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  1. Article: Comparison of the 2013 and 2019 Nationwide Surveys on the Management of Chronic Kidney Disease by General Practitioners in Japan.

    Tatematsu, Satoru / Kobayashi, Kazuo / Utsunomiya, Yasunori / Hatta, Tsuguru / Isozaki, Taisuke / Miyazaki, Masanobu / Nakayama, Yosuke / Kusumoto, Takuo / Hatori, Nobuo / Otani, Haruhisa

    Journal of clinical medicine

    2022  Volume 11, Issue 16

    Abstract: In 2019, the Japan Physicians Association conducted a second nationwide survey on the management of chronic kidney disease (CKD) among the Japanese general practitioners (GPs). We aimed to clarify the changes in the state of CKD medical care by GPs since ...

    Abstract In 2019, the Japan Physicians Association conducted a second nationwide survey on the management of chronic kidney disease (CKD) among the Japanese general practitioners (GPs). We aimed to clarify the changes in the state of CKD medical care by GPs since the 2013 survey. The 2013 and 2019 surveys included 2214 and 601 GPs, respectively, who voluntarily participated. The two surveys were compared, using propensity score matching to balance the background of the responded GPs. For the medical care of CKD, the frequency of urine or blood examination, use of estimated glomerular filtration rate (eGFR) value for CKD management, and continuous use of renin-angiotensin system inhibitors for their reno-protective effects were significantly higher in 2019 than in 2013 (all: p < 0.001). The medical cooperation in CKD management, the utilization of the clinical path for CKD management and the measurement of the eGFR during the medical health checkup were significantly increased in 2019, compared to those in 2013. More GPs felt dissatisfied with the components of CKD treatment by nephrologists (p < 0.001). The two surveys confirmed improvements in the level of medical care for CKD and a strengthening in cooperation. However, the dissatisfaction with the consultation with nephrologists did not necessarily improve.
    Language English
    Publishing date 2022-08-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11164779
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  2. Article ; Online: The influence of Japanese general practitioners' familiarity with nephrologists on the management of chronic kidney disease.

    Hatta, Tsuguru / Kobayashi, Kazuo / Tatematsu, Satoru / Utsunomiya, Yasunori / Isozaki, Taisuke / Miyazaki, Masanobu / Nakayama, Yosuke / Kusumoto, Takuo / Hatori, Nobuo / Otani, Haruhisa

    Journal of nephrology

    2022  Volume 35, Issue 8, Page(s) 2157–2163

    MeSH term(s) Humans ; General Practitioners ; Nephrologists ; Japan ; Renal Insufficiency, Chronic/diagnosis ; Renal Insufficiency, Chronic/therapy ; Attitude of Health Personnel
    Language English
    Publishing date 2022-08-24
    Publishing country Italy
    Document type Letter
    ZDB-ID 1093991-x
    ISSN 1724-6059 ; 1120-3625 ; 1121-8428
    ISSN (online) 1724-6059
    ISSN 1120-3625 ; 1121-8428
    DOI 10.1007/s40620-022-01423-9
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    Zs.A 3369: Show issues Location:
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  3. Article ; Online: Effect of Nonsupplemented Low-Protein Diet on the Initiation of Renal Replacement Therapy in Stage 4 and 5 Chronic Kidney Disease: A Retrospective Multicenter Cohort Study in Japan.

    Otani, Haruhisa / Okada, Tadashi / Saika, Yasushi / Sakagashira, Michiko / Oda, Hiroaki / Ito, Yoshiaki / Yasuda, Takashi / Kanno, Takeo / Shimazui, Miyuki / Yamao, Shoko / Kanazawa, Yoshie / Shimode, Machiko / Otani, Mami / Ueda, Shinichiro / Nakao, Toshiyuki / Yoshimura, Ashio

    Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation

    2023  Volume 33, Issue 5, Page(s) 649–656

    Abstract: Objective: In subjects with chronic kidney disease (CKD), the effect of low-protein diet (LPD) is expected to alleviate uremic symptoms. However, whether LPD is effective in preventing loss of kidney function is controversial. The aim of this study was ... ...

