LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 467

Search options

  1. Article: Determination of sediment sources following a major wildfire and evaluation of the use of color properties and polycyclic aromatic hydrocarbons (PAHs) as tracers.

    Kieta, K A / Owens, P N / Petticrew, E L

    Journal of soils and sediments

    2023  Volume 23, Issue 12, Page(s) 4187–4207

    Abstract: Purpose: This research aimed to determine if a severe wildfire caused changes in the source of sediment being delivered to downstream aquatic systems and evaluate the use of polycyclic aromatic hydrocarbons (PAHs) and color properties as tracers.: ... ...

    Abstract Purpose: This research aimed to determine if a severe wildfire caused changes in the source of sediment being delivered to downstream aquatic systems and evaluate the use of polycyclic aromatic hydrocarbons (PAHs) and color properties as tracers.
    Methods: Sediment samples were collected from 2018 to 2021 in three tributaries impacted by the 2018 Shovel Lake wildfire and from two sites on the mainstem of the Nechako River, British Columbia. Source samples were collected from burned and unburned soils as well as from channel banks and road-deposited sediment. Samples were analyzed for color properties and for the 16 US Environmental Protection Agency priority PAHs. After statistical tests to determine the conservatism and ability to discriminate between sources by the tracers, the MixSIAR unmixing model was used, and its outputs were tested using virtual mixtures.
    Result: In the tributaries, burned topsoil was an important contributor to sediment (up to 50%). The mainstem Nechako River was not influenced as significantly by the fires as the greatest contributor was banks (up to 89%). The color properties provided more realistic results than those based on PAHs.
    Conclusion: In smaller watersheds, the wildfire had a noticeable impact on sediment sources, though the impacts of the fire seemed to be diluted in the distal mainstem Nechako River. Color tracers behaved conservatively and discriminated between contrasting sources. Due to their low cost and reliability, they should be considered more widely. While PAHs did not work in this study, there are reasons to believe they could be a useful tracer, but more needs to be understood about their behavior and degradation over time.
    Supplementary information: The online version contains supplementary material available at 10.1007/s11368-023-03565-0.
    Language English
    Publishing date 2023-07-04
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2050898-0
    ISSN 1614-7480 ; 1439-0108
    ISSN (online) 1614-7480
    ISSN 1439-0108
    DOI 10.1007/s11368-023-03565-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Bonn / Germany

    Z 7702: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Article ; Online: Therapeutics targeting the metastatic breast cancer bone microenvironment.

    Ihle, Claire L / Wright-Hobart, Sabrina J / Owens, Philip

    Pharmacology & therapeutics

    2022  Volume 239, Page(s) 108280

    Abstract: Breast cancer (BC) patient prognosis has improved over the past 2 decades with a 99% 5-year survival rate for localized BC, yet metastatic breast cancer (mBC) continues to cause high mortality with a 5-year survival rate of 29%. Approximately 70% of BC ... ...

    Abstract Breast cancer (BC) patient prognosis has improved over the past 2 decades with a 99% 5-year survival rate for localized BC, yet metastatic breast cancer (mBC) continues to cause high mortality with a 5-year survival rate of 29%. Approximately 70% of BC metastases occur in the bone, with estrogen receptor (ER) positive BC exhibiting a particular affinity to bone. Once BC metastasizes to the bone, curative treatments are not available, thus therapeutic approaches are focused on palliative care and prevention of skeletal related events while attempting to slow metastatic progression. Recent advances in molecularly targeted agents have enhanced the repertoire of options for mBC patients, but immunotherapies have not yet been fully translated to ER+ tumors. Thus mBC patients have yet to fully benefit from novel therapies, which is currently obstructing patient survival. The unique tumor microenvironment (TME) of mBC in bone offers an array of targets for therapeutic development. The mBC TME in bone presents a predominantly osteolytic or destructive bone pathology, where bone mineral loss is driven by increased resorption of bone by osteoclasts. We discuss therapeutics targeting the mBC cells, bone cells, immune cells, and other stromal cells in the bone TME, including treatments that are currently used in the clinic, under development, and are potential new avenues for therapy. Therapeutic advancements targeting the TME of mBC in bone could be applied to other bone-resident cancers, including myeloma and metastatic prostate cancer bone lesions. These precision oncology approaches to mBC treatment will improve the quality of life and clinical outcomes of patients with mBC bone lesions.
    MeSH term(s) Male ; Humans ; Tumor Microenvironment ; Breast Neoplasms/drug therapy ; Breast Neoplasms/pathology ; Quality of Life ; Precision Medicine ; Bone Neoplasms/drug therapy ; Bone Neoplasms/pathology
    Language English
    Publishing date 2022-09-16
    Publishing country England
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 194735-7
    ISSN 1879-016X ; 0163-7258
    ISSN (online) 1879-016X
    ISSN 0163-7258
    DOI 10.1016/j.pharmthera.2022.108280
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1183: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Integrating the immune microenvironment of prostate cancer induced bone disease.

