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  1. Article ; Online: Parental consent and neonatal delivery room trials: walking an ethical tightrope.

    Owen, Louise S / Davis, Peter G

    Archives of disease in childhood. Fetal and neonatal edition

    2021  Volume 106, Issue 2, Page(s) 116–117

    MeSH term(s) Delivery Rooms ; Humans ; Infant, Newborn ; Neonatology/ethics ; Parental Consent/ethics ; Research Design ; Research Subjects ; Resuscitation/methods
    Language English
    Publishing date 2021-01-12
    Publishing country England
    Document type Editorial
    ZDB-ID 2007331-8
    ISSN 1468-2052 ; 1359-2998
    ISSN (online) 1468-2052
    ISSN 1359-2998
    DOI 10.1136/archdischild-2020-319355
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  2. Article ; Online: Nasal High-Flow Therapy during Neonatal Endotracheal Intubation. Reply.

    Hodgson, Kate A / Owen, Louise S / Manley, Brett J

    The New England journal of medicine

    2022  Volume 387, Issue 4, Page(s) 382

    MeSH term(s) Humans ; Infant, Newborn ; Intubation, Intratracheal ; Trachea
    Language English
    Publishing date 2022-08-08
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2207316
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  3. Article ; Online: Nasal Intermittent Positive Pressure Ventilation for Neonatal Respiratory Distress Syndrome.

    Rüegger, Christoph M / Owen, Louise S / Davis, Peter G

    Clinics in perinatology

    2021  Volume 48, Issue 4, Page(s) 725–744

    Abstract: Nasal or noninvaisve intermittent positive pressure ventilation (NIPPV) refers to well-established noninvasive respiratory support strategies combining a continuous distending pressure with intermittent pressure increases. Uncertainty remains regarding ... ...

    Abstract Nasal or noninvaisve intermittent positive pressure ventilation (NIPPV) refers to well-established noninvasive respiratory support strategies combining a continuous distending pressure with intermittent pressure increases. Uncertainty remains regarding the benefits provided by the various devices and techniques used to generate NIPPV. Our included meta-analyses of trials comparing NIPPV with continuous positive airway pressure (CPAP) in preterm infants demonstrate that both primary and postextubation NIPPV are superior to CPAP to prevent respiratory failure leading to additional ventilatory support. This short-term benefit is associated with a reduction in bronchopulmonary dysplasia, but not with mortality. Benefits are greatest when ventilator-generated, synchronized NIPPV is used.
    MeSH term(s) Bronchopulmonary Dysplasia/therapy ; Continuous Positive Airway Pressure ; Humans ; Infant ; Infant, Newborn ; Infant, Premature ; Intermittent Positive-Pressure Ventilation ; Noninvasive Ventilation ; Respiratory Distress Syndrome, Newborn/therapy
    Language English
    Publishing date 2021-10-02
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Review
    ZDB-ID 193116-7
    ISSN 1557-9840 ; 0095-5108
    ISSN (online) 1557-9840
    ISSN 0095-5108
    DOI 10.1016/j.clp.2021.07.004
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  4. Article ; Online: Impact of early respiratory care for extremely preterm infants.

    Owen, Louise S / Manley, Brett J / Hodgson, Kate A / Roberts, Calum T

    Seminars in perinatology

    2021  Volume 45, Issue 8, Page(s) 151478

    Abstract: Despite advances in neonatal intensive care, more than half of surviving infants born extremely preterm (EP; < 28 weeks' gestation) develop bronchopulmonary dysplasia (BPD). Prevention of BPD is critical because of its associated mortality and morbidity, ...

