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  1. Article ; Online: Longitudinal changes in depressive symptoms associated with social isolation after the Great East Japan Earthquake in Iwate Prefecture: findings from the TMM CommCohort study.

    Kotozaki, Yuka / Tanno, Kozo / Otsuka, Kotaro / Sasaki, Ryohei / Sasaki, Makoto

    BMC public health

    2023  Volume 23, Issue 1, Page(s) 1154

    Abstract: Background: Whether past disaster experiences affect the association between changes in social isolation and depressive symptoms is largely unknown. This study examined the association between changes in social isolation and depressive symptoms among ... ...

    Abstract Background: Whether past disaster experiences affect the association between changes in social isolation and depressive symptoms is largely unknown. This study examined the association between changes in social isolation and depressive symptoms among survivors who experienced earthquake damage in the aftermath of the Great East Japan Earthquake (GEJE).
    Methods: We analyzed longitudinal data from 10,314 participants who responded to self-report questionnaires on the Lubben Social Network Scale-6 (LSNS-6) and the Center for Epidemiological Studies-Depressive Scale (CES-D) in both the baseline survey (FY2013 to FY2015) and follow-up survey (FY2017 to FY2019) after the GEJE. According to changes in the presence of social isolation (< 12 of LSNS-6) at two time points, participants were categorized into four groups: "not socially isolated," "improved socially isolated," "newly socially isolated," and "continuously socially isolated." At the follow-up survey, a CES-D score of ≥ 16 indicates the presence of depressive symptoms. The adjusted odds ratios (AORs) and 95% confidence intervals (CIs) were estimated using the logistic regression analysis to examine the influence of the change in social isolation over four years on depressive symptoms.
    Results: Participants who were newly socially isolated had a significantly higher prevalence of depressive symptoms than those who were not socially isolated (AOR = 1.89, 95% CI = 1.61 - 2.23). In addition, AORs were highest for those who were continuously socially isolated and had experienced house damage (AOR = 2.17, 95% CI = 1.73 - 2.72) and those who were newly socially isolated and had not experienced the death of family members due to the GEJE (AOR = 1.88, 95%CI = 1.60 - 2.22).
    Conclusion: Our longitudinal findings suggest that being newly or continuously socially isolated is associated with a risk of depressive symptoms, not only among those who had experienced house damage or the death of a family member, but also those who had not, in the disaster-affected area. Our study underlines the clinical importance of social isolation after a large-scale natural disaster and draws attention to the need for appropriate prevention measures.
    MeSH term(s) Humans ; Earthquakes ; Japan/epidemiology ; Depression/epidemiology ; Disasters ; Social Isolation
    Language English
    Publishing date 2023-06-20
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2041338-5
    ISSN 1471-2458 ; 1471-2458
    ISSN (online) 1471-2458
    ISSN 1471-2458
    DOI 10.1186/s12889-023-16082-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Suicide prevention and postvention in hospitals in Japan: Current status and perspectives.

    Inoue, Keisuke / Kawanishi, Chiaki / Narita, Kenji / Cho, Yoshinori / Otsuka, Kotaro

    Psychiatry and clinical neurosciences

    2020  Volume 74, Issue 7, Page(s) 414–415

    MeSH term(s) Adult ; Clinical Competence ; Female ; Health Knowledge, Attitudes, Practice ; Hospitals ; Humans ; Inpatients ; Japan ; Male ; Middle Aged ; Personnel, Hospital/education ; Program Development ; Risk Assessment ; Suicide/prevention & control
    Language English
    Publishing date 2020-05-19
    Publishing country Australia
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 1292906-2
    ISSN 1440-1819 ; 1323-1316
    ISSN (online) 1440-1819
    ISSN 1323-1316
    DOI 10.1111/pcn.13015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Association between Social Isolation and Total Mortality after the Great East Japan Earthquake in Iwate Prefecture: Findings from the TMM CommCohort Study.

