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Article: Pralidoxime.

Ozawa, Akiko

Chudoku kenkyu : Chudoku Kenkyukai jun kikanshi = The Japanese journal of toxicology

2018 Volume 29, Issue 4, Page(s) 371–377

MeSH term(s)	Antidotes/adverse effects ; Antidotes/chemistry ; Antidotes/pharmacology ; Pralidoxime Compounds/adverse effects ; Pralidoxime Compounds/chemistry ; Pralidoxime Compounds/pharmacology
Chemical Substances	Antidotes ; Pralidoxime Compounds ; pralidoxime (P7MU9UTP52)
Language	Japanese
Publishing date	2018-11-21
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1154823-x
ISSN	0914-3777
ISSN	0914-3777
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Article: Oxytocin neurons in the paraventricular nucleus of the hypothalamus circuit-dependently regulates social behavior, which malfunctions in BTBR mouse model of autism.

Arakawa, Hiroyuki / Higuchi, Yuki / Ozawa, Akihiko

Research square

2023

Abstract: Oxytocin (OXT) a neuropeptide synthesized in the hypothalamic nuclei has a variety of function including socio-emotional processes in mammals. While the neural circuits and signaling pathways in central OXT converge in the paraventricular nucleus of the ... ...

Abstract	Oxytocin (OXT) a neuropeptide synthesized in the hypothalamic nuclei has a variety of function including socio-emotional processes in mammals. While the neural circuits and signaling pathways in central OXT converge in the paraventricular nucleus of the hypothalamus (PVN), we illuminate specific function of discrete PVN OXT circuits, which connect to the medial amygdala (MeA) and the bed nucleus of the stria terminalis (BnST) in mouse models. The OXT
Language	English
Publishing date	2023-03-01
Publishing country	United States
Document type	Preprint
DOI	10.21203/rs.3.rs-2621359/v1
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Article ; Online: Feedback-induced desynchronization and oscillation quenching in a population of globally coupled oscillators.

Ozawa, Ayumi / Kori, Hiroshi

Physical review. E

2021 Volume 103, Issue 6-1, Page(s) 62217

Abstract: Motivated from a wide range of applications, various methods to control synchronization in coupled oscillators have been proposed. Previous studies have demonstrated that global feedback typically induces three macroscopic behaviors: synchronization, ... ...

Abstract	Motivated from a wide range of applications, various methods to control synchronization in coupled oscillators have been proposed. Previous studies have demonstrated that global feedback typically induces three macroscopic behaviors: synchronization, desynchronization, and oscillation quenching. However, analyzing all of these transitions within a single theoretical framework is difficult, and thus the feedback effect is only partially understood in each framework. Herein, we analyze a model of globally coupled phase oscillators exposed to global feedback, which shows all of the typical macroscopic dynamical states. Analytical tractability of the model enables us to obtain detailed phase diagrams where transitions and bistabilities between different macroscopic states are identified. Additionally, we propose strategies to steer the oscillators into targeted states with minimal feedback strength. Our study provides a useful overview of the effect of global feedback and is expected to serve as a benchmark when more sophisticated feedback needs to be designed.
Language	English
Publishing date	2021-07-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	2844562-4
ISSN	2470-0053 ; 2470-0045
ISSN (online)	2470-0053
ISSN	2470-0045
DOI	10.1103/PhysRevE.103.062217
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Article ; Online: Chemogenetics drives paradigm change in the investigation of behavioral circuits and neural mechanisms underlying drug action.

Ozawa, Akihiko / Arakawa, Hiroyuki

Behavioural brain research

2021 Volume 406, Page(s) 113234

Abstract: Recent developments in chemogenetic approaches to the investigation of brain function have ushered in a paradigm change in the strategy for drug and behavior research and clinical drug-based medications. As the nature of the drug action is based on ... ...

