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Article ; Online: Will we see protection or reinfection in COVID-19?

Ota, Miyo

2020 Volume 20, Issue 6, Page(s) 351

Keywords	covid19
Language	English
Publishing date	2020-04-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2062776-2
ISSN	1474-1741 ; 1474-1733
ISSN (online)	1474-1741
ISSN	1474-1733
DOI	10.1038/s41577-020-0316-3
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Article: Will we see protection or reinfection in COVID-19?

Ota, Miyo

Nat Rev Immunol

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #71985
Database	COVID19

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Article ; Online: Will we see protection or reinfection in COVID-19?

Ota, Miyo

Nature Reviews Immunology

2020 Volume 20, Issue 6, Page(s) 351–351

Keywords	Immunology ; covid19
Language	English
Publisher	Springer Science and Business Media LLC
Publishing country	us
Document type	Article ; Online
ZDB-ID	2062776-2
ISSN	1474-1741 ; 1474-1733
ISSN (online)	1474-1741
ISSN	1474-1733
DOI	10.1038/s41577-020-0316-3
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Article ; Online: CD23

Ota, Miyo / Hoehn, Kenneth B / Fernandes-Braga, Weslley / Ota, Takayuki / Aranda, Carlos J / Friedman, Sara / Miranda-Waldetario, Mariana G C / Redes, Jamie / Suprun, Maria / Grishina, Galina / Sampson, Hugh A / Malbari, Alefiyah / Kleinstein, Steven H / Sicherer, Scott H / Curotto de Lafaille, Maria A

Science translational medicine

2024 Volume 16, Issue 733, Page(s) eadi0673

Abstract: Food allergy is caused by allergen-specific immunoglobulin E (IgE) antibodies, but little is known about the B cell memory of persistent IgE responses. Here, we describe, in human pediatric peanut allergy, a population of ... ...

Abstract	Food allergy is caused by allergen-specific immunoglobulin E (IgE) antibodies, but little is known about the B cell memory of persistent IgE responses. Here, we describe, in human pediatric peanut allergy, a population of CD23
MeSH term(s)	Humans ; Child ; Peanut Hypersensitivity ; Memory B Cells ; Immunoglobulin G ; Food Hypersensitivity ; Allergens ; Immunoglobulin E
Chemical Substances	Immunoglobulin G ; Allergens ; Immunoglobulin E (37341-29-0)
Language	English
Publishing date	2024-02-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	2518854-9
ISSN	1946-6242 ; 1946-6234
ISSN (online)	1946-6242
ISSN	1946-6234
DOI	10.1126/scitranslmed.adi0673
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Article: The memory of pathogenic IgE is contained within CD23

Ota, Miyo / Hoehn, Kenneth B / Ota, Takayuki / Aranda, Carlos J / Friedman, Sara / Braga, Weslley F / Malbari, Alefiyah / Kleinstein, Steven H / Sicherer, Scott H / Curotto de Lafaille, Maria A

bioRxiv : the preprint server for biology

2023

Abstract: Food allergy is caused by allergen-specific IgE antibodies but little is known about the B cell memory of persistent IgE responses. Here we describe in human pediatric peanut allergy CD23 : One-sentence summary: We describe a unique population of ... ...

Abstract	Food allergy is caused by allergen-specific IgE antibodies but little is known about the B cell memory of persistent IgE responses. Here we describe in human pediatric peanut allergy CD23 One-sentence summary: We describe a unique population of IgG
Language	English
Publishing date	2023-01-25
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.01.25.525506
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Article ; Online: IgG memory B cells expressing IL4R and FCER2 are associated with atopic diseases

Aranda, Carlos J. / Gonzalez‐Kozlova, Edgar / Saunders, Sean P. / Fernandes‐Braga, Weslley / Ota, Miyo / Narayanan, Sriram / He, Jin‐Shu / Del Duca, Ester / Swaroop, Bose / Gnjatic, Sacha / Shattner, Gail / Reibman, Joan / Soter, Nicholas A. / Guttman‐Yassky, Emma / Curotto de Lafaille, Maria A.

Allergy 2023 Mar., v. 78, no. 3, p. 752-766

2023 , Page(s) 752–766

Abstract: BACKGROUND: Atopic diseases are characterized by IgE antibody responses that are dependent on cognate CD4 T cell help and T cell‐produced IL‐4 and IL‐13. Current models of IgE cell differentiation point to the role of IgG memory B cells as precursors of ... ...

