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Article ; Online: Obesidad: factor de riesgo para psoriasis y COVID-19.

Llamas-Velasco, M / Ovejero-Merino, E / Salgado-Boquete, L

2020 Volume 112, Issue 6, Page(s) 489–494

Abstract: Obesity is a major health problem whose well-known association with psoriasis has been amply described. The importance of obesity as a risk factor for poor prognosis in the coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome ... ...

Title translation	Obesity - A Risk Factor for Psoriasis and COVID-19.
Abstract	Obesity is a major health problem whose well-known association with psoriasis has been amply described. The importance of obesity as a risk factor for poor prognosis in the coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 infection has recently been demonstrated. This review examines a possible relationship between obesity, psoriasis, and COVID-19, analyzing the pathophysiological links and their practical implications. On the one hand, a higher body mass index increases the risk of psoriasis and is also a factor in metabolic syndrome, which is common in patients with psoriasis and has been implicated in reducing the effectiveness of psoriasis treatments. On the other hand, obesity is a risk factor for severe COVID-19 and mortality. Obesity also promotes a proinflammatory state in the lung, where it compromises respiratory mechanics.
Language	Spanish
Publishing date	2020-12-24
Publishing country	Spain
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	390255-9
ISSN	1578-2190 ; 0001-7310 ; 1138-8196
ISSN (online)	1578-2190
ISSN	0001-7310 ; 1138-8196
DOI	10.1016/j.ad.2020.12.001
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Article: Bilateral Nipple Enlargement as a Secondary Effect of Anabolic Drugs: A Histopathological Mimicker of Smooth Muscle Hamartoma.

Llamas-Velasco, Mar / Bianciardi Valassina, Maria Francesca / Ovejero-Merino, Enrique / Massi, Guido / Mentzel, Thomas

Dermatopathology (Basel, Switzerland)

2021 Volume 8, Issue 2, Page(s) 103–106

Abstract: Smooth muscle hamartoma are usually solitary and congenital, may affect the genital area and nipples. Histopathologically, they are characterized by the presence of mature smooth muscle bundles. We present a 40 year-old male with bilateral nipple ... ...

Abstract	Smooth muscle hamartoma are usually solitary and congenital, may affect the genital area and nipples. Histopathologically, they are characterized by the presence of mature smooth muscle bundles. We present a 40 year-old male with bilateral nipple enlargement excised with clinical suspicion of bilateral leiomyoma. Skin biopsy shows mature, irregularly arranged smooth muscle bundles and lactiferous ducts between them. Immunohistochemistry is positive for smooth muscle actin, desmin and fumarase, but negative for estrogen and progestogen receptors. The presence of lactiferous ducts excludes bilateral leiomyomas. Even when, histopathologically, this can be interpreted as the nipple-type of muscular hamartoma of the breast, clinical history favors an anabolic drug-induced lesion. Bodybuilders present gynecomastia and nipple enlargement as frequent problems, but we have not found any histopathological description of these nipple lesions. We consider that dermatologists should be aware of the presence of them and dermatopathologists should know their histopathological features to avoid misdiagnosis as neoplasms.
Language	English
Publishing date	2021-04-15
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2777118-0
ISSN	2296-3529
ISSN	2296-3529
DOI	10.3390/dermatopathology8020016
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Article ; Online: Chemical pleurodesis with povidone-iodine for the management of pleuroperitoneal leak in peritoneal dialysis: a case report.

Guerra-Torres, Xavier E / Rodríguez Doyágüez, Pablo / Ovejero Merino, Enrique / Chávez Guillen, Alina Valeria / Bouarich, Hanane / Moreno Barrio, Fuensanta

Nefrologia

2022 Volume 42, Issue 2, Page(s) 213–215

MeSH term(s)	Humans ; Peritoneal Dialysis ; Peritoneal Dialysis, Continuous Ambulatory ; Pleurodesis ; Povidone-Iodine/therapeutic use
Chemical Substances	Povidone-Iodine (85H0HZU99M)
Language	English
Publishing date	2022-05-03
Publishing country	Spain
Document type	Case Reports ; Letter
ZDB-ID	2837917-2
ISSN	2013-2514 ; 2013-2514
ISSN (online)	2013-2514
ISSN	2013-2514
DOI	10.1016/j.nefroe.2020.09.010
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Article ; Online: Single metachronous bone metastasis following rectal adenocarcinoma: A case report.

