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Article ; Online: Phytochemical analysis and immunomodulatory activities in vitro and in vivo of Aframomum melegueta K Schum seed extracts.

Latif, Mounia / Elkoraichi, Ismail / El Faqer, Othman / Wahnou, Hicham / Mtairag, El Mostafa / Oudghiri, Mounia / Rais, Samira

Inflammopharmacology

2024 Volume 32, Issue 2, Page(s) 1621–1631

Abstract: Aframomum melegueta K Schum (A. melegueta), an herbaceous plant renowned for its medicinal seeds, was investigated for its potential immunomodulatory effects in vitro and in vivo using ethanolic and methanolic extracts. The immunomodulatory effect was ... ...

Abstract	Aframomum melegueta K Schum (A. melegueta), an herbaceous plant renowned for its medicinal seeds, was investigated for its potential immunomodulatory effects in vitro and in vivo using ethanolic and methanolic extracts. The immunomodulatory effect was evaluated by measuring antibody titers using the agglutination technique, while anti-inflammatory activity was assessed in a carrageenan-induced mouse paw edema model. In vitro immunomodulatory activity was measured by lysozyme release from neutrophils. Additionally, white blood cell counts were analyzed post-extracts treatment. The MTT assay was employed to determine cytotoxicity, and the biochemical parameters of liver toxicity were evaluated. Remarkably, both extracts exhibited a dose-dependent reduction in paw edema (p < 0.001), with the most significant reduction observed at 1 g/kg (78.13 and 74.27% for ethanolic and methanolic extracts, respectively). Neutrophil degranulation was significantly inhibited in a dose-dependent manner (p < 0.003), reaching maximal inhibition at 100 μg/mg (60.78 and 39.7% for ethanolic and methanolic extracts, respectively). In comparison to the control group, both antibody production and white blood cell counts were reduced. Neither of the extracts showcased any cytotoxicity or toxicity. These findings suggest that A. melegueta extracts exhibit immunosuppressive and anti-inflammatory activities due to the presence of various biomolecules.
MeSH term(s)	Mice ; Animals ; Plant Extracts/chemistry ; Seeds/chemistry ; Anti-Inflammatory Agents/pharmacology ; Methanol ; Ethanol ; Zingiberaceae/chemistry ; Edema
Chemical Substances	Plant Extracts ; Anti-Inflammatory Agents ; Methanol (Y4S76JWI15) ; Ethanol (3K9958V90M)
Language	English
Publishing date	2024-02-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1080058-x
ISSN	1568-5608 ; 0925-4692
ISSN (online)	1568-5608
ISSN	0925-4692
DOI	10.1007/s10787-023-01422-7
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Artemisia herba-alba: antioxidant capacity and efficacy in preventing chronic arthritis in vivo.

Wahnou, Hicham / Ndayambaje, Martin / Ouadghiri, Zaynab / Benayad, Salma / Elattar, Hicham / Chgari, Oumaima / Naya, Abdallah / Zaid, Younes / Oudghiri, Mounia

Inflammopharmacology

2024

Abstract: Arthritis is a debilitating condition impacting the quality of life for millions worldwide, characterized by pain and inflammation. Understanding the mechanisms of arthritis and developing effective treatments are crucial. This study investigated the ... ...

Abstract	Arthritis is a debilitating condition impacting the quality of life for millions worldwide, characterized by pain and inflammation. Understanding the mechanisms of arthritis and developing effective treatments are crucial. This study investigated the hydroethanolic extract of Artemisia herba-alba for its protective potential against arthritis hallmarks, oxidative stress, and lipid peroxidation in vitro. It also assessed its in vivo anti-arthritic activity. The phytochemical analysis identified various compounds within the extract, with high concentrations of polyphenols and flavonoids. These compounds are associated with numerous health benefits, making A. herba-alba a potential source of valuable phytochemicals. A. herba-alba demonstrated a notable effect in body weight loss, paw edema, and arthritic severity. Histopathological examination revealed structural improvements in bone and muscle tissues, emphasizing its therapeutic potential in managing chronic arthritis. Furthermore, while these findings are promising, further studies are necessary to delve deeper into the mechanisms underlying the observed hematological changes and to gain a more comprehensive understanding of the in vivo results. This research sets the stage for continued exploration, ultimately aiming to unlock the full potential of A. herba-alba in addressing chronic arthritis and enhancing the lives of those affected by this condition.
Language	English
Publishing date	2024-04-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1080058-x
ISSN	1568-5608 ; 0925-4692
ISSN (online)	1568-5608
ISSN	0925-4692
DOI	10.1007/s10787-024-01463-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Ursolic Acid's Alluring Journey: One Triterpenoid vs. Cancer Hallmarks.

