LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 6 of total 6

Search options

  1. Article ; Online: Association between mammillary body atrophy and memory impairment in retired athletes with a history of repetitive mild traumatic brain injury.

    Miyata, Mari / Takahata, Keisuke / Sano, Yasunori / Yamamoto, Yasuharu / Kurose, Shin / Kubota, Manabu / Endo, Hironobu / Matsuoka, Kiwamu / Tagai, Kenji / Oya, Masaki / Hirata, Kosei / Saito, Fumie / Mimura, Masaru / Kamagata, Koji / Aoki, Shigeki / Higuchi, Makoto

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 7129

    Abstract: Cognitive dysfunction, especially memory impairment, is a typical clinical feature of long-term symptoms caused by repetitive mild traumatic brain injury (rmTBI). The current study aims to investigate the relationship between regional brain atrophy and ... ...

    Abstract Cognitive dysfunction, especially memory impairment, is a typical clinical feature of long-term symptoms caused by repetitive mild traumatic brain injury (rmTBI). The current study aims to investigate the relationship between regional brain atrophy and cognitive impairments in retired athletes with a long history of rmTBI. Overall, 27 retired athletes with a history of rmTBI (18 boxers, 3 kickboxers, 2 wrestlers, and 4 others; rmTBI group) and 23 age/sex-matched healthy participants (control group) were enrolled. MPRAGE on 3 T MRI was acquired and segmented. The TBV and TBV-adjusted regional brain volumes were compared between groups, and the relationship between the neuropsychological test scores and the regional brain volumes were evaluated. Total brain volume (TBV) and regional brain volumes of the mammillary bodies (MBs), hippocampi, amygdalae, thalami, caudate nuclei, and corpus callosum (CC) were estimated using the SPM12 and ITK-SNAP tools. In the rmTBI group, the regional brain volume/TBV ratio (rmTBI vs. control group, Mann-Whitney U test, p < 0.05) underwent partial correlation analysis, adjusting for age and sex, to assess its connection with neuropsychological test results. Compared with the control group, the rmTBI group showed significantly lower the MBs volume/TBV ratio (0.13 ± 0.05 vs. 0.19 ± 0.03 × 10
    MeSH term(s) Humans ; Brain Concussion ; Mammillary Bodies ; Brain ; Memory Disorders/etiology ; Athletes/psychology ; Brain Injuries, Traumatic/complications
    Language English
    Publishing date 2024-03-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-57383-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Purpura on the truncus and extremities.

    Tanizaki, Ryutaro / Oya, Masaki / Takemura, Yousuke

    Emergency medicine journal : EMJ

    2016  Volume 34, Issue 3, Page(s) 174

    MeSH term(s) Adult ; Disseminated Intravascular Coagulation/etiology ; Down Syndrome/complications ; Down Syndrome/psychology ; Extremities/pathology ; Extremities/physiopathology ; Female ; Fever/etiology ; Humans ; Out-of-Hospital Cardiac Arrest/etiology ; Purpura Fulminans/complications ; Purpura Fulminans/diagnosis ; Sepsis/etiology ; Streptococcus pneumoniae/pathogenicity
    Language English
    Publishing date 2016-04-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2040124-3
    ISSN 1472-0213 ; 1472-0205
    ISSN (online) 1472-0213
    ISSN 1472-0205
    DOI 10.1136/emermed-2016-205777
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1941: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: An optimized reference tissue method for quantification of tau protein depositions in diverse neurodegenerative disorders by PET with

    Tagai, Kenji / Ikoma, Yoko / Endo, Hironobu / Debnath, Oiendrila Bhowmik / Seki, Chie / Matsuoka, Kiwamu / Matsumoto, Hideki / Oya, Masaki / Hirata, Kosei / Shinotoh, Hitoshi / Takahata, Keisuke / Kurose, Shin / Sano, Yasunori / Ono, Maiko / Shimada, Hitoshi / Kawamura, Kazunori / Zhang, Ming-Rong / Takado, Yuhei / Higuchi, Makoto

    NeuroImage

    2022  Volume 264, Page(s) 119763

    Abstract: Positron emission tomography (PET) ... ...

    Abstract Positron emission tomography (PET) with
    Language English
    Publishing date 2022-11-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1147767-2
    ISSN 1095-9572 ; 1053-8119
    ISSN (online) 1095-9572
    ISSN 1053-8119
    DOI 10.1016/j.neuroimage.2022.119763
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 3664: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 7: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Increased glutamate and glutamine levels and their relationship to astrocytes and dopaminergic transmissions in the brains of adults with autism.

