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  1. Article ; Online: Cardiac myxoma mimicking a spondyloarthritis flare.

    Delmotte, Anastasia / Ou, Phalla / Zouhry, Ilyass / Nataf, Patrick / Dieudé, Philippe

    The Lancet. Rheumatology

    2023  Volume 6, Issue 2, Page(s) e128

    MeSH term(s) Humans ; Heart Neoplasms/diagnosis ; Myxoma/diagnosis ; Respiratory Tract Neoplasms
    Language English
    Publishing date 2023-05-16
    Publishing country England
    Document type Journal Article
    ISSN 2665-9913
    ISSN (online) 2665-9913
    DOI 10.1016/S2665-9913(23)00093-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Four-Dimensional Flow Magnetic Resonance Imaging Features of a Platypnea-Orthodeoxia Syndrome Caused by a Patent Foramen Ovale.

    Sitbon, Samuel / Ou, Phalla / Nguyen, Caroline / Ehmer, Carsten / Garbarz, Eric / Brochet, Eric / Fuchs, Adeline / Aubry, Pierre / Abtan, Jeremie

    Circulation. Cardiovascular imaging

    2023  Volume 16, Issue 7, Page(s) 601–603

    MeSH term(s) Humans ; Foramen Ovale, Patent/complications ; Foramen Ovale, Patent/diagnostic imaging ; Platypnea Orthodeoxia Syndrome ; Dyspnea/diagnosis ; Dyspnea/etiology ; Hypoxia/diagnosis ; Hypoxia/etiology
    Language English
    Publishing date 2023-04-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2435045-X
    ISSN 1942-0080 ; 1941-9651
    ISSN (online) 1942-0080
    ISSN 1941-9651
    DOI 10.1161/CIRCIMAGING.122.014722
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Acute Pulmonary Edema After Double Mechanical Valve Replacement.

    Poulat, Audrey / Verdonk, Constance / Para, Marylou / Jendoubi, Ali / Khzouri, Takoua / Senemaud, Jean Nicolas / Castier, Yves / Richaud, Rainu / Ou, Phalla / Iung, Bernard / Nataf, Patrick

    JACC. Case reports

    2024  Volume 29, Issue 6, Page(s) 102237

    Abstract: We report a case of a 16-year-old man in cardiogenic shock secondary to On-X mitral prosthesis dysfunction due to leaflet embolization through aortic mechanical prosthesis. He underwent an emergency redo mitral valve replacement and, a few days later, ... ...

    Abstract We report a case of a 16-year-old man in cardiogenic shock secondary to On-X mitral prosthesis dysfunction due to leaflet embolization through aortic mechanical prosthesis. He underwent an emergency redo mitral valve replacement and, a few days later, leaflet removal by open aortic surgery with full recovery.
    Language English
    Publishing date 2024-02-09
    Publishing country Netherlands
    Document type Case Reports
    ISSN 2666-0849
    ISSN (online) 2666-0849
    DOI 10.1016/j.jaccas.2024.102237
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Case report of an isolated myocarditis due to COVID-19 infection in a paediatric patient.

    Fischer, Quentin / Brillat-Savarin, Nina / Ducrocq, Grégory / Ou, Phalla

    European heart journal. Case reports

    2020  Volume 4, Issue FI1, Page(s) 1–5

    Abstract: Background: Cardiovascular complications of COVID-19 have been reported in the adult population including myocarditis. However, less is known about the myocardial involvement in paediatric patients.: Case summary: A 15-year-old boy was admitted to ... ...

    Abstract Background: Cardiovascular complications of COVID-19 have been reported in the adult population including myocarditis. However, less is known about the myocardial involvement in paediatric patients.
    Case summary: A 15-year-old boy was admitted to our intensive cardiac care unit with COVID-19 and an isolated acute myocarditis, confirmed on cardiac magnetic resonance imaging. No pulmonary lesion was observed on the chest CT scan. We report here the initial presentation, medical care, and clinical course of this patient.
    Discussion: In the context of the acute COVID-19 outbreak, screening for COVID-19 infection should be performed in children presenting with myocardial injury in an inflammatory context.
    Keywords covid19
    Language English
    Publishing date 2020-07-03
    Publishing country England
    Document type Case Reports
    ISSN 2514-2119
    ISSN (online) 2514-2119
    DOI 10.1093/ehjcr/ytaa180
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Squamous cell carcinoma of the tongue with cardiac metastasis on 18F-FDG PET/CT: A case report and literature review.

