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Article ; Online: Organocatalyzed ring-opening reactions of γ-carbonyl-substituted ε-caprolactones.

Ota, Takayuki / Montagna, Valentina / Higuchi, Yuji / Kato, Takashi / Tanaka, Masaru / Sardon, Haritz / Fukushima, Kazuki

RSC advances

2023 Volume 13, Issue 40, Page(s) 27764–27771

Abstract: Side-chain-functionalized aliphatic polyesters are promising as functional biodegradable polymers. We have investigated ring-opening reactions of γ-carbonyl-substituted ε-caprolactones (gCCLs) to obtain poly(ε-caprolactone) (PCL) analogues. Organic ... ...

Abstract	Side-chain-functionalized aliphatic polyesters are promising as functional biodegradable polymers. We have investigated ring-opening reactions of γ-carbonyl-substituted ε-caprolactones (gCCLs) to obtain poly(ε-caprolactone) (PCL) analogues. Organic catalysts and Sn(Oct)
Language	English
Publishing date	2023-09-19
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/d3ra01025b
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Klebsiella invasive liver abscess syndrome presenting with a central nervous system manifestation secondary to latent cholecystitis: a case report.

Kinoshita, Osamu / Okamoto, Takanari / Ota, Takayuki / Takayama, Shun / Oi, Yuta / Tanaka, Sachie / Taniyama, Ichita / Naito, Kei / Inoue, Yasuo

Journal of medical case reports

2022 Volume 16, Issue 1, Page(s) 234

Abstract: Background: Brain abscess is a life-threatening event. Moreover, when Klebsiella pneumoniae is the cause, rapid diagnosis and appropriate treatment are required. Klebsiella invasive liver abscess syndrome, a bloodstream metastatic infection of ... ...

Abstract	Background: Brain abscess is a life-threatening event. Moreover, when Klebsiella pneumoniae is the cause, rapid diagnosis and appropriate treatment are required. Klebsiella invasive liver abscess syndrome, a bloodstream metastatic infection of potentially aggressive nature, has been recognized to cause infection in the central nervous system, and concern for Klebsiella liver abscess syndrome is increasing globally. Case presentation: A 73-year-old Japanese woman was admitted to the institution complaining of aggravated dysarthria and weakness in the right upper extremities with onset 5 days earlier. Magnetic resonance imaging revealed a brain abscess in the left basal ganglia, and abdominal computed tomography revealed a liver abscess in liver segment 7. The patient's dysarthria symptoms became increasingly worse over the next few days, so surgical drainage via frontotemporal craniotomy was performed on admission day 3, and subsequent culture from the brain abscess showed growth of Klebsiella pneumoniae. On admission day 9, percutaneous transhepatic drainage of the liver segment 7 abscess was undertaken. The pus culture also showed growth of Klebsiella pneumoniae, thus associating the liver abscess with the brain abscess. Following long-term conservative treatment with antibiotics and abscess drainage, the liver abscess disappeared. However, the patient continuously presented with right upper quadrant pain, and abdominal computed tomography showed swelling of the gallbladder. Consequently, percutaneous transhepatic gallbladder drainage was initially administered, and the bile culture was also positive for Klebsiella pneumoniae. For radical treatment, a laparoscopic cholecystectomy was performed on admission day 99. The postoperative period was complicated by an intraabdominal abscess; however, conservative therapy was successful. She was subsequently discharged, and 12-month follow-up revealed no further sequelae. Conclusions: We describe a rare case of Klebsiella liver abscess syndrome, which first presented with a central nervous system manifestation. Our patient was successfully treated via an early surgical intervention and subsequent antibiotic therapy. Although surgical drainage remains the cornerstone treatment for brain abscess, when a brain abscess is found, and there is a high index of suspicion for the existence of a liver abscess, Klebsiella liver abscess syndrome should be considered as a possible diagnosis.
MeSH term(s)	Aged ; Anti-Bacterial Agents/therapeutic use ; Brain Abscess/diagnostic imaging ; Brain Abscess/etiology ; Central Nervous System ; Cholecystitis ; Dysarthria ; Female ; Humans ; Klebsiella ; Klebsiella Infections/complications ; Klebsiella Infections/diagnosis ; Klebsiella Infections/therapy ; Klebsiella pneumoniae ; Liver Abscess/diagnostic imaging ; Liver Abscess/surgery ; Sepsis/drug therapy
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2022-06-07
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2269805-X
ISSN	1752-1947 ; 1752-1947
ISSN (online)	1752-1947
ISSN	1752-1947
DOI	10.1186/s13256-022-03325-7
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Article ; Online: CD23