    Kotozaki, Yuka / Tanno, Kozo / Sakata, Kiyomi / Otsuka, Kotaro / Sasaki, Ryohei / Takanashi, Nobuyuki / Satoh, Mamoru / Shimizu, Atsushi / Sasaki, Makoto

    International journal of environmental research and public health

    2022  Volume 19, Issue 7

    Abstract: This study aimed to investigate whether social isolation is associated with mortality, together with the effect of the Great East Japan Earthquake on mortality, due to the social isolation of community residents living in the affected areas, using data ... ...

    Abstract This study aimed to investigate whether social isolation is associated with mortality, together with the effect of the Great East Japan Earthquake on mortality, due to the social isolation of community residents living in the affected areas, using data from the Tohoku Medical Megabank Project Community-Based Cohort Study. A total of 22,933 participants (8059 men and 14,874 women), who were free from cancer and cardiovascular disease, were followed up with death as an endpoint for five years. Social isolation was assessed using the Lubben Social Network Scale (cut-off, 11/12). Using Cox proportional hazards models, hazard ratios (HRs) of total mortality and 95% confidence intervals (CIs) associated with social isolation (no isolation as the reference) were estimated. The latter was significantly associated with an increased risk of total mortality (1.38 (1.04-1.83) in men and 1.49 (1.02-2.19) in women). Moreover, among those with social isolation, the risk of mortality was significantly higher, especially for women with house damage and men who had experienced a death in the family. The disaster may have raised the risk of mortality due to social isolation.
    MeSH term(s) Cohort Studies ; Disasters ; Earthquakes ; Female ; Humans ; Japan/epidemiology ; Male ; Social Isolation
    Language English
    Publishing date 2022-04-05
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph19074343
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Lessons learned from psychosocial support and mental health surveys during the 10 years since the Great East Japan Earthquake: Establishing evidence-based disaster psychiatry.

    Kunii, Yasuto / Usukura, Hitomi / Otsuka, Kotaro / Maeda, Masaharu / Yabe, Hirooki / Takahashi, Sho / Tachikawa, Hirokazu / Tomita, Hiroaki

    Psychiatry and clinical neurosciences

    2022  Volume 76, Issue 6, Page(s) 212–221

    Abstract: Post-disaster mental health and psychosocial support have drawn attention in Japan after the 1995 Great Hanshin-Awaji Earthquake, with mental health care centers for the affected communities being organized. After the catastrophe, a reconstruction budget ...

    Abstract Post-disaster mental health and psychosocial support have drawn attention in Japan after the 1995 Great Hanshin-Awaji Earthquake, with mental health care centers for the affected communities being organized. After the catastrophe, a reconstruction budget was allocated to organize mental health care centers to provide psychosocial support for communities affected by the 2007 Chūetsu offshore earthquake, the 2011 Great East Japan Earthquake, and the 2016 Kumamoto Earthquake. There were several major improvements in post-disaster mental health measures after the Great East Japan Earthquake. The Disaster Psychiatric Assistance Team system was organized after the earthquake to orchestrate disaster response related to the psychiatric health system and mental health of the affected communities. Special mental health care efforts were drawn to the communities affected by the nuclear power plant accident through Chemical, Biological, Radiological, Nuclear, and high yield Explosives, being succeeded by measures against the coronavirus pandemic. As another new movement after the Great East Japan Earthquake, the number of surveys involving communities affected by disasters has soared. More than 10 times the number of scientific publications were made in English during the decade following the Great East Japan Earthquake, compared with the previous decades. In this review, we examined the results and issues acquired in the 10 years since the Great East Japan Earthquake, proposing evidence-based disaster psychiatry as the direction of future mental health measures related to emergency preparedness and response.
    MeSH term(s) Disasters ; Earthquakes ; Health Surveys ; Humans ; Japan/epidemiology ; Mental Health ; Psychiatry ; Psychosocial Support Systems
    Language English
    Publishing date 2022-03-01
    Publishing country Australia
    Document type Journal Article ; Review
    ZDB-ID 1292906-2
    ISSN 1440-1819 ; 1323-1316
    ISSN (online) 1440-1819
    ISSN 1323-1316
    DOI 10.1111/pcn.13339
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: [Task and prospects for emergency psychiatric care in Iwate School of Medicine in Japan].