    Ihle, Claire L / Owens, Philip

    Molecular carcinogenesis

    2020  Volume 59, Issue 7, Page(s) 822–829

    Abstract: Prostate cancer (PCa) is the most frequently diagnosed cancer for men in the U.S. but does not impede patient survival until the disease is metastatic. Metastatic lesions most frequently occur in the bone, which exhibits a distinct microenvironment of ... ...

    Abstract Prostate cancer (PCa) is the most frequently diagnosed cancer for men in the U.S. but does not impede patient survival until the disease is metastatic. Metastatic lesions most frequently occur in the bone, which exhibits a distinct microenvironment of immune and bone cell populations. Advances in the diagnosis and treatment of primary PCa allow for the use of tailored therapeutic approaches based on biomarkers, protein expression, and histopathology. Understanding the molecular and cellular characteristics of primary tumors has advanced therapeutic development and survival for patients with PCa. Personalized medicine has only recently emerged for the treatment of metastatic bone lesions. Tumor induced bone disease (TIBD) in patients with PCa can be classified into lytic, blastic, or mixed pathologies, with most patients exhibiting the blastic phenotype. Progress has been made in treating TIBD, but metastatic PCa has yet to be cured. Immune checkpoint inhibitors have exhibited limited responses in immunosuppressive PCa tumors, but have yet to be assessed in metastatic sites which may be susceptible to an increased inflammatory response. Recent discoveries have uncovered distinct tumor microenvironments (TMEs) of blastic and lytic bone metastases from patients with PCa, identifying actionable targets for therapeutic applications, including immune checkpoint inhibitors and targeted therapeutics. Enrichment for macrophages and T cells in patient samples suggests metastatic sites may be reappraised as immunologically targetable, despite their immunologically "cold" primary tumors. The practice of performing bone biopsies will help identify unique cellular and protein targets in the bone TME that can guide therapy decisions.
    MeSH term(s) Animals ; Bone Neoplasms/immunology ; Bone Neoplasms/pathology ; Bone Neoplasms/secondary ; Humans ; Male ; Prostatic Neoplasms/immunology ; Prostatic Neoplasms/pathology ; T-Lymphocytes/immunology ; Tumor Microenvironment/immunology
    Language English
    Publishing date 2020-03-31
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 1004029-8
    ISSN 1098-2744 ; 0899-1987
    ISSN (online) 1098-2744
    ISSN 0899-1987
    DOI 10.1002/mc.23192
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2664: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Post-wildfire contamination of soils and sediments by polycyclic aromatic hydrocarbons in north-central British Columbia, Canada

    Kieta, K. A. / Owens, P. N. / Petticrew, E. L.

    International Journal of Wildland Fire. 2023, v. 32, no. 7 p.1071-1088

    2023  

    Abstract: Background The Nechako River Basin (NRB) is a large, regulated basin in north-central British Columbia, Canada that has been impacted by numerous landscape disturbances, including a severe wildfire in 2018. Aims The aims of this study were to quantify ... ...

    Abstract Background The Nechako River Basin (NRB) is a large, regulated basin in north-central British Columbia, Canada that has been impacted by numerous landscape disturbances, including a severe wildfire in 2018. Aims The aims of this study were to quantify the post-wildfire temporal and spatial extent of contamination by polycyclic aromatic hydrocarbons (PAHs) of both soils and riverine sediments, and to identify the primary sources of PAHs in the watershed. Methods Soil samples were collected at burned and unburned sites in 2018 and at the burned sites in 2020 and 2021. Sediment samples were collected at three tributaries impacted by wildfire and three Nechako River mainstem (i.e. main channel) sites from 2018 to 2021. Samples were analysed for parent PAHs. Key results PAH concentrations decreased in soil samples from 2018 to 2021 but are not below the concentrations found in unburned samples. Tributary sediment samples showed higher concentrations immediately post-fire relative to the mainstem Nechako River, but in the years since, that trend has reversed. Conclusions PAHs persist in terrestrial and aquatic environments for years following wildfire, but at concentrations below various quality guidelines. PAHs were primarily derived from the wildfires, with some mixed sources at the downstream sites. Implications Wildfires are an important source of environmental contamination of terrestrial and aquatic environments.
    Keywords basins ; landscapes ; pollution ; riparian areas ; rivers ; sediments ; soil ; watersheds ; wildfires ; British Columbia ; Nechako River Basin ; polycyclic aromatic hydrocarbons ; post-wildfire contamination ; regional scale ; soils ; soil pollutants ; suspended sediment ; water pollutants ; water quality ; watershed
    Language English
    Size p. 1071-1088.
    Publishing place CSIRO Publishing
    Document type Article ; Online
    ZDB-ID 1331562-6
    ISSN 1448-5516 ; 1049-8001
    ISSN (online) 1448-5516
    ISSN 1049-8001
    DOI 10.1071/WF22211
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    In stock of ZB MED Bonn / Germany