Ota, Miyo / Hoehn, Kenneth B / Fernandes-Braga, Weslley / Ota, Takayuki / Aranda, Carlos J / Friedman, Sara / Miranda-Waldetario, Mariana G C / Redes, Jamie / Suprun, Maria / Grishina, Galina / Sampson, Hugh A / Malbari, Alefiyah / Kleinstein, Steven H / Sicherer, Scott H / Curotto de Lafaille, Maria A

Science translational medicine

2024 Volume 16, Issue 733, Page(s) eadi0673

Abstract: Food allergy is caused by allergen-specific immunoglobulin E (IgE) antibodies, but little is known about the B cell memory of persistent IgE responses. Here, we describe, in human pediatric peanut allergy, a population of ... ...

Abstract	Food allergy is caused by allergen-specific immunoglobulin E (IgE) antibodies, but little is known about the B cell memory of persistent IgE responses. Here, we describe, in human pediatric peanut allergy, a population of CD23
MeSH term(s)	Humans ; Child ; Peanut Hypersensitivity ; Memory B Cells ; Immunoglobulin G ; Food Hypersensitivity ; Allergens ; Immunoglobulin E
Chemical Substances	Immunoglobulin G ; Allergens ; Immunoglobulin E (37341-29-0)
Language	English
Publishing date	2024-02-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	2518854-9
ISSN	1946-6242 ; 1946-6234
ISSN (online)	1946-6242
ISSN	1946-6234
DOI	10.1126/scitranslmed.adi0673
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Article ; Online: Fusion of the molecular adjuvant C3d to cleavage-independent native-like HIV-1 Env trimers improves the elicited antibody response.

Bale, Shridhar / Yang, Lifei / Alirezaei, Mehrdad / Wilson, Richard / Ota, Takayuki / Doyle, Esmeralda D / Cottrell, Christopher A / Guenaga, Javier / Tran, Karen / Li, Wenjuan / Stamatatos, Leonidas / Nemazee, David / Ward, Andrew B / Wyatt, Richard T

Frontiers in immunology

2023 Volume 14, Page(s) 1180959

Abstract: An effective HIV vaccine likely requires the elicitation of neutralizing antibodies (NAbs) against multiple HIV-1 clades. The recently developed cleavage-independent native flexibly linked (NFL) envelope (Env) trimers exhibit well-ordered conformation ... ...

Abstract	An effective HIV vaccine likely requires the elicitation of neutralizing antibodies (NAbs) against multiple HIV-1 clades. The recently developed cleavage-independent native flexibly linked (NFL) envelope (Env) trimers exhibit well-ordered conformation and elicit autologous tier 2 NAbs in multiple animal models. Here, we investigated whether the fusion of molecular adjuvant C3d to the Env trimers can improve B- cell germinal center (GC) formation and antibody responses. To generate Env-C3d trimers, we performed a glycine-serine- based (G
MeSH term(s)	Animals ; Mice ; HIV Antibodies ; HIV-1 ; Antibody Formation ; env Gene Products, Human Immunodeficiency Virus ; HIV Seropositivity ; Antibodies, Neutralizing ; Adjuvants, Immunologic
Chemical Substances	HIV Antibodies ; env Gene Products, Human Immunodeficiency Virus ; Antibodies, Neutralizing ; Adjuvants, Immunologic
Language	English
Publishing date	2023-05-22
Publishing country	Switzerland
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1180959
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Article: The memory of pathogenic IgE is contained within CD23

Ota, Miyo / Hoehn, Kenneth B / Ota, Takayuki / Aranda, Carlos J / Friedman, Sara / Braga, Weslley F / Malbari, Alefiyah / Kleinstein, Steven H / Sicherer, Scott H / Curotto de Lafaille, Maria A

bioRxiv : the preprint server for biology

2023

Abstract: Food allergy is caused by allergen-specific IgE antibodies but little is known about the B cell memory of persistent IgE responses. Here we describe in human pediatric peanut allergy CD23 : One-sentence summary: We describe a unique population of ... ...