Limami, Youness / Pinon, Aline / Wahnou, Hicham / Oudghiri, Mounia / Liagre, Bertrand / Simon, Alain / Duval, Raphaël Emmanuel

Molecules (Basel, Switzerland)

2023 Volume 28, Issue 23

Abstract: Cancer is a multifactorial disease characterized by various hallmarks, including uncontrolled cell growth, evasion of apoptosis, sustained angiogenesis, tissue invasion, and metastasis, among others. Traditional cancer therapies often target specific ... ...

Abstract	Cancer is a multifactorial disease characterized by various hallmarks, including uncontrolled cell growth, evasion of apoptosis, sustained angiogenesis, tissue invasion, and metastasis, among others. Traditional cancer therapies often target specific hallmarks, leading to limited efficacy and the development of resistance. Thus, there is a growing need for alternative strategies that can address multiple hallmarks concomitantly. Ursolic acid (UA), a naturally occurring pentacyclic triterpenoid, has recently emerged as a promising candidate for multitargeted cancer therapy. This review aims to summarize the current knowledge on the anticancer properties of UA, focusing on its ability to modulate various cancer hallmarks. The literature reveals that UA exhibits potent anticancer effects through diverse mechanisms, including the inhibition of cell proliferation, induction of apoptosis, suppression of angiogenesis, inhibition of metastasis, and modulation of the tumor microenvironment. Additionally, UA has demonstrated promising activity against different cancer types (e.g., breast, lung, prostate, colon, and liver) by targeting various cancer hallmarks. This review discusses the molecular targets and signaling pathways involved in the anticancer effects of UA. Notably, UA has been found to modulate key signaling pathways, such as PI3K/Akt, MAPK/ERK, NF-κB, and Wnt/β-catenin, which play crucial roles in cancer development and progression. Moreover, the ability of UA to destroy cancer cells through various mechanisms (e.g., apoptosis, autophagy, inhibiting cell growth, dysregulating cancer cell metabolism, etc.) contributes to its multitargeted effects on cancer hallmarks. Despite promising anticancer effects, this review acknowledges hurdles related to UA's low bioavailability, emphasizing the need for enhanced therapeutic strategies.
MeSH term(s)	Male ; Humans ; Phosphatidylinositol 3-Kinases ; Triterpenes/pharmacology ; Triterpenes/therapeutic use ; Signal Transduction ; Neoplasms/drug therapy ; Apoptosis ; Cell Proliferation ; Cell Line, Tumor ; Tumor Microenvironment
Chemical Substances	Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Triterpenes
Language	English
Publishing date	2023-12-01
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28237897
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Article: Polyphenol-Based Nanoparticles: A Promising Frontier for Enhanced Colorectal Cancer Treatment.

Wahnou, Hicham / Liagre, Bertrand / Sol, Vincent / El Attar, Hicham / Attar, Rukset / Oudghiri, Mounia / Duval, Raphaël Emmanuel / Limami, Youness

Cancers

2023 Volume 15, Issue 15

Abstract: Colorectal cancer (CRC) poses a significant challenge in healthcare, necessitating the exploration of novel therapeutic strategies. Natural compounds such as polyphenols with inherent anticancer properties have gained attention as potential therapeutic ... ...

Abstract	Colorectal cancer (CRC) poses a significant challenge in healthcare, necessitating the exploration of novel therapeutic strategies. Natural compounds such as polyphenols with inherent anticancer properties have gained attention as potential therapeutic agents. This review highlights the need for novel therapeutic approaches in CRC, followed by a discussion on the synthesis of polyphenols-based nanoparticles. Various synthesis techniques, including dynamic covalent bonding, non-covalent bonding, polymerization, chemical conjugation, reduction, and metal-polyphenol networks, are explored. The mechanisms of action of these nanoparticles, encompassing passive and active targeting mechanisms, are also discussed. The review further examines the intrinsic anticancer activity of polyphenols and their enhancement through nano-based delivery systems. This section explores the natural anticancer properties of polyphenols and investigates different nano-based delivery systems, such as micelles, nanogels, liposomes, nanoemulsions, gold nanoparticles, mesoporous silica nanoparticles, and metal-organic frameworks. The review concludes by emphasizing the potential of nanoparticle-based strategies utilizing polyphenols for CRC treatment and highlights the need for future research to optimize their efficacy and safety. Overall, this review provides valuable insights into the synthesis, mechanisms of action, intrinsic anticancer activity, and enhancement of polyphenols-based nanoparticles for CRC treatment.
Language	English
Publishing date	2023-07-27
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15153826
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Article: The Promise of Piperine in Cancer Chemoprevention.

