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  1. AU="Ovchinnikova, Tatiana V"
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  1. Book ; Online: Marine Bioactive Peptides II: Structure, Function, and Therapeutic Potential

    Ovchinnikova, Tatiana V.

    2021  

    Keywords Medicine ; Spanish mackerel (Scomberomorous niphonius) ; muscle ; peptide ; antioxidant activity ; stability ; biological activity ; chemistry ; marine derived fungi ; peptides ; biotransformation ; laxaphycin ; autophagy ; apoptosis ; cyanobacteria ; bioactive peptides ; marine ; secondary structure ; proline ; mechanism of activity ; marine waste ; antimicrobial peptide ; polychaeta ; innate immunity ; BRICHOS domain ; recombinant peptide ; β-hairpin structure ; nuclear magnetic resonance (NMR) ; arenicin ; complement system ; complement regulation ; jellyfish ; Rhopilema esculentum ; Sanderia malayensis ; proteome ; venom ; toxin ; hydrolysate ; fish protein ; ageing ; physical function ; dietary assessment ; seafood intake ; healthy ageing ; marine organism ; anticancer medicine ; small peptide ; liner peptide ; cyclic peptide ; marine peptide ; dolastatin 10 ; antitumor ; lead exploration ; n/a
    Size 1 electronic resource (228 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel, Switzerland
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021289795
    ISBN 9783036525259 ; 3036525254
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: Marine Bioactive Peptides: Structure, Function, and Therapeutic Potential

    Ovchinnikova, Tatiana V.

    2019  

    Abstract: This Special Issue Book, "Marine Bioactive Peptides: Structure, Function, andTherapeutic Potential includes up-to-date information regarding bioactivepeptides isolated from marine organisms. Marine peptides have been found invarious phyla, and their ... ...

    Abstract This Special Issue Book, "Marine Bioactive Peptides: Structure, Function, andTherapeutic Potential includes up-to-date information regarding bioactivepeptides isolated from marine organisms. Marine peptides have been found invarious phyla, and their numbers have grown in recent years. These peptidesare diverse in structure and possess broad-spectrum activities that have greatpotential for medical applications. Various marine peptides are evolutionaryancient molecular factors of innate immunity that play a key role in host defense.A plethora of biological activities, including antibacterial, antifungal, antiviral,anticancer, anticoagulant, endotoxin-binding, immune-modulating, et cetera, makemarine peptides an attractive molecular basis for drug design. This Special IssueBook presents new results in the isolation, structural elucidation, functionalcharacterization, and therapeutic potential evaluation of peptides found inmarine organisms. Chemical synthesis and biotechnological production of marinepeptides and their mimetics is also a focus of this Special Issue Book
    Keywords Science (General) ; Biology (General)
    Size 1 electronic resource (442 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Document type Book ; Online
    Note eng ; Open Access
    HBZ-ID HT020324050
    ISBN 9783039215324 ; 9783039215331 ; 3039215329 ; 3039215337
    DOI 10.3390/books978-3-03921-533-1
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Marine Peptides: Structure, Bioactivities, and a New Hope for Therapeutic Application.

    Ovchinnikova, Tatiana V

    Marine drugs

    2021  Volume 19, Issue 8

    Abstract: Over the last years, plethora of bioactive peptides have been isolated from organisms which live in sea water [ ... ]. ...

    Abstract Over the last years, plethora of bioactive peptides have been isolated from organisms which live in sea water [...].
    MeSH term(s) Aquatic Organisms ; Peptides
    Chemical Substances Peptides
    Language English
    Publishing date 2021-07-23
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2175190-0
    ISSN 1660-3397 ; 1660-3397
    ISSN (online) 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md19080407
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Editorial: Aquatic genomics and transcriptomics for evolutionary biology.

    Ovchinnikova, Tatiana V / Shi, Qiong

    Frontiers in genetics

    2023  Volume 14, Page(s) 1183637

    Language English
    Publishing date 2023-05-05
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2606823-0
    ISSN 1664-8021
    ISSN 1664-8021
    DOI 10.3389/fgene.2023.1183637
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Marine Peptides: Structure, Bioactivities, and a New Hope for Therapeutic Application

    Ovchinnikova, Tatiana V.

    Marine drugs. 2021 July 23, v. 19, no. 8

    2021  

    Abstract: Over the last years, plethora of bioactive peptides have been isolated from organisms which live in sea water [ ... ] ...