Abstract	Food allergy is caused by allergen-specific IgE antibodies but little is known about the B cell memory of persistent IgE responses. Here we describe in human pediatric peanut allergy CD23 One-sentence summary: We describe a unique population of IgG
Language	English
Publishing date	2023-01-25
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.01.25.525506
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Monoether-Tagged Biodegradable Polycarbonate Preventing Platelet Adhesion and Demonstrating Vascular Cell Adhesion: A Promising Material for Resorbable Vascular Grafts and Stents

Fukushima, Kazuki / Haga Yuta / Honda Kota / Inoue Yuto / Ota Takayuki / Sato Chikako / Tanaka Masaru

Biomacromolecules. 2017 Nov. 13, v. 18, no. 11

2017

Abstract: We developed a biodegradable polycarbonate that demonstrates antithrombogenicity and vascular cell adhesion via organocatalytic ring-opening polymerization of a trimethylene carbonate (TMC) analogue bearing a methoxy group. The monoether-tagged ... ...

Abstract	We developed a biodegradable polycarbonate that demonstrates antithrombogenicity and vascular cell adhesion via organocatalytic ring-opening polymerization of a trimethylene carbonate (TMC) analogue bearing a methoxy group. The monoether-tagged polycarbonate demonstrates a platelet adhesion property that is 93 and 89% lower than those of poly(ethylene terephthalate) and polyTMC, respectively. In contrast, vascular cell adhesion properties of the polycarbonate are comparable to those controls, indicating a potential for selective cell adhesion properties. This difference in the cell adhesion property is well associated with surface hydration, which affects protein adsorption and denaturation. Fibrinogen is slightly denatured on the monoether-tagged polycarbonate, whereas fibronectin is highly activated to expose the RGD motif for favorable vascular cell adhesion. The surface hydration, mainly induced by the methoxy side chain, also contributes to slowing the enzymatic degradation. Consequently, the polycarbonate exhibits decent blood compatibility, vascular cell adhesion properties, and biodegradability, which is promising for applications in resorbable vascular grafts and stents.
Keywords	adhesion ; adsorption ; biodegradability ; blood platelets ; cell adhesion ; denaturation ; ethylene ; fibrinogen ; fibronectins ; polyethylene terephthalates ; polymerization
Language	English
Dates of publication	2017-1113
Size	p. 3834-3843.
Publishing place	American Chemical Society
Document type	Article
ISSN	1526-4602
DOI	10.1021%2Facs.biomac.7b01210
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: The first case of SMARCA4-deficient sarcoma of stomach.

Ota, Takayuki / Ishikawa, Takeshi / Yasuda, Ritsu / Yasuda, Tomoyo / Okayama, Tetsuya / Inoue, Ken / Dohi, Osamu / Yoshida, Naohisa / Kamada, Kazuhiro / Uchiyama, Kazuhiko / Takagi, Tomohiro / Konishi, Hideyuki / Naito, Yuji / Matsuyama, Kiichi / Yamaguchi, Tomohiro / Ootsuka, Kazuo / Yoshida, Akihiko / Kishimoto, Mitsuo / Itoh, Yoshito

Clinical journal of gastroenterology

2022 Volume 15, Issue 3, Page(s) 531–536

Abstract: SMARCA4-deficient sarcoma was first reported in the chest and recently in the uterus, but not in the stomach. Here, we present a patient diagnosed with SMARCA4-deficient sarcoma of the stomach, using histochemistry. An emergency operation was performed ... ...

