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Article ; Online: Millennium Development Goals in Europe.

Oudesluys-Murphy, Anne Marie

2015 Volume 100 Suppl 1, Page(s) S72–3

MeSH term(s)	Child ; Child Welfare/statistics & numerical data ; Europe ; Health Services Accessibility/statistics & numerical data ; Health Services Needs and Demand/statistics & numerical data ; Healthcare Disparities/statistics & numerical data ; Humans ; Poverty
Language	English
Publishing date	2015-02
Publishing country	England
Document type	Journal Article
ZDB-ID	524-1
ISSN	1468-2044 ; 0003-9888 ; 1359-2998
ISSN (online)	1468-2044
ISSN	0003-9888 ; 1359-2998
DOI	10.1136/archdischild-2013-305871
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Article ; Online: Valganciclovir in Infants with Hearing Loss and Clinically Inapparent Congenital Cytomegalovirus Infection: A Nonrandomized Controlled Trial.

Chung, Pui Khi / Schornagel, Fleurtje A J / Soede, Wim / van Zwet, Erik W / Kroes, Aloys C M / Oudesluys-Murphy, Anne Marie / Vossen, Ann C T M

The Journal of pediatrics

2024 Volume 268, Page(s) 113945

Abstract: Objective: To assess the efficacy of valganciclovir in infants with hearing loss and clinically inapparent congenital cytomegalovirus infection (cCMV), as there is no consensus on treatment of this group.: Study design: A nationwide, nonrandomized ... ...

Abstract	Objective: To assess the efficacy of valganciclovir in infants with hearing loss and clinically inapparent congenital cytomegalovirus infection (cCMV), as there is no consensus on treatment of this group. Study design: A nationwide, nonrandomized controlled trial, comparing 6 weeks of oral valganciclovir to no treatment in infants with cCMV, recruited after newborn hearing screening resulted in referral to an audiologist. The choice whether to treat was left to parents of subjects. Eligible subjects were full term infants aged <13 weeks with sensorineural hearing loss and diagnosed with cCMV through dried blood spot testing. The primary outcome, measured by linear and ordinal logistic regression, was change in best-ear hearing from baseline to follow-up at 18-22 months of age. Results: Thirty-seven participants were included in the final analysis, of whom 25 were in the treatment group and 12 in the control group. The majority of subjects in both groups had neuroimaging abnormalities, which were mostly mild. Hearing deterioration was more likely in the control group compared with the treatment group (common OR 0.10, 95% CI 0.02-0.45, P = .003). Mean best-ear hearing deteriorated by 13.7 dB in the control group, compared with improvement of 3.3 dB in the treatment group (difference 17 dB, 95% CI 2.6 - 31.4, P = .02). Conclusions: We investigated treatment in children with hearing loss and clinically inapparent cCMV. Although our study was nonrandomized, it is the first prospective and controlled trial in this population. Valganciclovir-treated children with hearing loss and inapparent cCMV had less hearing deterioration at 18 through 22 months of age than control subjects. Eudract registry number: 2013-003068-30.
MeSH term(s)	Humans ; Valganciclovir/therapeutic use ; Cytomegalovirus Infections/drug therapy ; Cytomegalovirus Infections/congenital ; Cytomegalovirus Infections/complications ; Antiviral Agents/therapeutic use ; Male ; Female ; Infant ; Infant, Newborn ; Hearing Loss, Sensorineural/drug therapy ; Treatment Outcome ; Ganciclovir/analogs & derivatives ; Ganciclovir/therapeutic use ; Neonatal Screening ; Prospective Studies ; Follow-Up Studies ; Administration, Oral
Chemical Substances	Valganciclovir (GCU97FKN3R) ; Antiviral Agents ; Ganciclovir (P9G3CKZ4P5)
Language	English
Publishing date	2024-02-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Controlled Clinical Trial
ZDB-ID	3102-1
ISSN	1097-6833 ; 0022-3476
ISSN (online)	1097-6833
ISSN	0022-3476
DOI	10.1016/j.jpeds.2024.113945
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Article ; Online: Targeted screening for congenital cytomegalovirus infection: clinical, audiological and neuroimaging findings.