    Abstract Objective: In subjects with chronic kidney disease (CKD), the effect of low-protein diet (LPD) is expected to alleviate uremic symptoms. However, whether LPD is effective in preventing loss of kidney function is controversial. The aim of this study was to evaluate the association between LPD and renal outcomes.
    Methods: We conducted a multicenter cohort study of 325 patients who suffered CKD stage 4 and 5 with eGFR ≥10 mL/min/1.73 m,
    Results: During a mean follow-up of 4.1 ± 2.2 years. Thirty-three patients (10.2%) died of all causes, 163 patients (50.2%) needed to start RRT, and 6 patients (1.8%) received a renal transplant. LPD therapy of 0.5 g/kg/day or less was significantly related to a lower risk of RRT and all-cause mortality [Hazard ratio = 0.656; 95% confidence interval, 0.438 to 0.984, P = .042].
    Conclusions: These results suggest that non-supplemented LPD therapy of 0.5 g/kg/day or less may prolong the initiation of RRT in stage 4 and 5 CKD patients.
    MeSH term(s) Humans ; Diet, Protein-Restricted ; Japan ; Cohort Studies ; Disease Progression ; Renal Insufficiency, Chronic ; Renal Replacement Therapy
    Language English
    Publishing date 2023-05-11
    Publishing country United States
    Document type Multicenter Study ; Journal Article
    ZDB-ID 1080003-7
    ISSN 1532-8503 ; 1051-2276
    ISSN (online) 1532-8503
    ISSN 1051-2276
    DOI 10.1053/j.jrn.2023.05.001
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    Zs.A 3273: Show issues Location:
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  4. Article ; Online: Nationwide questionnaire survey on the management of chronic kidney disease for general practitioners in Japan.

    Tatematsu, Satoru / Kobayashi, Kazuo / Utsunomiya, Yasunori / Isozaki, Taisuke / Hatta, Tsuguru / Kusumoto, Takuo / Miyazaki, Masanobu / Hatori, Nobuo / Otani, Haruhisa

    Clinical and experimental nephrology

    2021  Volume 25, Issue 10, Page(s) 1093–1102

    Abstract: Background: In 2019, a nationwide questionnaire survey on the management of chronic kidney disease (CKD) was circulated to general practitioners (GPs) throughout Japan by The Japan Physicians Association. The aim was to assess the current state of CKD ... ...

    Abstract Background: In 2019, a nationwide questionnaire survey on the management of chronic kidney disease (CKD) was circulated to general practitioners (GPs) throughout Japan by The Japan Physicians Association. The aim was to assess the current state of CKD medical care in the country and evaluate the utilization of CKD-specific guidelines in the treatment by GPs.
    Methods: The voluntary survey targeted all members of Japan Physicians Association, a nationwide organization consisting primarily of 15,000 GPs in clinics throughout the country. GPs were divided into groups: 171 GPs using and 414 GPs not using the guidelines. Comparisons between the groups' responses were made using propensity score matching and component cluster analysis.
    Results: Overall responses revealed that the estimated glomerular filtration rate's utilization rate was high (95.1%). However, evidence-practice gaps in urine protein quantification and anemia remedy were prominent. There were significantly favorable answers in terms of CKD management in the user group compared with those in the non-user group, except for the questions about a urine check at the first visit, stopping the use of renin-angiotensin system inhibitors, and the target blood pressure for elderly CKD patients. The differences suggest that utilization of the CKD guidelines has improved CKD management practices by GPs.
    Conclusions: Further promotion of CKD guidelines utilization (28% in this survey) is considered valid for CKD medical education.
    MeSH term(s) Adult ; Aged ; Anemia/blood ; Anemia/drug therapy ; Anemia/etiology ; General Practitioners/statistics & numerical data ; Glomerular Filtration Rate ; Guideline Adherence/statistics & numerical data ; Health Care Surveys ; Hematinics/therapeutic use ; Hemoglobins/metabolism ; Humans ; Japan ; Middle Aged ; Practice Guidelines as Topic ; Practice Patterns, Physicians'/statistics & numerical data ; Proteinuria/diagnosis ; Proteinuria/etiology ; Proteinuria/urine ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/physiopathology ; Renal Insufficiency, Chronic/therapy
    Chemical Substances Hematinics ; Hemoglobins
    Language English
    Publishing date 2021-07-12
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1338768-6
    ISSN 1437-7799 ; 1342-1751
    ISSN (online) 1437-7799
    ISSN 1342-1751
    DOI 10.1007/s10157-021-02084-x
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  5. Article ; Online: Association between serum lipids, polyunsaturated fatty acids, and prognosis in maintenance hemodialysis patients.