    Abstract Over the last years, plethora of bioactive peptides have been isolated from organisms which live in sea water [...]
    Keywords bioactive properties ; peptides ; seawater ; therapeutics
    Language English
    Dates of publication 2021-0723
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2175190-0
    ISSN 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md19080407
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: Immunomodulatory and Allergenic Properties of Antimicrobial Peptides.

    Guryanova, Svetlana V / Ovchinnikova, Tatiana V

    International journal of molecular sciences

    2022  Volume 23, Issue 5

    Abstract: With the growing problem of the emergence of antibiotic-resistant bacteria, the search for alternative ways to combat bacterial infections is extremely urgent. While analyzing the effect of antimicrobial peptides (AMPs) on immunocompetent cells, their ... ...

    Abstract With the growing problem of the emergence of antibiotic-resistant bacteria, the search for alternative ways to combat bacterial infections is extremely urgent. While analyzing the effect of antimicrobial peptides (AMPs) on immunocompetent cells, their effect on all parts of the immune system, and on humoral and cellular immunity, is revealed. AMPs have direct effects on neutrophils, monocytes, dendritic cells, T-lymphocytes, and mast cells, participating in innate immunity. They act on B-lymphocytes indirectly, enhancing the induction of antigen-specific immunity, which ultimately leads to the activation of adaptive immunity. The adjuvant activity of AMPs in relation to bacterial and viral antigens was the reason for their inclusion in vaccines and made it possible to formulate the concept of a "defensin vaccine" as an innovative basis for constructing vaccines. The immunomodulatory function of AMPs involves their influence on cells in the nearest microenvironment, recruitment and activation of other cells, supporting the response to pathogenic microorganisms and completing the inflammatory process, thus exhibiting a systemic effect. For the successful use of AMPs in medical practice, it is necessary to study their immunomodulatory activity in detail, taking into account their pleiotropy. The degree of maturity of the immune system and microenvironment can contribute to the prevention of complications and increase the effectiveness of therapy, since AMPs can suppress inflammation in some circumstances, but aggravate the response and damage of organism in others. It should also be taken into account that the real functions of one or another AMP depend on the types of total regulatory effects on the target cell, and not only on properties of an individual peptide. A wide spectrum of biological activity, including direct effects on pathogens, inactivation of bacterial toxins and influence on immunocompetent cells, has attracted the attention of researchers, however, the cytostatic activity of AMPs against normal cells, as well as their allergenic properties and low stability to host proteases, are serious limitations for the medical use of AMPs. In this connection, the tasks of searching for compounds that selectively affect the target and development of an appropriate method of application become critically important. The scope of this review is to summarize the current concepts and newest advances in research of the immunomodulatory activity of natural and synthetic AMPs, and to examine the prospects and limitations of their medical use.
    MeSH term(s) Allergens/pharmacology ; Antimicrobial Cationic Peptides/chemistry ; Antimicrobial Peptides ; Bacteria ; Immunity, Innate ; Immunomodulation
    Chemical Substances Allergens ; Antimicrobial Cationic Peptides ; Antimicrobial Peptides
    Language English
    Publishing date 2022-02-24
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23052499
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Innate Immunity Mechanisms in Marine Multicellular Organisms.

    Guryanova, Svetlana V / Ovchinnikova, Tatiana V

    Marine drugs

    2022  Volume 20, Issue 9

    Abstract: The innate immune system provides an adequate response to stress factors and pathogens through pattern recognition receptors (PRRs), located on the surface of cell membranes and in the cytoplasm. Generally, the structures of PRRs are formed by several ... ...

    Abstract The innate immune system provides an adequate response to stress factors and pathogens through pattern recognition receptors (PRRs), located on the surface of cell membranes and in the cytoplasm. Generally, the structures of PRRs are formed by several domains that are evolutionarily conserved, with a fairly high degree of homology in representatives of different species. The orthologs of TLRs, NLRs, RLRs and CLRs are widely represented, not only in marine chordates, but also in invertebrates. Study of the interactions of the most ancient marine multicellular organisms with microorganisms gives us an idea of the evolution of molecular mechanisms of protection against pathogens and reveals new functions of already known proteins in ensuring the body's homeostasis. The review discusses innate immunity mechanisms of protection of marine invertebrate organisms against infections, using the examples of ancient multicellular hydroids, tunicates, echinoderms, and marine worms in the context of searching for analogies with vertebrate innate immunity. Due to the fact that mucous membranes first arose in marine invertebrates that have existed for several hundred million years, study of their innate immune system is both of fundamental importance in terms of understanding molecular mechanisms of host defense, and of practical application, including the search of new antimicrobial agents for subsequent use in medicine, veterinary and biotechnology.
    MeSH term(s) Immunity, Innate ; Receptors, Pattern Recognition/metabolism ; Signal Transduction
    Chemical Substances Receptors, Pattern Recognition
    Language English
    Publishing date 2022-08-25
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2175190-0
    ISSN 1660-3397 ; 1660-3397
    ISSN (online) 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md20090549
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Structure, Function, and Therapeutic Potential of Marine Bioactive Peptides.