    Delabie, Pierre / Evrard, Diane / Zouhry, Ilyass / Ou, Phalla / Rouzet, François / Benali, Khadija / Piekarski, Eve

    Medicine

    2021  Volume 100, Issue 15, Page(s) e25529

    Abstract: Introduction: The most common malignancies metastasizing to the heart are cancers of the lung, breast, mesothelioma, melanoma, leukemia, and lymphoma. Cardiac metastasis from a tongue cancer is a rare finding and only a few cases have been reported ... ...

    Abstract Introduction: The most common malignancies metastasizing to the heart are cancers of the lung, breast, mesothelioma, melanoma, leukemia, and lymphoma. Cardiac metastasis from a tongue cancer is a rare finding and only a few cases have been reported previously in the literature. In this case report and literature review, we discuss the main clinical features of patients with cardiac metastases secondary to a tongue cancer and imaging modalities performed, especially the 18F-Fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT).
    Patient concerns: This is a case of a 39-year-old woman who in April 2018 was diagnosed with an invasive well differentiated squamous cell carcinoma of the movable tongue. She underwent a left hemiglossectomy followed by a revision of hemiglossectomy and ipsilateral selective neck lymph nodes dissection levels II to III because of pathological margins. An early inoperable clinical recurrence was diagnosed and she received radiochemotherapy with good clinical and metabolic response. She remained asymptomatic thereafter.
    Diagnosis: In January 2020, a pre-scheduled 18F-FDG PET/CT showed a diffuse cardiac involvement. In February 2020, a biopsy of the lesion revealed a metastatic squamous cell carcinoma.
    Interventions: She was deemed to not be a cardiac surgical candidate and treated by palliative chemotherapy: taxol-carboplatin associated with cetuximab then cetuximab alone because of adverse effects. A re-evaluation imaging performed in April 2020 evidenced a progression of the cardiac involvement, which led to switch chemotherapy by immunotherapy with nivolumab.
    Outcomes: This patient had a very poor prognosis and succumbed to major heart failure 4 months after the diagnosis of cardiac metastasis.
    Conclusion: In this case report, 18F-FDG PET/CT proved to be useful in detecting cardiac metastasis and changed the therapeutic management of the patient. It suggests that patients with tongue malignancies in a context of poor initial prognosis should be followed-up early by 18F-FDG PET/CT with HFLC diet to facilitate detection of recurrence.
    MeSH term(s) Adult ; Carcinoma, Squamous Cell/diagnostic imaging ; Carcinoma, Squamous Cell/secondary ; Fatal Outcome ; Female ; Fluorodeoxyglucose F18 ; Heart Neoplasms/diagnostic imaging ; Heart Neoplasms/secondary ; Humans ; Lymph Nodes/pathology ; Medical Illustration ; Neck Dissection ; Positron Emission Tomography Computed Tomography/methods ; Radiopharmaceuticals ; Tongue/diagnostic imaging ; Tongue/pathology ; Tongue Neoplasms/diagnostic imaging ; Tongue Neoplasms/pathology
    Chemical Substances Radiopharmaceuticals ; Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Language English
    Publishing date 2021-04-13
    Publishing country United States
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000025529
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Comparison of Direct Oral Anticoagulants vs Vitamin K Antagonists After Transcatheter Mitral Valve Replacement.

    El Bèze, Nathan / Himbert, Dominique / Suc, Gaspard / Brochet, Eric / Ajzenberg, Nadine / Cailliau, Audrey / Kikoïne, John / Delhomme, Clemence / Carrasco, Jose Luis / Ou, Phalla / Iung, Bernard / Urena, Marina

    Journal of the American College of Cardiology

    2023  Volume 83, Issue 2, Page(s) 334–346

    Abstract: Background: There is currently no established recommendation for antithrombotic treatment following transcatheter mitral valve replacement (TMVR). However, based on the analogy with surgical mitral bioprosthesis, vitamin K antagonists (VKAs) are ... ...