    Tanaka, Yusuke / Ohya, Masaki / Yano, Takuro / Minakata, Tomokazu / Higashiura, Masaki / Yamamoto, Shuto / Mima, Toru / Negi, Shigeo / Nakata, Hirosuke / Otani, Haruhisa / Kodama, Naoya / Kodama, Toshihiro / Shigematsu, Takashi

    Hemodialysis international. International Symposium on Home Hemodialysis

    2020  

    Abstract: Introduction: Risks of mortality and cardiovascular disease (CVD) are significantly higher in hemodialysis (HD) patients than in the general population, where dyslipidemia is an established risk factor for CVD and mortality. There is no clear conclusion, ...

    Abstract Introduction: Risks of mortality and cardiovascular disease (CVD) are significantly higher in hemodialysis (HD) patients than in the general population, where dyslipidemia is an established risk factor for CVD and mortality. There is no clear conclusion, however, whether dyslipidemia is a significant risk factor for CVD and mortality in HD patients. Similarly, the association between the polyunsaturated fatty acids (PUFAs) and the mortality is not clear in HD patients.
    Methods: We retrospectively investigated mortality and CVD events in 420 HD patients. We classified patients into high- and low-lipid groups depending on their lipid levels. Survival rates were calculated using the Kaplan-Meier analysis and evaluated by the log-rank test. The risk estimates were computed using a multivariate Cox proportional hazard analysis.
    Findings: During their follow-up (June 2011 to June 2016), 151 patients died (37 of CVD), and 112 patients experienced new CVD events. On Kaplan-Meier analysis, the number of all-cause deaths and CVD events were significantly higher in the low HDL-cholesterol group (P < 0.01, log-rank test). Similarly, the number of all-cause deaths was significantly higher in the high eicosapentaenoic acid/arachidonic acid ratio group (P < 0.01, log-rank test). Multivariate Cox proportional analysis showed that HDL-cholesterol was a significant prognostic indicator for new onset of CVD events (low: 0, high: 1, hazard ratio 0.66, 95% confidence interval 0.44-0.97; P = 0.04).
    Discussion: In HD patients, LDL-cholesterol and non-HDL-cholesterol levels are not associated with mortality or CVD events. The HDL-cholesterol level, however, is an independent predictor of new CVD events even in HD patients.
    Language English
    Publishing date 2020-10-08
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 2192458-2
    ISSN 1542-4758 ; 1492-7535
    ISSN (online) 1542-4758
    ISSN 1492-7535
    DOI 10.1111/hdi.12892
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    Zs.A 6091: Show issues Location:
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  6. Article: [Fish meat retarding the progression of chronic renal failure in spontaneously hypercholesterolemic rats].

    Liang, Xiang-ming / Otani, Haruhisa

    Wei sheng yan jiu = Journal of hygiene research

    2006  Volume 35, Issue 6, Page(s) 727–730

    Abstract: Objective: To investigate the effects of different dietary proteins of fish meat and casein upon the progression of chronic renal failure (CRF) in spontaneously hypercholesterolemic (SHC) rats.: Methods: 48 SHC rats of 10 weeks of age were randomly ... ...

    Abstract Objective: To investigate the effects of different dietary proteins of fish meat and casein upon the progression of chronic renal failure (CRF) in spontaneously hypercholesterolemic (SHC) rats.
    Methods: 48 SHC rats of 10 weeks of age were randomly divided into four groups, and placed on diets containing 20% and 40% casein or fish protein respectively till they were 22 weeks of age. 24-hour urine collections were obtained along with measurements of systolic blood pressure and blood were drew from their tail vein evry 4 weeks. Finally, the kidneys were removed and prepared for histological and immunohistochemistry study .
    Results: Fish meat diet slowed the progression of proteinuria, renal function failure and glomerular injury compared with the control casein diet in both 20% and 40% dietary groups.
    Conclusion: Fish meat retarded the progression of CRF in SHC rats compared with casein.
    MeSH term(s) Animals ; Caseins/administration & dosage ; Diet, Protein-Restricted/methods ; Dietary Proteins/administration & dosage ; Disease Progression ; Fish Products ; Hypercholesterolemia/diet therapy ; Hypercholesterolemia/physiopathology ; Kidney/physiopathology ; Male ; Random Allocation ; Rats ; Rats, Inbred Strains ; Renal Insufficiency/diet therapy ; Renal Insufficiency/physiopathology
    Chemical Substances Caseins ; Dietary Proteins
    Language Chinese
    Publishing date 2006-11
    Publishing country China
    Document type English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1050909-4
    ISSN 1000-8020
    ISSN 1000-8020
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    Zs.A 4878: Show issues Location:
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  7. Article ; Online: Vascular calcification estimated by aortic calcification area index is a significant predictive parameter of cardiovascular mortality in hemodialysis patients.

