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Article ; Online: Mapping the Distance: From Competence to Capability.

Jain, Vinayak / Oweis, Emil / Woods, Christian J

ATS scholar

2023 Volume 4, Issue 4, Page(s) 400–404

Language	English
Publishing date	2023-06-29
Publishing country	United States
Document type	Journal Article
ISSN	2690-7097
ISSN (online)	2690-7097
DOI	10.34197/ats-scholar.2023-0027VL
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Silver Stool.

Shehadeh, Malik / Oweis, Emil

The New England journal of medicine

2020 Volume 383, Issue 3, Page(s) 261

MeSH term(s)	Aged ; Colonic Neoplasms/pathology ; Color ; Feces/chemistry ; Female ; Humans ; Jaundice, Obstructive/complications ; Liver Neoplasms/complications ; Liver Neoplasms/diagnostic imaging ; Liver Neoplasms/secondary ; Melena ; Occult Blood ; Radiography, Abdominal ; Tomography, X-Ray Computed
Language	English
Publishing date	2020-07-15
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	207154-x
ISSN	1533-4406 ; 0028-4793
ISSN (online)	1533-4406
ISSN	0028-4793
DOI	10.1056/NEJMicm2000600
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Article ; Online: Assessing the need for transfer to the intensive care unit for Coronavirus-19 disease: Epidemiology and risk factors.

Hashmi, Muhammad Daniyal / Alnababteh, Muhtadi / Vedantam, Karthik / Alunikummannil, Jojo / Oweis, Emil S / Shorr, Andrew F

Respiratory medicine

2020 Volume 174, Page(s) 106203

Abstract: Background: Although many patients with coronavirus disease 2019 (Covid-19) require direct admission to the intensive care unit (ICU), some are sent after admission. Clinicians require an understanding of this phenomenon and various risk stratification ... ...

Abstract	Background: Although many patients with coronavirus disease 2019 (Covid-19) require direct admission to the intensive care unit (ICU), some are sent after admission. Clinicians require an understanding of this phenomenon and various risk stratification approaches for recognizing these subjects. Methods: We examined all Covid-19 patients sent initially to a ward who subsequently required care in the ICU. We examined the timing transfer and attempted to develop a risk score based on baseline variables to predict progressive disease. We evaluated the utility of the CURB-65 score at identifying the need for ICU transfer. Results: The cohort included 245 subjects (mean age 59.0 ± 14.2 years, 61.2% male) and 20% were eventually sent to the ICU. The median time to transfer was 2.5 days. Approximately 1/3rd of patients were not moved until day 4 or later and the main reason for transfer (79.2%) was worsening respiratory failure. A baseline absolute lymphocyte count (ALC) of ≤0.8 10 Conclusion: Covid-19 patients admitted to general wards face a significant risk for deterioration necessitating ICU admission and respiratory failure can occur late in this disease. Neither baseline clinical factors nor the CURB-65 score perform well as screening tests to categorize these subjects as likely to progress to ICU care.
MeSH term(s)	COVID-19/complications ; COVID-19/epidemiology ; COVID-19/virology ; Comorbidity ; Female ; Ferritins/blood ; Hospitalization ; Humans ; Intensive Care Units/statistics & numerical data ; Lymphocyte Count/methods ; Male ; Middle Aged ; Pandemics/statistics & numerical data ; Patient Transfer/organization & administration ; Research Design/standards ; Research Design/statistics & numerical data ; Respiratory Insufficiency/epidemiology ; Respiratory Insufficiency/etiology ; Retrospective Studies ; Risk Assessment ; Risk Factors ; SARS-CoV-2/genetics ; Time Factors
Chemical Substances	Ferritins (9007-73-2)
Keywords	covid19
Language	English
Publishing date	2020-10-27
Publishing country	England
Document type	Journal Article
ZDB-ID	1003348-8
ISSN	1532-3064 ; 0954-6111
ISSN (online)	1532-3064
ISSN	0954-6111
DOI	10.1016/j.rmed.2020.106203
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Article ; Online: PREDICTING THE NEED FOR INVASIVE MECHANICAL VENTILATION IN PATIENTS WITH CORONAVIRUS DISEASE 2019