    Otsuka, Kotaro

    Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica

    2006  Volume 108, Issue 10, Page(s) 1058–1065

    MeSH term(s) Algorithms ; Emergency Services, Psychiatric/methods ; Emergency Services, Psychiatric/trends ; Hospitals, University ; Humans ; Japan ; Mental Disorders/diagnosis ; Mental Disorders/therapy ; Schools, Medical ; Triage
    Language Japanese
    Publishing date 2006
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 604306-9
    ISSN 0033-2658
    ISSN 0033-2658
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: [Suicide prevention activities of psychiatry-related professional societies: the promotion of suicide prevention in psychiatric care].

    Otsuka, Kotaro / Kawanishi, Chiaki

    Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica

    2014  Volume 116, Issue 8, Page(s) 677–682

    Abstract: Suicide prevention is promoted nationally in Japan. In the General Principles of Suicide Prevention Policy determined in 2007, the areas in which, psychiatry contributed were shown to be important, for example, psychiatric care, suicide, aftercare ... ...

    Abstract Suicide prevention is promoted nationally in Japan. In the General Principles of Suicide Prevention Policy determined in 2007, the areas in which, psychiatry contributed were shown to be important, for example, psychiatric care, suicide, aftercare program for suicide attempters, mental health promotion, and actual elucidation of the cause of suicide. At a part of these national measures, guidelines on suicide attempters' care are devised by the Japanese Society for Emergency Medicine and the Japanese Association for Emergency Psychiatry, and a training workshop on caring for suicide attempters was held by the Ministry of Health, Labour and Welfare. The Japanese society for Emergency Medicine devised an educational program of care for patients with mental health problems in emergency care in cooperation with the Japanese Association for Emergency Psychiatry and Japanese Society of General Hospital Psychiatry. On the other hand, suicide prevention and staff care at hospitals are important problems, and the Japan Council for Quality Health Care devised a program and conducted a training workshop. Also, the Japanese Association for Suicide Prevention conducted workshops for both the educational program of cognitive-behavioral therapy and facilitator training program for gatekeeper. The Japanese Society of Mood Disorders conducted a training workshop involving clinical high-risk case discussion. Also, the Japanese Society of Psychiatry and Neurology devised clinical guidelines for suicide prevention and distributed them to all society members. In this society, on-site discussion of the guidelines and the holding of workshops are expected in the future. It is hoped that these guidelines will be utilized and training workshops will be held in the future.
    MeSH term(s) Emergency Medical Services ; Hospitals, General ; Humans ; Japan ; Mood Disorders/psychology ; Practice Guidelines as Topic ; Professional Role ; Suicide/prevention & control
    Language Japanese
    Publishing date 2014
    Publishing country Japan
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 604306-9
    ISSN 0033-2658
    ISSN 0033-2658
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Validation of the Effectiveness of Neutrophil-to-lymphocyte Ratio (NLR) as a Predictive Factor in Patients Undergoing Prostate Biopsy With Prostate Specific Antigen (PSA) Between 4.0 and 10.0 ng/ml.

    Masuda, Hiroshi / Mikami, Kosuke / Otsuka, Kotaro / Hou, Kyokusin / Suyama, Takahito / Araki, Kazuhiro / Kojima, Satoko / Naya, Yukio

    In vivo (Athens, Greece)

    2021  Volume 35, Issue 3, Page(s) 1641–1646

    Abstract: Background/aim: This study aimed to access the effectiveness of serum neutrophil-to-lymphocyte ratio (NLR) in patients undergoing prostate needle biopsy with a prostate specific antigen (PSA) between 4.0 and 10.0 ng/ml.: Patients and methods: A total ...

