Article ; Online: Ajwa dates (Phoenix dactylifera L.) attenuate cisplatin-induced nephrotoxicity in rats via augmenting Nrf2, modulating NADPH oxidase-4 and mitigating inflammatory/apoptotic mediators.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
2022 Volume 156, Page(s) 113836
Abstract: In the therapy of cisplatin (CP), nephrotoxicity is a main limiting issue that associated with oxidative stress and apoptosis. According to many studies, the antioxidant and anti-inflammatory properties of Ajwa dates are very strong, due to the unique ... ...
| Abstract | In the therapy of cisplatin (CP), nephrotoxicity is a main limiting issue that associated with oxidative stress and apoptosis. According to many studies, the antioxidant and anti-inflammatory properties of Ajwa dates are very strong, due to the unique phytochemical profile. Here, we investigated the possible mitigative effects of Ajwa dates fruits extract (ADFE) vs CP-induced nephrotoxicity in rats, in addition to phytochemical profiling of its components via LC-MS/MS. Six groups were formed from forty-two male rats. G1: control, G2: ADFE 0.25 g/kg, G3: ADFE 0.5 g/kg (for 21 days), G4: CP -intoxicated group (single i.p. dose of 7.0 mg/kg b.w) on day 16th, G5: ADFE 0.25 + CP, G6: ADFE 0.5 + CP. LC-MS/MS analysis revealed the tentative identification of 17 compounds of different chemical nature, including organic/phenolic acids, and flavonoids and their sulphated/glycosides derivatives. ADFE has considerable antioxidant potential (DPPH with IC |
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| MeSH term(s) | Animals ; Male ; Rats ; Antioxidants/therapeutic use ; Chromatography, Liquid ; Cisplatin/toxicity ; GA-Binding Protein Transcription Factor ; Hydrogen Peroxide/pharmacology ; Inflammation Mediators/pharmacology ; NF-E2-Related Factor 2 ; Oxidative Stress ; Phenols/pharmacology ; Phoeniceae/chemistry ; Plant Extracts/therapeutic use ; RNA, Messenger ; Tandem Mass Spectrometry |
| Chemical Substances | Antioxidants ; Cisplatin (Q20Q21Q62J) ; GA-Binding Protein Transcription Factor ; Hydrogen Peroxide (BBX060AN9V) ; Inflammation Mediators ; NF-E2-Related Factor 2 ; Phenols ; Plant Extracts ; RNA, Messenger ; Nox4 protein, rat (EC 1.6.3.-) |
| Language | English |
| Publishing date | 2022-10-12 |
| Publishing country | France |
| Document type | Journal Article |
| ZDB-ID | 392415-4 |
| ISSN | 1950-6007 ; 0753-3322 ; 0300-0893 |
| ISSN (online) | 1950-6007 |
| ISSN | 0753-3322 ; 0300-0893 |
| DOI | 10.1016/j.biopha.2022.113836 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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