Alnababteh, Muhtadi / Hashmi, Muhammad / Drescher, Gail / Vedantam, Karthik / Talish, Mishaal / Desai, Neerja / Oweis, Emil

Chest

Keywords	covid19
Publisher	Elsevier; PMC
Document type	Article ; Online
DOI	10.1016/j.chest.2020.09.009
Database	COVID19

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Article: Assessing the need for transfer to the intensive care unit for Coronavirus-19 disease: Epidemiology and risk factors

Hashmi, Muhammad Daniyal / Alnababteh, Muhtadi / Vedantam, Karthik / Alunikummannil, Jojo / Oweis, Emil S / Shorr, Andrew F

Respir Med

Abstract: BACKGROUND: Although many patients with coronavirus disease 2019 (Covid-19) require direct admission to the intensive care unit (ICU), some are sent after admission. Clinicians require an understanding of this phenomenon and various risk stratification ... ...

Abstract	BACKGROUND: Although many patients with coronavirus disease 2019 (Covid-19) require direct admission to the intensive care unit (ICU), some are sent after admission. Clinicians require an understanding of this phenomenon and various risk stratification approaches for recognizing these subjects. METHODS: We examined all Covid-19 patients sent initially to a ward who subsequently required care in the ICU. We examined the timing transfer and attempted to develop a risk score based on baseline variables to predict progressive disease. We evaluated the utility of the CURB-65 score at identifying the need for ICU transfer. RESULTS: The cohort included 245 subjects (mean age 59.0 ± 14.2 years, 61.2% male) and 20% were eventually sent to the ICU. The median time to transfer was 2.5 days. Approximately 1/3rd of patients were not moved until day 4 or later and the main reason for transfer (79.2%) was worsening respiratory failure. A baseline absolute lymphocyte count (ALC) of ≤0.8 103/ml and a serum ferritin ≥1000 ng/ml were independently associated with ICU transfer. Co-morbid illnesses did not correlate with eventual ICU care. Neither a risk score based on a low ALC and/or high ferritin nor the CURB-65 score performed well at predicting need for transfer. CONCLUSION: Covid-19 patients admitted to general wards face a significant risk for deterioration necessitating ICU admission and respiratory failure can occur late in this disease. Neither baseline clinical factors nor the CURB-65 score perform well as screening tests to categorize these subjects as likely to progress to ICU care.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #894196
Database	COVID19

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Article ; Online: INVESTIGATING THE RELATIONSHIP BETWEEN RACE/ETHNICITY AND CLINICAL OUTCOMES IN COVID-19

Alnababteh, Muhtadi / Drescher, Gail / Jayaram, Lakshmi / Kohli, Akshay / Hashmi, Muhammad / Hayat, Fatima / Chaturvedi, Mansi / Oweis, Emil / Zaaqoq, Akram

Chest

2020 Volume 158, Issue 4, Page(s) A2477–A2478

Keywords	Critical Care and Intensive Care Medicine ; Pulmonary and Respiratory Medicine ; Cardiology and Cardiovascular Medicine ; covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
ZDB-ID	1032552-9
ISSN	1931-3543 ; 0012-3692
ISSN (online)	1931-3543
ISSN	0012-3692
DOI	10.1016/j.chest.2020.09.054
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: EXTRACORPOREAL MEMBRANE OXYGENATION AS RESCUE THERAPY FOR COVID-19 INDUCED HYPOXIA

Alnababteh, Muhtadi / Hashmi, Muhammad / Drescher, Gail / Vedantam, Karthik / Kohli, Akshay / Hayat, Fatima / Chopra, Rajus / Oweis, Emil / Zaaqoq, Akram

Chest

SINGLE-CENTER STUDY

2020 Volume 158, Issue 4, Page(s) A2411

Keywords	Critical Care and Intensive Care Medicine ; Pulmonary and Respiratory Medicine ; Cardiology and Cardiovascular Medicine ; covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
ZDB-ID	1032552-9
ISSN	1931-3543 ; 0012-3692
ISSN (online)	1931-3543
ISSN	0012-3692
DOI	10.1016/j.chest.2020.09.010
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Extracorporeal membrane oxygenation for COVID-19 induced hypoxia: Single-center study.

