LIVIVO - Search results -

Search results

Result 1 - 10 of total 35

Search options

Article ; Online: Green-Synthesized Silver and Selenium Nanoparticles Using Berberine: A Comparative Assessment of In Vitro Anticancer Potential on Human Hepatocellular Carcinoma Cell Line (HepG2).

Khaled, Azza M / Othman, Mohamed S / Obeidat, Sofian T / Aleid, Ghada M / Aboelnaga, Shimaa M / Fehaid, Alaa / Hathout, Heba M R / Bakkar, Ashraf A / Moneim, Ahmed E Abdel / El-Garawani, Islam M / Morsi, Dalia S

Cells

2024 Volume 13, Issue 3

Abstract: A well-known natural ingredient found in several medicinal plants, berberine (Ber), has been shown to have anticancer properties against a range of malignancies. The limited solubility and bioavailability of berberine can be addressed using Ber-loaded ... ...

Abstract	A well-known natural ingredient found in several medicinal plants, berberine (Ber), has been shown to have anticancer properties against a range of malignancies. The limited solubility and bioavailability of berberine can be addressed using Ber-loaded nanoparticles. In this study, we compared the in vitro cytotoxic effects of both Ber-loaded silver nanoparticles (Ber-AgNPs) and Ber-loaded selenium nanoparticles (Ber-SeNPs) in the human liver cancer cell line (HepG2) and mouse normal liver cells (BNL). The IC
MeSH term(s)	Mice ; Animals ; Humans ; Carcinoma, Hepatocellular/drug therapy ; Carcinoma, Hepatocellular/pathology ; Selenium/pharmacology ; Berberine/pharmacology ; Silver/pharmacology ; Metal Nanoparticles ; Liver Neoplasms/pathology ; Cell Line
Chemical Substances	Selenium (H6241UJ22B) ; Berberine (0I8Y3P32UF) ; Silver (3M4G523W1G)
Language	English
Publishing date	2024-02-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells13030287
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article: The Potential Role of Zinc Oxide Nanoparticles in MicroRNAs Dysregulation in STZ-Induced Type 2 Diabetes in Rats

Othman, Mohamed S / Hafez, Mohamed M / Abdel Moneim, Ahmed E

Biological trace element research. 2020 Oct., v. 197, no. 2

2020

Abstract: Diabetes mellitus (DM) is a group of metabolic disorders that are characterized by a loss of glucose homeostasis and insufficiency in production or action of insulin. Development of newly antidiabetic molecules using a variety of organic compounds and ... ...

Abstract	Diabetes mellitus (DM) is a group of metabolic disorders that are characterized by a loss of glucose homeostasis and insufficiency in production or action of insulin. Development of newly antidiabetic molecules using a variety of organic compounds and biomolecules has been in practice for a long time. Recently, nanomaterials are also being used in antidiabetic studies for their unique properties. In this context, zinc nanoparticles have drawn attention due to the relationship between diabetes and imbalance of zinc homeostasis. Few studies have attempted to investigate the effect of zinc oxide nanoparticles (ZON) in microRNA dysregulations in diabetes. To evaluate the therapeutic effect of ZON on streptozotocin (STZ)-induced diabetic rats as well as its role in microRNA dysregulations. Diabetes was induced in rats by 60 mg/kg body weight (bwt) of STZ and then treated with ZON (5 mg/kg bwt) for 15 consecutive days. The levels of glucose, insulin, oxidative stress markers, and microRNAs expression were measured in liver and pancreas tissues. Intraperitoneal injection of 60 mg/kg bwt of STZ to Wistar rats caused significant decreases in the body weight and Zn contents of pancreas, liver, and kidney. Also, STZ injection increased the blood glucose level and oxidative stress (lipid peroxidation (LPO) and nitric oxide (NO). Meanwhile, STZ decreased blood insulin and pancreatic anti-oxidants. STZ also resulted in β cell dysfunction and destruction and altered the expression of certain pancreatic and liver microRNAs. ZON treatment for 15 days, at a dose of 5 mg/kg bwt resulted in marked improvements in the blood insulin, glucose tolerance, and structure and function of the pancreatic β cells. Furthermore, ZON administration reduced LPO and NO, and increased the levels of enzymatic and non-enzymatic anti-oxidants in STZ-induced diabetic rats. It was found also that ZON specifically regulated the expression of pancreatic and liver microRNAs that involved in diabetes development. The obtained results revealed that ZON is a promising antidiabetic agent. The antidiabetic effect of ZON was partially mediated by restoring the oxidants/antioxidants balance and by modulating the alerted microRNAs
Keywords	animal disease models ; antioxidants ; blood ; blood glucose ; body weight ; glucose ; glucose tolerance ; glycemic effect ; homeostasis ; hypoglycemic agents ; insulin ; intraperitoneal injection ; islets of Langerhans ; kidneys ; laboratory animals ; lipid peroxidation ; liver ; microRNA ; nanoparticles ; nitric oxide ; noninsulin-dependent diabetes mellitus ; oxidants ; oxidative stress ; rats ; streptozotocin ; therapeutics ; zinc ; zinc oxide
Language	English
Dates of publication	2020-10
Size	p. 606-618.
Publishing place	Springer US
Document type	Article
ZDB-ID	445336-0
ISSN	1559-0720 ; 0163-4984
ISSN (online)	1559-0720
ISSN	0163-4984
DOI	10.1007/s12011-019-02012-x
Database	NAL-Catalogue (AGRICOLA)