    Abstract Background: There is currently no established recommendation for antithrombotic treatment following transcatheter mitral valve replacement (TMVR). However, based on the analogy with surgical mitral bioprosthesis, vitamin K antagonists (VKAs) are predominantly used.
    Objectives: The purpose of this study was to compare bleeding and thrombotic events associated with direct oral anticoagulants (DOACs) or VKAs in a prospective cohort of TMVR patients.
    Methods: We enrolled consecutive patients who underwent transseptal TMVR using a SAPIEN family prosthesis at our center between 2011 and 2023. The primary outcome was the occurrence of bleeding. VKAs were administered to patients until October 2019, after which DOACs were prescribed. The median follow-up was 4.7 months (Q1-Q3: 2.6-6.7 months).
    Results: A total of 156 patients were included. The mean age was 65 ± 18.5 years, and 103 patients (66%) were women. The median EuroSCORE II was 7.48% (Q1-Q3: 3.80%-12.97%). Of the participants, 20.5% received DOACs and 79.5% were treated with VKAs. The primary outcome was observed in 50 (40%) patients in the VKA group and 3 (9%) patients in the DOAC group (adjusted HR: 0.21; 95% CI: 0.06-0.74; P = 0.02). Treatment with DOAC was associated with a shorter length of hospital stay. No significant differences were found in terms of thrombotic events, major vascular complications, stroke, or death.
    Conclusions: The use of DOACs after TMVR, compared with VKAs, appears to reduce the risk of bleeding complications and decrease the length of hospital stay for patients, without a significant increase in the risk of thrombotic events.
    MeSH term(s) Humans ; Female ; Middle Aged ; Aged ; Aged, 80 and over ; Male ; Fibrinolytic Agents ; Mitral Valve/surgery ; Prospective Studies ; Anticoagulants/therapeutic use ; Vitamin K
    Chemical Substances Fibrinolytic Agents ; Anticoagulants ; Vitamin K (12001-79-5)
    Language English
    Publishing date 2023-12-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605507-2
    ISSN 1558-3597 ; 0735-1097
    ISSN (online) 1558-3597
    ISSN 0735-1097
    DOI 10.1016/j.jacc.2023.10.031
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Acute myocarditis revealing autoimmune and inflammatory disorders: Clinical presentation and outcome.

    Chaligne, Camille / Mageau, Arthur / Ducrocq, Gregory / Ou, Phalla / Alexandra, Jean-Francois / Mutuon, Pierre / Papo, Thomas / Sacre, Karim

    International journal of cardiology

    2021  Volume 351, Page(s) 84–88

    Abstract: Background: Acute myocarditis (AM) may be the heralding manifestation of autoimmune and inflammatory disorders (AIID). We aimed to describe the clinical presentation and outcome of patients with AM revealing AIID.: Methods: All consecutive adult ... ...

