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  1. Article: Hemostasis for a Post-tonsillectomy Hemorrhage in a Patient With Coronavirus Disease.

    Iokura, Daisuke / Kojima, Tsuyoshi / Okanoue, Yusuke / Otsuki, Shuya

    Cureus

    2023  Volume 15, Issue 5, Page(s) e39432

    Abstract: During the coronavirus disease 2019 (COVID-19) pandemic, otolaryngologists should be careful when performing upper airway surgery because of the risk of aerosol generation. This paper describes the case of a 23-year-old male who was diagnosed with COVID- ... ...

    Abstract During the coronavirus disease 2019 (COVID-19) pandemic, otolaryngologists should be careful when performing upper airway surgery because of the risk of aerosol generation. This paper describes the case of a 23-year-old male who was diagnosed with COVID-19 four days after undergoing tonsillectomy. COVID-19 was complicated by pulmonary thromboembolism, and anticoagulation was administered, which caused postoperative hemorrhage. The patient had to undergo another surgery for the control of hemorrhage, during the infective period of COVID-19. COVID-19 is sometimes associated with venous embolism, and for postoperative patients, treatment should be carefully considered because of the risk of bleeding. The administration of heparin as an anticoagulant would be preferable because heparin allows for dosage adjustment by measuring activated partial thromboplastin time and also allows the rapid cessation of the anticoagulant effect when the administration is discontinued together with antagonization by protamine administration, even if bleeding occurs. When performing surgery for patients with COVID-19, special care is necessary in order not to spread the infection. Even if the preoperative polymerase chain reaction (PCR) test is negative, the patient may be in the incubation period of COVID-19; therefore, caution should be exercised when performing upper respiratory tract surgery such as tonsillectomy.
    Language English
    Publishing date 2023-05-24
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.39432
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Safety and efficacy of high tracheostomy with inferior retraction of the thyroid isthmus.

    Iokura, Daisuke / Okanoue, Yusuke / Otsuki, Shuya / Oe, Kengo / Takata, Kuniaki / Tarui, Akihito / Kojima, Tsuyoshi

    Auris, nasus, larynx

    2023  Volume 51, Issue 2, Page(s) 231–235

    Abstract: Objective: In typical surgical tracheostomy, the thyroid isthmus is divided or retracted superiorly and preserved. However, at our institution, the thyroid isthmus is retracted inferiorly and preserved. Thereafter, a tracheal incision is made above the ... ...

    Abstract Objective: In typical surgical tracheostomy, the thyroid isthmus is divided or retracted superiorly and preserved. However, at our institution, the thyroid isthmus is retracted inferiorly and preserved. Thereafter, a tracheal incision is made above the thyroid isthmus. This method, hereinafter defined as high tracheostomy, has the advantage of facilitating immediate access to the trachea in a superficial position; moreover, it can be quickly replaced with cricothyrotomy in emergency situations. However, tracheotomies placed too high can potentially damage the cricoid cartilage, thereby causing subglottic granulation and tracheal stenosis. We aimed to validate the safety and efficacy of high tracheostomy with inferior retraction of the thyroid isthmus.
    Methods: This was a retrospective cohort analysis. We analyzed the operative method and other relevant characteristics of 90 patients who underwent surgical tracheostomy between April 2016 and June 2022. For those who underwent high tracheostomies, we analyzed the duration of surgery, amount of intraoperative bleeding, occurrence of complications, problems with stoma closure, and perioperative mortality.
    Results: High tracheostomy was performed in 73 patients. Subglottic granulation occurred in one patient, and the granulation tissue spontaneously shrank. Subcutaneous emphysema occurred in two patients. No patient developed wound infection or tracheoinnominate artery fistula. Moreover, no patient experienced false route tracheotomy tube insertion because the thyroid glands were located under the stoma.
    Conclusion: The frequency of complications was comparable to that reported in other studies on tracheostomy. Additionally, no patient developed tracheal stenosis secondary to tracheostomy above the thyroid isthmus. Therefore, high tracheostomy with inferior retraction and preservation of the thyroid isthmus is safe and advantageous.
    MeSH term(s) Humans ; Tracheostomy/methods ; Thyroid Gland/surgery ; Tracheal Stenosis/surgery ; Tracheal Stenosis/etiology ; Retrospective Studies ; Trachea/surgery ; Postoperative Complications/epidemiology ; Postoperative Complications/surgery
    Language English
    Publishing date 2023-11-04
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 604552-2
    ISSN 1879-1476 ; 0385-8146
    ISSN (online) 1879-1476
    ISSN 0385-8146
    DOI 10.1016/j.anl.2023.10.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1675: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Novel evaluation method for facial nerve palsy using 3D facial recognition system in iPhone.