    Abstract Despite advances in neonatal intensive care, more than half of surviving infants born extremely preterm (EP; < 28 weeks' gestation) develop bronchopulmonary dysplasia (BPD). Prevention of BPD is critical because of its associated mortality and morbidity, including adverse neurodevelopmental outcomes and respiratory health in later childhood and beyond. The respiratory care of EP infants begins before birth, then continues in the delivery room and throughout the primary hospitalization. This chapter will review the evidence for interventions after birth that might improve outcomes for infants born EP, including the timing of umbilical cord clamping, strategies to avoid or minimize exposure to mechanical ventilation, modes of mechanical ventilation and non-invasive respiratory support, oxygen saturation targets, postnatal corticosteroids and other adjunct therapies.
    MeSH term(s) Bronchopulmonary Dysplasia/prevention & control ; Child ; Female ; Glucocorticoids ; Humans ; Infant ; Infant, Extremely Premature ; Infant, Newborn ; Oxygen Saturation ; Pregnancy ; Umbilical Cord Clamping
    Chemical Substances Glucocorticoids
    Language English
    Publishing date 2021-08-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 752403-1
    ISSN 1558-075X ; 0146-0005
    ISSN (online) 1558-075X
    ISSN 0146-0005
    DOI 10.1016/j.semperi.2021.151478
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    Zs.A 1339: Show issues Location:
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  5. Article ; Online: Neonatal Golden Hour: A survey of Australian and New Zealand Neonatal Network units' early stabilisation practices for very preterm infants.

    Hodgson, Kate A / Owen, Louise S / Lui, Kei / Shah, Vibhuti

    Journal of paediatrics and child health

    2021  Volume 57, Issue 7, Page(s) 990–997

    Abstract: Aim: To identify current 'Golden Hour' practices for initial stabilisation of very preterm infants <32 weeks' gestational age (GA) within tertiary neonatal intensive care units (NICUs) in the Australian and New Zealand Neonatal Network (ANZNN).: ... ...

    Abstract Aim: To identify current 'Golden Hour' practices for initial stabilisation of very preterm infants <32 weeks' gestational age (GA) within tertiary neonatal intensive care units (NICUs) in the Australian and New Zealand Neonatal Network (ANZNN).
    Methods: A 76-question survey regarding delivery room (DR) and NICU stabilisation practices was distributed electronically to directors of tertiary perinatal NICUs in the ANZNN in January 2019. Responses were categorised into GA subgroups: 23-24, 25-27 and 28-31 weeks' GA.
    Results: The response rate was 100% (24/24 units). Delayed cord clamping (DCC) was practised 'always' or 'often' by 21 units (88%). All units used oximetry to target oxygen saturations, and 23/24 (96%) commenced resuscitation in <40% oxygen. Ten units (42%) routinely used DR electrocardiography monitoring. CPAP was preferred as primary respiratory support in one-third of units for infants born 23-24 weeks' GA, compared with 19 units (79%) at 25-27 weeks' GA and 23 units (96%) at 28-31 weeks' GA. DR skin-to-skin care was uncommon, particularly at lower GAs. Five units (21%) used minimally invasive surfactant therapy for non-intubated infants at 23-24 weeks' GA, 13 units (54%) at 25-27 weeks' GA and 16 units (67%) at 28-31 weeks' GA.
    Conclusions: Most Golden Hour stabilisation practices align with international guidelines. Consistency exists with respect to DCC, oxygen saturation targeting and primary CPAP use for infants 25 weeks' GA and above. Where evidence is less certain, practices vary across ANZNN NICUs. Time targets for stabilisation measures may help standardise practice for this population.
    MeSH term(s) Australia ; Female ; Gestational Age ; Humans ; Infant ; Infant, Newborn ; Infant, Premature ; Infant, Very Low Birth Weight ; Intensive Care Units, Neonatal ; New Zealand ; Pregnancy
    Language English
    Publishing date 2021-02-05
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 1024476-1
    ISSN 1440-1754 ; 1034-4810
    ISSN (online) 1440-1754
    ISSN 1034-4810
    DOI 10.1111/jpc.15360
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    Zs.A 227: Show issues Location:
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  6. Article ; Online: Delivery room emergencies: Respiratory emergencies in the DR.