Matías-García, Belén / Mendoza-Moreno, Fernando / Díez-Alonso, Manuel / Ovejero-Merino, Enrique / Vera-Mansilla, Cristina / Blázquez-Martín, Alma / Quiroga-Valcárcel, Ana / Jiménez-Martín, Rubén / D'amico, Rebeca / Lasa-Unzúe, Inmaculada / Gutiérrez-Calvo, Alberto

Medicine international

2024 Volume 4, Issue 1, Page(s) 6

Abstract: Colorectal cancer (CRC) ranks as the third leading cause of cancer-related mortality in developed countries. While its incidence in early stages has increased due to screening programs, a significant number of patients experience the development of ... ...

Abstract	Colorectal cancer (CRC) ranks as the third leading cause of cancer-related mortality in developed countries. While its incidence in early stages has increased due to screening programs, a significant number of patients experience the development of metastases either at the time of diagnosis or during follow-ups. Unlike certain other types of cancer, such as breast, prostate, or lung cancer, where bone tissue is a common site for secondary dissemination, CRC primarily spreads to the lymph nodes, liver and lungs. The occurrence of bone metastases from CRC is rare and usually coincides with tumor involvement in other locations. Risk factors for bone metastases include the location of the primary tumor, the age of the patients, KRAS mutations and the degree of tumor differentiation. Unlike metastases to the liver and lungs, bone metastases tend to be symptomatic, affecting the patient's quality of life and resulting in a poorer prognosis with shorter survival rates. The approach to patient management needs to be personalized. The present study describes the of a patient who underwent surgery for stage IV rectal adenocarcinoma and later developed a metastasis in the costal wall 79 months post-intervention, with no evidence of recurrence at other sites.
Language	English
Publishing date	2024-01-03
Publishing country	England
Document type	Case Reports
ISSN	2754-1304
ISSN (online)	2754-1304
DOI	10.3892/mi.2024.130
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Article ; Online: Collision of Subungual Neurofibroma and Onychomatricoma: S100 Positivity as a Clue.

Llamas-Velasco, Mar / Espinosa, Pablo / Ovejero-Merino, Enrique / Pérez-González, Yosmar Carolina

The American Journal of dermatopathology

2019 Volume 41, Issue 9, Page(s) 649–651

Abstract: We present a 41-year-old man with a hemionychodystrophy of the first toe, appearing as a longitudinal thickening of the nail plate, overcurved and with holes in its thickened free margin, thus leading to the clinical diagnosis of onychomatricoma. ... ...

Abstract	We present a 41-year-old man with a hemionychodystrophy of the first toe, appearing as a longitudinal thickening of the nail plate, overcurved and with holes in its thickened free margin, thus leading to the clinical diagnosis of onychomatricoma. Complete excision showed typical nail plate of onychomatricoma and, underlying it, curvy disorganized neural-looking fascicles without atypia and with diffuse positivity for S100, interpreted as subungual neurofibroma (NF). Subungual NF is a very rare tumor, with only 12 previous cases reported. Its diagnosis is based on histopathology, as the tumor presents waves or whorls of disorganized neural-looking cells positive for S100. Regarding onychomatricoma, it is characterized by typical glove finger digitations (which were present in our case) and an underlying stroma composed by a cellular superficial layer (this layer expresses CD34 but not CD99) and a more sclerotic and deeper area. As we did not find information on S100 expression in the stroma of onychomatricoma, we have stained 4 typical cases, and all were negative with S100 and positive with CD34, as expected. In conclusion, as "subungual NF" is so rare and, in our case, seems to collide with a typical onychomatricoma, we recommend adding S100 staining to properly characterize tumors involving nail plate, to detect underlying neural tumors, as has happened in our case.
MeSH term(s)	Adult ; Biopsy, Needle ; Diagnosis, Differential ; Humans ; Immunohistochemistry ; Male ; Nail Diseases/pathology ; Nail Diseases/surgery ; Nails, Malformed/pathology ; Nails, Malformed/surgery ; Neurofibroma/pathology ; Neurofibroma/surgery ; Rare Diseases ; Skin Neoplasms/pathology ; Skin Neoplasms/surgery ; Treatment Outcome
Language	English
Publishing date	2019-02-06
Publishing country	United States
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	448469-1
ISSN	1533-0311 ; 0193-1091
ISSN (online)	1533-0311
ISSN	0193-1091
DOI	10.1097/DAD.0000000000001357
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Article ; Online: Spontaneous cervical hematoma caused by giant parathyroid adenoma in an elderly patient: A case report.