    Z 6872: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Article ; Online: Characterization of nutrient runoff from perennial and annual forages following broiler litter application

    Katuwal, S. / Ashworth, A. J. / Moore, P. A., Jr / Owens, P. R.

    Journal of Environmental Quality. 2023 Jan., v. 52, no. 1 p.88-99

    2023  

    Abstract: Information on how forage species influence sediment and nutrient transport in runoff is required for limiting non‐point source pollution from broiler litter applications. In this study, we examined the effects of five forage species (eastern gamagrass [ ... ...

    Abstract Information on how forage species influence sediment and nutrient transport in runoff is required for limiting non‐point source pollution from broiler litter applications. In this study, we examined the effects of five forage species (eastern gamagrass [Tripsacum dactyloides (L.) L.], Kernza [Thinopyrum intermedium (Host) Barkworth & D.R. Dewey], silphium [Silphium integrifolium Michx.], switchgrass [Panicum virgatum L.], and winter wheat [Triticum aestivum L.]) on runoff nutrient losses from broiler litter–amended (5.6 Mg ha⁻¹) and non‐amended plots (control) following four simulated rainfall (5 cm h⁻¹) events that were applied to these plots in late spring and early fall of 2019 and 2021. Runoff collected for 30 min was analyzed for total suspended solids (TSS) and nutrients (total organic carbon [TOC], soluble reactive phosphorus [SRP], total dissolved phosphorus [TDP], total phosphorus [TP], total nitrogen [TN], ammonium‐nitrogen [NH₄–N], and nitrate‐nitrogen [NO₃–N]). Total sediment and nutrient losses increased 5‐ to 19‐fold following litter application for all species, which reduced to background levels during fall rainfall events. Across the four simulated rainfall events, switchgrass resulted in lower cumulative losses of TSS, TOC, SRP, TDP, TP, and NO₃–N than gamagrass and wheat but did not differ from Kernza and silphium for litter‐amended treatments. The performance of newly introduced perennial crops (Kernza and silphium) was similar or better than that of gamagrass in terms of cumulative runoff sediment and nutrient losses. Results show high potential for Kernza, silphium, and switchgrass to improve water quality when used in forage–vegetative filter strip systems.
    Keywords Panicum virgatum ; Silphium ; Thinopyrum intermedium ; Tripsacum dactyloides ; Triticum aestivum ; ammonium nitrogen ; autumn ; forage ; nitrate nitrogen ; nonpoint source pollution ; nutrient transport ; poultry manure ; rain ; rainfall simulation ; reactive phosphorus ; runoff ; sediments ; spring ; total dissolved phosphorus ; total nitrogen ; total organic carbon ; water quality ; winter wheat
    Language English
    Dates of publication 2023-01
    Size p. 88-99.
    Publishing place John Wiley & Sons, Ltd
    Document type Article ; Online
    Note JOURNAL ARTICLE
    ZDB-ID 120525-0
    ISSN 1537-2537 ; 0047-2425
    ISSN (online) 1537-2537
    ISSN 0047-2425
    DOI 10.1002/jeq2.20425
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    In stock of ZB MED Bonn / Germany

    Z 2687: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Article ; Online: Characterization of nutrient runoff from perennial and annual forages following broiler litter application.

    Katuwal, S / Ashworth, A J / Moore, P A / Owens, P R

    Journal of environmental quality

    2022  

    Abstract: Information on how forage species influence sediment and nutrient transport in runoff is required for limiting non-point source pollution from broiler litter applications. In this study, we examined the effects of five forage species (eastern gamagrass [ ... ...