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.B 2323: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Echinops spinosus effect against diabetes and its hepatorenal complications: total extract and flavonoids fraction.

Othman, Mohamed S / Khaled, Azza M / Al-Bagawi, Amal H / Fareid, Mohamed A / Hameed, Reda A / Zahra, Fatama A Abu / Moneim, Ahmed E Abdel

Environmental science and pollution research international

2022 Volume 29, Issue 25, Page(s) 38606–38617

Abstract: The perennial plant Echinops spinosus (ES) grows in the Hail area of Saudi Arabia, and its traditional formulations are often employed in folk medicine. The goal of this study is to identify the active components present in Hail Echinops spinosus and to ... ...

Abstract	The perennial plant Echinops spinosus (ES) grows in the Hail area of Saudi Arabia, and its traditional formulations are often employed in folk medicine. The goal of this study is to identify the active components present in Hail Echinops spinosus and to investigate the anti-diabetic properties of both ES total extract (ESTE) and its high flavonoids fraction (ESHFF) in experimental diabetes induced by streptozotocin (STZ) injection in rats. Forty-two rats were divided into six groups. Diabetes was induced using STZ (55 mg/kg). Seven days after STZ administration, the diabetic animals were treated daily with ESTE, ESHFF, or metformin (MET) as a standard anti-diabetic drug for 28 days. Blood and tissues samples were collected for biochemical, molecular, and histological investigations. Both ESTE and ESHFF demonstrated anti-diabetic properties, as evidenced by lowering glucose levels and increasing the levels of insulin, insulin receptor expression rate, and glycogen synthesis. Additionally, ESTE as well as ESHFF alleviated diabetic complications in the kidneys and liver by decreasing oxidative stress, modulating inflammatory mediators, and suppressing the apoptotic cascade along with correcting diabetic dyslipidemia. It could be deduced that Hail ES extracts could play a role in the treatment of type 2 diabetes and diabetes-related lesions as well as oxidative damage in hepatic and renal tissues.
MeSH term(s)	Animals ; Blood Glucose/metabolism ; Diabetes Mellitus, Type 2/metabolism ; Flavonoids/metabolism ; Flavonoids/pharmacology ; Hypoglycemic Agents/pharmacology ; Hypoglycemic Agents/therapeutic use ; Liver ; Oxidative Stress ; Plant Extracts/chemistry ; Rats ; Streptozocin/metabolism ; Streptozocin/pharmacology ; Streptozocin/therapeutic use ; Tenrecidae
Chemical Substances	Blood Glucose ; Flavonoids ; Hypoglycemic Agents ; Plant Extracts ; Streptozocin (5W494URQ81)
Language	English
Publishing date	2022-01-26
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-022-18824-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Bonn / Germany

Z 5915: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article ; Online: Evaluation of antiobesity and hepatorenal protective activities of Salvia officinalis extracts pre-treatment in high-fat diet-induced obese rats

Othman, Mohamed S. / Khaled, Azza M. / Aleid, Ghada M. / Fareid, Mohamed A. / Hameed, Reda A. / Abdelfattah, Mohamed S. / Aldin, Doaa Ezz / Moneim, Ahmed E. Abdel

Environ Sci Pollut Res. 2022 Oct., v. 29, no. 49 p.75043-75056

2022

Abstract: The present study evaluated the effects of Hail Salvia officinalis total extract (SOTE) and its high flavonoid fraction (SOHFF) on the high-fat diet (HFD)-induced obesity and hepatorenal damage in rats. Salvia officinalis plants were collected from Hail ... ...