Abstract	SMARCA4-deficient sarcoma was first reported in the chest and recently in the uterus, but not in the stomach. Here, we present a patient diagnosed with SMARCA4-deficient sarcoma of the stomach, using histochemistry. An emergency operation was performed due to perforation of the tumor. However, one month after the operation, two nodes recurred, and six cycles of combination chemotherapy consisting of adriamycin and ifosfamide were administered. The combination chemotherapy showed a remarkable effect, and complete remission was achieved. The patient was alive without recurrence after 48-month follow-up. SMARCA4-deficient sarcoma is an exceedingly rare tumor with an extremely poor therapeutic response to anticancer drugs. Herein, we present the first case of SMARCA4-deficient sarcoma of the stomach, where a complete response to chemotherapy was achieved.
MeSH term(s)	Antineoplastic Agents/therapeutic use ; Biomarkers, Tumor ; DNA Helicases ; Female ; Humans ; Nuclear Proteins/genetics ; Nuclear Proteins/therapeutic use ; Sarcoma/diagnosis ; Sarcoma/drug therapy ; Sarcoma/genetics ; Stomach/pathology ; Stomach Neoplasms/metabolism ; Transcription Factors/genetics ; Transcription Factors/therapeutic use
Chemical Substances	Antineoplastic Agents ; Biomarkers, Tumor ; Nuclear Proteins ; Transcription Factors ; SMARCA4 protein, human (EC 3.6.1.-) ; DNA Helicases (EC 3.6.4.-)
Language	English
Publishing date	2022-02-17
Publishing country	Japan
Document type	Case Reports ; Journal Article
ZDB-ID	2429411-1
ISSN	1865-7265 ; 1865-7257
ISSN (online)	1865-7265
ISSN	1865-7257
DOI	10.1007/s12328-022-01606-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Water-soluble dietary fiber alleviates cancer-induced muscle wasting through changes in gut microenvironment in mice.

Sakakida, Tomoki / Ishikawa, Takeshi / Doi, Toshifumi / Morita, Ryuichi / Endo, Yuki / Matsumura, Shinya / Ota, Takayuki / Yoshida, Juichiro / Hirai, Yasuko / Mizushima, Katsura / Higashimura, Yasuki / Inoue, Ken / Okayama, Tetsuya / Uchiyama, Kazuhiko / Takagi, Tomohisa / Abe, Aya / Inoue, Ryo / Itoh, Yoshito / Naito, Yuji

Cancer science

2022 Volume 113, Issue 5, Page(s) 1789–1800

Abstract: Cancer cachexia and the associated skeletal muscle wasting are considered poor prognostic factors, although effective treatment has not yet been established. Recent studies have indicated that the pathogenesis of skeletal muscle loss may involve ... ...

Abstract	Cancer cachexia and the associated skeletal muscle wasting are considered poor prognostic factors, although effective treatment has not yet been established. Recent studies have indicated that the pathogenesis of skeletal muscle loss may involve dysbiosis of the gut microbiota and the accompanying chronic inflammation or altered metabolism. In this study, we evaluated the possible effects of modifying the gut microenvironment with partially hydrolyzed guar gum (PHGG), a soluble dietary fiber, on cancer-related muscle wasting and its mechanism using a colon-26 murine cachexia model. Compared with a fiber-free (FF) diet, PHGG contained fiber-rich (FR) diet-attenuated skeletal muscle loss in cachectic mice by suppressing the elevation of the major muscle-specific ubiquitin ligases Atrogin-1 and MuRF1, as well as the autophagy markers LC3 and Bnip3. Although tight-junction markers were partially reduced in both FR and FF diet-fed cachectic mice, the abundance of Bifidobacterium, Akkermansia, and unclassified S24-7 family increased by FR diet, contributing to the retention of the colonic mucus layer. The reinforcement of the gut barrier function resulted in the controlled entry of pathogens into the host system and reduced circulating levels of lipopolysaccharide-binding protein (LBP) and IL-6, which in turn led to the suppression of proteolysis by downregulating the ubiquitin-proteasome system and autophagy pathway. These results suggest that dietary fiber may have the potential to alleviate skeletal muscle loss in cancer cachexia, providing new insights for developing effective strategies in the future.
MeSH term(s)	Animals ; Cachexia/etiology ; Cachexia/prevention & control ; Dietary Fiber/metabolism ; Dietary Fiber/pharmacology ; Humans ; Mice ; Muscle, Skeletal ; Muscular Atrophy/pathology ; Neoplasms/pathology ; Tumor Microenvironment ; Ubiquitin/metabolism ; Water/metabolism
Chemical Substances	Dietary Fiber ; Ubiquitin ; Water (059QF0KO0R)
Language	English
Publishing date	2022-03-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2115647-5
ISSN	1349-7006 ; 1349-7006
ISSN (online)	1349-7006
ISSN	1349-7006
DOI	10.1111/cas.15306
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Monoether-Tagged Biodegradable Polycarbonate Preventing Platelet Adhesion and Demonstrating Vascular Cell Adhesion: A Promising Material for Resorbable Vascular Grafts and Stents.