Abstract	BACKGROUND: Atopic diseases are characterized by IgE antibody responses that are dependent on cognate CD4 T cell help and T cell‐produced IL‐4 and IL‐13. Current models of IgE cell differentiation point to the role of IgG memory B cells as precursors of pathogenic IgE plasma cells. The goal of this work was to identify intrinsic features of memory B cells that are associated with IgE production in atopic diseases. METHODS: Peripheral blood B lymphocytes were collected from individuals with physician diagnosed asthma or atopic dermatitis (AD) and from non‐atopic individuals. These samples were analyzed by spectral flow cytometry, single cell RNA sequencing (scRNAseq), and in vitro activation assays. RESULTS: We identified a novel population of IgG memory B cells characterized by the expression of IL‐4/IL‐13 regulated genes FCER2/CD23, IL4R, IL13RA1, and IGHE, denoting a history of differentiation during type 2 immune responses. CD23⁺IL4R⁺IgG⁺ memory B cells had increased occurrence in individuals with atopic disease. Importantly, the frequency of CD23⁺IL4R⁺IgG⁺ memory B cells correlated with levels of circulating IgE. Consistently, in vitro stimulated B cells from atopic individuals generated more IgE⁺ cells than B cells from non‐atopic subjects. CONCLUSIONS: These findings suggest that CD23⁺IL4R⁺ IgG⁺ memory B cells transcribing IGHE are potential precursors of IgE plasma cells and are linked to pathogenic IgE production.
Keywords	CD4-positive T-lymphocytes ; RNA ; antibodies ; asthma ; atopic dermatitis ; cell differentiation ; flow cytometry ; interleukin-13 ; interleukin-4 ; memory
Language	English
Dates of publication	2023-03
Size	p. 752-766.
Publishing place	John Wiley & Sons, Inc
Document type	Article ; Online
Note	JOURNAL ARTICLE
ZDB-ID	391933-x
ISSN	1398-9995 ; 0105-4538
ISSN (online)	1398-9995
ISSN	0105-4538
DOI	10.1111/all.15601
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: IgG memory B cells expressing IL4R and FCER2 are associated with atopic diseases.

Aranda, Carlos J / Gonzalez-Kozlova, Edgar / Saunders, Sean P / Fernandes-Braga, Weslley / Ota, Miyo / Narayanan, Sriram / He, Jin-Shu / Del Duca, Ester / Swaroop, Bose / Gnjatic, Sacha / Shattner, Gail / Reibman, Joan / Soter, Nicholas A / Guttman-Yassky, Emma / Curotto de Lafaille, Maria A

Allergy

2022 Volume 78, Issue 3, Page(s) 752–766

Abstract: Background: Atopic diseases are characterized by IgE antibody responses that are dependent on cognate CD4 T cell help and T cell-produced IL-4 and IL-13. Current models of IgE cell differentiation point to the role of IgG memory B cells as precursors of ...

Abstract	Background: Atopic diseases are characterized by IgE antibody responses that are dependent on cognate CD4 T cell help and T cell-produced IL-4 and IL-13. Current models of IgE cell differentiation point to the role of IgG memory B cells as precursors of pathogenic IgE plasma cells. The goal of this work was to identify intrinsic features of memory B cells that are associated with IgE production in atopic diseases. Methods: Peripheral blood B lymphocytes were collected from individuals with physician diagnosed asthma or atopic dermatitis (AD) and from non-atopic individuals. These samples were analyzed by spectral flow cytometry, single cell RNA sequencing (scRNAseq), and in vitro activation assays. Results: We identified a novel population of IgG memory B cells characterized by the expression of IL-4/IL-13 regulated genes FCER2/CD23, IL4R, IL13RA1, and IGHE, denoting a history of differentiation during type 2 immune responses. CD23 Conclusions: These findings suggest that CD23
MeSH term(s)	Humans ; Memory B Cells ; Receptors, IgE/metabolism ; Interleukin-13 ; Interleukin-4 ; Immunoglobulin E ; Immunoglobulin G ; Interleukin-4 Receptor alpha Subunit ; Lectins, C-Type
Chemical Substances	Receptors, IgE ; Interleukin-13 ; Interleukin-4 (207137-56-2) ; Immunoglobulin E (37341-29-0) ; Immunoglobulin G ; IL4R protein, human ; Interleukin-4 Receptor alpha Subunit ; FCER2 protein, human ; Lectins, C-Type
Language	English
Publishing date	2022-12-19
Publishing country	Denmark
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	391933-x
ISSN	1398-9995 ; 0105-4538
ISSN (online)	1398-9995
ISSN	0105-4538
DOI	10.1111/all.15601
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Article ; Online: Postmarketing surveillance evaluating the safety and effectiveness of golimumab in Japanese patients with rheumatoid arthritis.