Abstract	The present study evaluated the effects of Hail Salvia officinalis total extract (SOTE) and its high flavonoid fraction (SOHFF) on the high-fat diet (HFD)-induced obesity and hepatorenal damage in rats. Salvia officinalis plants were collected from Hail region, Saudi Arabia. Rats were fed HFD and supplemented orally with SOTE (250 mg kg⁻¹) or SOHFF (100 mg kg⁻¹) or simvastatin (SVS; 10 mg kg⁻¹) every day for 8 weeks. Compared to the controls, HFD-induced obesity led to significant increases in body weight, body weight gained, blood insulin, leptin, cardiac enzymes (LDH and CPK) activity, and atherogenic index (AI). HFD rats also showed higher levels of hepatic and renal function biomarkers (ALT, urea, and creatinine), as well as lower levels of PPARγ and Nrf2-gene expression and a disrupted lipid profile. Moreover, HFD rats had lower levels of hepatic and renal antioxidant biomarkers (CAT, GPx, SOD, GR, and GSH), accompanied by higher levels of hepatic and renal lipid peroxidation (LPO), nitric oxide (NO), and inflammatory mediators (interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α)). In addition, histological examination of hepatic and renal tissues revealed histopathological changes that validated the biochemical findings. Compared to HFD group, SOTE and SOHFF treatment led to marked amelioration of all the aforementioned parameters. Collectively, supplementation with SOTE and SOHFF effectively reversed HFD-induced alterations through its antioxidant, hypolipidemic, and anti-inflammatory properties. Hence, SOTE and SOHFF have therapeutic potential in controlling obesity and related pathologies.
Keywords	Salvia officinalis ; antioxidant biomarkers ; antioxidants ; blood ; creatinine ; flavonoids ; high fat diet ; histology ; histopathology ; insulin ; leptin ; lipid composition ; lipid peroxidation ; necrosis ; neoplasms ; nitric oxide ; obesity ; renal function ; simvastatin ; therapeutics ; urea ; Saudi Arabia
Language	English
Dates of publication	2022-10
Size	p. 75043-75056.
Publishing place	Springer Berlin Heidelberg
Document type	Article ; Online
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-022-21092-2
Database	NAL-Catalogue (AGRICOLA)

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Bonn / Germany

Z 5915: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article ; Online: Echinops spinosus effect against diabetes and its hepatorenal complications: total extract and flavonoids fraction

Othman, Mohamed S. / Khaled, Azza M. / Al-Bagawi, Amal H. / Fareid, Mohamed A. / Hameed, Reda A. / Zahra, Fatama A. Abu / Moneim, Ahmed E. Abdel

Environ Sci Pollut Res. 2022 May, v. 29, no. 25 p.38606-38617

2022

Abstract	The perennial plant Echinops spinosus (ES) grows in the Hail area of Saudi Arabia, and its traditional formulations are often employed in folk medicine. The goal of this study is to identify the active components present in Hail Echinops spinosus and to investigate the anti-diabetic properties of both ES total extract (ESTE) and its high flavonoids fraction (ESHFF) in experimental diabetes induced by streptozotocin (STZ) injection in rats. Forty-two rats were divided into six groups. Diabetes was induced using STZ (55 mg/kg). Seven days after STZ administration, the diabetic animals were treated daily with ESTE, ESHFF, or metformin (MET) as a standard anti-diabetic drug for 28 days. Blood and tissues samples were collected for biochemical, molecular, and histological investigations. Both ESTE and ESHFF demonstrated anti-diabetic properties, as evidenced by lowering glucose levels and increasing the levels of insulin, insulin receptor expression rate, and glycogen synthesis. Additionally, ESTE as well as ESHFF alleviated diabetic complications in the kidneys and liver by decreasing oxidative stress, modulating inflammatory mediators, and suppressing the apoptotic cascade along with correcting diabetic dyslipidemia. It could be deduced that Hail ES extracts could play a role in the treatment of type 2 diabetes and diabetes-related lesions as well as oxidative damage in hepatic and renal tissues.
Keywords	Echinops ; apoptosis ; blood ; flavonoids ; glucose ; glycogen ; histology ; hyperlipidemia ; insulin ; insulin receptors ; liver ; metformin ; noninsulin-dependent diabetes mellitus ; oxidative stress ; perennials ; streptozotocin ; traditional medicine ; Saudi Arabia
Language	English
Dates of publication	2022-05
Size	p. 38606-38617.
Publishing place	Springer Berlin Heidelberg
Document type	Article ; Online
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-022-18824-9
Database	NAL-Catalogue (AGRICOLA)