    Abstract Information on how forage species influence sediment and nutrient transport in runoff is required for limiting non-point source pollution from broiler litter applications. In this study, we examined the effects of five forage species (eastern gamagrass [Tripsacum dactyloides (L.) L.], Kernza [Thinopyrum intermedium (Host) Barkworth & D.R. Dewey], silphium [Silphium integrifolium Michx.], switchgrass [Panicum virgatum L.], and winter wheat [Triticum aestivum L.]) on runoff nutrient losses from broiler litter-amended (5.6 Mg ha
    Language English
    Publishing date 2022-10-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 120525-0
    ISSN 1537-2537 ; 0047-2425
    ISSN (online) 1537-2537
    ISSN 0047-2425
    DOI 10.1002/jeq2.20425
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2958: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Multivariate evaluation of watershed health based on longitudinal pasture management.

    Ashworth, A J / Katuwal, S / Moore, P A / Owens, P R

    The Science of the total environment

    2022  Volume 824, Page(s) 153725

    Abstract: Watershed and pasture health is a transdisciplinary concern and crucial to promoting sustainable practices. The aim of this study is to identify effective systems-level conservation pasture management practices in a longitudinal study following 14 years ... ...

    Abstract Watershed and pasture health is a transdisciplinary concern and crucial to promoting sustainable practices. The aim of this study is to identify effective systems-level conservation pasture management practices in a longitudinal study following 14 years of consistent management by i) teasing apart complex relationships between multivariate water and soil quality using principal component analysis (PCA); and ii) identifying interactions among variables that contribute most to watershed health within catchments using partial least squares-path modeling (PLS-PM) based on five treatments: hayed (H), continuously grazed (CG), rotationally grazed (R), rotationally grazed with an unfertilized buffer strip (RB), and rotationally grazed with an unfertilized fenced riparian buffer (RBR). Over 14 years, H and RBR systems had greater watershed health based on runoff water quality parameters. Therefore, management systems that keep forage heights >10-cm, have less frequent vegetative removal, and riparian filter strips promote watershed health. Of the over 20 runoff variables measured over 14 study years, only electrical conductivity and annual total suspended solid loads constructed a significant water quality PLS-PM model. Water quality was positively influenced by pasture management and precipitation, with long-term pasture management driving runoff parameters and water quality. Overall, animal grazing days was not only related to grazing intensity, but to animal manure inputs and soil compaction, and adversely related to watershed health. Study results denote that best management strategies such as rotational grazing and riparian buffer strips prevent pasture system degradation and maintain carrying capacity while reducing anthropogenic pressure on soil and water systems.
    MeSH term(s) Animals ; Conservation of Natural Resources ; Longitudinal Studies ; Manure ; Soil ; Water Quality
    Chemical Substances Manure ; Soil
    Language English
    Publishing date 2022-02-09
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2022.153725
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 949: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Transient bilateral chorea secondary to digoxin toxicity in a female with acute kidney injury: a case report.

    Mannion, James / Tariq, Samreen / Owens, Patrick

    European heart journal. Case reports

    2021  Volume 5, Issue 2, Page(s) ytab022

    Abstract: Background: Chorea secondary to digoxin toxicity is rare, with only three published cases describing the phenomenon. We report the case of a 78-year-old female presenting with intermittent vomiting and diarrhoea for 4 weeks. She had a history of chronic ...

    Abstract Background: Chorea secondary to digoxin toxicity is rare, with only three published cases describing the phenomenon. We report the case of a 78-year-old female presenting with intermittent vomiting and diarrhoea for 4 weeks. She had a history of chronic kidney disease and digoxin use for atrial fibrillation.
    Case summary: A 78-year-old lady presented to the emergency department with a 4-week history of intermittent vomiting and diarrhoea. These symptoms commenced after a course of antibiotics prescribed by her general practitioner for a urinary tract infection. Her admission electrocardiogram demonstrated atrial fibrillation at a rate of 32, with evidence of digitalis toxicity. Her creatinine was 396 µmol/L (44-80 µmol/L) with digoxin level 8.1 nmol/L (0.77-1.5 nmol/L). Initially, treatment was with digoxin-specific antibody (FAB) and fluid resuscitation. Within 24 h, she developed transient head, neck, and bilateral upper limb chorea. Review of medications revealed no other likely causative agent. Neuroimaging showed no new ischaemia, but stable established bilateral infarcts of the basal ganglia. Haloperidol 0.5 mg twice daily was commenced. Three days later as digoxin levels normalized, the chorea resolved entirely without recurrence.
    Discussion: We have identified three reported cases of digoxin-induced chorea. Our case resembles two of the published cases where a transient bilateral chorea, associated with digitalis toxicity and resolving within a few days of normalization of digoxin levels was demonstrated. There were no other focal neurological signs or symptoms. It has been postulated that an alteration to dopaminergic neuronal activity is a potential mechanism, as digoxin also demonstrates neuropsychiatric side effects such as psychosis and depression.
    Language English
    Publishing date 2021-02-04
    Publishing country England
    Document type Case Reports
    ISSN 2514-2119
    ISSN (online) 2514-2119
    DOI 10.1093/ehjcr/ytab022
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  9. Article ; Online: Unique macrophage phenotypes activated by BMP signaling in breast cancer bone metastases.