Alnababteh, Muhtadi / Hashmi, Muhammad D / Vedantam, Karthik / Chopra, Rajus / Kohli, Akshay / Hayat, Fatima / Kriner, Eric / Molina, Ezequiel / Pratt, Alexandra / Oweis, Emil / Zaaqoq, Akram M

Perfusion

2020 Volume 36, Issue 6, Page(s) 564–572

Abstract: Introduction: The pandemic of the coronavirus disease 2019 (COVID-19) and associated pneumonia represent a clinical and scientific challenge. The role of Extracorporeal Membrane Oxygenation (ECMO) in such a crisis remains unclear.: Methods: We ... ...

Abstract	Introduction: The pandemic of the coronavirus disease 2019 (COVID-19) and associated pneumonia represent a clinical and scientific challenge. The role of Extracorporeal Membrane Oxygenation (ECMO) in such a crisis remains unclear. Methods: We examined COVID-19 patients who were supported for acute respiratory failure by both conventional mechanical ventilation (MV) and ECMO at a tertiary care institution in Washington DC. The study period extended from March 23 to April 29. We identified 59 patients who required invasive mechanical ventilation. Of those, 13 patients required ECMO. Results: Nine out of 13 ECMO (69.2%) patients were decannulated from ECMO. All-cause ICU mortality was comparable between both ECMO and MV groups (6 patients [46.15%] vs. 22 patients [47.82 %], p = 0.92). ECMO non-survivors vs survivors had elevated D-dimer (9.740 mcg/ml [4.84-20.00] vs. 3.800 mcg/ml [2.19-9.11], p = 0.05), LDH (1158 ± 344.5 units/L vs. 575.9 ± 124.0 units/L, p = 0.001), and troponin (0.4315 ± 0.465 ng/ml vs. 0.034 ± 0.043 ng/ml, p = 0.04). Time on MV as expected was significantly longer in ECMO groups (563.3 hours [422.1-613.9] vs. 247.9 hours [101.8-479] in MV group, p = 0.0009) as well as ICU length of stay 576.2 hours [457.5-652.8] in ECMO group vs. 322.2 hours [120.6-569.3] in MV group, p = 0.012). Conclusion: ECMO is a supportive intervention for COVID-19 associated pneumonia that could be considered if the optimum mechanical ventilation is deemed ineffective. Biomarkers such as D-dimer, LDH, and troponin could help with discerning the clinical prognosis in patients with COVID-19 pneumonia.
MeSH term(s)	COVID-19 ; Extracorporeal Membrane Oxygenation/adverse effects ; Humans ; Hypoxia ; Respiratory Distress Syndrome ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-10-06
Publishing country	England
Document type	Journal Article
ZDB-ID	645038-6
ISSN	1477-111X ; 0267-6591
ISSN (online)	1477-111X
ISSN	0267-6591
DOI	10.1177/0267659120963885
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Article: Extracorporeal membrane oxygenation for COVID-19 induced hypoxia: Single-center study

Alnababteh, Muhtadi / Hashmi, Muhammad D / Vedantam, Karthik / Chopra, Rajus / Kohli, Akshay / Hayat, Fatima / Kriner, Eric / Molina, Ezequiel / Pratt, Alexandra / Oweis, Emil / Zaaqoq, Akram M

Perfusion

Abstract: INTRODUCTION: The pandemic of the coronavirus disease 2019 (COVID-19) and associated pneumonia represent a clinical and scientific challenge. The role of Extracorporeal Membrane Oxygenation (ECMO) in such a crisis remains unclear. METHODS: We examined ... ...