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Bonn / Germany

Z 5915: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article ; Online: The Potential Role of Zinc Oxide Nanoparticles in MicroRNAs Dysregulation in STZ-Induced Type 2 Diabetes in Rats.

Othman, Mohamed S / Hafez, Mohamed M / Abdel Moneim, Ahmed E

Biological trace element research

2019 Volume 197, Issue 2, Page(s) 606–618

Abstract	Diabetes mellitus (DM) is a group of metabolic disorders that are characterized by a loss of glucose homeostasis and insufficiency in production or action of insulin. Development of newly antidiabetic molecules using a variety of organic compounds and biomolecules has been in practice for a long time. Recently, nanomaterials are also being used in antidiabetic studies for their unique properties. In this context, zinc nanoparticles have drawn attention due to the relationship between diabetes and imbalance of zinc homeostasis. Few studies have attempted to investigate the effect of zinc oxide nanoparticles (ZON) in microRNA dysregulations in diabetes. To evaluate the therapeutic effect of ZON on streptozotocin (STZ)-induced diabetic rats as well as its role in microRNA dysregulations. Diabetes was induced in rats by 60 mg/kg body weight (bwt) of STZ and then treated with ZON (5 mg/kg bwt) for 15 consecutive days. The levels of glucose, insulin, oxidative stress markers, and microRNAs expression were measured in liver and pancreas tissues. Intraperitoneal injection of 60 mg/kg bwt of STZ to Wistar rats caused significant decreases in the body weight and Zn contents of pancreas, liver, and kidney. Also, STZ injection increased the blood glucose level and oxidative stress (lipid peroxidation (LPO) and nitric oxide (NO). Meanwhile, STZ decreased blood insulin and pancreatic anti-oxidants. STZ also resulted in β cell dysfunction and destruction and altered the expression of certain pancreatic and liver microRNAs. ZON treatment for 15 days, at a dose of 5 mg/kg bwt resulted in marked improvements in the blood insulin, glucose tolerance, and structure and function of the pancreatic β cells. Furthermore, ZON administration reduced LPO and NO, and increased the levels of enzymatic and non-enzymatic anti-oxidants in STZ-induced diabetic rats. It was found also that ZON specifically regulated the expression of pancreatic and liver microRNAs that involved in diabetes development. The obtained results revealed that ZON is a promising antidiabetic agent. The antidiabetic effect of ZON was partially mediated by restoring the oxidants/antioxidants balance and by modulating the alerted microRNAs.
MeSH term(s)	Animals ; Blood Glucose ; Diabetes Mellitus, Experimental/drug therapy ; Diabetes Mellitus, Type 2/drug therapy ; Hypoglycemic Agents/pharmacology ; Insulin/metabolism ; Metal Nanoparticles ; MicroRNAs/genetics ; Oxidative Stress ; Rats ; Rats, Wistar ; Streptozocin ; Zinc ; Zinc Oxide
Chemical Substances	Blood Glucose ; Hypoglycemic Agents ; Insulin ; MicroRNAs ; Streptozocin (5W494URQ81) ; Zinc (J41CSQ7QDS) ; Zinc Oxide (SOI2LOH54Z)
Language	English
Publishing date	2019-12-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	445336-0
ISSN	1559-0720 ; 0163-4984
ISSN (online)	1559-0720
ISSN	0163-4984
DOI	10.1007/s12011-019-02012-x
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.B 2323: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article: Hypoglycemic potential of selenium nanoparticles capped with polyvinyl-pyrrolidone in streptozotocin-induced experimental diabetes in rats.