Kanbori, Masayoshi / Suzuka, Hiroshi / Yajima, Tsutomu / Kishino, Emika / Morishige, Ryuji / Momohara, Shigeki / Kawakami, Atsushi / Ota, Miyo

Modern rheumatology

2018 Volume 28, Issue 1, Page(s) 66–75

Abstract: Objectives: The purpose of this study was to evaluate the real-world safety and effectiveness of golimumab (GLM) in Japanese patients with rheumatoid arthritis.: Methods: A postmarketing surveillance of 5154 patients was conducted with a follow-up ... ...

Abstract	Objectives: The purpose of this study was to evaluate the real-world safety and effectiveness of golimumab (GLM) in Japanese patients with rheumatoid arthritis. Methods: A postmarketing surveillance of 5154 patients was conducted with a follow-up duration of at least 24 weeks. Patients were divided into four groups based on the initial treatment: 50 mg or 100 mg of GLM with concomitant use of methotrexate (MTX) and 50 mg or 100 mg of GLM monotherapy. Patient characteristics at baseline, safety and effectiveness were assessed for each group. Results: Over 70% of patients received 50 mg of GLM with concomitant MTX, and approximately, 20% received monotherapy. The incidence rate of adverse events was 45.40 per 100 patient-years. The incidence of adverse events including serious adverse events was comparable across all groups. The proportion of patients showing remission or low disease activity increased from 13.69% to 46.21% at the final evaluation, and no differences were observed in the percentage of remission across the four groups. Concomitant MTX use was associated with higher probability of continuing therapy. Conclusions: GLM showed effectiveness in Japanese rheumatoid arthritis patients with an acceptable safety profile.
MeSH term(s)	Adult ; Aged ; Antibodies, Monoclonal/administration & dosage ; Antibodies, Monoclonal/adverse effects ; Antibodies, Monoclonal/therapeutic use ; Antirheumatic Agents/administration & dosage ; Antirheumatic Agents/adverse effects ; Antirheumatic Agents/therapeutic use ; Arthritis, Rheumatoid/drug therapy ; Drug Therapy, Combination ; Female ; Humans ; Male ; Methotrexate/administration & dosage ; Methotrexate/adverse effects ; Methotrexate/therapeutic use ; Middle Aged ; Product Surveillance, Postmarketing
Chemical Substances	Antibodies, Monoclonal ; Antirheumatic Agents ; golimumab (91X1KLU43E) ; Methotrexate (YL5FZ2Y5U1)
Language	English
Publishing date	2018-01
Publishing country	United States
Document type	Clinical Trial ; Journal Article ; Observational Study
ZDB-ID	2078157-X
ISSN	1439-7609 ; 1439-7595
ISSN (online)	1439-7609
ISSN	1439-7595
DOI	10.1080/14397595.2017.1325058
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Article ; Online: Skewed primary Igκ repertoire and V-J joining in C57BL/6 mice: implications for recombination accessibility and receptor editing.

Aoki-Ota, Miyo / Torkamani, Ali / Ota, Takayuki / Schork, Nicholas / Nemazee, David

Journal of immunology (Baltimore, Md. : 1950)

2012 Volume 188, Issue 5, Page(s) 2305–2315

Abstract: Previous estimates of the diversity of the mouse Ab repertoire have been based on fragmentary data as a result of many technical limitations, in particular, the many samples necessary to provide adequate coverage. In this study, we used 5'-coding end ... ...

