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Article ; Online: The Application of the Big Data Medical Imaging System in Improving the Medical and Health Examination.

Zhou, Xiaojuan / Ouyang, Wenjun

2021 Volume 2021, Page(s) 8251702

Abstract: To explore the application effect of the big data medical imaging tertiary diagnostic system in improving the medical and health examination, cases in township health centers were collected by the medical imaging tertiary diagnosis system. Clinical cases ...

Abstract	To explore the application effect of the big data medical imaging tertiary diagnostic system in improving the medical and health examination, cases in township health centers were collected by the medical imaging tertiary diagnosis system. Clinical cases examined by the tertiary diagnostic system of big data medical imaging will be set as the observation group. Clinical cases not involved in the tertiary diagnostic system of big data medical imaging were set as the control group. The qualified rate, film positive rate, and film diagnosis accuracy between the two groups are compared, and X-ray perspective, X-ray examination, and CT multiple medical imaging examinations are used in two groups. The experimental results showed that the pass rate was 86.57%, positive rate was 72.32%, and diagnosis rate was 80.17%. Pass rate, positive rate, and diagnostic accuracy were higher than the control group (
MeSH term(s)	Big Data ; Humans ; Radiography ; Tomography, X-Ray Computed
Language	English
Publishing date	2021-09-16
Publishing country	England
Document type	Journal Article
ZDB-ID	2545054-2
ISSN	2040-2309 ; 2040-2295
ISSN (online)	2040-2309
ISSN	2040-2295
DOI	10.1155/2021/8251702
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Article ; Online: Application of PET Imaging in the Brain Regions of the Emotional Control Loop in Patients with Generalized Anxiety Disorder.

Li, Jing / Ouyang, Wenjun

Journal of healthcare engineering

2021 Volume 2021, Page(s) 4505227

Abstract: Objective: This study uses PET imaging to observe the uptake and metabolism of 18F-fluorodeoxyglucose (: Methods: The thesis clinically collected 20 GAD patients and 20 healthy subjects. Dynamic PET-CT scans were used. At the same time, : Results: ...

Abstract	Objective: This study uses PET imaging to observe the uptake and metabolism of 18F-fluorodeoxyglucose ( Methods: The thesis clinically collected 20 GAD patients and 20 healthy subjects. Dynamic PET-CT scans were used. At the same time, Results: Compared with the healthy control group, the peak uptake of the bilateral prefrontal cortex and the average uptake rate before the peak in GAD patients were significantly reduced ( Conclusion: There are
MeSH term(s)	Anxiety Disorders/diagnostic imaging ; Brain/diagnostic imaging ; Fluorodeoxyglucose F18 ; Humans ; Positron Emission Tomography Computed Tomography ; Positron-Emission Tomography
Chemical Substances	Fluorodeoxyglucose F18 (0Z5B2CJX4D)
Language	English
Publishing date	2021-07-22
Publishing country	England
Document type	Journal Article
ZDB-ID	2545054-2
ISSN	2040-2309 ; 2040-2295
ISSN (online)	2040-2309
ISSN	2040-2295
DOI	10.1155/2021/4505227
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Article ; Online: IL-10 Family Cytokines IL-10 and IL-22: from Basic Science to Clinical Translation.

Ouyang, Wenjun / O'Garra, Anne

Immunity

2019 Volume 50, Issue 4, Page(s) 871–891

Abstract: Cytokines are among the most important effector and messenger molecules in the immune system. They profoundly participate in immune responses during infection and inflammation, protecting against or contributing to diseases such as allergy, autoimmunity, ...