Abstract	INTRODUCTION: The pandemic of the coronavirus disease 2019 (COVID-19) and associated pneumonia represent a clinical and scientific challenge. The role of Extracorporeal Membrane Oxygenation (ECMO) in such a crisis remains unclear. METHODS: We examined COVID-19 patients who were supported for acute respiratory failure by both conventional mechanical ventilation (MV) and ECMO at a tertiary care institution in Washington DC. The study period extended from March 23 to April 29. We identified 59 patients who required invasive mechanical ventilation. Of those, 13 patients required ECMO. RESULTS: Nine out of 13 ECMO (69.2%) patients were decannulated from ECMO. All-cause ICU mortality was comparable between both ECMO and MV groups (6 patients [46.15%] vs. 22 patients [47.82 %], p = 0.92). ECMO non-survivors vs survivors had elevated D-dimer (9.740 mcg/ml [4.84-20.00] vs. 3.800 mcg/ml [2.19-9.11], p = 0.05), LDH (1158 ± 344.5 units/L vs. 575.9 ± 124.0 units/L, p = 0.001), and troponin (0.4315 ± 0.465 ng/ml vs. 0.034 ± 0.043 ng/ml, p = 0.04). Time on MV as expected was significantly longer in ECMO groups (563.3 hours [422.1-613.9] vs. 247.9 hours [101.8-479] in MV group, p = 0.0009) as well as ICU length of stay 576.2 hours [457.5-652.8] in ECMO group vs. 322.2 hours [120.6-569.3] in MV group, p = 0.012). CONCLUSION: ECMO is a supportive intervention for COVID-19 associated pneumonia that could be considered if the optimum mechanical ventilation is deemed ineffective. Biomarkers such as D-dimer, LDH, and troponin could help with discerning the clinical prognosis in patients with COVID-19 pneumonia.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #817962
Database	COVID19

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Article ; Online: Extracorporeal membrane oxygenation for COVID-19 induced hypoxia

Alnababteh, Muhtadi / Hashmi, Muhammad D / Vedantam, Karthik / Chopra, Rajus / Kohli, Akshay / Hayat, Fatima / Kriner, Eric / Molina, Ezequiel / Pratt, Alexandra / Oweis, Emil / Zaaqoq, Akram M

Perfusion

Single-center study

2020 , Page(s) 26765912096388

Abstract	Introduction: The pandemic of the coronavirus disease 2019 (COVID-19) and associated pneumonia represent a clinical and scientific challenge. The role of Extracorporeal Membrane Oxygenation (ECMO) in such a crisis remains unclear. Methods: We examined COVID-19 patients who were supported for acute respiratory failure by both conventional mechanical ventilation (MV) and ECMO at a tertiary care institution in Washington DC. The study period extended from March 23 to April 29. We identified 59 patients who required invasive mechanical ventilation. Of those, 13 patients required ECMO. Results: Nine out of 13 ECMO (69.2%) patients were decannulated from ECMO. All-cause ICU mortality was comparable between both ECMO and MV groups (6 patients [46.15%] vs. 22 patients [47.82 %], p = 0.92). ECMO non-survivors vs survivors had elevated D-dimer (9.740 mcg/ml [4.84-20.00] vs. 3.800 mcg/ml [2.19-9.11], p = 0.05), LDH (1158 ± 344.5 units/L vs. 575.9 ± 124.0 units/L, p = 0.001), and troponin (0.4315 ± 0.465 ng/ml vs. 0.034 ± 0.043 ng/ml, p = 0.04). Time on MV as expected was significantly longer in ECMO groups (563.3 hours [422.1-613.9] vs. 247.9 hours [101.8-479] in MV group, p = 0.0009) as well as ICU length of stay 576.2 hours [457.5-652.8] in ECMO group vs. 322.2 hours [120.6-569.3] in MV group, p = 0.012). Conclusion: ECMO is a supportive intervention for COVID-19 associated pneumonia that could be considered if the optimum mechanical ventilation is deemed ineffective. Biomarkers such as D-dimer, LDH, and troponin could help with discerning the clinical prognosis in patients with COVID-19 pneumonia.
Keywords	Radiology Nuclear Medicine and imaging ; Advanced and Specialised Nursing ; Safety Research ; Cardiology and Cardiovascular Medicine ; General Medicine ; covid19
Language	English
Publisher	SAGE Publications
Publishing country	us
Document type	Article ; Online
ZDB-ID	645038-6
ISSN	1477-111X ; 0267-6591
ISSN (online)	1477-111X
ISSN	0267-6591
DOI	10.1177/0267659120963885
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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