    Ohya, Masaki / Otani, Haruhisa / Kimura, Keigo / Saika, Yasushi / Fujii, Ryoichi / Yukawa, Susumu / Shigematsu, Takashi

    Clinical and experimental nephrology

    2011  Volume 15, Issue 6, Page(s) 877–883

    Abstract: Background: Vascular calcification is a feature of arteriosclerosis. In hemodialysis (HD) patients, vascular calcification progresses rapidly. This study used the aortic calcification area index (ACAI), an index of vascular calcification, to evaluate ... ...

    Abstract Background: Vascular calcification is a feature of arteriosclerosis. In hemodialysis (HD) patients, vascular calcification progresses rapidly. This study used the aortic calcification area index (ACAI), an index of vascular calcification, to evaluate vascular calcification factors in HD patients, to investigate correlations between ACAI and long-term prognosis and to assess correlations between various factors and long-term prognosis.
    Methods: Subjects comprised 137 patients on maintenance HD. ACAI was measured as an index of vascular calcification as measured by abdominal plain computed tomography. The patients were divided into a high ACAI (H) group and a low ACAI (L) group according to whether the ACAI was below or above the mean value (21.4%) of ACAI, and long-term all-cause death and cardiovascular death rates were compared between groups. Risk factors for all-cause death and cardiovascular death were examined by Cox hazard analysis.
    Results: During follow-up (mean follow-up period 95.3 ± 50.3 months), 76 patients died, including 46 cardiovascular deaths. Deaths included 51 of 70 patients (67.1%) in Group H and 25 of 67 patients (37.3%) in Group L. Cardiovascular death rates were 51.4 and 14.9%, respectively. On Kaplan-Meier analysis, the number of all-cause deaths was significantly higher in Group H (P < 0.001, log-rank test). Similarly, the number of cardiovascular deaths was significantly higher in Group H. Multivariate Cox proportional hazards analysis showed that ACAI (%) was a significant prognostic indicator for cardiovascular death (hazard ratio 1.03; 95% confidence interval 1.00-1.06, P = 0.03).
    Conclusion: High ACAI was clearly correlated with mortality rate in HD patients, particularly cardiovascular mortality rate. ACAI was a useful long-term prognostic indicator in HD patients.
    MeSH term(s) Adult ; Aged ; Aortic Diseases/complications ; Aortic Diseases/diagnostic imaging ; Aortic Diseases/mortality ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/mortality ; Cause of Death ; Chi-Square Distribution ; Disease Progression ; Female ; Humans ; Japan ; Kaplan-Meier Estimate ; Kidney Diseases/complications ; Kidney Diseases/mortality ; Kidney Diseases/therapy ; Male ; Middle Aged ; Predictive Value of Tests ; Proportional Hazards Models ; Renal Dialysis/adverse effects ; Renal Dialysis/mortality ; Risk Assessment ; Risk Factors ; Severity of Illness Index ; Time Factors ; Tomography, X-Ray Computed ; Treatment Outcome ; Vascular Calcification/complications ; Vascular Calcification/diagnostic imaging ; Vascular Calcification/mortality
    Language English
    Publishing date 2011-08-19
    Publishing country Japan
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1338768-6
    ISSN 1437-7799 ; 1342-1751
    ISSN (online) 1437-7799
    ISSN 1342-1751
    DOI 10.1007/s10157-011-0517-y
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    Zs.A 4922: Show issues Location:
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  8. Article ; Online: Improved assessment of aortic calcification in Japanese patients undergoing maintenance hemodialysis.

    Ohya, Masaki / Otani, Haruhisa / Kimura, Keigo / Saika, Yasushi / Fujii, Ryoichi / Yukawa, Susumu / Shigematsu, Takashi

    Internal medicine (Tokyo, Japan)

    2010  Volume 49, Issue 19, Page(s) 2071–2075

    Abstract: Objective: Vascular calcification is a feature of arteriosclerosis and in hemodialysis (HD) patients it may be severe, even at a relatively young age, and is closely related to the overall prognosis. We used the aortic calcification area index (ACAI), ... ...