El-Borady, Ola M / Othman, Mohamed S / Atallah, Heba H / Abdel Moneim, Ahmed E

Heliyon

2020 Volume 6, Issue 5, Page(s) e04045

Abstract: This study was aimed to evaluate the efficacy of synthesized selenium nanoparticles (SeNPs) capped with glucose and polyvinyl-pyrrolidone (PVP) on the hyperglycemia and prooxidants/antioxidants imbalance present in model streptozotocin (STZ)-induced ... ...

Abstract	This study was aimed to evaluate the efficacy of synthesized selenium nanoparticles (SeNPs) capped with glucose and polyvinyl-pyrrolidone (PVP) on the hyperglycemia and prooxidants/antioxidants imbalance present in model streptozotocin (STZ)-induced diabetic rats. SeNPs were synthesized and characterized. Twenty-four albino male rats were grouped into four different groups. After the rats were induced to have type 2 diabetes by STZ, the SeNPs-treated groups received a dose of 0.5 mg/ml of SeNPs for seven days. Plasma glucose and insulin levels, pancreatic insulin expression, the levels of lipid peroxidation (LPO), nitric oxide (NO), glutathione peroxidase (GPx) and glutathione (GSH) were evaluated. TEM images revealed the formation of semispherical particles with average size between 40 and 50 nm. SeNPs administration successfully reduced the hyperglycemia, raised the levels of insulin in both the pancreas and the plasma and restored the damaged pancreatic tissue. SeNPs also showed enhancement of the elimination of the diabetes-induced oxidative stress injuries by decreasing the pancreatic LPO and NO levels. Furthermore, the activities of the antioxidant enzyme GPx and GSH levels of the diabetic rats were increased. In conclusion, SeNPs capped with PVP could be used in the future as an agent that could manage Diabetes mellitus.
Language	English
Publishing date	2020-05-30
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2020.e04045
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: The Protective Effects of Melatonin on Aluminum-Induced Hepatotoxicity and Nephrotoxicity in Rats.

Othman, Mohamed S / Fareid, Mohamed A / Abdel Hameed, Reda S / Abdel Moneim, Ahmed E

Oxidative medicine and cellular longevity

2020 Volume 2020, Page(s) 7375136

Abstract: Aluminum (Al) is a ubiquitous element with known toxicity for both humans and animals. Herein, we aimed to investigate the potential role of melatonin (MEL) in hepatotoxicity and nephrotoxicity following aluminum chloride ( ... ...

Abstract	Aluminum (Al) is a ubiquitous element with known toxicity for both humans and animals. Herein, we aimed to investigate the potential role of melatonin (MEL) in hepatotoxicity and nephrotoxicity following aluminum chloride (AlCl
MeSH term(s)	Aluminum/toxicity ; Animals ; Antioxidants/metabolism ; Biomarkers/blood ; Cytokines/metabolism ; Gene Expression Regulation/drug effects ; Inflammation Mediators/metabolism ; Kidney/drug effects ; Kidney/enzymology ; Kidney/pathology ; Kidney/physiopathology ; Liver/drug effects ; Liver/enzymology ; Liver/pathology ; Liver/physiopathology ; Male ; Melatonin/pharmacology ; NF-E2-Related Factor 2/genetics ; NF-E2-Related Factor 2/metabolism ; Oxidative Stress/drug effects ; Protective Agents/pharmacology ; Proto-Oncogene Proteins c-bcl-2/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Rats, Sprague-Dawley
Chemical Substances	Antioxidants ; Biomarkers ; Cytokines ; Inflammation Mediators ; NF-E2-Related Factor 2 ; Protective Agents ; Proto-Oncogene Proteins c-bcl-2 ; RNA, Messenger ; Aluminum (CPD4NFA903) ; Melatonin (JL5DK93RCL)
Language	English
Publishing date	2020-10-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	2455981-7
ISSN	1942-0994 ; 1942-0994
ISSN (online)	1942-0994
ISSN	1942-0994
DOI	10.1155/2020/7375136
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Pergularia tomentosa coupled with selenium nanoparticles salvaged lead acetate-induced redox imbalance, inflammation, apoptosis, and disruption of neurotransmission in rats’ brain

Othman Mohamed S. / Obeidat Sofian T. / Aleid Ghada M. / Abdel-Daim Mohamed M. / Habotta Ola A. / Schwartz Laurent / Al-Bagawi Amal H. / Hussein Manal M. / Bakkar Ashraf

Open Chemistry, Vol 20, Iss 1, Pp 1313-

2022 Volume 1326

Abstract: In this study, the neuroprotective potential of either Pergularia tomentosa leaf methanolic extract (PtE) alone or in combination with selenium nanoparticles (SeNPs-PtE) was investigated against lead acetate (PbAc)-induced neurotoxicity. Experimental ... ...