Fukushima, Kazuki / Inoue, Yuto / Haga, Yuta / Ota, Takayuki / Honda, Kota / Sato, Chikako / Tanaka, Masaru

Biomacromolecules

2017 Volume 18, Issue 11, Page(s) 3834–3843

Abstract	We developed a biodegradable polycarbonate that demonstrates antithrombogenicity and vascular cell adhesion via organocatalytic ring-opening polymerization of a trimethylene carbonate (TMC) analogue bearing a methoxy group. The monoether-tagged polycarbonate demonstrates a platelet adhesion property that is 93 and 89% lower than those of poly(ethylene terephthalate) and polyTMC, respectively. In contrast, vascular cell adhesion properties of the polycarbonate are comparable to those controls, indicating a potential for selective cell adhesion properties. This difference in the cell adhesion property is well associated with surface hydration, which affects protein adsorption and denaturation. Fibrinogen is slightly denatured on the monoether-tagged polycarbonate, whereas fibronectin is highly activated to expose the RGD motif for favorable vascular cell adhesion. The surface hydration, mainly induced by the methoxy side chain, also contributes to slowing the enzymatic degradation. Consequently, the polycarbonate exhibits decent blood compatibility, vascular cell adhesion properties, and biodegradability, which is promising for applications in resorbable vascular grafts and stents.
MeSH term(s)	Biocompatible Materials/chemical synthesis ; Biocompatible Materials/chemistry ; Biocompatible Materials/pharmacology ; Biodegradable Plastics/chemical synthesis ; Biodegradable Plastics/chemistry ; Biodegradable Plastics/pharmacology ; Blood Platelets/drug effects ; Cell Adhesion/drug effects ; Endothelial Cells/drug effects ; Human Umbilical Vein Endothelial Cells ; Humans ; Platelet Adhesiveness/drug effects ; Polycarboxylate Cement/chemical synthesis ; Polycarboxylate Cement/chemistry ; Polycarboxylate Cement/pharmacology ; Stents ; Vascular Grafting/methods
Chemical Substances	Biocompatible Materials ; Biodegradable Plastics ; Polycarboxylate Cement ; polycarbonate (25766-59-0)
Language	English
Publishing date	2017-11-13
Publishing country	United States
Document type	Journal Article
ISSN	1526-4602
ISSN (online)	1526-4602
DOI	10.1021/acs.biomac.7b01210
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Methoxy-Functionalized Glycerol-Based Aliphatic Polycarbonate: Organocatalytic Synthesis, Blood Compatibility, and Hydrolytic Property.

Montagna, Valentina / Takahashi, Junko / Tsai, Meng-Yu / Ota, Takayuki / Zivic, Nicolas / Kawaguchi, Seigou / Kato, Takashi / Tanaka, Masaru / Sardon, Haritz / Fukushima, Kazuki

ACS biomaterials science & engineering

2021 Volume 7, Issue 2, Page(s) 472–481

Abstract: Polymers that are biocompatible and degradable are desired for tissue engineering approaches in the treatment of vascular diseases, especially for those involving small-diameter blood vessels. Herein, we report the compatibility of a newly developed ... ...

Abstract	Polymers that are biocompatible and degradable are desired for tissue engineering approaches in the treatment of vascular diseases, especially for those involving small-diameter blood vessels. Herein, we report the compatibility of a newly developed glycerol-based aliphatic polycarbonate possessing simple methoxy side groups, named poly(5-methoxy-1,3-dioxan-2-one) (PMDO), with blood cells and plasma proteins as well as its susceptibility to hydrolysis. As a consequence of the organocatalytic ring-opening polymerization (ROP) of a methoxy-functionalized cyclic carbonate derived from glycerol, PMDO with a sufficiently high molecular weight (
MeSH term(s)	Carbonates ; Glycerol ; Hydrolysis ; Polycarboxylate Cement ; Polymers
Chemical Substances	Carbonates ; Polycarboxylate Cement ; Polymers ; polycarbonate (25766-59-0) ; Glycerol (PDC6A3C0OX)
Language	English
Publishing date	2021-01-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2373-9878
ISSN (online)	2373-9878
DOI	10.1021/acsbiomaterials.0c01460
Database	MEDical Literature Analysis and Retrieval System OnLINE

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