    Abstract Objective: Vascular calcification is a feature of arteriosclerosis and in hemodialysis (HD) patients it may be severe, even at a relatively young age, and is closely related to the overall prognosis. We used the aortic calcification area index (ACAI), derived from the aortic calcification index (ACI), to evaluate and analyze the risk factors for abdominal aortic calcification in HD patients.
    Patients and methods: Subjects comprised 137 patients on maintenance HD. ACAI was measured on abdominal plain computed tomography: 10 slices of the abdominal aorta were obtained at 1-cm intervals from the bifurcation of the common iliac artery and the area of the aortic cross-section and calcification was measured using image software. The calcification area was divided by the cross-sectional area and expressed as a percentage (%). The mean value for the 10 slices was also calculated. Patients were divided into 2 groups according to ACAI being lower or higher than the mean value and the risk factors in each group were compared by multivariate analysis. Results Group comparison showed significant differences in age, systolic blood pressure, serum calcium, and lipoprotein(a). On multiple regression analysis, age, systolic blood pressure, and serum calcium were independent risk factors. On logistic regression analysis, age, duration of dialysis, systolic blood pressure, and serum calcium were independent risk factors.
    Conclusion: Risk factors for abdominal aortic calcification in HD patients include age, systolic blood pressure, and serum calcium, according to ACAI evaluation. The ACAI was accurate and useful for evaluating abdominal calcification.
    MeSH term(s) Adult ; Aged ; Aorta, Abdominal/diagnostic imaging ; Aortic Diseases/diagnostic imaging ; Aortic Diseases/etiology ; Asian Continental Ancestry Group ; Calcinosis/diagnostic imaging ; Calcinosis/etiology ; Coronary Artery Disease/diagnostic imaging ; Coronary Artery Disease/etiology ; Female ; Humans ; Japan ; Kidney Failure, Chronic/complications ; Kidney Failure, Chronic/therapy ; Male ; Middle Aged ; Renal Dialysis/adverse effects ; Risk Factors ; Tomography, X-Ray Computed
    Language English
    Publishing date 2010-10-01
    Publishing country Japan
    Document type Clinical Trial ; Journal Article
    ZDB-ID 32371-8
    ISSN 1349-7235 ; 0021-5120 ; 0918-2918
    ISSN (online) 1349-7235
    ISSN 0021-5120 ; 0918-2918
    DOI 10.2169/internalmedicine.49.3752
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  9. Article: Tonsillectomy with steroid pulse therapy has more effect on the relapse rate than steroid pulse monotherapy in IgA nephropathy patients.

    Ohya, Masaki / Otani, Haruhisa / Minami, Yoshinobu / Yamanaka, Shintaro / Mima, Toru / Negi, Shigeo / Yukawa, Susumu / Shigematsu, Takashi

    Clinical nephrology

    2013  Volume 80, Issue 1, Page(s) 47–52

    Abstract: Aims: Both steroid pulse (SP) monotherapy and the combination of tonsillectomy and SP therapy (TSP) are effective for achieving clinical remission (CR), defined as negative hematuria and proteinuria, in patients with IgA nephropathy (IgAN). The role of ... ...