    Owen, Louise S / Manley, Brett J / Davis, Peter G

    Seminars in fetal & neonatal medicine

    2019  Volume 24, Issue 6, Page(s) 101039

    Abstract: The majority of newborns transition to extra uterine life without support. However, respiratory emergencies in the delivery room are a common occurrence. Whilst some situations are predictable e.g. the anticipated birth of an extremely preterm infant, ... ...

    Abstract The majority of newborns transition to extra uterine life without support. However, respiratory emergencies in the delivery room are a common occurrence. Whilst some situations are predictable e.g. the anticipated birth of an extremely preterm infant, others are less so. In this chapter we address the most frequent scenarios that result in delivery room respiratory emergencies and discuss the latest recommendations for their management. We outline the need for a trained resuscitation team and appropriate equipment to provide respiratory support at every birth. We address the basic care that all infants should receive, the detailed application of non-invasive ventilation and the use of advanced airway techniques. We discuss the unique challenges presented by extreme prematurity including umbilical cord management, use of supplemental oxygen, initial modes of respiratory support and surfactant delivery. We will explore optimal techniques in the management of infants with lung hypoplasia, pneumothorax and meconium aspiration.
    MeSH term(s) Airway Management/methods ; Continuous Positive Airway Pressure/methods ; Delivery Rooms/organization & administration ; Emergencies ; Humans ; Infant, Extremely Premature/physiology ; Infant, Newborn ; Meconium Aspiration Syndrome/diagnosis ; Meconium Aspiration Syndrome/physiopathology ; Meconium Aspiration Syndrome/therapy ; Noninvasive Ventilation/methods ; Pulmonary Surfactants/therapeutic use ; Respiratory Distress Syndrome, Newborn/diagnosis ; Respiratory Distress Syndrome, Newborn/physiopathology ; Respiratory Distress Syndrome, Newborn/therapy ; Resuscitation/methods
    Chemical Substances Pulmonary Surfactants
    Language English
    Publishing date 2019-10-15
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2174416-6
    ISSN 1878-0946 ; 1744-165X
    ISSN (online) 1878-0946
    ISSN 1744-165X
    DOI 10.1016/j.siny.2019.101039
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    Zs.A 4798: Show issues Location:
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  7. Article ; Online: Bronchopulmonary dysplasia as a trial endpoint: time for re-evaluation?

    Owen, Louise S / Cheong, Jeanie L Y / Davis, Peter G

    The Lancet. Child & adolescent health

    2019  Volume 3, Issue 12, Page(s) 842–844

    MeSH term(s) Bronchopulmonary Dysplasia/classification ; Bronchopulmonary Dysplasia/mortality ; Bronchopulmonary Dysplasia/physiopathology ; Child ; Child, Preschool ; Clinical Decision Rules ; Gestational Age ; Humans ; Infant ; Infant, Newborn ; Neurodevelopmental Disorders/epidemiology ; Outcome Assessment, Health Care ; Severity of Illness Index ; Ventilation/methods ; Ventilation/statistics & numerical data ; Ventilator-Induced Lung Injury/complications ; Ventilator-Induced Lung Injury/epidemiology
    Language English
    Publishing date 2019-10-01
    Publishing country England
    Document type Journal Article
    ISSN 2352-4650
    ISSN (online) 2352-4650
    DOI 10.1016/S2352-4642(19)30321-9
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  8. Article ; Online: Nasal high flow therapy for neonates: Current evidence and future directions.

    Hodgson, Kate A / Davis, Peter G / Owen, Louise S

    Journal of paediatrics and child health

    2019  Volume 55, Issue 3, Page(s) 285–290

    Abstract: Nasal high flow (nHF) therapy is a commonly used method of providing non-invasive respiratory support for neonates. It has several potential mechanisms of action: continuous distending pressure, nasopharyngeal dead space washout, provision of heated and ... ...