Matías-García, Belén / Mendoza-Moreno, Fernando / Díez-Alonso, Manuel / Ovejero-Merino, Enrique / Vera-Mansilla, Cristina / Blázquez-Martín, Alma / Quiroga-Valcárcel, Ana / Jiménez-Martín, Rubén / D'Amico, Rebeca / Lasa-Unzúe, Inmaculada / Gutiérrez-Calvo, Alberto

Medicine international

2023 Volume 4, Issue 1, Page(s) 1

Abstract: Spontaneous cervical hematoma usually occurs as a consequence of extracapsular bleeding from a parathyroid gland, generally due to the presence of an adenoma (giant adenoma), glandular hyperplasia, cystic component, or, less frequently, due to the ... ...

Abstract	Spontaneous cervical hematoma usually occurs as a consequence of extracapsular bleeding from a parathyroid gland, generally due to the presence of an adenoma (giant adenoma), glandular hyperplasia, cystic component, or, less frequently, due to the existence of a carcinoma. The hematoma can be confined to the cervical compartment or extend to the mediastinum, potentially causing airway compression. Despite this, the recommended management in hemodynamically stable patients consists of surveillance and hospital monitoring with delayed surgery after a few weeks. On the other hand, in those patients with airway compromise and instability, emergency surgery, consisting of cervicotomy and drainage, is mandatory. The present study describes the case of a 78-year-old patient with a medical history of high blood pressure, non-insulin-dependent diabetes mellitus, dyslipidemia, moderate aortic stenosis, chronic kidney disease and sarcoidosis under pharmacological treatment who attended the emergency department due to symptoms of neck pain, an increase in soft tissue, and dyspnea on moderate exertion with an evolution leading to respiratory failure. This was secondary to a diagnosis of spontaneous cervical hematoma that required urgent surgical intervention. The results of histopathological analysis revealed that a giant parathyroid adenoma was responsible for the bleeding. The patient had a complicated post-operative period with a prolonged admission to the intensive care unit.
Language	English
Publishing date	2023-11-30
Publishing country	England
Document type	Case Reports
ISSN	2754-1304
ISSN (online)	2754-1304
DOI	10.3892/mi.2023.125
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Article ; Online: Malignant adipocytic tumours: A 20‑year single‑centre retrospective study.

Mendoza-Moreno, Fernando / Matías-García, Belén / Quiroga-Valcárcel, Ana / García-Moreno Nisa, Francisca / Díez-Corral, Cristina / Blázquez-Martín, Alma / Vera-Mansilla, Cristina / Ovejero-Merino, Enrique / Díez-Alonso, Manuel / Diego-García, Lucía / Alvarez-Mon, Melchor / Ortega, Miguel A / Gutiérrez-Calvo, Alberto

Oncology letters

2023 Volume 25, Issue 6, Page(s) 247

Abstract: Adipocytic tumours are the most common soft tissue neoplasms. Among them, liposarcoma is the most frequent malignant neoplasm. However, to the best of our knowledge, no previously published study has assessed the evolution and oncological prognosis of ... ...