    Abstract Aims: Both steroid pulse (SP) monotherapy and the combination of tonsillectomy and SP therapy (TSP) are effective for achieving clinical remission (CR), defined as negative hematuria and proteinuria, in patients with IgA nephropathy (IgAN). The role of tonsillectomy in the treatment of IgAN has been analyzed only from the aspect of CR or renal survival after TSP treatment, so there is no evidence of its effect on the relapse after CR.
    Methods: We retrospectively investigated relapse (re-appearance of urinary abnormalities) from CR after TSP or SP monotherapy in 62 IgAN patients (mean follow-up, 70.1 ± 35.3 months). The SP therapy comprised 0.5 g methylprednisolone administered intravenously on 3 consecutive days followed by oral prednisolone (30 mg/day) on 4 consecutive days, with the course repeated 3 times. Oral prednisolone (30 mg/day) was then given on alternative days and gradually tapered and finished over 1 year. Tonsillectomy was performed either before or within 6 months of starting SP therapy.
    Results: At baseline, the mean age was 34.6 years, the mean serum creatinine (Cr) level was 0.9 mg/dl, and the mean level of proteinuria was 876 mg/day. There were no differences between the TSP group (41 patients) and SP monotherapy group (21 patients). In total, 24 of the TSP and 10 of the SP patients achieved CR. Of the 34 patients who achieved CR, 13 relapsed after TSP or SP monotherapy. Using Kaplan-Meier analysis, tonsillectomy was associated with a lower incidence of relapse from CR after treatment (p = 0.045). Multivariate Cox regression analysis revealed that tonsillectomy reduced the rate of from CR after SP therapy.
    Conclusion: Tonsillectomy was associated with a reduction in the relapse rate from CR after SP therapy in IgAN patients.
    MeSH term(s) Adult ; Anti-Inflammatory Agents/administration & dosage ; Anti-Inflammatory Agents/therapeutic use ; Combined Modality Therapy ; Creatinine/blood ; Female ; Glomerulonephritis, IGA/blood ; Glomerulonephritis, IGA/therapy ; Glomerulonephritis, IGA/urine ; Humans ; Kaplan-Meier Estimate ; Male ; Methylprednisolone/administration & dosage ; Methylprednisolone/therapeutic use ; Middle Aged ; Multivariate Analysis ; Prednisolone/administration & dosage ; Proportional Hazards Models ; Proteinuria/urine ; Recurrence ; Remission Induction/methods ; Retrospective Studies ; Tonsillectomy ; Young Adult
    Chemical Substances Anti-Inflammatory Agents ; Prednisolone (9PHQ9Y1OLM) ; Creatinine (AYI8EX34EU) ; Methylprednisolone (X4W7ZR7023)
    Language English
    Publishing date 2013-07
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 185101-9
    ISSN 0301-0430
    ISSN 0301-0430
    DOI 10.5414/CN107861
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  10. Article: Effects of antioxidants on kidney disease.

    Mune, Masatoshi / Otani, Haruhisa / Yukawa, Susumu

    Mechanisms of ageing and development

    2001  Volume 123, Issue 8, Page(s) 1041–1046

    Abstract: Kidney mesangial cells (MCs) and vascular smooth muscle cells (VSMCs) are closely related in terms of origin, microscopic anatomy, histochemistry, and contractility. This relationship suggests a similarity between kidney glomerular sclerosis and ... ...

    Abstract Kidney mesangial cells (MCs) and vascular smooth muscle cells (VSMCs) are closely related in terms of origin, microscopic anatomy, histochemistry, and contractility. This relationship suggests a similarity between kidney glomerular sclerosis and atherosclerosis. Vitamin E appears beneficial in the prevention and treatment of coronary disease and also inhibits the proliferation of VSMCs in vitro. We used vitamin E and probucol to treat glomerular sclerosis and MC-proliferative glomerulonephritis (GN) in two animal models of glomerular disease. Using rats, a remnant kidney model accelerated with hyperlipidemia was employed to reflect progressive glomerular sclerosis leading to chronic renal failure, and an anti-thymocyte serum treatment was used to model acute MC-proliferative GN. Supplemental dietary antioxidants suppress MC proliferation and glomerular sclerosis in models of glomerular disease in rats. These results suggest that treatment with antioxidants may be a promising intervention to prevent progression of kidney disease.
    MeSH term(s) Animals ; Antioxidants/therapeutic use ; Cholesterol, Dietary/adverse effects ; Dietary Supplements ; Disease Models, Animal ; Glomerulonephritis, Membranoproliferative/chemically induced ; Glomerulonephritis, Membranoproliferative/drug therapy ; Glomerulonephritis, Membranoproliferative/metabolism ; Glomerulonephritis, Membranoproliferative/physiopathology ; Glomerulosclerosis, Focal Segmental/chemically induced ; Glomerulosclerosis, Focal Segmental/drug therapy ; Glomerulosclerosis, Focal Segmental/immunology ; Glomerulosclerosis, Focal Segmental/metabolism ; Kidney Cortex/metabolism ; Macrophages/cytology ; Male ; Rats ; Rats, Inbred BN ; Rats, Inbred F344 ; Rats, Sprague-Dawley ; Thy-1 Antigens/immunology ; Vitamin E/therapeutic use
    Chemical Substances Antioxidants ; Cholesterol, Dietary ; Thy-1 Antigens ; Vitamin E (1406-18-4)
    Language English
    Publishing date 2001-02-23
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 183915-9
    ISSN 1872-6216 ; 0047-6374
    ISSN (online) 1872-6216
    ISSN 0047-6374
    DOI 10.1016/s0047-6374(01)00387-6
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