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  1. Article ; Online: Trichoscopy - a valuable tool for identifying conditions mimicking androgenetic alopecia.

    Khutsishvili, Nino / Rudnicka, Lidia / Ovcharenko, Yuliya / Starace, Michela / Buchukuri, Irma / Pataraia, Salome / Lortkipanidze, Nino

    International journal of dermatology

    2023  Volume 63, Issue 1, Page(s) 23–31

    Abstract: Androgenetic alopecia (AGA) is the most prevalent type of hair loss in women and men. Recently, a European consensus group published guidelines for the diagnostic evaluation of AGA in men, women, and adolescents. This S1 guideline presents expert opinion- ...

    Abstract Androgenetic alopecia (AGA) is the most prevalent type of hair loss in women and men. Recently, a European consensus group published guidelines for the diagnostic evaluation of AGA in men, women, and adolescents. This S1 guideline presents expert opinion-based recommendations for gender-dependent steps in the diagnostic procedure, which can easily be implemented in the daily clinical routine. For diagnosing AGA, detailed anamnesis and objective learning are not enough because there are several conditions mimicking this disease. Trichoscopy can be considered an important, non-invasive tool for diagnosing hair and scalp disorders that may have similar clinical signs to AGA.
    MeSH term(s) Male ; Adolescent ; Humans ; Female ; Alopecia/diagnosis ; Hair/diagnostic imaging ; Dermoscopy ; Learning
    Language English
    Publishing date 2023-11-11
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 412254-9
    ISSN 1365-4632 ; 0011-9059 ; 1461-1244
    ISSN (online) 1365-4632
    ISSN 0011-9059 ; 1461-1244
    DOI 10.1111/ijd.16895
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Novel Frameshift Mutation in TRPS1 in a Ukrainian Patient with Trichorhinophalangeal Syndrome Type I.

    Ovcharenko, Yuliya / Ramot, Yuval

    International journal of trichology

    2014  Volume 5, Issue 3, Page(s) 159–160

    Abstract: Trichorhinophalangeal syndrome (TRPS) type I is a rare autosomal dominant disorder, caused by mutations in the TRPS1 gene. It is characterized by slowly growing hair, craniofacial manifestations and orthopedic abnormalities. We present a 17-year-old ... ...

    Abstract Trichorhinophalangeal syndrome (TRPS) type I is a rare autosomal dominant disorder, caused by mutations in the TRPS1 gene. It is characterized by slowly growing hair, craniofacial manifestations and orthopedic abnormalities. We present a 17-year-old female of Ukrainian origin who presented to the hair clinic with the complaint of hair loss. Further examination revealed the presence of craniofacial features characteristic for TRPS type I. Sequence analysis of the TRPS1 gene revealed a novel c. 2396_2397 insG frameshift mutation in exon 5, leading to a premature stop at codon 800. This case underlines the importance of the hair phenotype to the diagnosis of this syndrome and emphasizes the fact that when encountered with a severe alopecia in young age, the possibility of a congenital hair disease should always be borne in mind.
    Language English
    Publishing date 2014-01-19
    Publishing country India
    Document type Case Reports
    ZDB-ID 2570982-3
    ISSN 0974-9241 ; 0974-7753
    ISSN (online) 0974-9241
    ISSN 0974-7753
    DOI 10.4103/0974-7753.125620
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Renbök phenomenon in an alopecia areata patient with psoriasis.

    Ovcharenko, Yuliya / Serbina, Inessa / Zlotogorski, Abraham / Ramot, Yuval

    International journal of trichology

    2014  Volume 5, Issue 4, Page(s) 194–195

    Abstract: The Renbök phenomenon designates the withdrawal of a lesion when a different one appears. We describe a 23-year-old patient with psoriasis, who experienced regression of a psoriatic plaque on the scalp concurrently with the appearance of a patch of ... ...

