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  1. Article ; Online: Mohs micrographic surgery reduces the need for a repeat surgery for primary Merkel cell carcinoma when compared to wide local excision: A retrospective cohort study of a commercial insurance claims database.

    Tran, Duy C / Ovits, Channa / Wong, Priscilla / Kim, Randie H

    JAAD international

    2022  Volume 9, Page(s) 97–99

    Language English
    Publishing date 2022-08-27
    Publishing country United States
    Document type Journal Article
    ISSN 2666-3287
    ISSN (online) 2666-3287
    DOI 10.1016/j.jdin.2022.08.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Necrolytic acral erythema in a patient with sarcoidosis.

    Shah, Payal / Ovits, Channa / Brinster, Nooshin / Lo Sicco, Kristen

    JAAD case reports

    2020  Volume 6, Issue 11, Page(s) 1162–1164

    Language English
    Publishing date 2020-05-06
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2834220-3
    ISSN 2352-5126
    ISSN 2352-5126
    DOI 10.1016/j.jdcr.2020.04.035
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Acquired Epidermodysplasia Verruciformis and Its Relationship to Immunosuppressive Therapy: Report of a Case and Review of the Literature.

    Ovits, Channa G / Amin, Bijal D / Halverstam, Caroline

    Journal of drugs in dermatology : JDD

    2017  Volume 16, Issue 7, Page(s) 701–704

    Abstract: Introduction: Epidermodysplasia verruciformis (EV) is a rare inherited dermatosis characterized by increased susceptibility to human papilloma virus infection. Acquired EV occurs in patients with compromised cell-mediated immunity, such as patients with ...

    Abstract Introduction: Epidermodysplasia verruciformis (EV) is a rare inherited dermatosis characterized by increased susceptibility to human papilloma virus infection. Acquired EV occurs in patients with compromised cell-mediated immunity, such as patients with HIV and transplant recipients. Optimal management of acquired EV has not yet been established, as cases are rare and are due to a variety of underlying conditions. Additionally, no distinctions have been made between different immunosuppressive medications and their respective link to EV.
    Methods and results: We report a patient with systemic lupus erythematosus who developed EV while on azathioprine and prednisone. The patient's lesions resolved completely after she was switched from azathioprine to mycophenolate mofetil. Her lesions recurred when her immunosuppressive regimen was again changed from mycophenolate mofetil to methotrexate. A review of the literature revealed azathioprine to be related to other cases of acquired EV.
    Discussion: This case indicates a possible link between specific immunosuppressive drugs and the development of EV, allowing for new EV treatment considerations. In this case and previous cases, azathioprine is indicated as being particularly linked with the development of EV, while mycophenolate mofetil may be an immunosuppressive option that is less likely to induce EV in patients predisposed to this condition. J Drugs Dermatol. 2017;16(7):701-704.
    Language English
    Publishing date 2017-07-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2145090-0
    ISSN 1545-9616
    ISSN 1545-9616
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5931: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Random mutagenesis of the proton-coupled folate transporter (SLC46A1), clustering of mutations, and the bases for associated losses of function.

    Zhao, Rongbao / Shin, Daniel Sanghoon / Diop-Bove, Ndeye / Ovits, Channa Gila / Goldman, I David

    The Journal of biological chemistry

    2011  Volume 286, Issue 27, Page(s) 24150–24158

    Abstract: Loss-of-function mutations in the proton-coupled folate transporter (PCFT, SLC46A1) result in the autosomal recessive disorder, hereditary folate malabsorption (HFM). Identification and characterization of HFM mutations provide a wealth of information on ...