Chung, Pui Khi / Schornagel, Fleurtje / Oudesluys-Murphy, Anne Marie / de Vries, Linda S / Soede, Wim / van Zwet, Erik / Vossen, Ann

Archives of disease in childhood. Fetal and neonatal edition

2022 Volume 108, Issue 3, Page(s) 302–308

Abstract: Objective: To evaluate clinical, audiological and neuroimaging findings in a cohort of infants diagnosed with congenital cytomegalovirus (cCMV) infection after failure at newborn hearing screening.: Methods: A prospective observational study in the ... ...

Abstract	Objective: To evaluate clinical, audiological and neuroimaging findings in a cohort of infants diagnosed with congenital cytomegalovirus (cCMV) infection after failure at newborn hearing screening. Methods: A prospective observational study in the Netherlands, using the existing newborn hearing screening infrastructure for well babies. Between July 2012 and November 2016, cytomegalovirus (CMV) PCR testing of neonatally obtained dried blood spots (DBS) was offered to all infants who failed newborn hearing screening. Clinical, neuroimaging and audiological data were collected. Results: DBS of 1374 infants were successfully tested and 59 were positive for CMV (4.3%). Data of 54 infants were retrieved. Three were small for gestational age and six had microcephaly. Forty-eight (89%) had sensorineural hearing loss (SNHL), of whom half had unilateral SNHL. In both unilaterally and bilaterally affected children, the majority of the impaired ears had severe or profound hearing loss. Neuroimaging abnormalities were found in 40 of 48 (83%) children who had evaluable cranial ultrasound and/or cerebral MRI. The abnormalities were mild in 34, moderate in 3 and severe in 3 infants. The degree of SNHL and the severity of neuroimaging abnormalities were found to be correlated (p=0.002). Conclusions: The yield of targeted cCMV screening following newborn hearing screening failure was eight times higher than the estimated national birth prevalence of cCMV. The majority of this cohort of infants with clinically unsuspected cCMV disease had confirmed SNHL, neuroimaging abnormalities and lower than average birth weights and head circumferences. Newborns who fail newborn hearing screening should be tested for CMV to ensure appropriate clinical, neurodevelopmental and audiological follow-up.
MeSH term(s)	Infant ; Child ; Infant, Newborn ; Humans ; Hearing Tests/methods ; Neonatal Screening/methods ; Cytomegalovirus Infections/diagnosis ; Cytomegalovirus Infections/epidemiology ; Hearing Loss, Sensorineural/diagnosis ; Hearing Loss, Sensorineural/epidemiology ; Hearing Loss, Sensorineural/congenital ; Cytomegalovirus ; Neuroimaging
Language	English
Publishing date	2022-12-22
Publishing country	England
Document type	Observational Study ; Journal Article
ZDB-ID	2007331-8
ISSN	1468-2052 ; 1359-2998
ISSN (online)	1468-2052
ISSN	1359-2998
DOI	10.1136/archdischild-2022-324699
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Article ; Online: Tumours: Less lactation may explain cancer rise.

Oudesluys-Murphy, Anne Marie

Nature

2012 Volume 486, Issue 7404, Page(s) 473

MeSH term(s)	Animals ; Biomarkers, Tumor/analysis ; Breast/anatomy & histology ; Breast/pathology ; Breast Neoplasms/diagnosis ; Breast Neoplasms/drug therapy ; Breast Neoplasms/epidemiology ; Breast Neoplasms/etiology ; Breast Neoplasms/genetics ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Breast Neoplasms/prevention & control ; Breast Neoplasms/therapy ; Breast Neoplasms, Male ; Clinical Trials as Topic/methods ; Disease Susceptibility ; Exercise/physiology ; Female ; Gene-Environment Interaction ; Humans ; Male ; Mammography/statistics & numerical data ; Neoplasm Metastasis/drug therapy ; Neoplasm Metastasis/pathology ; Neoplasm Metastasis/prevention & control ; Pregnancy ; Pregnancy Complications, Neoplastic/therapy ; Research Design
Chemical Substances	Biomarkers, Tumor
Language	English
Publishing date	2012-06-27
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/486473c
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Article ; Online: Specialized outpatient clinic for deaf and hard-of-hearing patients in the Netherlands: Lessons learned in an attempt to improve health care.