Abstract	Recent developments in chemogenetic approaches to the investigation of brain function have ushered in a paradigm change in the strategy for drug and behavior research and clinical drug-based medications. As the nature of the drug action is based on humoral regulation, it is a challenge to identify the neuronal mechanisms responsible for the expression of certain targeted behavior induced by drug application. The development of chemogenetic approaches has allowed researchers to control neural activities in targeted neurons through a toolbox, including engineered G protein-coupled receptors or ligand-gated ion channels together with exogenously inert synthetic ligands. This review provides a brief overview of the chemogenetics toolbox with an emphasis on the DREADDs (Designer Receptors Exclusively Activated by Designer Drugs) technique used in rodent models, which is applicable to the investigation of how specific neural circuits regulate behavioral processes. The use of chemogenetics has had a significant impact on basic neuroscience for a better understanding of the relationships between brain activity and the expression of behaviors with cell- and circuit-specific orders. Furthermore, chemogenetics is potentially a useful tool to deconstruct the neuropathological mechanisms of mental diseases and its regulation by drug, and provide us with transformative therapeutics with medication. We also review recent findings in the use of chemogenetic techniques to uncover functional circuit connections of serotonergic neurons in rodent models.
MeSH term(s)	Animals ; Behavior, Animal/drug effects ; Disease Models, Animal ; Drug Design ; Genetic Techniques ; Genetic Vectors ; Ligand-Gated Ion Channels ; Mice ; Molecular Targeted Therapy ; Neurotransmitter Agents ; Pharmacogenetics ; Protein Engineering ; Psychopharmacology ; Receptors, G-Protein-Coupled
Chemical Substances	Ligand-Gated Ion Channels ; Neurotransmitter Agents ; Receptors, G-Protein-Coupled
Language	English
Publishing date	2021-03-16
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	449927-x
ISSN	1872-7549 ; 0166-4328
ISSN (online)	1872-7549
ISSN	0166-4328
DOI	10.1016/j.bbr.2021.113234
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Book ; Online: Effective Tight-Binding Model of Compensated Ferrimagnetic Weyl Semimetal with Spontaneous Orbital Magnetization

Meguro, Tomonari / Ozawa, Akihiro / Kobayashi, Koji / Nomura, Kentaro

2023

Abstract: The effective tight-binding model with compensated ferrimagnetic inverse-Heusler lattice Ti$_{2}$MnAl, candidate material of magnetic Weyl semimetal, is proposed. The energy spectrum near the Fermi level, the configurations of the Weyl points, and the ... ...

Abstract	The effective tight-binding model with compensated ferrimagnetic inverse-Heusler lattice Ti$_{2}$MnAl, candidate material of magnetic Weyl semimetal, is proposed. The energy spectrum near the Fermi level, the configurations of the Weyl points, and the anomalous Hall conductivity are calculated. We found that the orbital magnetization is finite, while the total spin magnetization vanishes, at the energy of the Weyl points. The magnetic moments at each site are correlated with the orbital magnetization, and can be controlled by the external magnetic field. Comment: 8 pages, 5 figures
Keywords	Condensed Matter - Mesoscale and Nanoscale Physics ; Condensed Matter - Materials Science
Publishing date	2023-04-27
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online: Self-consistent Analysis of Doping Effect for Magnetic Ordering in Stacked-Kagome Weyl System

Ozawa, Akihiro / Nomura, Kentaro

2021

Abstract: We theoretically study the carrier doping effect for magnetism in a stacked-kagome system $\rm{{Co}_3{Sn}_2{S}_2}$ based on an effective model and the Hartree-Fock method. We show the electron filling and temperature dependences of the magnetic order ... ...

Abstract	We theoretically study the carrier doping effect for magnetism in a stacked-kagome system $\rm{{Co}_3{Sn}_2{S}_2}$ based on an effective model and the Hartree-Fock method. We show the electron filling and temperature dependences of the magnetic order parameter. The perpendicular ferromagnetic ordering is suppressed by hole doping, wheres undoped $\rm{{Co}_3{Sn}_2{S}_2}$ shows magnetic Weyl semimetal state. Additionally, in the electron-doped regime, we find a non-collinear antiferromagnetic ordering. Especially, in the non-collinear antiferromagnetic state, by considering a certain spin-orbit coupling, the finite orbital magnetization and the anomalous Hall conductivity are obtained. Comment: 7 pages, 4 figures
Keywords	Condensed Matter - Materials Science
Publishing date	2021-10-18
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: New decolorization method produces more information from tissue sections stained with hematoxylin and eosin stain and masson-trichrome stain.

Ozawa, Aisa / Sakaue, Motoharu

Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft

2019 Volume 227, Page(s) 151431

Abstract: Histological analysis is a fundamental and principal method used in biological research and even for disease diagnosis. The result shows the status of cells and tissues in organs and enables us to infer the condition of the whole body. The tissue ... ...