    Abstract Loss-of-function mutations in the proton-coupled folate transporter (PCFT, SLC46A1) result in the autosomal recessive disorder, hereditary folate malabsorption (HFM). Identification and characterization of HFM mutations provide a wealth of information on the structure-function relationship of this transporter. In the current study, PCR-based random mutagenesis was employed to generate unbiased loss-of-function mutations of PCFT, simulating the spectrum of alterations that might occur in the human disorder. A total of 26 mutations were generated and 4 were identical to HFM mutations. Eleven were base deletion or insertion mutations that led to a frameshift and, along with similar HFM mutations, are predominantly localized to two narrow regions of the pcft gene at the 5'-end. Base substitution mutations identified in the current study and HFM patients were largely distributed across the pcft gene. Elimination of the ATG initiation codon by a one-base substitution (G > A) did not result in a complete lack of translation at the same codon consistent with rare non-ATG translation initiation. Among six missense mutants evaluated, three mutant PCFTs were not detected at the plasma membrane, one mutation resulted in decreased binding to folate substrate, and one had a reduced rate of conformational change associated with substrate translocation. The remaining PCFT mutant had defects in both processes. These results broaden understanding of the regions of the pcft gene prone to base insertion and deletion and inform further approaches to the analysis of the structure-function of PCFT.
    MeSH term(s) HeLa Cells ; Humans ; Metabolism, Inborn Errors/genetics ; Metabolism, Inborn Errors/metabolism ; Mutagenesis ; Mutation ; Proton-Coupled Folate Transporter/genetics ; Proton-Coupled Folate Transporter/metabolism ; Structure-Activity Relationship
    Chemical Substances Proton-Coupled Folate Transporter ; SLC46A1 protein, human
    Language English
    Publishing date 2011-05-20
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1074/jbc.M111.236539
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.108: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Cyclosporine A immunosuppression drives catastrophic squamous cell carcinoma through IL-22.

    Abikhair, Melody / Mitsui, Hiroshi / Yanofsky, Valerie / Roudiani, Nazanin / Ovits, Channa / Bryan, Teddy / Oberyszyn, Tatiana M / Tober, Kathleen L / Gonzalez, Juana / Krueger, James G / Felsen, Diane / Carucci, John A

    JCI insight

    2016  Volume 1, Issue 8, Page(s) e86434

    Abstract: Immune-suppressed organ transplant recipients (OTRs) can develop catastrophic squamous cell carcinoma (SCC), characterized by multiple primary tumors, extensive body surface area involvement, or metastases. There are currently no curative systemic ... ...

    Abstract Immune-suppressed organ transplant recipients (OTRs) can develop catastrophic squamous cell carcinoma (SCC), characterized by multiple primary tumors, extensive body surface area involvement, or metastases. There are currently no curative systemic therapies available. We previously showed that IL-22 enhances SCC proliferation. Herein, we examined links between cyclosporine (CSA), IL-22, and SCC in patients, cell lines, and mice with UV light-induced SCC. Eighteen of 114 OTRs developed catastrophic SCC, which was strongly associated with CSA treatment. We found that CSA drives T cell polarization toward IL-22-producing T22 cells, and CSA treatment increased IL-22 receptor in SCC cells. SCC tissue from OTRs showed increased expression of IL-22RA1. CSA potentiated rescue by IL-22 of serum-starved SCC cells; treatment of SCC cells with IL-22 and CSA increased both their migratory and invasive capacity. In a UV-induced model of SCC in SKH-1 immunocompetent mice, treatment with anti-IL-22 antibody reduced tumor number and tumor burden. We found that catastrophic SCC in OTRs is associated with CSA use, which may be acting by favoring T22 polarization. Since anti-IL-22 antibody administration decreased tumor number and tumor burden in vivo, blockade of the IL-22 axis may be developed as a viable therapeutic option for catastrophic SCC.
    MeSH term(s) Animals ; Carcinoma, Squamous Cell/chemically induced ; Cell Line, Tumor ; Cyclosporine/pharmacology ; Humans ; Immunosuppressive Agents/pharmacology ; Interleukins/metabolism ; Mice ; Receptors, Interleukin/metabolism ; Skin Neoplasms/chemically induced ; Interleukin-22
    Chemical Substances Immunosuppressive Agents ; Interleukins ; Receptors, Interleukin ; interleukin-22 receptor ; Cyclosporine (83HN0GTJ6D)
    Language English
    Publishing date 2016-06-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2379-3708
    ISSN 2379-3708
    DOI 10.1172/jci.insight.86434
    Database MEDical Literature Analysis and Retrieval System OnLINE

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