Smeijers, Anika / van den Bogaerde, Beppie / Ens-Dokkum, Martina / Oudesluys-Murphy, Anne Marie

Journal of evaluation in clinical practice

2020 Volume 26, Issue 6, Page(s) 1588–1591

Abstract: Rationale, aims, and objective: A group of organizations and individuals in the Netherlands collaborated to attempt to improve access to health care and health education for deaf and hard of hearing (DHH) patients in the country. The outcome was the ... ...

Abstract	Rationale, aims, and objective: A group of organizations and individuals in the Netherlands collaborated to attempt to improve access to health care and health education for deaf and hard of hearing (DHH) patients in the country. The outcome was the start of a specialized outpatient clinic named PoliDOSH. An independent research group was set up to evaluate the effect of this specialized clinic. Even though the initiative did not succeed and was closed after 2 years, an extensive analysis of the start-up and functioning of the whole process was made. Methods: Structured and nonstructured questionnaires and structured interviews. Results: Only a small group of DHH patients indicated that they felt a need for consultations at the PoliDOSH. It became clear that to ensure successful functioning of a specialized facility the team members should include a representative group of DHH members. All key functions should be filled by top experts in the relevant fields as well as an expert in communication and needs of the target group. Conclusions: There is a great need for facilities to collect and disseminate information to and about DHH patients. The information should be aimed at providing psycho-education for the DHH persons themselves and health care professionals, concerning the specific needs and problems of this patient group. If a similar facility is set up in the future, thorough market research prior to start up is needed to enable the facility to connect with the needs of patients. The start-up period should allow sufficient time for the project to become known and for patients to become familiar with it and trust it.
MeSH term(s)	Ambulatory Care Facilities ; Delivery of Health Care ; Hearing ; Humans ; Netherlands ; Persons With Hearing Impairments
Language	English
Publishing date	2020-02-26
Publishing country	England
Document type	Journal Article
ZDB-ID	1327355-3
ISSN	1365-2753 ; 1356-1294
ISSN (online)	1365-2753
ISSN	1356-1294
DOI	10.1111/jep.13369
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Article ; Online: Early detection of hearing impairment reflected in better reading ability in teenage years.

Oudesluys-Murphy, Anne Marie / Korver, Anna Maria Helena

Evidence-based medicine

2016 Volume 21, Issue 4, Page(s) 155

MeSH term(s)	Adolescent ; Hearing Loss/diagnosis ; Humans ; Reading
Language	English
Publishing date	2016
Publishing country	England
Document type	Journal Article ; Comment
ZDB-ID	1324346-9
ISSN	1473-6810 ; 1356-5524
ISSN (online)	1473-6810
ISSN	1356-5524
DOI	10.1136/ebmed-2016-110466
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Article ; Online: Children with specific language impairment are more likely to reach motor milestones late.

Diepeveen, F Babette / van Dommelen, Paula / Oudesluys-Murphy, Anne Marie / Verkerk, Paul H

Child: care, health and development

2018 Volume 44, Issue 6, Page(s) 857–862

Abstract: Background: Delayed language development without an obvious cause is considered an isolated developmental disorder and is called specific language impairment (SLI). SLI is probably the most prevalent developmental disorder in childhood with a generally ... ...