    Ihle, Claire L / Straign, Desiree M / Canari, Johana A / Torkko, Kathleen C / Zolman, Kathryn L / Smith, Elizabeth E / Owens, Philip

    JCI insight

    2024  Volume 9, Issue 1

    Abstract: Metastatic breast cancer (mBC) tissue in bone was systematically profiled to define the composition of the tumor microenvironment. Gene expression identified a high myeloid signature of patients with improved survival outcomes. Bone metastases were ... ...

    Abstract Metastatic breast cancer (mBC) tissue in bone was systematically profiled to define the composition of the tumor microenvironment. Gene expression identified a high myeloid signature of patients with improved survival outcomes. Bone metastases were profiled by spatial proteomics to examine myeloid populations within the stroma that correlated with macrophage functions. Single-cell spatial analysis uncovered macrophage activation in the stroma of mBC bone lesions. Matched BC patient samples of primary breast tumor and bone metastasis tissues were compared for gene expression in the bone, where bone morphogenetic protein 2 (BMP2) was most significantly upregulated. Immune cell changes from breast to bone demonstrated a loss of lymphoid cells but a consistent population of macrophages. BMP-activated macrophages were increased uniquely in bone. Bone marrow-derived macrophage activation coupled with BMP inhibition increased inflammatory responses. Using experimental mouse models of mBC bone metastasis and trained immunity, we found that BMP inhibition restricts progression of metastases early in the macrophage activation state but not after tumors were established in the bone. This study revealed unique myeloid BMP activation states that are distinctly integrated with bone metastases.
    MeSH term(s) Animals ; Female ; Humans ; Mice ; Bone and Bones ; Bone Neoplasms/secondary ; Breast Neoplasms/pathology ; Macrophages ; Phenotype ; Tumor Microenvironment ; Bone Morphogenetic Proteins/metabolism
    Chemical Substances Bone Morphogenetic Proteins
    Language English
    Publishing date 2024-01-09
    Publishing country United States
    Document type Journal Article
    ISSN 2379-3708
    ISSN (online) 2379-3708
    DOI 10.1172/jci.insight.168517
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  10. Article ; Online: Do they stay, or do they go? Children presenting to five emergency departments across New South Wales, Australia with acute burn injuries: a retrospective review.

    Phillips, Wayne / Southern, Erin / Cattell, Carol / Owens, Penny / Jaques, Madeleine / Melbourne, Gregory / Kezhekkekara, Shwetha / Frost, Steven A

    BMJ open

    2024  Volume 14, Issue 3, Page(s) e079306

    Abstract: Objective: The overall objective of the study was to describe the disposition status of children presenting with a burn injury to five emergency departments (ED) across New South Wales (NSW), Australia.: Design: A retrospective study design was used ... ...

    Abstract Objective: The overall objective of the study was to describe the disposition status of children presenting with a burn injury to five emergency departments (ED) across New South Wales (NSW), Australia.
    Design: A retrospective study design was used to review routinely collected ED data.
    Setting: Study sites included five acute hospitals across NSW, Australia.
    Participants: During the 5-year study period between 1 January 2015 to 31 December 2020, there were 5213 paediatric burn injury presentations.
    Results: The mean age of burn injury presentations was 24 months (Inter-Quartile-Range (IQR) 12-84), of which 57% (2951/5213) were males. The most common presentation time was between 16:00 and 23:59 hours (63%, 3297/5213), and the median time spent in the ED was 3 hours (IQR 1-4). The majority (80%, 4196/5213) of the burn injuries presentations did not require hospital admission. The most common principal diagnoses were 'Burn body region unspecified' (n=1916) and 'Burn of wrist and hand' (n=1060).
    Conclusion: Most children who presented to the hospital with a burn injury were not admitted. Often the details of these burns were poorly recorded and a complete picture of the true burden of burn injury in children, especially the ongoing care given outside the acute hospital setting, is missing. This information is crucial, as it would inform future models of care as the paradigm shifts rapidly towards primary, ambulatory and outpatient models of care.
    MeSH term(s) Male ; Child ; Humans ; Child, Preschool ; Female ; Retrospective Studies ; New South Wales/epidemiology ; Burns/epidemiology ; Burns/therapy ; Australia ; Emergency Service, Hospital
    Language English
    Publishing date 2024-03-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2023-079306
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top