    Ovchinnikova, Tatiana V

    Marine drugs

    2019  Volume 17, Issue 9

    Abstract: In recent years, bioactive peptides from marine organisms have gained increasing attention in the field of pharmaceutical, cosmeceutical, and nutraceutical product development owing to their interesting biological properties [ ... ]. ...

    Abstract In recent years, bioactive peptides from marine organisms have gained increasing attention in the field of pharmaceutical, cosmeceutical, and nutraceutical product development owing to their interesting biological properties [...].
    MeSH term(s) Animals ; Aquatic Organisms/chemistry ; Biological Products/chemistry ; Biological Products/pharmacology ; Biological Products/therapeutic use ; Drug Discovery ; Humans ; Molecular Structure ; Peptides/chemistry ; Peptides/pharmacokinetics ; Peptides/therapeutic use
    Chemical Substances Biological Products ; Peptides
    Language English
    Publishing date 2019-08-28
    Publishing country Switzerland
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 2175190-0
    ISSN 1660-3397 ; 1660-3397
    ISSN (online) 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md17090505
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Innate Immunity Mechanisms in Marine Multicellular Organisms

    Guryanova, Svetlana V. / Ovchinnikova, Tatiana V.

    Marine drugs. 2022 Aug. 25, v. 20, no. 9

    2022  

    Abstract: The innate immune system provides an adequate response to stress factors and pathogens through pattern recognition receptors (PRRs), located on the surface of cell membranes and in the cytoplasm. Generally, the structures of PRRs are formed by several ... ...

    Abstract The innate immune system provides an adequate response to stress factors and pathogens through pattern recognition receptors (PRRs), located on the surface of cell membranes and in the cytoplasm. Generally, the structures of PRRs are formed by several domains that are evolutionarily conserved, with a fairly high degree of homology in representatives of different species. The orthologs of TLRs, NLRs, RLRs and CLRs are widely represented, not only in marine chordates, but also in invertebrates. Study of the interactions of the most ancient marine multicellular organisms with microorganisms gives us an idea of the evolution of molecular mechanisms of protection against pathogens and reveals new functions of already known proteins in ensuring the body’s homeostasis. The review discusses innate immunity mechanisms of protection of marine invertebrate organisms against infections, using the examples of ancient multicellular hydroids, tunicates, echinoderms, and marine worms in the context of searching for analogies with vertebrate innate immunity. Due to the fact that mucous membranes first arose in marine invertebrates that have existed for several hundred million years, study of their innate immune system is both of fundamental importance in terms of understanding molecular mechanisms of host defense, and of practical application, including the search of new antimicrobial agents for subsequent use in medicine, veterinary and biotechnology.
    Keywords Urochordata ; biotechnology ; cytoplasm ; evolution ; homeostasis ; innate immunity ; invertebrates ; medicine ; stress response ; vertebrates
    Language English
    Dates of publication 2022-0825
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2175190-0
    ISSN 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md20090549
    Database NAL-Catalogue (AGRICOLA)

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  10. Article: Structure, Function, and Therapeutic Potential of Marine Bioactive Peptides

    Ovchinnikova, Tatiana V

    Marine drugs. 2019 Aug. 28, v. 17, no. 9

    2019  

    Abstract: In recent years, bioactive peptides from marine organisms have gained increasing attention in the field of pharmaceutical, cosmeceutical, and nutraceutical product development owing to their interesting biological properties [ ... ] ...

    Abstract In recent years, bioactive peptides from marine organisms have gained increasing attention in the field of pharmaceutical, cosmeceutical, and nutraceutical product development owing to their interesting biological properties [...]
    Keywords aquatic organisms ; cosmetics ; dietary supplements ; peptides ; product development ; therapeutics
    Language English
    Dates of publication 2019-0828
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2175190-0
    ISSN 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md17090505
    Database NAL-Catalogue (AGRICOLA)

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