Abstract	Background: Delayed language development without an obvious cause is considered an isolated developmental disorder and is called specific language impairment (SLI). SLI is probably the most prevalent developmental disorder in childhood with a generally cited prevalence of 7%. This study aimed to investigate whether SLI is always an isolated disorder or if children with SLI also have delayed motor development. Methods: We used data of an earlier study with a prospective nested case-control design in which developmental data were collected from child health care files. Cases were children (4-11 years) with diagnosed SLI. They were matched by sex and date of birth with control children attending mainstream education. Data of both groups on seven gross and six fine motor milestones which had been registered in the Dutch Developmental Instrument between the ages of 15-36 months were retrieved from child health care files. McNemar tests were performed to test for differences in reaching motor milestones at the age norm between the case and control group. Results: Data from 253 children in each group were available. A significant difference was found between both groups in the proportion failing to reach three of the seven investigated gross motor milestones at the age norm (p < 0.05). The proportion of children not reaching the motor milestone at the age norm was significantly higher for five of the six fine motor milestones in children with SLI compared with control children (p < 0.05). Conclusions: More children with SLI are late in reaching motor milestones than children without SLI. This means that it is debatable whether SLI can be regarded as a "specific" impairment, which is not associated with other developmental problems. A broader developmental assessment is therefore indicated when diagnosing SLI.
MeSH term(s)	Case-Control Studies ; Child ; Child, Preschool ; Developmental Disabilities/epidemiology ; Female ; Humans ; Language Development ; Language Development Disorders/epidemiology ; Language Development Disorders/physiopathology ; Language Development Disorders/psychology ; Male ; Motor Skills Disorders/epidemiology ; Motor Skills Disorders/physiopathology ; Motor Skills Disorders/psychology ; Prevalence ; Prospective Studies
Language	English
Publishing date	2018-08-29
Publishing country	England
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	223039-2
ISSN	1365-2214 ; 0305-1862
ISSN (online)	1365-2214
ISSN	0305-1862
DOI	10.1111/cch.12614
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Article ; Online: Concise tool based on language milestones identifies children with specific language impairment at 24-45 months of age.

Diepeveen, F Babette / van Dommelen, Paula / Oudesluys-Murphy, Anne Marie / Verkerk, Paul H

Acta paediatrica (Oslo, Norway : 1992)

2018 Volume 107, Issue 12, Page(s) 2125–2130

Abstract: Aim: This study aimed to develop a concise tool with acceptable predictive properties to identify young children with specific language impairment (SLI).: Methods: In this nested case-control study children with SLI attending two special needs ... ...

Abstract	Aim: This study aimed to develop a concise tool with acceptable predictive properties to identify young children with specific language impairment (SLI). Methods: In this nested case-control study children with SLI attending two special needs schools for severe speech and language difficulties in the Netherlands were matched by date of birth and sex with control children attending mainstream education. This study analysed the predictive validity for having SLI at a mean age of eight years and three months (range 4-11 years) using combinations of six language milestones that were registered at 24, 36 and 45 months and retrieved from the children's healthcare files in 2012. Results: We included 253 pairs of children with and without SLI. During a single visit, combinations of two milestones at one age achieved a specificity of at least 97% and sensitivities ranged from 32% to 64%. However, the concise tool, which combined five milestones at three different ages - 24, 36 and 45 months - had a specificity of 96% (95% confidence interval 94-99%) and a sensitivity of 71% (95% confidence interval 66-77%). Conclusion: Combining milestones at different ages provided a concise tool that could help to detect children with SLI at a young age.
MeSH term(s)	Case-Control Studies ; Child ; Child, Preschool ; Female ; Humans ; Language Development ; Language Development Disorders/diagnosis ; Male ; Predictive Value of Tests
Language	English
Publishing date	2018-10-17
Publishing country	Norway
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	203487-6
ISSN	1651-2227 ; 0365-1436 ; 0803-5253
ISSN (online)	1651-2227
ISSN	0365-1436 ; 0803-5253
DOI	10.1111/apa.14596
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Article ; Online: Failure to meet language milestones at two years of age is predictive of specific language impairment.