    Hasebe, Koki / Kojima, Tsuyoshi / Okanoue, Yusuke / Yuki, Ryohei / Yamamoto, Hirotaka / Otsuki, Shuya / Fujimura, Shintaro / Hori, Ryusuke

    Auris, nasus, larynx

    2024  Volume 51, Issue 3, Page(s) 460–464

    Abstract: Objective: While subjective methods like the Yanagihara system and the House-Brackmann system are standard in evaluating facial paralysis, they are limited by intra- and inter-observer variability. Meanwhile, quantitative objective methods such as ... ...

    Abstract Objective: While subjective methods like the Yanagihara system and the House-Brackmann system are standard in evaluating facial paralysis, they are limited by intra- and inter-observer variability. Meanwhile, quantitative objective methods such as electroneurography and electromyography are time-consuming. Our aim was to introduce a swift, objective, and quantitative method for evaluating facial movements.
    Methods: We developed an application software (app) that utilizes the facial recognition functionality of the iPhone (Apple Inc., Cupertino, USA) for facial movement evaluation. This app leverages the phone's front camera, infrared radiation, and infrared camera to provide detailed three-dimensional facial topology. It quantitatively compares left and right facial movements by region and displays the movement ratio of the affected side to the opposite side. Evaluations using the app were conducted on both normal and facial palsy subjects and were compared with conventional methods.
    Results: Our app provided an intuitive user experience, completing evaluations in under a minute, and thus proving practical for regular use. Its evaluation scores correlated highly with the Yanagihara system, the House-Brackmann system, and electromyography. Furthermore, the app outperformed conventional methods in assessing detailed facial movements.
    Conclusion: Our novel iPhone app offers a valuable tool for the comprehensive and efficient evaluation of facial palsy.
    MeSH term(s) Humans ; Facial Paralysis/physiopathology ; Smartphone ; Mobile Applications ; Electromyography/methods ; Electromyography/instrumentation ; Adult ; Imaging, Three-Dimensional ; Female ; Male ; Software ; Middle Aged ; Automated Facial Recognition/methods ; Young Adult ; Movement
    Language English
    Publishing date 2024-03-22
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 604552-2
    ISSN 1879-1476 ; 0385-8146
    ISSN (online) 1879-1476
    ISSN 0385-8146
    DOI 10.1016/j.anl.2024.02.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1675: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Impact of Changing Surgical Strategies on Clinical Outcomes in Patients with Parotid Carcinoma: A 53-Year Single-Institution Experience.

    Yamamoto, Hirotaka / Kojima, Tsuyoshi / Okanoue, Yusuke / Otsuki, Shuya / Hasebe, Koki / Yuki, Ryohei / Hori, Ryusuke

    Medicina (Kaunas, Lithuania)

    2021  Volume 57, Issue 8

    Abstract: Background and ... ...

    Abstract Background and Objectives
    MeSH term(s) Carcinoma ; Facial Nerve ; Humans ; Parotid Gland/surgery ; Parotid Neoplasms/surgery ; Postoperative Complications/epidemiology ; Retrospective Studies
    Language English
    Publishing date 2021-07-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina57080745
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    Zs.A 6270: Show issues Location:
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  5. Article ; Online: Parathyroid carcinoma: impact of preoperative diagnosis on the choice of surgical procedure.

    Kawai, Yoshitaka / Kishimoto, Yo / Tamaki, Hisanobu / Fujiwara, Takashi / Asato, Ryo / Ushiro, Koji / Shinohara, Shogo / Kada, Shinpei / Takebayashi, Shinji / Kojima, Tsuyoshi / Otsuki, Shuya / Miyazaki, Masakazu / Kumabe, Yohei / Omori, Koichi

    Endocrine journal

    2023  Volume 70, Issue 10, Page(s) 969–976

    Abstract: The operative procedure in the surgical treatment of parathyroid carcinoma differs from that of benign hyperparathyroidism. However, preoperative differentiation is often difficult. This study elucidated how clinicians diagnose parathyroid carcinoma and ... ...