    Abstract Nasal high flow (nHF) therapy is a commonly used method of providing non-invasive respiratory support for neonates. It has several potential mechanisms of action: continuous distending pressure, nasopharyngeal dead space washout, provision of heated and humidified gases and reduction of work of breathing. nHF is used in a number of clinical scenarios for preterm and term infants, including primary respiratory and post-extubation support. In recent years, large trials have generated evidence pertinent to these indications. Novel applications for nHF in neonates warrant further research: during endotracheal intubation, for initial delivery room stabilisation of preterm infants and in conjunction with minimally invasive surfactant therapy.
    MeSH term(s) Administration, Intranasal ; Humans ; Infant, Newborn ; Infant, Premature ; Oxygen Inhalation Therapy/methods
    Language English
    Publishing date 2019-01-07
    Publishing country Australia
    Document type Journal Article ; Review
    ZDB-ID 1024476-1
    ISSN 1440-1754 ; 1034-4810
    ISSN (online) 1440-1754
    ISSN 1034-4810
    DOI 10.1111/jpc.14374
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  9. Article ; Online: High-flow nasal cannula: Mechanisms, evidence and recommendations.

    Manley, Brett J / Owen, Louise S

    Seminars in fetal & neonatal medicine

    2016  Volume 21, Issue 3, Page(s) 139–145

    Abstract: The use of high-flow nasal cannula (HF) therapy as respiratory support for preterm infants is rapidly increasing, due to its perceived ease of use and other potential benefits over the standard 'non-invasive' respiratory support, continuous positive ... ...

    Abstract The use of high-flow nasal cannula (HF) therapy as respiratory support for preterm infants is rapidly increasing, due to its perceived ease of use and other potential benefits over the standard 'non-invasive' respiratory support, continuous positive airway pressure (CPAP). The evidence from randomized trials suggests that HF is an alternative to CPAP for post-extubation support of preterm infants. Limited data are available from randomized trials comparing HF with CPAP as primary support, and few trials have included extremely preterm infants. This review discusses the proposed mechanisms of action of HF, the evidence from clinical trials of HF use in preterm infants, and proposes recommendations for evidence-based practice.
    MeSH term(s) Continuous Positive Airway Pressure/instrumentation ; Continuous Positive Airway Pressure/methods ; Humans ; Infant, Newborn ; Respiratory Distress Syndrome, Newborn/therapy ; Treatment Outcome
    Language English
    Publishing date 2016
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2174416-6
    ISSN 1878-0946 ; 1744-165X
    ISSN (online) 1878-0946
    ISSN 1744-165X
    DOI 10.1016/j.siny.2016.01.002
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    Zs.A 4798: Show issues Location:
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  10. Article ; Online: Nasal intermittent positive pressure ventilation in preterm infants: Equipment, evidence, and synchronization.

    Owen, Louise S / Manley, Brett J

    Seminars in fetal & neonatal medicine

    2016  Volume 21, Issue 3, Page(s) 146–153

    Abstract: The use of nasal intermittent positive pressure ventilation (NIPPV) as respiratory support for preterm infants is well established. Evidence from randomized trials indicates that NIPPV is advantageous over continuous positive airway pressure (CPAP) as ... ...

    Abstract The use of nasal intermittent positive pressure ventilation (NIPPV) as respiratory support for preterm infants is well established. Evidence from randomized trials indicates that NIPPV is advantageous over continuous positive airway pressure (CPAP) as post-extubation support, albeit with varied outcomes between NIPPV techniques. Randomized data comparing NIPPV with CPAP as primary support, and for the treatment of apnea, are conflicting. Intrepretation of outcomes is limited by the multiple techniques and devices used to generate and deliver NIPPV. This review discusses the potential mechanisms of action of NIPPV in preterm infants, the evidence from clinical trials, and summarizes recommendations for practice.
    MeSH term(s) Animals ; Humans ; Infant, Newborn ; Intermittent Positive-Pressure Ventilation/instrumentation ; Intermittent Positive-Pressure Ventilation/methods ; Respiratory Distress Syndrome, Newborn/therapy
    Language English
    Publishing date 2016-06
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2174416-6
    ISSN 1878-0946 ; 1744-165X
    ISSN (online) 1878-0946
    ISSN 1744-165X
    DOI 10.1016/j.siny.2016.01.003
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