    Abstract Background/aim: This study aimed to access the effectiveness of serum neutrophil-to-lymphocyte ratio (NLR) in patients undergoing prostate needle biopsy with a prostate specific antigen (PSA) between 4.0 and 10.0 ng/ml.
    Patients and methods: A total of 633 cases were eligible. We evaluated several factors including age, PSA, PSA-density (PSAD), platelet-to-lymphocyte ratio (PLR) and NLR in the presence or absence of prostate cancer (PCa), retrospectively. We evaluated statistically the associations between each factor and pathological findings or Gleason score.
    Results: A total of 201 were evaluated in this study. Regarding the presence or absence of prostate cancer, there were statistically significant differences in age, PSA levels, PSAD, the PLR and NLR. The mean NLR value of the patients with PCa was significantly lower compared to the entire cohort. Multivariate analysis showed that age, PSAD, and NLR were independent risk factors predicting PCa.
    Conclusion: For patients having a PSA between 4.0 and 10.0 ng/ml, NLR was a predicting factor of PCa prior to prostate needle biopsy and an effective biomarker and useful tool for avoiding unnecessary biopsies.
    MeSH term(s) Biopsy ; Humans ; Lymphocytes ; Male ; Neutrophils ; Predictive Value of Tests ; Prostate ; Prostate-Specific Antigen ; Prostatic Neoplasms/diagnosis ; Retrospective Studies
    Chemical Substances Prostate-Specific Antigen (EC 3.4.21.77)
    Language English
    Publishing date 2021-04-28
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 807031-3
    ISSN 1791-7549 ; 0258-851X
    ISSN (online) 1791-7549
    ISSN 0258-851X
    DOI 10.21873/invivo.12422
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The Association Between Hot Flashes and Renal Dysfunction After Androgen Deprivation Therapy With Radiotherapy in Japanese Patients With High-risk Prostate Cancer.

    Masuda, Hiroshi / Mikami, Kosuke / Otsuka, Kotaro / Hou, Kyokusin / Suyama, Takahito / Araki, Kazuhiro / Kojima, Satoko / Naya, Yukio

    In vivo (Athens, Greece)

    2021  Volume 35, Issue 6, Page(s) 3489–3493

    Abstract: Background/aim: We investigated the changes in and characteristics of renal function in Japanese patients with high-risk prostate cancer (PCa) who underwent radiotherapy and long-term androgen deprivation therapy (ADT), including those seen after the ... ...

    Abstract Background/aim: We investigated the changes in and characteristics of renal function in Japanese patients with high-risk prostate cancer (PCa) who underwent radiotherapy and long-term androgen deprivation therapy (ADT), including those seen after the ADT was discontinued.
    Patients and methods: Among 60 patients who were pathologically diagnosed with PCa and received ADT for 24 months and radiotherapy, 36 patients who underwent treatment for stage B or C PCa were eligible. We assessed renal function using the estimated glomerular filtration rate (eGFR) and investigated the rate of change in the eGFR (ΔeGFR) during and after ADT. Univariate and multivariate logistic analyses were carried out to identify clinical factors that were significantly associated with renal dysfunction at 36 months.
    Results: The incidence of renal dysfunction at 36 months was 75% (27/36). Multivariate analysis showed that the presence/absence of HF was an independent predictor of renal dysfunction at 36 months.
    Conclusion: Renal function tended to recover after ADT was received for 24 months and subsequently discontinued. The presence/absence of HF represents new and meaningful information for patients receiving ADT, and high-risk PCa patients prior to ADT.
    MeSH term(s) Androgen Antagonists/adverse effects ; Androgens ; Hot Flashes ; Humans ; Japan/epidemiology ; Kidney Diseases ; Male ; Prostatic Neoplasms/drug therapy ; Prostatic Neoplasms/radiotherapy
    Chemical Substances Androgen Antagonists ; Androgens
    Language English
    Publishing date 2021-10-31
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 807031-3
    ISSN 1791-7549 ; 0258-851X
    ISSN (online) 1791-7549
    ISSN 0258-851X
    DOI 10.21873/invivo.12650
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Successful Response to Nivolumab Plus Ipilimumab Therapy in a Hemodialysis Patient With Metastatic Renal Cell Carcinoma.