    Oya, Masaki / Matsuoka, Kiwamu / Kubota, Manabu / Fujino, Junya / Tei, Shisei / Takahata, Keisuke / Tagai, Kenji / Yamamoto, Yasuharu / Shimada, Hitoshi / Seki, Chie / Itahashi, Takashi / Aoki, Yuta Y / Ohta, Haruhisa / Hashimoto, Ryu-Ichiro / Sugihara, Genichi / Obata, Takayuki / Zhang, Ming-Rong / Suhara, Tetsuya / Nakamura, Motoaki /
    Kato, Nobumasa / Takado, Yuhei / Takahashi, Hidehiko / Higuchi, Makoto

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 11655

    Abstract: Increased excitatory neuronal tones have been implicated in autism, but its mechanism remains elusive. The amplified glutamate signals may arise from enhanced glutamatergic circuits, which can be affected by astrocyte activation and suppressive signaling ...

    Abstract Increased excitatory neuronal tones have been implicated in autism, but its mechanism remains elusive. The amplified glutamate signals may arise from enhanced glutamatergic circuits, which can be affected by astrocyte activation and suppressive signaling of dopamine neurotransmission. We tested this hypothesis using magnetic resonance spectroscopy and positron emission tomography scan with
    MeSH term(s) Male ; Adult ; Humans ; Glutamine/metabolism ; Glutamic Acid/metabolism ; Autistic Disorder/metabolism ; Astrocytes/metabolism ; Dopamine/metabolism ; Brain/diagnostic imaging ; Brain/metabolism ; Gyrus Cinguli/diagnostic imaging ; Gyrus Cinguli/metabolism
    Chemical Substances Glutamine (0RH81L854J) ; Glutamic Acid (3KX376GY7L) ; Dopamine (VTD58H1Z2X)
    Language English
    Publishing date 2023-07-19
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-38306-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: A Machine Learning-Based Approach to Discrimination of Tauopathies Using [<sup>18</sup> F]PM-PBB3 PET Images.

    Endo, Hironobu / Tagai, Kenji / Ono, Maiko / Ikoma, Yoko / Oyama, Asaka / Matsuoka, Kiwamu / Kokubo, Naomi / Hirata, Kosei / Sano, Yasunori / Oya, Masaki / Matsumoto, Hideki / Kurose, Shin / Seki, Chie / Shimizu, Hiroshi / Kakita, Akiyoshi / Takahata, Keisuke / Shinotoh, Hitoshi / Shimada, Hitoshi / Tokuda, Takahiko /
    Kawamura, Kazunori / Zhang, Ming-Rong / Oishi, Kenichi / Mori, Susumu / Takado, Yuhei / Higuchi, Makoto

    Movement disorders : official journal of the Movement Disorder Society

    2022  Volume 37, Issue 11, Page(s) 2236–2246

    Abstract: Background: We recently developed a positron emission tomography (PET) probe, [ ... 18 ... F]PM-PBB3, to detect tau lesions in diverse tauopathies, including mixed three-repeat and four-repeat (3R + 4R) tau fibrils in Alzheimer's disease (AD) and 4R ... ...

    Abstract Background: We recently developed a positron emission tomography (PET) probe, [<sup>18</sup> F]PM-PBB3, to detect tau lesions in diverse tauopathies, including mixed three-repeat and four-repeat (3R + 4R) tau fibrils in Alzheimer's disease (AD) and 4R tau aggregates in progressive supranuclear palsy (PSP). For wider availability of this technology for clinical settings, bias-free quantitative evaluation of tau images without a priori disease information is needed.
    Objective: We aimed to establish tau PET pathology indices to characterize PSP and AD using a machine learning approach and test their validity and tracer capabilities.
    Methods: Data were obtained from 50 healthy control subjects, 46 patients with PSP Richardson syndrome, and 37 patients on the AD continuum. Tau PET data from 114 regions of interest were subjected to Elastic Net cross-validation linear classification analysis with a one-versus-the-rest multiclass strategy to obtain a linear function that discriminates diseases by maximizing the area under the receiver operating characteristic curve. We defined PSP- and AD-tau scores for each participant as values of the functions optimized for differentiating PSP (4R) and AD (3R + 4R), respectively, from others.
    Results: The discriminatory ability of PSP- and AD-tau scores assessed as the area under the receiver operating characteristic curve was 0.98 and 1.00, respectively. PSP-tau scores correlated with the PSP rating scale in patients with PSP, and AD-tau scores correlated with Mini-Mental State Examination scores in healthy control-AD continuum patients. The globus pallidus and amygdala were highlighted as regions with high weight coefficients for determining PSP- and AD-tau scores, respectively.
    Conclusions: These findings highlight our technology's unbiased capability to identify topologies of 3R + 4R versus 4R tau deposits. © 2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
    MeSH term(s) Humans ; tau Proteins/metabolism ; Brain/pathology ; Tauopathies/diagnostic imaging ; Tauopathies/pathology ; Supranuclear Palsy, Progressive/pathology ; Positron-Emission Tomography ; Alzheimer Disease/diagnostic imaging ; Alzheimer Disease/pathology ; Movement Disorders ; Machine Learning
    Chemical Substances tau Proteins
    Language English
    Publishing date 2022-08-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 607633-6
    ISSN 1531-8257 ; 0885-3185
    ISSN (online) 1531-8257
    ISSN 0885-3185
    DOI 10.1002/mds.29173
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2555: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 238: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article: [Levels of serum ascorbate and its metabolites in hemodialysis patients].