    Abstract Background: Acute myocarditis (AM) may be the heralding manifestation of autoimmune and inflammatory disorders (AIID). We aimed to describe the clinical presentation and outcome of patients with AM revealing AIID.
    Methods: All consecutive adult patients with AM admitted in a department of Cardiology (Bichat Hospital, Paris, France) from January 2011 to January 2019 were included. Diagnosis of AM was based on clinical manifestations, elevated Troponin, myocardial inflammation on CMR and no evidence for coronary artery disease. AIID were classified using international criteria.
    Results: Two-hundred and eighteen (35.3 [26.4-47.1] years, 75.2% males) patients with AM were included. Overall, AM revealed AIID in 15 (6.9%), including systemic lupus erythematosus (n = 3), adult onset Still's disease (n = 3), sarcoidosis (n = 2), mixed connective tissue disease (n = 1), anti-Jo1 syndrome (n = 1), eosinophilic granulomatosis with polyangiitis (n = 1), antiphospholipid syndrome (n = 1), reactive arthritis (n = 1), Graves' disease (n = 1) and Crohn's colitis (n = 1). Left ventricular ejection fraction (LVEF) at onset was <30% in 5 (33.3%) patients with AIID. All but 2 patients with AIID were treated with steroids, immunosuppressive and/or immunomodulatory drugs and LVEF normalized in all by the end of follow-up. By comparing patients with AIID to patients with idiopathic AM (n = 203), multivariable analysis showed that pericardial effusion, lack of chest pain and high CRP level at onset were independently associated with AIID.
    Conclusion: Acute myocarditis revealing AIID may be life-threatening at the acute phase but has an overall good prognosis under specific treatment. Pericardial effusion and CRP level at admission suggest an AIID as the cause for AM.
    MeSH term(s) Acute Disease ; Adult ; Churg-Strauss Syndrome/complications ; Female ; Granulomatosis with Polyangiitis/complications ; Humans ; Male ; Myocarditis/complications ; Myocarditis/diagnostic imaging ; Retrospective Studies ; Stroke Volume ; Ventricular Function, Left
    Language English
    Publishing date 2021-12-31
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 779519-1
    ISSN 1874-1754 ; 0167-5273
    ISSN (online) 1874-1754
    ISSN 0167-5273
    DOI 10.1016/j.ijcard.2021.12.058
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  8. Article ; Online: Case report of an isolated myocarditis due to COVID-19 infection in a paediatric patient

    Fischer, Quentin / Brillat-Savarin, Nina / Ducrocq, Grégory / Ou, Phalla

    European Heart Journal - Case Reports

    2020  Volume 4, Issue FI1, Page(s) 1–5

    Abstract: Abstract Background Cardiovascular complications of COVID-19 have been reported in the adult population including myocarditis. However, less is known about the myocardial involvement in paediatric patients. Case summary A 15-year-old boy was admitted to ... ...

    Abstract Abstract Background Cardiovascular complications of COVID-19 have been reported in the adult population including myocarditis. However, less is known about the myocardial involvement in paediatric patients. Case summary A 15-year-old boy was admitted to our intensive cardiac care unit with COVID-19 and an isolated acute myocarditis, confirmed on cardiac magnetic resonance imaging. No pulmonary lesion was observed on the chest CT scan. We report here the initial presentation, medical care, and clinical course of this patient. Discussion In the context of the acute COVID-19 outbreak, screening for COVID-19 infection should be performed in children presenting with myocardial injury in an inflammatory context.
    Keywords covid19
    Language English
    Publisher Oxford University Press (OUP)
    Publishing country uk
    Document type Article ; Online
    ISSN 2514-2119
    DOI 10.1093/ehjcr/ytaa180
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Management and outcomes of carcinoid heart disease with liver metastases of midgut neuroendocrine tumours.

    Suc, Gaspard / Cachier, Agnès / Hentic, Olivia / Bazire, Baptiste / Sannier, Aurélie / Delhomme, Clémence / Nataf, Patrick / Laschet, Jamila / Deschamps, Lydia / Garbarz, Eric / Ou, Phalla / Caligiuri, Giuseppina / Iung, Bernard / Ruszniewski, Philippe / de Mestier, Louis / Arangalage, Dimitri

    Heart (British Cardiac Society)

    2023  Volume 110, Issue 2, Page(s) 132–139

    Abstract: Objective: Despite recent advances in surgical and interventional techniques, knowledge on the management of carcinoid heart disease (CHD) remains limited. In a cohort of patients with liver metastases of midgut neuroendocrine tumours (NETs), we aimed ... ...