    Abstract The operative procedure in the surgical treatment of parathyroid carcinoma differs from that of benign hyperparathyroidism. However, preoperative differentiation is often difficult. This study elucidated how clinicians diagnose parathyroid carcinoma and the relationship between preoperative diagnosis and the operative course. Using a retrospective chart review, twenty cases of parathyroid carcinoma from nine participating centers were examined. In 11 cases with preoperative suspicion of malignancy, at least one of these three features was found: elevated serum calcium level (>14 mg/dL), palpable mass, and irregular margin on ultrasonography. Although an intact parathyroid hormone (iPTH) threshold to suspect malignancy has not been established, six cases showed marked iPTH elevation exceeding 8.0 times the upper limit of normal. One case was excluded from analysis due to hemodialysis. Compared with the four cases that showed calcium elevation, the iPTH threshold might represent better sensitivity. Among 9 cases of benign preoperative diagnosis, six cases were performed with pericapsular resection. In three cases where malignancy was suspected in the middle of the operation, the recommended en bloc resection with ipsilateral thyroid lobectomy was not performed but a parathyroidectomy with surrounding soft tissue. In contrast, 10 preoperatively suspected cases underwent en bloc resection, and one case underwent pericapsular resection followed by supplementary ipsilateral hemithyroidectomy due to the uncertain pre- and intraoperative findings to determine the diagnosis. In conclusion, the surgical procedure for parathyroid carcinoma strongly depends on the preoperative diagnosis. The presence of excessive iPTH levels might contribute to improved preoperative diagnostic sensitivity for parathyroid carcinoma.
    MeSH term(s) Humans ; Parathyroid Neoplasms/diagnosis ; Parathyroid Neoplasms/surgery ; Parathyroid Neoplasms/pathology ; Calcium ; Retrospective Studies ; Hyperparathyroidism ; Parathyroid Hormone
    Chemical Substances Calcium (SY7Q814VUP) ; Parathyroid Hormone
    Language English
    Publishing date 2023-08-26
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1151918-6
    ISSN 1348-4540 ; 0918-8959
    ISSN (online) 1348-4540
    ISSN 0918-8959
    DOI 10.1507/endocrj.EJ23-0149
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    Uh III Zs.207: Show issues Location:
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  6. Article ; Online: Real-world 2-year long-term outcomes and prognostic factors in patients receiving nivolumab therapy for recurrent or metastatic squamous cell carcinoma of the head and neck.

    Otsuki, Shuya / Hori, Ryusuke / Shinohara, Shogo / Kojima, Tsuyoshi / Tamaki, Hisanobu / Asato, Ryo / Kitamura, Morimasa / Ichimaru, Kazuyuki / Kitani, Yoshiharu / Kumabe, Yohei / Honda, Keigo / Tsujimura, Takashi / Harada, Hiroyuki / Ushiro, Koji / Omori, Koichi

    Auris, nasus, larynx

    2022  Volume 49, Issue 5, Page(s) 834–844

    Abstract: Objective: Real-world outcomes and prognostic factors in Japanese patients receiving nivolumab therapy for recurrent or metastatic head and neck carcinoma (RMHNC) with an observation period of 1 year have been previously reported. The 1-year follow-up ... ...

    Abstract Objective: Real-world outcomes and prognostic factors in Japanese patients receiving nivolumab therapy for recurrent or metastatic head and neck carcinoma (RMHNC) with an observation period of 1 year have been previously reported. The 1-year follow-up data have been subsequently accumulated, and the long-term real-world outcomes have been analyzed. This study aimed to investigate the 2-year long-term outcomes and prognostic factors associated with the response to nivolumab.
    Methods: This was a multi-institutional retrospective study. In total, 88 RMHNC Japanese patients with squamous cell carcinoma who received nivolumab between May 2017 and May 2018 were retrospectively reviewed. Overall survival (OS), progression-free survival (PFS), and best overall response (BOR) were evaluated. Univariate and multivariable analyses were performed to identify the prognostic factors.
    Results: The median follow-up periods for monitoring OS and PFS were 73.1 and 48.1 weeks, respectively. The median OS was 74.1 weeks, and the 2-year survival rate was 33.4%. The median PFS was 18.5 weeks, and the 2-year PFS rate was 22.5%. The BOR rate was 10.2%, 19.3%, 25.0%, and 44.3% in patients who achieved complete response, partial response, stable disease, and progressive disease (PD), respectively. Among the 88 patients with RMHNC, a total of 40 immune-related adverse events (irAEs) were reported in 30 patients. Four patients continued nivolumab, while 84 patients discontinued nivolumab at the data cut-off date. The most common reason for discontinuation was PD in 61 patients, irAEs in 14 patients, and patients' wishes in 7 patients. Of the 61 patients who discontinued nivolumab because of PD, 28 patients received subsequent treatment. Statistical analyses revealed radiotherapy history, performance status, platinum-refractory carcinoma, irAEs, age, and post-nivolumab treatment as the important prognostic factors associated with OS in patients with RMHNC, and the magnitude of BOR was significantly associated with OS. Additionally, patients with subsequent treatment, including molecular targeted therapy and/or chemotherapy, had significantly prolonged OS compared to patients without subsequent treatment in cases with nivolumab discontinuation because of PD.
    Conclusion: These findings could be a useful guide for future treatment strategies for head and neck carcinoma. Considering the limitations of our cohort, further larger-scale studies with long-term follow-up are needed to substantiate the results of this study.
    MeSH term(s) Carcinoma ; Head and Neck Neoplasms/drug therapy ; Humans ; Neoplasm Recurrence, Local/pathology ; Nivolumab/therapeutic use ; Prognosis ; Retrospective Studies ; Squamous Cell Carcinoma of Head and Neck/drug therapy
    Chemical Substances Nivolumab (31YO63LBSN)
    Language English
    Publishing date 2022-02-26
    Publishing country Netherlands
    Document type Journal Article ; Multicenter Study
    ZDB-ID 604552-2
    ISSN 1879-1476 ; 0385-8146
    ISSN (online) 1879-1476
    ISSN 0385-8146
    DOI 10.1016/j.anl.2022.02.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1675: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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