl-β-d-glucose (IAGlc) synthase which glucosylates indole-3-acetic acid (IAA) and thus abolishes its auxinic activity affecting plant hormonal homeostasis. Substrate ... ...

Abstract	Here, we report a biochemical characterization of recombinant maize indole-3-acetyl-β-d-glucose (IAGlc) synthase which glucosylates indole-3-acetic acid (IAA) and thus abolishes its auxinic activity affecting plant hormonal homeostasis. Substrate specificity analysis revealed that IAA is a preferred substrate of IAGlc synthase; however, the enzyme can also glucosylate indole-3-butyric acid and indole-3-propionic acid with the relative activity of 66% and 49.7%, respectively.
MeSH term(s)	2,4-Dichlorophenoxyacetic Acid/chemistry ; Adenosine Triphosphate/chemistry ; Amino Acid Motifs ; Binding Sites ; Cations ; Enzyme Inhibitors/pharmacology ; Escherichia coli/metabolism ; Glucose/chemistry ; Glucosephosphates/chemistry ; Glucosyltransferases/antagonists & inhibitors ; Glucosyltransferases/chemistry ; Homeostasis ; Hydrogen-Ion Concentration ; Kinetics ; Molecular Docking Simulation ; Plant Growth Regulators/metabolism ; Recombinant Proteins/chemistry ; Substrate Specificity ; Uridine Diphosphate Glucose/chemistry ; Zea mays/drug effects ; Zea mays/enzymology
Chemical Substances	Cations ; Enzyme Inhibitors ; Glucosephosphates ; Plant Growth Regulators ; Recombinant Proteins ; 2,4-Dichlorophenoxyacetic Acid (2577AQ9262) ; Adenosine Triphosphate (8L70Q75FXE) ; glucose-1-phosphate (CIX3U01VAU) ; Glucosyltransferases (EC 2.4.1.-) ; indole-3-acetate beta-glucosyltransferase (EC 2.4.1.121) ; Glucose (IY9XDZ35W2) ; Uridine Diphosphate Glucose (V50K1D7P4Y)
Language	English
Publishing date	2021-03-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms22073355
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Article ; Online: Comparative Intra-Subject Analysis of Gene Expression and Protein Abundance of Major and Minor Drug Metabolizing Enzymes in Healthy Human Jejunum and Liver.

Wenzel, Christoph / Lapczuk-Romanska, Joanna / Malinowski, Damian / Ostrowski, Marek / Drozdzik, Marek / Oswald, Stefan

Clinical pharmacology and therapeutics

2023 Volume 115, Issue 2, Page(s) 221–230

Abstract: First pass metabolism by phase I and phase II enzymes in the intestines and liver is a major determinant of the oral bioavailability of many drugs. Several studies analyzed expressions of major drug-metabolizing enzymes (DMEs), such as CYP3A4 and UGT1A1 ... ...

Abstract	First pass metabolism by phase I and phase II enzymes in the intestines and liver is a major determinant of the oral bioavailability of many drugs. Several studies analyzed expressions of major drug-metabolizing enzymes (DMEs), such as CYP3A4 and UGT1A1 in the human gut and liver. However, there is still a lack of knowledge regarding other DMEs (i.e., "minor" DMEs), although several clinically relevant drugs are affected by those enzymes. Moreover, there is very limited intra-subject data on hepatic and intestinal expression levels of minor DMEs. To fill this gap of knowledge, we analyzed gene expression (quantitative real-time polymerase chain reaction) and protein abundance (targeted proteomics) of 24 clinically relevant DMEs, that is, carboxylesterases (CES), UDP-glucuronosyltransferases (UGT), and cytochrome P450 (CYP)-enzymes. We performed our analysis using jejunum and liver tissue specimens from the same 11 healthy organ donors (8 men and 3 women, aged 19-60 years). Protein amounts of all investigated DMEs, with the exception of CYP4A11, were detected in human liver samples. CES2, CYP2C18, CYP3A4, and UGT2B17 protein abundance was similar or even higher in the jejunum, and all other DMEs were found in higher amounts in the liver. Significant correlations between gene expression and protein levels were observed only for 2 of 15 jejunal, but 13 of 23 hepatic DMEs. Intestinal and hepatic protein amounts only significantly correlated for CYP3A4 and UGT1A3. Our results demonstrated a notable variability between the individuals, which was even higher in the intestines than in the liver. Our intrasubject analysis of DMEs in the jejunum and liver from healthy donors, may be useful for physiologically-based pharmacokinetic-based modeling and prediction in order to improve efficacy and safety of oral drug therapy.
MeSH term(s)	Male ; Humans ; Female ; Jejunum/metabolism ; Cytochrome P-450 CYP3A/genetics ; Cytochrome P-450 CYP3A/metabolism ; Liver/metabolism ; Cytochrome P-450 Enzyme System/genetics ; Cytochrome P-450 Enzyme System/metabolism ; Gene Expression ; Imidazoles ; Organosilicon Compounds
Chemical Substances	Cytochrome P-450 CYP3A (EC 1.14.14.1) ; dimethylethylsilylimidazole (62365-34-8) ; Cytochrome P-450 Enzyme System (9035-51-2) ; Imidazoles ; Organosilicon Compounds
Language	English
Publishing date	2023-10-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	123793-7
ISSN	1532-6535 ; 0009-9236
ISSN (online)	1532-6535
ISSN	0009-9236
DOI	10.1002/cpt.3055
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