Abstract	Adipocytic tumours are the most common soft tissue neoplasms. Among them, liposarcoma is the most frequent malignant neoplasm. However, to the best of our knowledge, no previously published study has assessed the evolution and oncological prognosis of the different subtypes of liposarcoma at the retroperitoneal level compared with at other locations. The present study is a retrospective observational study in which all patients were operated on between October 2000 and January 2020 with a histological diagnosis of liposarcoma. Variables, such as age, sex, location, histological type, recurrence, type of treatment and mortality, among others, were analysed. The patients were divided into two groups: Group A (retroperitoneal location) and group B (non-retroperitoneal location). A total of 52 patients with a diagnosis of liposarcoma (17 women and 35 men) and a mean age of 57.2±15.9 years were assessed. A total of 16 patients were classified into group A and 36 into group B. The OR of recurrence was 1.5 (P=0.02) for R1 vs. R0 resection in group A. The OR of recurrence in group B for R1 vs. R0 resection was 1.8 (P=0.77), whereas for R2 vs. R0 resection, the OR was 69 (P=0.011). In conclusion, 52 cases of malignant adipocytic tumours collected during 2000-2020 were analysed with the new World Health Organization classification (updated 2020). Although its recurrence potential and capacity for distant metastasis depended on each histological type, surgical treatment with unaffected margins was the main prognostic factor for survival. The present study identified differences in relation to the survival of each histological subtype and its location, finding greater survival in dedifferentiated liposarcoma, myxoid liposarcoma and pleomorphic liposarcoma located at the extraperitoneal level than in the retroperitoneal location. Resectability was not influenced by liposarcoma location.
Language	English
Publishing date	2023-04-21
Publishing country	Greece
Document type	Journal Article
ZDB-ID	2573196-8
ISSN	1792-1082 ; 1792-1074
ISSN (online)	1792-1082
ISSN	1792-1074
DOI	10.3892/ol.2023.13833
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Article ; Online: Cutaneous side effects in a cohort of patients with chronic myeloid leukemia treated with tyrosine kinase inhibitors: General description and further characterization, correlation with photoexposition and study of hypopigmentation as treatment's prognostic factor.

Llamas-Velasco, Mar / Ovejero-Merino, Enrique / García-Diez, Amaro / Requena, Luis / Daudén, Esteban / Steegmann, Juan Luis

Dermatologic therapy

2020 Volume 33, Issue 6, Page(s) e14428

Abstract: Cutaneous adverse effects (AE) related to tyrosine-kinase inhibitor (TKI) drugs have been mainly described as case reports. We have characterized their appearance and correlation with patient's photoexposition habits and, further, with treatment response, ...

Abstract	Cutaneous adverse effects (AE) related to tyrosine-kinase inhibitor (TKI) drugs have been mainly described as case reports. We have characterized their appearance and correlation with patient's photoexposition habits and, further, with treatment response, in 61 patients with chronic myelogenous leukemia (CML) treated with TKI drugs. We have found hypopigmentation in 49.2% of the cases and a statistically significant association with interferon (IFN) intake. Eyelid edema's frequency was 45.4%. Mean photo-exposure was 1.95 h/day and only 8.3% of the patients used sunscreen daily. 44.3% of the patients reported a lighter skin color with the treatment and a statistically significant relationship with conjunctival hemorrhage was also found. Concordance between patients and dermatologist was moderate (kappa index 0.41). We found xerosis (21.3%), eczematous eruptions (21.3%), melasma (4.9%) and other isolated skin problems (ie, granulomatous panniculitis) in up to 16.4% of cases. Appearance of hypopigmented macules is associated to vascular conjunctival fragility and these patients need a slightly longer time to reach a complete molecular response, but without additional changes in survival or relapse frequency. We have stablished a specific dermatologic diagnosis in all the cases and we have not found the previously published as maculopapular rashes. Hypopigmentation, the more frequent AE, was not perceived as a relevant side effect. Photosensitivity, in our cases, was not reported, although imatinib-treated patients avoided sun-exposure. In addition, we identified some nonpreviously described dermatologic conditions in patients taking TKI drugs, like granulomatous panniculitis tufted folliculitis or oral spindle cell lipoma.
MeSH term(s)	Humans ; Hypopigmentation/chemically induced ; Hypopigmentation/diagnosis ; Hypopigmentation/epidemiology ; Imatinib Mesylate/adverse effects ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy ; Prognosis ; Protein Kinase Inhibitors/adverse effects
Chemical Substances	Protein Kinase Inhibitors ; Imatinib Mesylate (8A1O1M485B)
Language	English
Publishing date	2020-11-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	1354801-3
ISSN	1529-8019 ; 1396-0296
ISSN (online)	1529-8019
ISSN	1396-0296
DOI	10.1111/dth.14428
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Article ; Online: Chemical pleurodesis with povidone-iodine for the management of pleuroperitoneal leak in peritoneal dialysis: A case report.