Abstract	Cytokines are among the most important effector and messenger molecules in the immune system. They profoundly participate in immune responses during infection and inflammation, protecting against or contributing to diseases such as allergy, autoimmunity, and cancer. Manipulating cytokine pathways, therefore, is one of the most effective strategies to treat various diseases. IL-10 family cytokines exert essential functions to maintain tissue homeostasis during infection and inflammation through restriction of excessive inflammatory responses, upregulation of innate immunity, and promotion of tissue repairing mechanisms. Their important functions in diseases are supported by data from many preclinical models, human genetic studies, and clinical interventions. Despite significant efforts, however, there is still no clinically approved therapy through manipulating IL-10 family cytokines. Here, we summarize the recent progress in understanding the biology of this family of cytokines, suggesting more specific strategies to maneuver these cytokines for the effective treatment of inflammatory diseases and cancers.
MeSH term(s)	Animals ; Autoimmune Diseases/immunology ; Autoimmune Diseases/therapy ; Cytokines/classification ; Cytokines/genetics ; Gene Expression Regulation ; Humans ; Immunity, Innate ; Infections/immunology ; Infections/therapy ; Inflammation/immunology ; Inflammation/therapy ; Interleukin-10/genetics ; Interleukin-10/immunology ; Interleukins/genetics ; Interleukins/immunology ; Lymphocyte Subsets/immunology ; Mice ; Multigene Family ; Myeloid Cells/immunology ; Neoplasms/immunology ; Neoplasms/therapy ; Signal Transduction ; Transcription Factors/physiology ; Interleukin-22
Chemical Substances	Cytokines ; IL10 protein, human ; Interleukins ; Transcription Factors ; Interleukin-10 (130068-27-8)
Language	English
Publishing date	2019-04-17
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1217235-2
ISSN	1097-4180 ; 1074-7613
ISSN (online)	1097-4180
ISSN	1074-7613
DOI	10.1016/j.immuni.2019.03.020
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Article ; Online: TRIMming TGF-β signals in Th17 cells.

Rapaport, Aaron S / Ouyang, Wenjun

The Journal of experimental medicine

2018 Volume 215, Issue 7, Page(s) 1775–1776

Abstract: The precise downstream mediators of TGF-β signaling in Th17 and T reg cells remain unclear. In this issue ... ...

Abstract	The precise downstream mediators of TGF-β signaling in Th17 and T reg cells remain unclear. In this issue of
MeSH term(s)	Interleukin-17 ; T-Lymphocytes, Regulatory ; Th17 Cells ; Transforming Growth Factor beta
Chemical Substances	Interleukin-17 ; Transforming Growth Factor beta
Language	English
Publishing date	2018-06-26
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	218343-2
ISSN	1540-9538 ; 0022-1007
ISSN (online)	1540-9538
ISSN	0022-1007
DOI	10.1084/jem.20180986
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Ua VI Zs.107: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MG 45: Show issues

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Article ; Online: Human Anti-tumor Immunity: Insights from Immunotherapy Clinical Trials.

Egen, Jackson G / Ouyang, Wenjun / Wu, Lawren C

Immunity

2020 Volume 52, Issue 1, Page(s) 36–54

Abstract: Therapeutics that target the T cell inhibitory checkpoint proteins CTLA-4 and PD(L)1 are efficacious across a broad range of cancers, resulting in reductions in tumor burden and increased long-term survival in subsets of patients. The significant and ... ...

Abstract	Therapeutics that target the T cell inhibitory checkpoint proteins CTLA-4 and PD(L)1 are efficacious across a broad range of cancers, resulting in reductions in tumor burden and increased long-term survival in subsets of patients. The significant and wide-ranging effects of these immunotherapies have prompted the clinical investigation of additional therapies that modulate anti-tumor immunity through effects on T cells, myeloid cells, and other cell types within the tumor microenvironment. The clinical activity of these newer investigational therapies has been mixed, with some therapeutics showing promise but others not exhibiting appreciable efficacy. In this review, we summarize the results of select recent clinical studies of cancer immunotherapies beyond anti-CTLA-4 and anti-PD(L)1 and discuss how these results are providing new insights into the regulation of human anti-tumor immunity.
MeSH term(s)	Antibodies, Monoclonal/therapeutic use ; B7-H1 Antigen/antagonists & inhibitors ; CTLA-4 Antigen/antagonists & inhibitors ; Humans ; Immunotherapy/methods ; Lymphocyte Activation/immunology ; Neoplasms/immunology ; Neoplasms/therapy ; Programmed Cell Death 1 Receptor/antagonists & inhibitors ; T-Lymphocytes/immunology ; Tumor Microenvironment/immunology
Chemical Substances	Antibodies, Monoclonal ; B7-H1 Antigen ; CD274 protein, human ; CTLA-4 Antigen ; CTLA4 protein, human ; PDCD1 protein, human ; Programmed Cell Death 1 Receptor
Language	English
Publishing date	2020-01-24
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1217235-2
ISSN	1097-4180 ; 1074-7613
ISSN (online)	1097-4180
ISSN	1074-7613
DOI	10.1016/j.immuni.2019.12.010
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Zs.A 4227: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 69: Show issues

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Article ; Online: Distinct roles of IL-22 in human psoriasis and inflammatory bowel disease.