    Abstract The Renbök phenomenon designates the withdrawal of a lesion when a different one appears. We describe a 23-year-old patient with psoriasis, who experienced regression of a psoriatic plaque on the scalp concurrently with the appearance of a patch of alopecia areata (AA). In 3 months, plaques of psoriasis appeared inside the patch of hair loss, accompanied by terminal hair growth in the plaques. Such rapid interchange between these two autoimmune disorders have not been described previously, and might reflect a quick substitution between two different T-cell populations, namely Th-17 and Th-1. Better understanding of the trigger for such an exchange can help in elucidating the pathogenesis for AA.
    Language English
    Publishing date 2014-03-20
    Publishing country India
    Document type Case Reports
    ZDB-ID 2570982-3
    ISSN 0974-9241 ; 0974-7753
    ISSN (online) 0974-9241
    ISSN 0974-7753
    DOI 10.4103/0974-7753.130397
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The Alopecia Areata Severity and Morbidity Index (ASAMI) Study: Results From a Global Expert Consensus Exercise on Determinants of Alopecia Areata Severity.

    Moussa, Anthony / Bennett, Michaela / Wall, Dmitri / Meah, Nekma / York, Katherine / Bokhari, Laita / Asfour, Leila / Rees, Huw / Abraham, Leonardo Spagnol / Asz-Sigall, Daniel / Basmanav, Fitnat Buket / Bergfeld, Wilma / Betz, Regina C / Bhoyrul, Bevin / Blume-Peytavi, Ulrike / Callender, Valerie / Chitreddy, Vijaya / Combalia, Andrea / Cotsarelis, George /
    Craiglow, Brittany / Dhurat, Rachita / Donovan, Jeff / Doroshkevich, Andrei / Eisman, Samantha / Farrant, Paul / Ferrando, Juan / Gadzhigoroeva, Aida / Green, Jack / Grimalt, Ramon / Harries, Matthew / Hordinsky, Maria / Irvine, Alan / Jolliffe, Victoria / Kaiumov, Spartak / King, Brett / Lee, Joyce / Lee, Won-Soo / Li, Jane / Lortkipanidze, Nino / McMichael, Amy / Mesinkovska, Natasha Atanaskova / Messenger, Andrew / Mirmirani, Paradi / Olsen, Elise / Orlow, Seth J / Ovcharenko, Yuliya / Piraccini, Bianca Maria / Pirmez, Rodrigo / Rakowska, Adriana / Reygagne, Pascal / Rudnicka, Lidia / Corralo, David Saceda / Senna, Maryanne / Shapiro, Jerry / Sharma, Pooja / Siliuk, Tatiana / Starace, Michela / Suchonwanit, Poonkiat / Takwale, Anita / Tosti, Antonella / Vañó-Galván, Sergio / Visser, Willem I / Vogt, Annika / Wade, Martin / Yip, Leona / Zhou, Cheng / Sinclair, Rodney

    JAMA dermatology

    2024  Volume 160, Issue 3, Page(s) 341–350

    Abstract: Importance: Current measures of alopecia areata (AA) severity, such as the Severity of Alopecia Tool score, do not adequately capture overall disease impact.: Objective: To explore factors associated with AA severity beyond scalp hair loss, and to ... ...