    Masuda, Hiroshi / Mikami, Kosuke / Otsuka, Kotaro / Hou, Kyokusin / Suyama, Takahito / Araki, Kazuhiro / Kojima, Satoko / Naya, Yukio

    Cancer diagnosis & prognosis

    2021  Volume 1, Issue 3, Page(s) 207–211

    Abstract: Background/aim: There are few reports about the administration of nivolumab plus ipilimumab to hemodialysis patients and their efficacy and safety have not been established yet.: Case report: A 74-year-old male, who was receiving hemodialysis, was ... ...

    Abstract Background/aim: There are few reports about the administration of nivolumab plus ipilimumab to hemodialysis patients and their efficacy and safety have not been established yet.
    Case report: A 74-year-old male, who was receiving hemodialysis, was presented with metastatic renal cell carcinoma (mRCC). Two years later, more metastases were found, hence, immunotherapy involving nivolumab plus ipilimumab was initiated. After two doses of immunotherapy, interstitial pneumonia was observed. Thus, steroid pulse therapy was administered immediately. Subsequently, computed tomography (CT) findings and symptoms improved markedly. One month later, a CT scan showed a nodular shadow and an air cavity. A fungal infection was strongly suspected, so an antifungal drug was administered.
    Conclusion: Combination immunotherapy with nivolumab plus ipilimumab was demonstrated to be effective in a hemodialysis patient with mRCC.
    Language English
    Publishing date 2021-07-03
    Publishing country Greece
    Document type Case Reports
    ISSN 2732-7787
    ISSN (online) 2732-7787
    DOI 10.21873/cdp.10028
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Multi-institutional survey of suicide death among inpatients with schizophrenia in comparison with depression.

    Inoue, Keisuke / Otsuka, Kotaro / Onishi, Hideki / Cho, Yoshinori / Shiraishi, Masaki / Narita, Kenji / Kawanishi, Chiaki

    Asian journal of psychiatry

    2019  Volume 48, Page(s) 101908

    Abstract: Suicide is a major cause of death among inpatients with schizophrenia. However, there are only a limited number of surveys of suicide among such patients, especially in Asia. Therefore, we conducted a multi-institutional survey on suicide death among ... ...

    Abstract Suicide is a major cause of death among inpatients with schizophrenia. However, there are only a limited number of surveys of suicide among such patients, especially in Asia. Therefore, we conducted a multi-institutional survey on suicide death among inpatients with schizophrenia in Japan. We investigated the characteristics of patients with schizophrenia who died by suicide during hospitalization in psychiatric wards, and simultaneously, those of patients with depression. Forty-five suicides of patients with schizophrenia occurred in 27 hospitals, and 46 suicides of patients with depression occurred in 33 hospitals. Hanging was the most common suicide method in both diagnostic groups. More than half of the patients with schizophrenia had histories of suicide attempts, although there was no significant difference in previous suicide attempts or self-harm between both diagnostic groups. Medical staff should confirm whether inpatients with schizophrenia have such histories. In this study, there was no significant difference in characteristics between inpatients with schizophrenia or depression. In order to prevent suicides of patients with schizophrenia during hospitalization, nonspecific suicide attempt prevention needs to be undertaken, such as ensuring comprehension of the general risk factors of suicide among medical staff.
    MeSH term(s) Adult ; Cause of Death ; Depressive Disorder/epidemiology ; Hospitalization/statistics & numerical data ; Hospitals, Psychiatric/statistics & numerical data ; Humans ; Inpatients/statistics & numerical data ; Japan/epidemiology ; Risk Factors ; Schizophrenia/epidemiology ; Schizophrenia/therapy ; Suicide, Attempted/statistics & numerical data ; Suicide, Completed/statistics & numerical data
    Language English
    Publishing date 2019-12-17
    Publishing country Netherlands
    Document type Comparative Study ; Journal Article
    ZDB-ID 2456678-0
    ISSN 1876-2026 ; 1876-2018
    ISSN (online) 1876-2026
    ISSN 1876-2018
    DOI 10.1016/j.ajp.2019.101908
    Database MEDical Literature Analysis and Retrieval System OnLINE

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