Ouyang, Wenjun

Cytokine & growth factor reviews

2010 Volume 21, Issue 6, Page(s) 435–441

Abstract: IL-22, an IL-10 family cytokine, is produced by different leukocyte subsets, including T cells, NK cells and lymphoid tissue inducer (LTi) cells. IL-22 mediates the crosstalk between leukocytes and tissue epithelia because its receptor is preferentially ... ...

Abstract	IL-22, an IL-10 family cytokine, is produced by different leukocyte subsets, including T cells, NK cells and lymphoid tissue inducer (LTi) cells. IL-22 mediates the crosstalk between leukocytes and tissue epithelia because its receptor is preferentially expressed on various tissue epithelial cells. IL-22 is essential for host defense against infections of extracellular pathogens, such as bacteria and yeasts, by eliciting various innate defensive mechanisms from tissue epithelial cells and promoting wound-healing responses. In autoimmune diseases, however, diverse tissue microenvironments and underlying pathogenic mechanisms may result in opposing contributions of IL-22 in disease progression. For example, in psoriasis, IL-22 can synergize with other proinflammatory cytokines to induce many of the pathogenic phenotypes from keratinocytes and exacerbate disease progression. In contrast, IL-22 plays a beneficial role in IBD by enhancing barrier integrity and epithelial innate immunity of intestinal tract.
MeSH term(s)	Animals ; Humans ; Immunity, Innate ; Inflammatory Bowel Diseases/immunology ; Interleukins/physiology ; Mice ; Psoriasis/immunology ; Interleukin-22
Chemical Substances	Interleukins
Language	English
Publishing date	2010-11-23
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1330534-7
ISSN	1879-0305 ; 1359-6101
ISSN (online)	1879-0305
ISSN	1359-6101
DOI	10.1016/j.cytogfr.2010.10.007
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Zs.A 2653: Show issues

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Article ; Online: Dual Mechanisms for Balancing Th17 and Treg Cell Fate by CREB.

Symons, Antony / Ouyang, Wenjun

EBioMedicine

2017 Volume 25, Page(s) 20–21

Abstract: Th17 cells, which express the cytokine IL-17A, and master regulator RORγt, are important in the inflammatory response to fungal and bacterial pathogens, but also have a pathogenic role in many inflammatory disorders. In contrast, regulatory T cells (Treg) ...

Abstract	Th17 cells, which express the cytokine IL-17A, and master regulator RORγt, are important in the inflammatory response to fungal and bacterial pathogens, but also have a pathogenic role in many inflammatory disorders. In contrast, regulatory T cells (Treg), expressing the Foxp3 transcription factor, have a suppressive function and can dampen an immune response. The appropriate balance of these distinct effector functions is critical for an effective immune response and autoimmunity can arise if this process goes awry. In this issue, Wang et al. demonstrate a critical role for the transcription factor CREB (cyclic AMP-responsive element binding protein) in regulating the balance between inflammatory Th17 and suppressive Treg cells with implications for autoimmunity.
MeSH term(s)	Autoimmunity ; Forkhead Transcription Factors ; Nuclear Receptor Subfamily 1, Group F, Member 3 ; T-Lymphocytes, Regulatory ; Th17 Cells
Chemical Substances	Forkhead Transcription Factors ; Nuclear Receptor Subfamily 1, Group F, Member 3
Language	English
Publishing date	2017-11-10
Publishing country	Netherlands
Document type	Journal Article ; Comment
ZDB-ID	2851331-9
ISSN	2352-3964
ISSN (online)	2352-3964
DOI	10.1016/j.ebiom.2017.10.031
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Zs.A 7090: Show issues

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Article ; Online: The dynamics of charge transfer with and without a barrier: A very simplified model of cyclic voltammetry.

Ouyang, Wenjun / Subotnik, Joseph E

The Journal of chemical physics

2017 Volume 146, Issue 17, Page(s) 174103

Abstract: Using the Anderson-Holstein model, we investigate charge transfer dynamics between a molecule and a metal surface for two extreme cases. (i) With a large barrier, we show that the dynamics follow a single exponential decay as expected; (ii) without any ... ...