Abstract	Histological analysis is a fundamental and principal method used in biological research and even for disease diagnosis. The result shows the status of cells and tissues in organs and enables us to infer the condition of the whole body. The tissue staining method known as hematoxylin and eosin staining (HE) is one of the most general methods of investigating the status of cells and tissues. Hematoxylin stains the nucleus violet and eosin stains cytosol pink. HE staining shows the unique morphologies of tissues and cells. However, after being stained with HE, tissues are very difficult to use in another histological analysis because hematoxylin is hard to remove from the sections due to its stain stability. Therefore, serial sections of the tissue are used to obtain more information through another staining, including immunohistochemistry. The adjacent tissue section is not the same as the HE-stained section, however, so the results from the adjacent sections can cause confusion or ambiguity. The present study showed that our decolorization solution can decolor the hematoxylin or iron hematoxylin stain from stained structures, including the nucleus, and the decolored section could be stained again in another staining, including immunohistochemistry. This decolorization method is very valuable, in that it can determine the accurate distribution of substances and features in cells and tissues, and thus it can improve the robustness of the resulting data.
MeSH term(s)	Animals ; Azo Compounds/metabolism ; Carboxylic Acids/chemistry ; Chelating Agents/chemistry ; Coloring Agents/metabolism ; Eosine Yellowish-(YS)/metabolism ; Fluorescent Dyes/metabolism ; Hematoxylin/metabolism ; Immunohistochemistry ; Methyl Green/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Inbred ICR ; Microscopy, Fluorescence ; Phosphoric Acids/chemistry ; Silver Nitrate/metabolism ; Tromethamine/chemistry
Chemical Substances	Azo Compounds ; Carboxylic Acids ; Chelating Agents ; Coloring Agents ; Fluorescent Dyes ; Fontana-Masson stain ; Phosphoric Acids ; trichrome stain ; Tromethamine (023C2WHX2V) ; Methyl Green (82-94-0) ; Silver Nitrate (95IT3W8JZE) ; phosphoric acid (E4GA8884NN) ; Eosine Yellowish-(YS) (TDQ283MPCW) ; Hematoxylin (YKM8PY2Z55)
Language	English
Publishing date	2019-10-18
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1106738-x
ISSN	1618-0402 ; 0940-9602
ISSN (online)	1618-0402
ISSN	0940-9602
DOI	10.1016/j.aanat.2019.151431
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Article ; Online: The NOP Receptor System in Neurological and Psychiatric Disorders: Discrepancies, Peculiarities and Clinical Progress in Developing Targeted Therapies.

Toll, Lawrence / Cippitelli, Andrea / Ozawa, Akihiko

CNS drugs

2021 Volume 35, Issue 6, Page(s) 591–607

Abstract: The nociceptin opioid peptide (NOP) receptor and its endogenous ligand nociceptin/orphanin FQ (N/OFQ) are the fourth members of the opioid receptor and opioid peptide families. Although they have considerable sequence homology to the other family members, ...

Abstract	The nociceptin opioid peptide (NOP) receptor and its endogenous ligand nociceptin/orphanin FQ (N/OFQ) are the fourth members of the opioid receptor and opioid peptide families. Although they have considerable sequence homology to the other family members, they are not considered opioid per se because they do not have pharmacological profiles similar to the other family members. The number of NOP receptors in the brain is higher than the other family members, and NOP receptors can be found throughout the brain. Because of the widespread distribution of NOP receptors, N/OFQ and other peptide and small molecule agonists and antagonists have extensive CNS activities. Originally thought to be anti-opioid, NOP receptor agonists block some opioid activities, potentiate others, and modulate other activities not affected by traditional opiates. Because the effect of receptor activation can be dependent upon site of administration, state of the animal, and other variables, the study of NOP receptors has been fraught with contradictions and inconsistencies. In this article, the actions and controversies pertaining to NOP receptor activation and inhibition are discussed with respect to CNS disorders including pain (acute, chronic, and migraine), drug abuse, anxiety and depression. In addition, progress towards clinical use of NOP receptor-directed compounds is discussed.
MeSH term(s)	Animals ; Central Nervous System Diseases/drug therapy ; Central Nervous System Diseases/physiopathology ; Drug Development ; Humans ; Mental Disorders/drug therapy ; Mental Disorders/physiopathology ; Molecular Targeted Therapy ; Opioid Peptides/metabolism ; Receptors, Opioid/metabolism ; Nociceptin Receptor ; Nociceptin
Chemical Substances	Opioid Peptides ; Receptors, Opioid ; Nociceptin Receptor ; OPRL1 protein, human
Language	English
Publishing date	2021-05-31
Publishing country	New Zealand
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	1203800-3
ISSN	1179-1934 ; 1172-7047
ISSN (online)	1179-1934
ISSN	1172-7047
DOI	10.1007/s40263-021-00821-0
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Article ; Online: Mixed-Lineage Leukaemia Gene Regulates Glucose-Sensitive Gene Expression and Insulin Secretion in Pancreatic Beta Cells.