    Abstract Objective: Despite recent advances in surgical and interventional techniques, knowledge on the management of carcinoid heart disease (CHD) remains limited. In a cohort of patients with liver metastases of midgut neuroendocrine tumours (NETs), we aimed to describe the perioperative management and short-term outcomes of CHD.
    Methods: From January 2003 to June 2022, consecutive patients with liver metastases of midgut NETs and severe CHD (severe valve disease with symptoms and/or right ventricular enlargement) were included at Beaujon and Bichat hospitals. All patients underwent clinical evaluation and echocardiography.
    Results: Out of 43 (16%) consecutive patients with severe CHD and liver metastases of midgut NETs, 79% presented with right-sided heart failure. Tricuspid valve replacement was performed in 26 (53%) patients including 19 (73%) cases of combined pulmonary valve replacement. The 30-day postoperative mortality rate was high (19%), and preoperative heart failure was associated with worse survival (p=0.02). Epicardial pacemakers were systematically implanted in operated patients and 25% were permanently paced. A postoperative positive right ventricular remodelling was observed (p<0.001). A greater myofibroblastic infiltration was observed in pulmonary versus tricuspid valves (p<0.001), suggesting that they may have been explanted at an earlier stage of the disease than the tricuspid valve, with therefore potential for evolution.
    Conclusions: We observed a high postoperative mortality rate and baseline right-sided heart failure was associated with worse outcome. In surviving patients, a positive right ventricular remodelling was observed. Prospective, multicentre studies are warranted to better define the management strategy and to identify biomarkers associated with outcome in CHD.
    MeSH term(s) Humans ; Carcinoid Heart Disease/complications ; Heart Valve Prosthesis Implantation/methods ; Neuroendocrine Tumors/surgery ; Neuroendocrine Tumors/complications ; Prospective Studies ; Ventricular Remodeling ; Heart Failure/complications ; Liver Neoplasms/complications
    Language English
    Publishing date 2023-12-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 1303417-0
    ISSN 1468-201X ; 1355-6037
    ISSN (online) 1468-201X
    ISSN 1355-6037
    DOI 10.1136/heartjnl-2023-322945
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Vascular and Liver Homeostasis in Juvenile Mice Require Endothelial Cyclic AMP-Dependent Protein Kinase A.

    Nedvetsky, Pavel I / Cornelissen, Ivo / Mathivet, Thomas / Bouleti, Claire / Ou, Phalla / Baatsen, Pieter / Zhao, Xiaocheng / Schuit, Frans / Stanchi, Fabio / Mostov, Keith E / Gerhardt, Holger

    International journal of molecular sciences

    2022  Volume 23, Issue 19

    Abstract: During vascular development, endothelial cAMP-dependent protein kinase A (PKA) regulates angiogenesis by controlling the number of tip cells, and PKA inhibition leads to excessive angiogenesis. Whether this role of endothelial PKA is restricted to ... ...

    Abstract During vascular development, endothelial cAMP-dependent protein kinase A (PKA) regulates angiogenesis by controlling the number of tip cells, and PKA inhibition leads to excessive angiogenesis. Whether this role of endothelial PKA is restricted to embryonic and neonatal development or is also required for vascular homeostasis later on is unknown. Here, we show that perinatal (postnatal days P1-P3) of later (P28-P32) inhibition of endothelial PKA using dominant-negative PKA expressed under the control of endothelial-specific Cdh5-CreERT2 recombinase (dnPKA
    MeSH term(s) Albumins ; Animals ; Blood Vessels/metabolism ; Blood Vessels/physiology ; Cyclic AMP ; Cyclic AMP-Dependent Protein Kinase Catalytic Subunits/metabolism ; Cyclic AMP-Dependent Protein Kinase Catalytic Subunits/physiology ; Cyclic AMP-Dependent Protein Kinases/metabolism ; Cyclic AMP-Dependent Protein Kinases/physiology ; Endothelial Cells/metabolism ; Endothelial Cells/physiology ; Homeostasis ; Hypoalbuminemia ; Hypoglycemia ; Liver/metabolism ; Liver/physiology ; Mice ; Recombinases
    Chemical Substances Albumins ; Recombinases ; Cyclic AMP (E0399OZS9N) ; Cyclic AMP-Dependent Protein Kinase Catalytic Subunits (EC 2.7.11.11) ; Cyclic AMP-Dependent Protein Kinases (EC 2.7.11.11) ; Prkaca protein, mouse (EC 2.7.11.11)
    Language English
    Publishing date 2022-09-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms231911419
    Database MEDical Literature Analysis and Retrieval System OnLINE

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