    Hirano, Hiroko / Tone, Yoshinori / Otani, Haruhisa / Oya, Masaki / Kimura, Keigo / Saika, Yasushi / Fujii, Ryoichi / Mune, Masatoshi / Ichinose, Masakazu / Yukawa, Susumu

    Nihon Jinzo Gakkai shi

    2004  Volume 46, Issue 5, Page(s) 426–433

    Abstract: The status of ascorbic acid (AA) in dialysis patients is the subject of debate. Some reports have found AA to be deficient in dialysis patients, while others have found that AA is not deficient. In an attempt to confirm AA serum concentrations in ... ...

    Abstract The status of ascorbic acid (AA) in dialysis patients is the subject of debate. Some reports have found AA to be deficient in dialysis patients, while others have found that AA is not deficient. In an attempt to confirm AA serum concentrations in dialysis patients, we analyzed the concentrations of AA as well as its metabolites using the specific determination of AA with chemical derivatization and the HPLC method. We studied 131 patients under maintenance hemodialysis therapy (HD), 23 patients with chronic renal failure (CRF) and 48 healthy controls (C). Serum concentrations of AA and the AA metabolites dehydroascorbic acid (DHA) and 2, 3-diketogulonate (DKG) were measured by HPLC. Nine HD patients were taking AA supplements. Seventy-six (62.3%) of the 122 HD patients not taking AA supplements exhibited deficient levels of AA (< 20 microM), while 13 (56.5%) of the 23 CRF patients and 9 (18.8%) of the 48 C showed deficient levels of AA. Analysis of AA metabolites in the normal-range AA (20-80 microM) group revealed that the DHA/AA ratio in HD patients was significantly higher than in C (3.3 +/- 2.6% and 1.2 +/- 2.2%, respectively). The DKG/AA ratio in HD patients was higher than in CRF patients (3.6 +/- 5.2% vs. 0.9 +/- 1.9%), whereas DKG was not detected in C. When compared to serum levels before the start of dialysis, serum AA, DHA and DKG concentrations at the end of the dialysis session decreased by an average of 74.2, 84.0 and 78.8% respectively. In HD patients, serum levels of thiobarbituric reactive substances (TBARS) were significantly lower in the higher AA (> 80 microM) group than in the deficient and normal-range AA groups. In 12 AA-deficient patients, after 1 month of taking AA supplements (200 mg/day), serum AA levels rose to 79.9 microM, while serum TBARS level declined when compared with levels before supplementation. In conclusion, the frequency of AA deficiency in dialysis patients is extremely high. AA deficiency in HD patients may result in high TBARS levels, which reflect increased oxidative stress. Adequate AA supplementation should therefore be considered in such patients.
    MeSH term(s) 2,3-Diketogulonic Acid/blood ; Administration, Oral ; Aged ; Aorta/pathology ; Ascorbic Acid/administration & dosage ; Ascorbic Acid/blood ; Ascorbic Acid Deficiency/etiology ; Calcinosis ; Calcium Oxalate/blood ; Chromatography, High Pressure Liquid ; Dehydroascorbic Acid/blood ; Female ; Humans ; Kidney Failure, Chronic/blood ; Kidney Failure, Chronic/pathology ; Male ; Middle Aged ; Oxidative Stress ; Renal Dialysis/adverse effects ; Thiobarbituric Acid Reactive Substances
    Chemical Substances Thiobarbituric Acid Reactive Substances ; Calcium Oxalate (2612HC57YE) ; 2,3-Diketogulonic Acid (3409-57-2) ; Ascorbic Acid (PQ6CK8PD0R) ; Dehydroascorbic Acid (Y2Z3ZTP9UM)
    Language Japanese
    Publishing date 2004-07
    Publishing country Japan
    Document type English Abstract ; Journal Article
    ZDB-ID 1195538-7
    ISSN 0385-2385
    ISSN 0385-2385
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1383: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top