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  1. AU="Otake, Yoshiaki"
  2. AU="Argyrakos, Theodoros"

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  1. Article ; Online: Functional opsin patterning for Drosophila color vision is established through signaling pathways in adjacent object-detection neurons.

    Kitamata, Manabu / Otake, Yoshiaki / Kitagori, Hideaki / Zhang, Xuanshuo / Maki, Yusuke / Boku, Rika / Takeuchi, Masato / Nakagoshi, Hideki

    Development (Cambridge, England)

    2024  Volume 151, Issue 6

    Abstract: Vision is mainly based on two different tasks, object detection and color discrimination, carried out by photoreceptor (PR) cells. The Drosophila compound eye consists of ∼800 ommatidia. Every ommatidium contains eight PR cells, six outer cells (R1-R6) ... ...

    Abstract Vision is mainly based on two different tasks, object detection and color discrimination, carried out by photoreceptor (PR) cells. The Drosophila compound eye consists of ∼800 ommatidia. Every ommatidium contains eight PR cells, six outer cells (R1-R6) and two inner cells (R7 and R8), by which object detection and color vision are achieved, respectively. Expression of opsin genes in R7 and R8 is highly coordinated through the instructive signal from R7 to R8, and two major ommatidial subtypes are distributed stochastically; pale type expresses Rh3/Rh5 and yellow type expresses Rh4/Rh6 in R7/R8. The homeodomain protein Defective proventriculus (Dve) is expressed in yellow-type R7 and in six outer PRs, and it is involved in Rh3 repression to specify the yellow-type R7. dve mutant eyes exhibited atypical coupling, Rh3/Rh6 and Rh4/Rh5, indicating that Dve activity is required for proper opsin coupling. Surprisingly, Dve activity in R1 is required for the instructive signal, whereas activity in R6 and R7 blocks the signal. Our results indicate that functional coupling of two different neurons is established through signaling pathways from adjacent neurons that are functionally different.
    MeSH term(s) Animals ; Drosophila/genetics ; Drosophila/metabolism ; Opsins/genetics ; Opsins/metabolism ; Color Vision/genetics ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Neurons/metabolism ; Signal Transduction/genetics ; Photoreceptor Cells, Invertebrate/physiology ; Drosophila melanogaster/genetics ; Drosophila melanogaster/metabolism
    Chemical Substances Opsins ; Drosophila Proteins
    Language English
    Publishing date 2024-03-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 90607-4
    ISSN 1477-9129 ; 0950-1991
    ISSN (online) 1477-9129
    ISSN 0950-1991
    DOI 10.1242/dev.202388
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Article ; Online: Interlocked feedforward loops control cell-type-specific Rhodopsin expression in the Drosophila eye.

    Johnston, Robert J / Otake, Yoshiaki / Sood, Pranidhi / Vogt, Nina / Behnia, Rudy / Vasiliauskas, Daniel / McDonald, Elizabeth / Xie, Baotong / Koenig, Sebastian / Wolf, Reinhard / Cook, Tiffany / Gebelein, Brian / Kussell, Edo / Nakagoshi, Hideki / Desplan, Claude

    Cell

    2011  Volume 145, Issue 6, Page(s) 956–968

    Abstract: How complex networks of activators and repressors lead to exquisitely specific cell-type determination during development is poorly understood. In the Drosophila eye, expression patterns of Rhodopsins define at least eight functionally distinct though ... ...

    Abstract How complex networks of activators and repressors lead to exquisitely specific cell-type determination during development is poorly understood. In the Drosophila eye, expression patterns of Rhodopsins define at least eight functionally distinct though related subtypes of photoreceptors. Here, we describe a role for the transcription factor gene defective proventriculus (dve) as a critical node in the network regulating Rhodopsin expression. dve is a shared component of two opposing, interlocked feedforward loops (FFLs). Orthodenticle and Dve interact in an incoherent FFL to repress Rhodopsin expression throughout the eye. In R7 and R8 photoreceptors, a coherent FFL relieves repression by Dve while activating Rhodopsin expression. Therefore, this network uses repression to restrict and combinatorial activation to induce cell-type-specific expression. Furthermore, Dve levels are finely tuned to yield cell-type- and region-specific repression or activation outcomes. This interlocked FFL motif may be a general mechanism to control terminal cell-fate specification.
    MeSH term(s) Animals ; Drosophila/cytology ; Drosophila/embryology ; Drosophila/metabolism ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Eye/embryology ; Feedback, Physiological ; Gene Expression Regulation, Developmental ; Gene Regulatory Networks ; Homeodomain Proteins/metabolism ; Photoreceptor Cells, Invertebrate/metabolism ; Rhodopsin/genetics ; Transcription Factors/metabolism
    Chemical Substances Drosophila Proteins ; Homeodomain Proteins ; Transcription Factors ; dve protein, Drosophila ; oc protein, Drosophila ; salm protein, Drosophila ; Rhodopsin (9009-81-8)
    Language English
    Publishing date 2011-05-24
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2011.05.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Interlocked Feedforward Loops Control Cell-Type-Specific Rhodopsin Expression in the Drosophila Eye

    Johnston, Robert J., Jr. / Otake, Yoshiaki / Sood, Pranidhi / Vogt, Nina / Behnia, Rudy / Vasiliauskas, Daniel / McDonald, Elizabeth / Xie, Baotong / Koenig, Sebastian / Wolf, Reinhard / Cook, Tiffany / Gebelein, Brian / Kussell, Edo / Nakagoshi, Hideki / Desplan, Claude

    Cell

    Volume v. 145,, Issue no. 6

    Abstract: How complex networks of activators and repressors lead to exquisitely specific cell-type determination during development is poorly understood. In the Drosophila eye, expression patterns of Rhodopsins define at least eight functionally distinct though ... ...

    Abstract How complex networks of activators and repressors lead to exquisitely specific cell-type determination during development is poorly understood. In the Drosophila eye, expression patterns of Rhodopsins define at least eight functionally distinct though related subtypes of photoreceptors. Here, we describe a role for the transcription factor gene defective proventriculus (dve) as a critical node in the network regulating Rhodopsin expression. dve is a shared component of two opposing, interlocked feedforward loops (FFLs). Orthodenticle and Dve interact in an incoherent FFL to repress Rhodopsin expression throughout the eye. In R7 and R8 photoreceptors, a coherent FFL relieves repression by Dve while activating Rhodopsin expression. Therefore, this network uses repression to restrict and combinatorial activation to induce cell-type-specific expression. Furthermore, Dve levels are finely tuned to yield cell-type- and region-specific repression or activation outcomes. This interlocked FFL motif may be a general mechanism to control terminal cell-fate specification.
    Keywords cells ; photoreceptors ; rhodopsin ; genes ; transcription factors ; proventriculus ; Drosophila ; eyes
    Language English
    Document type Article
    ISSN 0092-8674
    Database AGRIS - International Information System for the Agricultural Sciences and Technology

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