Guerra-Torres, Xavier E / Rodríguez Doyágüez, Pablo / Ovejero Merino, Enrique / Chávez Guillen, Alina Valeria / Bouarich, Hanane / Moreno Barrio, Fuensanta

Nefrologia

2020

Title translation	Pleurodesis química con povidona yodada para el manejo de la fuga peritoneo-pleural en diálisis peritoneal: a propósito de un caso.
Language	Spanish
Publishing date	2020-12-14
Publishing country	Spain
Document type	Letter
ZDB-ID	2837917-2
ISSN	2013-2514 ; 2013-2514
ISSN (online)	2013-2514
ISSN	2013-2514
DOI	10.1016/j.nefro.2020.09.003
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Article: Prognostic Factors of Survival in Patients with Peritoneal Metastasis from Colorectal Cancer.

Mendoza-Moreno, Fernando / Diez-Alonso, Manuel / Matías-García, Belén / Ovejero-Merino, Enrique / Gómez-Sanz, Remedios / Blázquez-Martín, Alma / Quiroga-Valcárcel, Ana / Vera-Mansilla, Cristina / Molina, Raquel / San-Juan, Alberto / Barrena-Blázquez, Silvestra / Ortega, Miguel A / Alvarez-Mon, Melchor / Gutiérrez-Calvo, Alberto

Journal of clinical medicine

2022 Volume 11, Issue 16

Abstract: Objectives: The aim of this study was to analyze the prognostic factors of survival in patients with peritoneal metastasis (PM) from colorectal cancer (CRC). The type of relationship between survival and the PM time of detection was used to determine ... ...

Abstract	Objectives: The aim of this study was to analyze the prognostic factors of survival in patients with peritoneal metastasis (PM) from colorectal cancer (CRC). The type of relationship between survival and the PM time of detection was used to determine whether it was synchronous with the primary tumor or metachronous. Patients and Methods: Retrospective observational study. It included patients treated for colorectal adenocarcinoma diagnosed between January 2005 and December 2019 who presented PM at the time of diagnosis or during follow-up. Variables, such as sex, age, differentiation grade, positive adenopathy (pN+), tumor size (pT), tumor location, mucinous component, peritoneal carcinomatosis index (PCI), and KRAS mutational status, were analyzed. Results: During the study period, 1882 patients were surgically treated for CRC in our hospital. Of these, 240 patients (12.8%) were included in the study after evidence of PM. The mean age was 67 ± 12 years (range: 32−92 years), and 114 patients were female (47.5%). The mean follow-up was 20 ± 13 months (median 12 months). The Kaplan−Meier survival at 36 months was higher in patients with metachronous PM (24% vs. 8%; p = 0.002), WT-KRAS tumors (31% vs. 15%; p < 0.001), N0 stage (30% vs. 19%; p < 0.001), T3 stage tumors (18% vs. 19% in T4A and 3% in T4B; p > 0.001), and tumors with classic adenocarcinoma histology (18% vs. 8%; p = 0.011). Patients with a PCI of 1−10 showed a likelihood of survival at 36 months of 56%, which was longer than that found in patients with a PCI of 11−20 (8%) or a PCI of >20 (0%) (p < 0.001). In the multiple regression analysis, the factors with an independent prognostic value were: poor grade of differentiation (HR 1.995; 95% CI: 1.294−3.077), KRAS mutation (HR 1.751; 95% CI: 1.188−2.581), PCI 11−20 (HR: 9.935; 95% CI: 5.204−18.966) and PCI > 20 (HR: 4.011; 95% CI: 2.291−7.023). Conclusions: PCI should continue as the as the most useful prognostic indicator in order to assess prognostic estimations as well as therapeutic and surgical decisions, but tumor grade and KRAS mutational status may help in the treatment decision process by providing complementary information. The time of PM detection did not achieve statistical significance in the multiple regression analysis.
Language	English
Publishing date	2022-08-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm11164922
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