    Abstract Importance: Current measures of alopecia areata (AA) severity, such as the Severity of Alopecia Tool score, do not adequately capture overall disease impact.
    Objective: To explore factors associated with AA severity beyond scalp hair loss, and to support the development of the Alopecia Areata Severity and Morbidity Index (ASAMI).
    Evidence review: A total of 74 hair and scalp disorder specialists from multiple continents were invited to participate in an eDelphi project consisting of 3 survey rounds. The first 2 sessions took place via a text-based web application following the Delphi study design. The final round took place virtually among participants via video conferencing software on April 30, 2022.
    Findings: Of all invited experts, 64 completed the first survey round (global representation: Africa [4.7%], Asia [9.4%], Australia [14.1%], Europe [43.8%], North America [23.4%], and South America [4.7%]; health care setting: public [20.3%], private [28.1%], and both [51.6%]). A total of 58 specialists completed the second round, and 42 participated in the final video conference meeting. Overall, consensus was achieved in 96 of 107 questions. Several factors, independent of the Severity of Alopecia Tool score, were identified as potentially worsening AA severity outcomes. These factors included a disease duration of 12 months or more, 3 or more relapses, inadequate response to topical or systemic treatments, rapid disease progression, difficulty in cosmetically concealing hair loss, facial hair involvement (eyebrows, eyelashes, and/or beard), nail involvement, impaired quality of life, and a history of anxiety, depression, or suicidal ideation due to or exacerbated by AA. Consensus was reached that the Alopecia Areata Investigator Global Assessment scale adequately classified the severity of scalp hair loss.
    Conclusions and relevance: This eDelphi survey study, with consensus among global experts, identified various determinants of AA severity, encompassing not only scalp hair loss but also other outcomes. These findings are expected to facilitate the development of a multicomponent severity tool that endeavors to competently measure disease impact. The findings are also anticipated to aid in identifying candidates for current and emerging systemic treatments. Future research must incorporate the perspectives of patients and the public to assign weight to the domains recognized in this project as associated with AA severity.
    MeSH term(s) Humans ; Alopecia/diagnosis ; Alopecia Areata/diagnosis ; Consensus ; Morbidity ; Quality of Life
    Language English
    Publishing date 2024-02-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2701761-8
    ISSN 2168-6084 ; 2168-6068
    ISSN (online) 2168-6084
    ISSN 2168-6068
    DOI 10.1001/jamadermatol.2023.5869
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Trichodynia and telogen effluvium in COVID-19 patients: Results of an international expert opinion survey on diagnosis and management.

    Starace, Michela / Iorizzo, Matilde / Sechi, Andrea / Alessandrini, Aurora Maria / Carpanese, Miriam / Bruni, Francesca / Vara, Giulio / Apalla, Zoe / Asz-Sigall, Daniel / Barruscotti, Stefania / Camacho, Francisco / Doche, Isabella / Estrada, Bruna Duque / Dhurat, Rachita / Gavazzoni, Maria Fernanda / Grimalt, Ramon / Harries, Matthew / Ioannidis, Dimitrios / McMichael, Amy /
    Melo, Daniel Fernandes / Oliveira, Rui / Ovcharenko, Yuliya / Pirmez, Rodrigo / Ramot, Yuval / Rudnicka, Lidia / Shapiro, Jerry / Silyuk, Tatiana / Sinclair, Rodney / Tosti, Antonella / Vano-Galvan, Sergio / Piraccini, Bianca Maria

    JAAD international

    2021  Volume 5, Page(s) 11–18

    Abstract: Background: The cutaneous manifestations of COVID-19 may be useful disease markers and prognostic indicators. Recently, postinfectious telogen effluvium and trichodynia have also been reported.: Objective: To evaluate the presence of trichodynia and ... ...

    Abstract Background: The cutaneous manifestations of COVID-19 may be useful disease markers and prognostic indicators. Recently, postinfectious telogen effluvium and trichodynia have also been reported.
    Objective: To evaluate the presence of trichodynia and telogen effluvium in patients with COVID-19 and describe their characteristics in relation to the other signs and symptoms of the disease.
    Methods: Patients with a history of COVID-19 presenting to the clinics of a group of hair experts because of telogen effluvium and/or scalp symptoms were questioned about their hair signs and symptoms in relation to the severity of COVID-19 and associated symptoms.
    Results: Data from 128 patients were collected. Telogen effluvium was observed in 66.3% of the patients and trichodynia in 58.4%. Trichodynia was associated with telogen effluvium in 42.4% of the cases and anosmia and ageusia in 66.1% and 44.1% of the cases, respectively. In majority (62.5%) of the patients, the hair signs and symptoms started within the first month after COVID-19 diagnosis, and in 47.8% of the patients, these started after 12 weeks or more.
    Limitations: The recruitment of patients in specialized hair clinics, lack of a control group, and lack of recording of patient comorbidities.
    Conclusion: The severity of postviral telogen effluvium observed in patients with a history of COVID-19 infection may be influenced by COVID-19 severity. We identified early-onset (<4 weeks) and late-onset (>12 weeks) telogen effluvium.
    Language English
    Publishing date 2021-08-03
    Publishing country United States
    Document type Journal Article
    ISSN 2666-3287
    ISSN (online) 2666-3287
    DOI 10.1016/j.jdin.2021.07.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: A Global eDelphi Exercise to Identify Core Domains and Domain Items for the Development of a Global Registry of Alopecia Areata Disease Severity and Treatment Safety (GRASS).