Abstract	In this study, the neuroprotective potential of either Pergularia tomentosa leaf methanolic extract (PtE) alone or in combination with selenium nanoparticles (SeNPs-PtE) was investigated against lead acetate (PbAc)-induced neurotoxicity. Experimental rats were pretreated with PtE (100 mg/kg) or SeNPs-PtE (0.5 mg/kg) and injected intraperitoneally with PbAc (20 mg/kg) for 2 weeks. Notably, SeNPs-PtE decreased brain Pb accumulation and enhanced the level of dopamine and the activity of AChE compared to the control rats. In addition, elevated neural levels of superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, and glutathione along with decreased lipid peroxidation levels were noticed in pretreated groups with SeNPs-PtE. Moreover, SeNPs-PtE significantly suppressed neural inflammation, as indicated by lower levels of interleukin-1 beta, interleukin-6, tumor necrosis factor-alpha, nuclear factor-kappa B p65, and nitric oxide in the examined brain tissue. The molecular results also unveiled significant down-regulation in iNOS gene expression in the brains of SeNPs-PtE-treated rats. In addition, SeNPs-PtE administration counteracted the neural loss by increasing B-cell lymphoma 2 (Bcl-2) and brain-derived neurotrophic factor levels as well as decreasing BCL2-associated X protein and caspase-3 levels. To sum up, our data suggest that P. tomentosa extract alone or in combination with SeNPs has great potential in reversing the neural tissue impairment induced by PbAc via its antioxidant, anti-inflammatory, and anti-apoptotic activities. This study might have therapeutic implications in preventing and treating several lead-induced neurological disorders.
Keywords	pergularia tomentosa ; selenium nanoparticles ; lead acetate ; oxidative stress ; neuroinflammation ; apoptosis ; Chemistry ; QD1-999
Subject code	500
Language	English
Publishing date	2022-11-01T00:00:00Z
Publisher	De Gruyter
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Hypoglycemic potential of selenium nanoparticles capped with polyvinyl-pyrrolidone in streptozotocin-induced experimental diabetes in rats

El-Borady, Ola M / Othman, Mohamed S / Atallah, Heba H / Abdel Moneim, Ahmed E

Heliyon. 2020 May, v. 6, no. 5

2020

Abstract	This study was aimed to evaluate the efficacy of synthesized selenium nanoparticles (SeNPs) capped with glucose and polyvinyl-pyrrolidone (PVP) on the hyperglycemia and prooxidants/antioxidants imbalance present in model streptozotocin (STZ)-induced diabetic rats. SeNPs were synthesized and characterized. Twenty-four albino male rats were grouped into four different groups. After the rats were induced to have type 2 diabetes by STZ, the SeNPs-treated groups received a dose of 0.5 mg/ml of SeNPs for seven days. Plasma glucose and insulin levels, pancreatic insulin expression, the levels of lipid peroxidation (LPO), nitric oxide (NO), glutathione peroxidase (GPx) and glutathione (GSH) were evaluated. TEM images revealed the formation of semispherical particles with average size between 40 and 50 nm. SeNPs administration successfully reduced the hyperglycemia, raised the levels of insulin in both the pancreas and the plasma and restored the damaged pancreatic tissue. SeNPs also showed enhancement of the elimination of the diabetes-induced oxidative stress injuries by decreasing the pancreatic LPO and NO levels. Furthermore, the activities of the antioxidant enzyme GPx and GSH levels of the diabetic rats were increased. In conclusion, SeNPs capped with PVP could be used in the future as an agent that could manage Diabetes mellitus.
Keywords	albino ; antioxidant enzymes ; blood glucose ; glucose ; glutathione ; glutathione peroxidase ; hyperglycemia ; insulin ; lipid peroxidation ; males ; nitric oxide ; noninsulin-dependent diabetes mellitus ; oxidative stress ; pancreas ; polyvinylpyrrolidone ; selenium ; streptozotocin
Language	English
Dates of publication	2020-05
Publishing place	Elsevier Ltd
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2020.e04045
Database	NAL-Catalogue (AGRICOLA)

Order via subito

To top

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

Full text online

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

Full text online

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito