LIVIVO - Das Suchportal für Lebenswissenschaften

switch to English language
Zurück zur letzten Suche Suchhistorie
Erweiterte Suche

Ihre letzten Suchen

  1. AU="Ou Li"
  2. AU="Ting Chen" AU="Ting Chen"
  3. AU="Wilson, Jaymi"
  4. AU="Vane, Christopher H"
  5. AU="Mabbott, Donald"
  6. AU="Martín-Trejo, Jorge Alfonso"
  7. AU=Rieder Hans L

Suchergebnis

Treffer 1 - 10 von insgesamt 244

Suchoptionen

  1. Artikel: Nonviral delivery of nCas9 for "safe harbor" integration to treat MPS IVA.

    Ou, Li

    Molecular therapy. Methods & clinical development

    2023  Band 32, Heft 1, Seite(n) 101178

    Sprache Englisch
    Erscheinungsdatum 2023-12-29
    Erscheinungsland United States
    Dokumenttyp News
    ZDB-ID 2872938-9
    ISSN 2329-0501 ; 2329-0501
    ISSN (online) 2329-0501
    ISSN 2329-0501
    DOI 10.1016/j.omtm.2023.101178
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 7107: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  2. Artikel: AAV Engineering for Improving Tropism to the Central Nervous System.

    Ghauri, Muhammad S / Ou, Li

    Biology

    2023  Band 12, Heft 2

    Abstract: Adeno-associated virus (AAV) is a non-pathogenic virus that mainly infects primates with the help of adenoviruses. AAV is being widely used as a delivery vector for in vivo gene therapy, as evidenced by five currently approved drugs and more than 255 ... ...

    Abstract Adeno-associated virus (AAV) is a non-pathogenic virus that mainly infects primates with the help of adenoviruses. AAV is being widely used as a delivery vector for in vivo gene therapy, as evidenced by five currently approved drugs and more than 255 clinical trials across the world. Due to its relatively low immunogenicity and toxicity, sustained efficacy, and broad tropism, AAV holds great promise for treating many indications, including central nervous system (CNS), ocular, muscular, and liver diseases. However, low delivery efficiency, especially for the CNS due to the blood-brain barrier (BBB), remains a significant challenge for more clinical application of AAV gene therapy. Thus, there is an urgent need for utilizing AAV engineering to discover next-generation capsids with improved properties, e.g., enhanced BBB penetrance, lower immunogenicity, and higher packaging efficiency. AAV engineering methods, including directed evolution, rational design, and in silico design, have been developed, resulting in the discovery of novel capsids (e.g., PhP.B, B10, PAL1A/B/C). In this review, we discuss key studies that identified engineered CNS capsids and/or established methodological improvements. Further, we also discussed important issues that need to be addressed, including cross-species translatability, cell specificity, and modular engineering to improve multiple properties simultaneously.
    Sprache Englisch
    Erscheinungsdatum 2023-01-26
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2661517-4
    ISSN 2079-7737
    ISSN 2079-7737
    DOI 10.3390/biology12020186
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  3. Artikel ; Online: AAV Engineering for Improving Tropism to the Central Nervous System

    Ghauri, Muhammad S. / Ou, Li

    Biology (Basel). 2023 Jan. 26, v. 12, no. 2

    2023  

    Abstract: Adeno-associated virus (AAV) is a non-pathogenic virus that mainly infects primates with the help of adenoviruses. AAV is being widely used as a delivery vector for in vivo gene therapy, as evidenced by five currently approved drugs and more than 255 ... ...

    Abstract Adeno-associated virus (AAV) is a non-pathogenic virus that mainly infects primates with the help of adenoviruses. AAV is being widely used as a delivery vector for in vivo gene therapy, as evidenced by five currently approved drugs and more than 255 clinical trials across the world. Due to its relatively low immunogenicity and toxicity, sustained efficacy, and broad tropism, AAV holds great promise for treating many indications, including central nervous system (CNS), ocular, muscular, and liver diseases. However, low delivery efficiency, especially for the CNS due to the blood-brain barrier (BBB), remains a significant challenge for more clinical application of AAV gene therapy. Thus, there is an urgent need for utilizing AAV engineering to discover next-generation capsids with improved properties, e.g., enhanced BBB penetrance, lower immunogenicity, and higher packaging efficiency. AAV engineering methods, including directed evolution, rational design, and in silico design, have been developed, resulting in the discovery of novel capsids (e.g., PhP.B, B10, PAL1A/B/C). In this review, we discuss key studies that identified engineered CNS capsids and/or established methodological improvements. Further, we also discussed important issues that need to be addressed, including cross-species translatability, cell specificity, and modular engineering to improve multiple properties simultaneously.
    Schlagwörter Adenoviridae ; Dependoparvovirus ; blood-brain barrier ; capsid ; cell specificity ; central nervous system ; computer simulation ; directed evolution ; gene therapy ; immunogenicity ; liver ; penetrance ; toxicity ; viruses
    Sprache Englisch
    Erscheinungsverlauf 2023-0126
    Erscheinungsort Multidisciplinary Digital Publishing Institute
    Dokumenttyp Artikel ; Online
    ZDB-ID 2661517-4
    ISSN 2079-7737
    ISSN 2079-7737
    DOI 10.3390/biology12020186
    Datenquelle NAL Katalog (AGRICOLA)

    Zusatzmaterialien

    Kategorien

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  4. Artikel: The implementation of simulators in neurosurgery training. The application of the simulator program in Peru.

    Aguilar-Zegarra, Luis Fernando / Quiroz-Marcelo, Diego Alonso / Ou-Li, Fanny Shuyi / Nombera-Aznarán, Milagros Fernanda

    Surgical neurology international

    2023  Band 14, Seite(n) 356

    Sprache Englisch
    Erscheinungsdatum 2023-10-06
    Erscheinungsland United States
    Dokumenttyp Editorial
    ISSN 2229-5097
    ISSN 2229-5097
    DOI 10.25259/SNI_755_2023
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  5. Artikel: Effect of Industrial Solid Waste as Fillers on the Rheology and Surface Free Energy of Asphalt Mastic.

    Ou, Li / Zhu, Hongzhou / Chen, Ruipu / Su, Chunli / Yang, Xiaosi

    Materials (Basel, Switzerland)

    2024  Band 17, Heft 5

    Abstract: The continuous growth of industrial solid waste production has generated many environmental problems. We evaluated the potential of industrial solid waste as a substitute filler in asphalt mastic, with the aim of increasing the use of sustainable road ... ...

    Abstract The continuous growth of industrial solid waste production has generated many environmental problems. We evaluated the potential of industrial solid waste as a substitute filler in asphalt mastic, with the aim of increasing the use of sustainable road construction materials. In this study, X-ray fluorescence spectroscopy (XRF) and scanning electron microscopy (SEM) were used to characterize the oxide composition and micromorphology of limestone (LS), red mud (RM), steel slag (SS), and ground granulated blast-furnace slag (GGBFS). Four asphalt mastics containing LS, RM, SS, and GGBFS with a filler-to-binder weight ratio of one were prepared. An evaluation of the rheology and wetting of the solid-waste-filler asphalt mastic was conducted using a frequency sweep, temperature sweep, linear amplitude sweep (LAS), multiple stress creep and recovery (MSCR), and surface free energy (SFE) methods. The results showed that SS increased the complex modulus, elastic component of the asphalt mastic and decreased the nonrecoverable creep compliance at stress levels of 0.1 and 3.2 kPa, which improved the rutting resistance of the asphalt mastic and reduced deformation under high-temperature conditions. The RM and GGBFS increased the fatigue performance of the asphalt mastic under strain loading, enhanced its fatigue life, and maintained good performance under long-term loading. The dispersive component of the SFE parameter of the solid-waste-filler asphalt mastic was larger than the polar component for the largest share of the surface energy composition. The SFE of the asphalt mastic prepared from the industrial solid-waste filler was reduced; however, the difference was insignificant compared to the limestone asphalt mastic. Solid-waste-filler asphalt mastic has performance characteristics, and its actual application can be based on different performance characteristics to select an appropriate solid-waste filler. The results of this study provide new technological solutions for solving the utilization rate of solid waste materials and sustainable road construction in the future.
    Sprache Englisch
    Erscheinungsdatum 2024-02-29
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma17051125
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  6. Artikel: Precast Assembled Road Paving Technology: Progress and Prospects.

    Tan, Qiqi / Zhu, Hongzhou / Yang, Song / Yang, Xiaosi / Ou, Li

    Materials (Basel, Switzerland)

    2024  Band 17, Heft 10

    Abstract: This article presents a systematic review of the most cutting-edge research on precast pavement technology for the first time. Firstly, precast pavement is divided into two categories, precast cement concrete pavement and precast carpeted flexible ... ...

    Abstract This article presents a systematic review of the most cutting-edge research on precast pavement technology for the first time. Firstly, precast pavement is divided into two categories, precast cement concrete pavement and precast carpeted flexible pavement, according to the application of precast technology in pavement engineering. Subsequently, the structural characteristics, advantages, and disadvantages of various precast pavement systems are compared and analyzed; technical problems in precast pavement systems are explained; and future development directions are identified. In addition, the text specifically mentions the great contribution of precast carpeted flexible pavement technology in reducing the harmful effects of asphalt fumes on humans and the environment. This work will promote the application of prefabrication in road engineering and provide suggestions and references for subsequent research.
    Sprache Englisch
    Erscheinungsdatum 2024-05-10
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma17102245
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  7. Artikel ; Online: Corrigendum: rAAV immunogenicity, toxicity, and durability in 255 clinical trials: A meta-analysis.

    Shen, Weiran / Liu, Shengjiang / Ou, Li

    Frontiers in immunology

    2023  Band 13, Seite(n) 1104646

    Abstract: This corrects the article DOI: 10.3389/fimmu.2022.1001263.]. ...

    Abstract [This corrects the article DOI: 10.3389/fimmu.2022.1001263.].
    Sprache Englisch
    Erscheinungsdatum 2023-01-18
    Erscheinungsland Switzerland
    Dokumenttyp Published Erratum
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.1104646
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  8. Artikel ; Online: Editorial: Immunogenicity and toxicity of AAV gene therapy.

    Bradbury, Allison / Markusic, David / Muhuri, Manish / Ou, Li

    Frontiers in immunology

    2023  Band 14, Seite(n) 1227231

    Mesh-Begriff(e) Genetic Therapy/adverse effects ; Gene Transfer Techniques
    Sprache Englisch
    Erscheinungsdatum 2023-06-22
    Erscheinungsland Switzerland
    Dokumenttyp Editorial
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1227231
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  9. Artikel ; Online: Three pediatric massage schools in treating recurrent respiratory tract Infection

    Ou-Li Fu / Qing Ji

    Journal of Hainan Medical University, Vol 26, Iss 2, Pp 62-

    2020  Band 66

    Abstract: This paper describes the similarities and differences between three-character scripture school from Shandong, Shanghai pediatric massage and Hunan Liu Kaiyun pediatric massage in the treatment of Recurrent respiratory tract in order to standardize ... ...

    Abstract This paper describes the similarities and differences between three-character scripture school from Shandong, Shanghai pediatric massage and Hunan Liu Kaiyun pediatric massage in the treatment of Recurrent respiratory tract in order to standardize operation, collect references and provide the basis for local infantile massage school.
    Schlagwörter pediatric massage ; recurrent respiratory tract infection ; various genresdifferences ; Medicine ; R
    Sprache Englisch
    Erscheinungsdatum 2020-01-01T00:00:00Z
    Verlag Editorial Board of Journal of Hainan Medical University
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

    Zusatzmaterialien

    Kategorien

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  10. Artikel: Evaluation of recombinant baculovirus clearance during rAAV production in Sf9 cells using a newly developed fluorescent-TCID

    Luo, Ningguang / Chen, Xiangqun / Li, Jinzhong / Huynh, Derrick / Li, Ying / Ou, Li / Liu, Shengjiang

    Frontiers in medicine

    2024  Band 11, Seite(n) 1302648

    Abstract: Introduction: Recombinant adeno-associated virus (rAAV) vectors provide a safe and efficient means for : Methods: The present study utilized a newly developed fluorescent-TCID: Results and discussion: The results showed that a combination of ... ...

    Abstract Introduction: Recombinant adeno-associated virus (rAAV) vectors provide a safe and efficient means for
    Methods: The present study utilized a newly developed fluorescent-TCID
    Results and discussion: The results showed that a combination of sodium lauryl sulfate (SLS) and Triton X-100 lysis, AAVx affinity chromatography, low pH hold (pH3.0), CsCl ultracentrifugation, and NFR filtration led to effective removal and/or inactivation of recombinant baculoviruses, and achieved a log reduction value (LRV) of more than 18.9 for the entire AAV purification process. In summary, this study establishes a standard protocol for downstream baculovirus removal and inactivation and a reliable F-TCID
    Sprache Englisch
    Erscheinungsdatum 2024-01-22
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2024.1302648
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

Zum Seitenanfang