Diepeveen, F Babette / Dusseldorp, Elise / Bol, Gerard W / Oudesluys-Murphy, Anne Marie / Verkerk, Paul H

Acta paediatrica (Oslo, Norway : 1992)

2016 Volume 105, Issue 3, Page(s) 304–310

Abstract: Aim: This study established predictive properties of single language milestones for specific language impairment (SLI) after the age of four, as these had not previously been reported in the literature.: Methods: In this nested case-control study, ... ...

Abstract	Aim: This study established predictive properties of single language milestones for specific language impairment (SLI) after the age of four, as these had not previously been reported in the literature. Methods: In this nested case-control study, children attending special needs schools for severe speech and language difficulties were matched with children attending mainstream schools. Data covering the ages of zero to four years were retrieved from well-child care clinics and the outcomes of 23 language milestones in the Dutch Developmental Instrument were analysed. The predictive properties were expressed as positive likelihood ratios, sensitivity and specificity. Results: We included 253 pairs of children with and without SLI, aged from four to 11 years. The mean age was eight years and three months, and 77% were boys. From the age of 18 months, cases and controls differed significantly on all milestones (p < 0.01). After 24 months, the language milestones had positive likelihood ratios that ranging from 6 to 108. In general, language milestones had a high specificity (range 77-100%), but the sensitivity was relatively low (range 0-68%). Conclusion: Failure to meet language milestones from the age of 24 months was predictive of SLI, but the use of separate milestones had limited value due to low sensitivity.
MeSH term(s)	Case-Control Studies ; Child, Preschool ; Female ; Humans ; Language Development ; Language Development Disorders/diagnosis ; Male ; Prospective Studies
Language	English
Publishing date	2016-03
Publishing country	Norway
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	203487-6
ISSN	1651-2227 ; 0365-1436 ; 0803-5253
ISSN (online)	1651-2227
ISSN	0365-1436 ; 0803-5253
DOI	10.1111/apa.13271
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Article ; Online: Accuracy of a Screening Tool for Early Identification of Language Impairment.

Uilenburg, Noëlle / Wiefferink, Karin / Verkerk, Paul / van Denderen, Margot / van Schie, Carla / Oudesluys-Murphy, Anne-Marie

Journal of speech, language, and hearing research : JSLHR

2018 Volume 61, Issue 1, Page(s) 104–113

Abstract: Purpose: A screening tool called the VTO Language Screening Instrument (VTO-LSI) was developed to enable more uniform and earlier detection of language impairment. This report, consisting of 2 retrospective studies, focuses on the effects of using the ... ...

Abstract	Purpose: A screening tool called the VTO Language Screening Instrument (VTO-LSI) was developed to enable more uniform and earlier detection of language impairment. This report, consisting of 2 retrospective studies, focuses on the effects of using the VTO-LSI compared to regular detection procedures. Method: Study 1 retrospectively compared VTO-LSI with regular detection procedures. Outcome measure was the detection rate of language impairment among 24-month-old children. Data were retrieved from medical records of children attending a youth health care center. Study 2 retrospectively compared the effects of VTO-LSI and regular detection procedures on the age at referral for diagnostic investigations and the influence of sex. Data were retrieved from medical records from the speech and hearing center and analyzed with multivariate analysis of variance. Results: With the VTO-LSI, significantly more cases with language impairment were identified compared with the regular detection procedure (2.4% vs. 0.4%). In regions where the VTO-LSI was used, girls were almost 2 years younger, and boys were 1 year younger when referred to diagnostic investigations than in regions with regular detection procedures. Conclusion: The VTO-LSI was more effective than regular detection procedures.
MeSH term(s)	Age Factors ; Child ; Child Language ; Child, Preschool ; Female ; Humans ; Infant ; Language Development Disorders/diagnosis ; Language Tests ; Male ; Referral and Consultation ; Retrospective Studies ; Sex Factors ; Socioeconomic Factors
Language	English
Publishing date	2018-01-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	1364086-0
ISSN	1558-9102 ; 1092-4388
ISSN (online)	1558-9102
ISSN	1092-4388
DOI	10.1044/2017_JSLHR-L-16-0173
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