Benayad, Salma / Wahnou, Hicham / El Kebbaj, Riad / Liagre, Bertrand / Sol, Vincent / Oudghiri, Mounia / Saad, El Madani / Duval, Raphaël Emmanuel / Limami, Youness

Cancers

2023 Volume 15, Issue 22

Abstract: Cancer, characterized by the unregulated growth and dissemination of malignantly transformed cells, presents a significant global health challenge. The multistage process of cancer development involves intricate biochemical and genetic alterations within ...

Abstract	Cancer, characterized by the unregulated growth and dissemination of malignantly transformed cells, presents a significant global health challenge. The multistage process of cancer development involves intricate biochemical and genetic alterations within target cells. Cancer chemoprevention has emerged as a vital strategy to address this complex issue to mitigate cancer's impact on healthcare systems. This approach leverages pharmacologically active agents to block, suppress, prevent, or reverse invasive cancer development. Among these agents, piperine, an active alkaloid with a wide range of therapeutic properties, including antioxidant, anti-inflammatory, and immunomodulatory effects, has garnered attention for its potential in cancer prevention and treatment. This comprehensive review explores piperine's multifaceted role in inhibiting the molecular events and signaling pathways associated with various stages of cancer development, shedding light on its promising prospects as a versatile tool in cancer chemoprevention. Furthermore, the review will also delve into how piperine enhances the effectiveness of conventional treatments such as UV-phototherapy and TRAIL-based therapy, potentially synergizing with existing therapeutic modalities to provide more robust cancer management strategies. Finally, a crucial perspective of the long-term safety and potential side effects of piperine-based therapies and the need for clinical trials is also discussed.
Language	English
Publishing date	2023-11-20
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15225488
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Article: Shining a Light on Prostate Cancer: Photodynamic Therapy and Combination Approaches.

Wahnou, Hicham / Youlyouz-Marfak, Ibtissam / Liagre, Bertrand / Sol, Vincent / Oudghiri, Mounia / Duval, Raphaël Emmanuel / Limami, Youness

Pharmaceutics

2023 Volume 15, Issue 6

Abstract: Prostate cancer is a major health concern worldwide, and current treatments, such as surgery, radiation therapy, and chemotherapy, are associated with significant side effects and limitations. Photodynamic therapy (PDT) is a promising alternative that ... ...

Abstract	Prostate cancer is a major health concern worldwide, and current treatments, such as surgery, radiation therapy, and chemotherapy, are associated with significant side effects and limitations. Photodynamic therapy (PDT) is a promising alternative that has the potential to provide a minimally invasive and highly targeted approach to treating prostate cancer. PDT involves the use of photosensitizers (PSs) that are activated by light to produce reactive oxygen species (ROS), which can induce tumor cell death. There are two main types of PSs: synthetic and natural. Synthetic PSs are classified into four generations based on their structural and photophysical properties, while natural PSs are derived from plant and bacterial sources. Combining PDT with other therapies, such as photothermal therapy (PTT), photoimmunotherapy (PIT), and chemotherapy (CT), is also being explored as a way to improve its efficacy. This review provides an overview of conventional treatments for prostate cancer, the underlying principles of PDT, and the different types of PSs used in PDT as well as ongoing clinical studies. It also discusses the various forms of combination therapy being explored in the context of PDT for prostate cancer, as well as the challenges and opportunities associated with this approach. Overall, PDT has the potential to provide a more effective and less invasive treatment option for prostate cancer, and ongoing research is aimed at improving its selectivity and efficacy in clinical settings.
Language	English
Publishing date	2023-06-19
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527217-2
ISSN	1999-4923
ISSN	1999-4923
DOI	10.3390/pharmaceutics15061767
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Antitumoral activity of

Samiry, Inass / Pinon, Aline / Limami, Youness / Rais, Samira / Zaid, Younes / Oudghiri, Mounia / Liagre, Bertrand / Mtairag, El Mostafa

Journal of toxicology and environmental health. Part A

2023 Volume 86, Issue 7, Page(s) 230–240

Abstract: Caralluma ... ...