Abstract	Previous estimates of the diversity of the mouse Ab repertoire have been based on fragmentary data as a result of many technical limitations, in particular, the many samples necessary to provide adequate coverage. In this study, we used 5'-coding end amplification of Igκ mRNAs from bone marrow, splenic, and lymph node B cells of C57BL/6 mice combined with amplicon pyrosequencing to assess the functional and nonfunctional Vκ repertoire. To evaluate the potential effects of receptor editing, we also compared V/J associations and usage in bone marrows of mouse mutants under constitutive negative selection or an altered ability to undergo secondary recombination. To focus on preimmune B cells, our cell sorting strategy excluded memory B cells and plasma cells. Analysis of ~90 Mbp, representing >250,000 individual transcripts from 59 mice, revealed that 101 distinct functional Vκ genes are used but at frequencies ranging from ~0.001 to ~10%. Usage of seven Vκ genes made up >40% of the repertoire. A small class of transcripts from apparently nonfunctional Vκ genes was found, as were occasional transcripts from several apparently functional genes that carry aberrant recombination signals. Of 404 potential V-J combinations (101 Vκs × 4 Jκs), 398 (98.5%) were found at least once in our sample. For most Vκ transcripts, all Jκs were used, but V-J association biases were common. Usage patterns were remarkably stable in different selective conditions. Overall, the primary κ repertoire is highly skewed by preferred rearrangements, limiting Ab diversity, but potentially facilitating receptor editing.
MeSH term(s)	Animals ; Antibody Diversity/genetics ; B-Lymphocyte Subsets/immunology ; B-Lymphocyte Subsets/metabolism ; Bone Marrow Cells/immunology ; Bone Marrow Cells/metabolism ; Female ; Gene Rearrangement, B-Lymphocyte, Light Chain ; Immunoglobulin Joining Region/biosynthesis ; Immunoglobulin Joining Region/genetics ; Immunoglobulin Joining Region/metabolism ; Immunoglobulin Variable Region/biosynthesis ; Immunoglobulin Variable Region/genetics ; Immunoglobulin Variable Region/metabolism ; Immunoglobulin kappa-Chains/biosynthesis ; Immunoglobulin kappa-Chains/genetics ; Immunoglobulin kappa-Chains/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; RNA Editing/genetics ; RNA Editing/immunology ; Recombination, Genetic/immunology ; Sequence Analysis, DNA
Chemical Substances	Immunoglobulin Joining Region ; Immunoglobulin Variable Region ; Immunoglobulin kappa-Chains
Language	English
Publishing date	2012-01-27
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	3056-9
ISSN	1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
ISSN (online)	1550-6606
ISSN	0022-1767 ; 1048-3233 ; 1047-7381
DOI	10.4049/jimmunol.1103484
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Article ; Online: Suppression of IgE B cells and IgE binding to Fc(epsilon)RI by gene therapy with single-chain anti-IgE.

Ota, Takayuki / Aoki-Ota, Miyo / Duong, Bao Hoa / Nemazee, David

Journal of immunology (Baltimore, Md. : 1950)

2009 Volume 182, Issue 12, Page(s) 8110–8117

Abstract: IgE plays a pivotal role in allergic reactions and asthma through its ability to bind to the mast cell FcR for IgE (FcepsilonRI). Current therapies to suppress such reactions include passive treatment with neutralizing Abs to IgE that block its binding ... ...

Abstract	IgE plays a pivotal role in allergic reactions and asthma through its ability to bind to the mast cell FcR for IgE (FcepsilonRI). Current therapies to suppress such reactions include passive treatment with neutralizing Abs to IgE that block its binding to FcepsilonRI. In theory, induction of immune tolerance in the B lymphocytes that carry IgE Ag receptors and give rise to IgE-secreting cells should provide longer term efficacy. However, recent data have suggested that such memory cells may lack cell surface IgE. Using a gene therapy approach, we show that a recombinant single-chain neutralizing anti-IgE could not only neutralize circulating IgE, but also reduce IgE(+) B cell numbers and H chain transcripts. Therapeutic anti-IgE stimulated a calcium response in primary B cells or in a B cell line expressing membrane IgE and suppressed IgE secretion in vitro, suggesting that active signaling through membrane IgE likely promoted tolerance. Interestingly, upon subsequent challenge of anti-IgE-treated mice with an IgE cross-linking reagent capable of inducing activation of IgE-decorated mast cells, an anaphylaxis reaction was induced, apparently via a FcgammaRIII pathway involving recognition of anti-IgE Ab itself. These studies have important implications for the optimal design of safe and effective anti-IgE therapies and suggest that the IgE memory B cells may be targeted by such genetic Ab therapies.
MeSH term(s)	Anaphylaxis/immunology ; Animals ; B-Lymphocytes/immunology ; B-Lymphocytes/metabolism ; Cell Line ; Genetic Therapy ; Humans ; Immunization ; Immunoglobulin E/genetics ; Immunoglobulin E/immunology ; Immunoglobulin E/metabolism ; Mice ; Mice, Inbred BALB C ; Protein Binding/immunology ; Receptors, IgE/deficiency ; Receptors, IgE/genetics ; Receptors, IgE/immunology ; Receptors, IgE/metabolism ; Recombinant Proteins/genetics ; Recombinant Proteins/immunology ; Recombinant Proteins/metabolism
Chemical Substances	Receptors, IgE ; Recombinant Proteins ; Immunoglobulin E (37341-29-0)
Language	English
Publishing date	2009-06-03
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	3056-9
ISSN	1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
ISSN (online)	1550-6606
ISSN	0022-1767 ; 1048-3233 ; 1047-7381
DOI	10.4049/jimmunol.0900300
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