Yoshino, Satoshi / Ishida, Emi / Horiguchi, Kazuhiko / Matsumoto, Shunichi / Nakajima, Yasuyo / Ozawa, Atsushi / Yamada, Masanobu / Yamada, Eijiro

International journal of molecular sciences

2024 Volume 25, Issue 9

Abstract: The escalating prevalence of diabetes mellitus underscores the need for a comprehensive understanding of pancreatic beta cell function. Interest in glucose effectiveness has prompted the exploration of novel regulatory factors. The myeloid/lymphoid or ... ...

Abstract	The escalating prevalence of diabetes mellitus underscores the need for a comprehensive understanding of pancreatic beta cell function. Interest in glucose effectiveness has prompted the exploration of novel regulatory factors. The myeloid/lymphoid or mixed-lineage leukaemia gene (
MeSH term(s)	Animals ; Insulin-Secreting Cells/metabolism ; Glucose/metabolism ; Mice ; Insulin Secretion ; Myeloid-Lymphoid Leukemia Protein/metabolism ; Myeloid-Lymphoid Leukemia Protein/genetics ; Histone-Lysine N-Methyltransferase/metabolism ; Histone-Lysine N-Methyltransferase/genetics ; Glucose Transporter Type 2/metabolism ; Glucose Transporter Type 2/genetics ; Gene Expression Regulation ; Mice, Knockout ; Insulin/metabolism ; Glucose Transporter Type 1/metabolism ; Glucose Transporter Type 1/genetics ; Cell Line ; Male
Chemical Substances	Glucose (IY9XDZ35W2) ; Myeloid-Lymphoid Leukemia Protein (149025-06-9) ; Histone-Lysine N-Methyltransferase (EC 2.1.1.43) ; Glucose Transporter Type 2 ; Insulin ; Slc2a2 protein, mouse ; Kmt2a protein, mouse (EC 2.1.1.43) ; Glucose Transporter Type 1 ; Slc2a1 protein, mouse
Language	English
Publishing date	2024-04-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25094704
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Article ; Online: Epidemiological analysis of the patients with psoriasis in Asian countries and region using the same clinical case cards between 2020 and 2022.

Tokuyama, Michio / Fan, Pingshen / Wang, Gang / Choe, Yong Beom / Song, Hae Jun / Tsai, Dino / Sindhvananda, Jirot / Mabuchi, Tomotaka / Ozawa, Akira

The Journal of dermatology

2024 Volume 51, Issue 4, Page(s) 567–583

Abstract: Although many epidemiological surveys for patients with psoriasis have been reported based on individual countries or facilities, there has been no study encompassing the major countries or the region in Asia. The Asian Society for Psoriasis (ASP) has ... ...

Abstract	Although many epidemiological surveys for patients with psoriasis have been reported based on individual countries or facilities, there has been no study encompassing the major countries or the region in Asia. The Asian Society for Psoriasis (ASP) has been conducting an epidemiological study across various Asian countries and regions to elucidate the and compare the epidemiology of psoriasis. A total of 1948 cases were analyzed, with 938 cases from Japan, 530 cases from China, 325 cases from Korea, 141 cases from Chinese Taipei, and 14 cases from Thailand, all of which were enrolled between 2020 and 2022. In the Asian region total, the male-female ratio was 1.87:1 and the peak age at disease onset was 20-29 years. The proportion of psoriasis vulgaris (PsV), psoriatic arthritis (PsA), and pustular psoriasis (PP) was 80.1%, 17.7%, and 2.2%, respectively, and PsA was more commonly associated with nail symptoms than psoriasis vulgaris (PsV). Of the patients, 13% had a familial history of psoriasis and the most frequently affected family member was the father. Regarding treatment, 78.3% of the patients received topical medications, 9.0% underwent phototherapy, 34.0% received oral medications, and 36.1% were treated with biological agents. This study provided valuable information on the epidemiology and treatment of psoriasis using the registry data collected with the common reporting form in the same period in major Asian countries and regions. Male predominance is a distinctive feature of psoriasis in Asia. This epidemiological data registry in the ASP will continue afterwards.
MeSH term(s)	Humans ; Male ; Female ; Young Adult ; Adult ; Arthritis, Psoriatic/diagnosis ; Arthritis, Psoriatic/epidemiology ; Psoriasis/epidemiology ; Psoriasis/therapy ; Psoriasis/diagnosis ; Japan/epidemiology ; Surveys and Questionnaires ; Thailand/epidemiology
Language	English
Publishing date	2024-02-12
Publishing country	England
Document type	Journal Article
ZDB-ID	800103-0
ISSN	1346-8138 ; 0385-2407
ISSN (online)	1346-8138
ISSN	0385-2407
DOI	10.1111/1346-8138.17132
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