Abstract	Caralluma europaea
MeSH term(s)	Humans ; Male ; Apocynaceae ; Prostatic Neoplasms/drug therapy ; Apoptosis ; HCT116 Cells ; Methanol ; Colorectal Neoplasms/drug therapy
Chemical Substances	Methanol (Y4S76JWI15)
Language	English
Publishing date	2023-02-22
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1413345-3
ISSN	1528-7394 ; 0098-4108 ; 1087-2620
ISSN	1528-7394 ; 0098-4108 ; 1087-2620
DOI	10.1080/15287394.2023.2181898
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Zs.A 1268: Show issues

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Article: Exploring the multifaceted effects of

Ndayambaje, Martin / Wahnou, Hicham / Sow, Marieme / Chgari, Oumaima / Habyarimana, Thierry / Karkouri, Mehdi / Limami, Youness / Naya, Abdallah / Oudghiri, Mounia

Journal of toxicology and environmental health. Part A

2023 Volume 87, Issue 4, Page(s) 150–165

Abstract: ... Ammi ... ...

Abstract	Ammi visnaga
MeSH term(s)	Rats ; Female ; Mice ; Animals ; Plant Extracts/chemistry ; Ammi/chemistry ; Khellin/chemistry ; Khellin/pharmacology ; Antioxidants/pharmacology ; Hydrogen Peroxide ; Molecular Docking Simulation ; Rats, Wistar ; Flavonoids/pharmacology ; Anti-Inflammatory Agents/pharmacology
Chemical Substances	Plant Extracts ; Khellin (5G117T0TJZ) ; Antioxidants ; Hydrogen Peroxide (BBX060AN9V) ; Flavonoids ; Anti-Inflammatory Agents
Language	English
Publishing date	2023-12-26
Publishing country	England
Document type	Journal Article
ZDB-ID	1413345-3
ISSN	1528-7394 ; 0098-4108 ; 1087-2620
ISSN	1528-7394 ; 0098-4108 ; 1087-2620
DOI	10.1080/15287394.2023.2289430
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Article: In vivo anti-inflammatory and antiarthritic activities of aqueous extracts from Thymelaea hirsuta.

Azza, Zora / Oudghiri, Mounia

Pharmacognosy research

2015 Volume 7, Issue 2, Page(s) 213–216

Abstract: Background: The aerial parts of Thymelaea hirsuta (TH) are used as a decoction in the treatment of different pathologies in folk medicine in Morocco.: Objective: The aqueous extracts were evaluated for its anti-inflammatory activity and in inhibition ...

Abstract	Background: The aerial parts of Thymelaea hirsuta (TH) are used as a decoction in the treatment of different pathologies in folk medicine in Morocco. Objective: The aqueous extracts were evaluated for its anti-inflammatory activity and in inhibition of adjuvant induction arthritis in male Wistar rats. Materials and methods: The anti-inflammatory activity was carried out using carrageenan-induced rat paw edema model, and the antiarthritic activity was carried out using complete Freund's adjuvant-induced arthritis model. Results: The plant extract (500 mg/kg body weight) exhibited significant activity in acute inflammation produced 60% of inhibition after 4 h as compared with that of the standard anti-inflammatory drug, the diclofenac (100 mg/kg) which showed 40% of inhibition. In arthritis model, the extract produced 85% inhibition after 18 days when compared with the diclofenac (10 mg/kg; 72%). Conclusion: These results indicate that the aqueous extract of TH had an anti-inflammatory activity and inhibited the induction of adjuvant arthritis in male Wistar rats.
Language	English
Publishing date	2015-03-06
Publishing country	India
Document type	Journal Article
ZDB-ID	2580264-1
ISSN	0974-8490 ; 0976-4836
ISSN (online)	0974-8490
ISSN	0976-4836
DOI	10.4103/0974-8490.150510
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Article ; Online: Aspirin use Reduces Platelet Hyperreactivity and Degranulation in COVID-19 Patients.

Zaid, Younes / Lahlimi, Qamar / Khalki, Loubna / Zaid, Nabil / Oudghiri, Mounia / Cheikh, Amine / Naya, Abdallah / Merhi, Yahye / Guessous, Fadila

Seminars in thrombosis and hemostasis

2022

Language	English
Publishing date	2022-03-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	196901-8
ISSN	1098-9064 ; 0094-6176
ISSN (online)	1098-9064
ISSN	0094-6176
DOI	10.1055/s-0042-1744281
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