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  1. AU="Otten, Gisela"
  2. AU="Elhence, Anshuman"
  3. AU="Tinneberg, H-R"
  4. AU="Puro, Neeraj"
  5. AU=Yang Chi-Fu Jeffrey
  6. AU="Oliveira, Giuliana S"
  7. AU="Maria Cecilia Jocson"
  8. AU="Tollman, Stephen"
  9. AU="Cherry, Katie E."
  10. AU="Nazet, Ute"
  11. AU="Kranzer, K"
  12. AU="Avelino, Samuel"
  13. AU="Sun, Xiang-Dong"
  14. AU="Vogl, Thomas J."
  15. AU="Johnson, C R"
  16. AU="Gil-Pérez, Pablo"
  17. AU="Donno, Federica"
  18. AU="Vom Saal, Frederick S."
  19. AU="Gazzana, S"
  20. AU="Viswanadha, Vijaya P"
  21. AU="Anastasi, G A"
  22. AU="Romerosa, Antonio"
  23. AU=Gupta Gaorav P
  24. AU="Fernández-Susavila, Héctor"

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  1. Artikel ; Online: Correction: Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity.

    Carroll, Bernadette / Maetzel, Dorothea / Maddocks, Oliver Dk / Otten, Gisela / Ratcliff, Matthew / Smith, Graham R / Dunlop, Elaine A / Passos, João F / Davies, Owen Richard / Jaenisch, Rudolf / Tee, Andrew R / Sarkar, Sovan / Korolchuk, Viktor I

    eLife

    2020  Band 9

    Sprache Englisch
    Erscheinungsdatum 2020-12-16
    Erscheinungsland England
    Dokumenttyp Published Erratum
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.65744
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity.

    Carroll, Bernadette / Maetzel, Dorothea / Maddocks, Oliver Dk / Otten, Gisela / Ratcliff, Matthew / Smith, Graham R / Dunlop, Elaine A / Passos, João F / Davies, Owen R / Jaenisch, Rudolf / Tee, Andrew R / Sarkar, Sovan / Korolchuk, Viktor I

    eLife

    2016  Band 5

    Abstract: The mammalian target of rapamycin complex 1 (mTORC1) is the key signaling hub that regulates cellular protein homeostasis, growth, and proliferation in health and disease. As a prerequisite for activation of mTORC1 by hormones and mitogens, there first ... ...

    Abstract The mammalian target of rapamycin complex 1 (mTORC1) is the key signaling hub that regulates cellular protein homeostasis, growth, and proliferation in health and disease. As a prerequisite for activation of mTORC1 by hormones and mitogens, there first has to be an available pool of intracellular amino acids. Arginine, an amino acid essential during mammalian embryogenesis and early development is one of the key activators of mTORC1. Herein, we demonstrate that arginine acts independently of its metabolism to allow maximal activation of mTORC1 by growth factors via a mechanism that does not involve regulation of mTORC1 localization to lysosomes. Instead, arginine specifically suppresses lysosomal localization of the TSC complex and interaction with its target small GTPase protein, Rheb. By interfering with TSC-Rheb complex, arginine relieves allosteric inhibition of Rheb by TSC. Arginine cooperates with growth factor signaling which further promotes dissociation of TSC2 from lysosomes and activation of mTORC1. Arginine is the main amino acid sensed by the mTORC1 pathway in several cell types including human embryonic stem cells (hESCs). Dependence on arginine is maintained once hESCs are differentiated to fibroblasts, neurons, and hepatocytes, highlighting the fundamental importance of arginine-sensing to mTORC1 signaling. Together, our data provide evidence that different growth promoting cues cooperate to a greater extent than previously recognized to achieve tight spatial and temporal regulation of mTORC1 signaling.
    Mesh-Begriff(e) Arginine/metabolism ; Cell Differentiation ; Embryonic Stem Cells/physiology ; Humans ; Mechanistic Target of Rapamycin Complex 1 ; Monomeric GTP-Binding Proteins/metabolism ; Multiprotein Complexes/metabolism ; Neuropeptides/metabolism ; Ras Homolog Enriched in Brain Protein ; Signal Transduction ; TOR Serine-Threonine Kinases/metabolism ; Tuberous Sclerosis Complex 2 Protein ; Tumor Suppressor Proteins/metabolism
    Chemische Substanzen Multiprotein Complexes ; Neuropeptides ; RHEB protein, human ; Ras Homolog Enriched in Brain Protein ; TSC2 protein, human ; Tuberous Sclerosis Complex 2 Protein ; Tumor Suppressor Proteins ; Arginine (94ZLA3W45F) ; Mechanistic Target of Rapamycin Complex 1 (EC 2.7.11.1) ; TOR Serine-Threonine Kinases (EC 2.7.11.1) ; Monomeric GTP-Binding Proteins (EC 3.6.5.2)
    Sprache Englisch
    Erscheinungsdatum 2016-01-07
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.11058
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Kategorien

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

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