    Wall, Dmitri / Meah, Nekma / York, Katherine / Bhoyrul, Bevin / Bokhari, Laita / Abraham, Leonardo Spagnol / Adams, Roisín / Bergfeld, Wilma / Betz, Regina C / Blume-Peytavi, Ulrike / Callender, Valerie / Campbell, Chel / Chambers, Jen / Chen, Gang / Chitreddy, Vijaya / Cotsarelis, George / Craiglow, Brittany / Dhurat, Rachita / Dlova, Ncoza /
    Donovan, Jeff / Duque-Estrada, Bruna / Eisman, Samantha / Ellison, Abby / Farrant, Paul / Barberá, Juan Ferrando / Gadzhigoroeva, Aida / Grimalt, Ramon / Harries, Matthew / Hordinsky, Maria / Irvine, Alan D / Jolliffe, Victoria / Jones, Leslie / King, Brett / Lee, Won-Soo / Lortkipanidze, Nino / McMichael, Amy / Messenger, Andrew / Mirmirani, Paradi / Olsen, Elise / Orlow, Seth J / Ovcharenko, Yuliya / Piraccini, Bianca Maria / Pirmez, Rodrigo / Rakowska, Adriana / Reygagne, Pascal / Riley, Melissa / Rudnicka, Lidia / Saceda Corralo, David / Shapiro, Jerry / Sharma, Pooja / Silyuk, Tatiana / Kaiumov, Spartak / Tobin, Desmond J / Tosti, Antonella / Vañó-Galván, Sergio / Vogt, Annika / Wade, Martin / Yip, Leona / Zlotogorski, Abraham / Zhou, Cheng / Sinclair, Rodney

    JAMA dermatology

    2021  Volume 157, Issue 4, Page(s) 1–11

    Abstract: Importance: A recent expert consensus exercise emphasized the importance of developing a global network of patient registries for alopecia areata to redress the paucity of comparable, real-world data regarding the effectiveness and safety of existing ... ...

    Abstract Importance: A recent expert consensus exercise emphasized the importance of developing a global network of patient registries for alopecia areata to redress the paucity of comparable, real-world data regarding the effectiveness and safety of existing and emerging therapies for alopecia areata.
    Objective: To generate core domains and domain items for a global network of alopecia areata patient registries.
    Evidence review: Sixty-six participants, representing physicians, patient organizations, scientists, the pharmaceutical industry, and pharmacoeconomic experts, participated in a 3-round eDelphi process, culminating in a face-to-face meeting at the World Congress of Dermatology, Milan, Italy, June 14, 2019.
    Findings: Ninety-two core data items, across 25 domains, achieved consensus agreement. Twenty further noncore items were retained to facilitate data harmonization in centers that wish to record them. Broad representation across multiple stakeholder groups was sought; however, the opinion of physicians was overrepresented.
    Conclusions and relevance: This study identifies the domains and domain items required to develop a global network of alopecia areata registries. These domains will facilitate a standardized approach that will enable the recording of a comprehensive, comparable data set required to oversee the introduction of new therapies and harness real-world evidence from existing therapies at a time when the alopecia areata treatment paradigm is being radically and positively disrupted. Reuse of similar, existing frameworks in atopic dermatitis, produced by the Treatment of Atopic Eczema (TREAT) Registry Taskforce, increases the potential to reuse existing resources, creates opportunities for comparison of data across dermatology subspecialty disease areas, and supports the concept of data harmonization.
    MeSH term(s) Alopecia Areata/diagnosis ; Alopecia Areata/epidemiology ; Alopecia Areata/therapy ; Consensus ; Delphi Technique ; Humans ; Internationality ; Registries ; Severity of Illness Index ; Surveys and Questionnaires
    Language English
    Publishing date 2021-03-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2701761-8
    ISSN 2168-6084 ; 2168-6068
    ISSN (online) 2168-6084
    ISSN 2168-6068
    DOI 10.1001/jamadermatol.2020.5839
    Database MEDical Literature Analysis and Retrieval System OnLINE

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