Abstract	Using the Anderson-Holstein model, we investigate charge transfer dynamics between a molecule and a metal surface for two extreme cases. (i) With a large barrier, we show that the dynamics follow a single exponential decay as expected; (ii) without any barrier, we show that the dynamics are more complicated. On the one hand, if the metal-molecule coupling is small, single exponential dynamics persist. On the other hand, when the coupling between the metal and the molecule is large, the dynamics follow a biexponential decay. We analyze the dynamics using the Smoluchowski equation, develop a simple model, and explore the consequences of biexponential dynamics for a hypothetical cyclic voltammetry experiment.
Language	English
Publishing date	2017-05-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	3113-6
ISSN	1089-7690 ; 0021-9606
ISSN (online)	1089-7690
ISSN	0021-9606
DOI	10.1063/1.4979620
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Article ; Online: Targeting IL-10 Family Cytokines for the Treatment of Human Diseases.

Wang, Xiaoting / Wong, Kit / Ouyang, Wenjun / Rutz, Sascha

Cold Spring Harbor perspectives in biology

2019 Volume 11, Issue 2

Abstract: Members of the interleukin (IL)-10 family of cytokines play important roles in regulating immune responses during host defense but also in autoimmune disorders, inflammatory diseases, and cancer. Although IL-10 itself primarily acts on leukocytes and has ...

Abstract	Members of the interleukin (IL)-10 family of cytokines play important roles in regulating immune responses during host defense but also in autoimmune disorders, inflammatory diseases, and cancer. Although IL-10 itself primarily acts on leukocytes and has potent immunosuppressive functions, other family members preferentially target nonimmune compartments, such as tissue epithelial cells, where they elicit innate defense mechanisms to control viral, bacterial, and fungal infections, protect tissue integrity, and promote tissue repair and regeneration. As cytokines are prime drug targets, IL-10 family cytokines provide great opportunities for the treatment of autoimmune diseases, tissue damage, and cancer. Yet no therapy in this space has been approved to date. Here, we summarize the diverse biology of the IL-10 family as it relates to human disease and review past and current strategies and challenges to target IL-10 family cytokines for clinical use.
MeSH term(s)	Autoimmune Diseases/drug therapy ; Autoimmune Diseases/immunology ; Cytokines/genetics ; Cytokines/metabolism ; Cytokines/therapeutic use ; Gene Expression Regulation/drug effects ; Humans ; Inflammation/drug therapy ; Inflammation/immunology ; Interleukin-10/chemistry ; Interleukin-10/physiology ; Interleukin-10/therapeutic use ; Neoplasms/drug therapy ; Neoplasms/immunology
Chemical Substances	Cytokines ; Interleukin-10 (130068-27-8)
Language	English
Publishing date	2019-02-01
Publishing country	United States
Document type	Journal Article ; Review
ISSN	1943-0264
ISSN (online)	1943-0264
DOI	10.1101/cshperspect.a028548
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Article ; Online: A comparison of surface hopping approaches for capturing metal-molecule electron transfer: A broadened classical master equation versus independent electron surface hopping.

Miao, Gaohan / Ouyang, Wenjun / Subotnik, Joseph

The Journal of chemical physics

2019 Volume 150, Issue 4, Page(s) 41711

Abstract: Within a generalized Anderson-Holstein model, we investigate electron transfer rates using two different surface hopping algorithms: a broadened classical master equation (BCME) and independent electron surface hopping (IESH). We find that for large ... ...

Abstract	Within a generalized Anderson-Holstein model, we investigate electron transfer rates using two different surface hopping algorithms: a broadened classical master equation (BCME) and independent electron surface hopping (IESH). We find that for large enough bandwidth and density of one electron states, and in the presence of external friction, the IESH results converge to the BCME results for impurity-bath model systems, recovering both relaxation rates and equilibrium populations. Without external friction, however, the BCME and IESH results can strongly disagree, and preliminary evidence suggests that IESH does not always recover the correct equilibrium state. Finally, we also demonstrate that adding an electronic thermostat to IESH does help drive the metallic substrate to the correct equilibrium state, but this improvement can sometimes come at the cost of worse short time dynamics. Overall, our results should be of use for all computational chemists looking to model either gas phase scattering or electrochemical dynamics at a metal interface.
Language	English
Publishing date	2019-01-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	3113-6
ISSN	1089-7690 ; 0021-9606
ISSN (online)	1089-7690
ISSN	0021-9606
DOI	10.1063/1.5050235
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