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  1. Book ; Conference proceedings: Harmonic analysis and nonlinear partial differential equations

    Ozawa, Tohru / Sugimoto, Mitsuru

    July 2 - 4, 2012

    (RIMS kōkyūroku : Bessatsu ; B42)

    2013  

    Event/congress RIMS Symposium "Harmonic Analysis and Nonlinear Partial Differential Equations" (2012.07.02-04, KyotoJapan)
    Author's details edited by Mitsuru Sugimoto; Tohru Ozawa
    Series title RIMS kōkyūroku : Bessatsu ; B42
    Keywords Differential equations, Nonlinear ; Harmonic analysis
    Language English
    Size 170 S., graf. Darst.
    Publisher Research Institute for Mathematical Sciences, Kyoto University
    Publishing place Kyoto
    Document type Book ; Conference proceedings
    Note "This volume collects original papers written by the speakers of a RIMS Symposium "Harmonic Analysis and Nonlinear Partial Differential Equations" held at Research Institute for Mathematical Sciences, Kyoto University, in July 2 - 4, 2012."--Preface ; Literaturangaben
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  2. Book: Lectures on nonlinear dispersive equations

    Ozawa, Tohru

    (GAKUTO international series : Mathematical sciences and applications ; 27)

    2006  

    Author's details Ed. by Tohru Ozawa
    Series title GAKUTO international series : Mathematical sciences and applications ; 27
    Language English
    Size VI, 176 S.
    Publisher Gakkōtosho
    Publishing place Tokyo
    Document type Book
    Note Literaturangaben
    ISBN 476250436X ; 9784762504365
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  3. Article: Hardy type inequalities in [Formula: see text] with sharp remainders.

    Ioku, Norisuke / Ishiwata, Michinori / Ozawa, Tohru

    Journal of inequalities and applications

    2017  Volume 2017, Issue 1, Page(s) 5

    Abstract: Sharp remainder terms are explicitly given on the standard Hardy inequalities in [Formula: see text] with [Formula: see text]. Those remainder terms provide a direct and exact understanding of Hardy type inequalities in the framework of equalities as ... ...

    Abstract Sharp remainder terms are explicitly given on the standard Hardy inequalities in [Formula: see text] with [Formula: see text]. Those remainder terms provide a direct and exact understanding of Hardy type inequalities in the framework of equalities as well as of the nonexistence of nontrivial extremals.
    Language English
    Publishing date 2017-01-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2028512-7
    ISSN 1029-242X ; 1025-5834
    ISSN (online) 1029-242X
    ISSN 1025-5834
    DOI 10.1186/s13660-016-1271-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book: Nonlinear dispersive equations

    Ozawa, Tohru / Tsutsumi, Yoshio

    (GAKUTO international series : Mathematical sciences and applications ; 26)

    2006  

    Author's details Ed. by Tohru Ozawa; Yoshio Tsutsumi
    Series title GAKUTO international series : Mathematical sciences and applications ; 26
    Language English
    Size 237 S.
    Publisher Gakkōtosho
    Publishing place Tokyo
    Document type Book
    Note Literaturangaben
    ISBN 4762504351 ; 9784762504358
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  5. Article ; Online: Regularity Criterion for Weak Solutions to the Navier-Stokes Equations in Terms of the Gradient of the Pressure

    Ozawa Tohru / Fan Jishan

    Journal of Inequalities and Applications, Vol 2008, Iss 1, p

    2008  Volume 412678

    Abstract: Abstract We prove a regularity criterion ... for weak solutions to the Navier-Stokes equations in three-space dimensions. This improves the available result with ... . ...

    Abstract Abstract We prove a regularity criterion <graphic file="1029-242X-2008-412678-i1.gif"/> for weak solutions to the Navier-Stokes equations in three-space dimensions. This improves the available result with <graphic file="1029-242X-2008-412678-i2.gif"/> .
    Keywords Mathematics ; QA1-939 ; Science ; Q ; DOAJ:Mathematics ; DOAJ:Mathematics and Statistics
    Language English
    Publishing date 2008-01-01T00:00:00Z
    Publisher Springer
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: In vitro and in vivo pharmacological characterization of ASP8477: A novel highly selective fatty acid amide hydrolase inhibitor.

    Watabiki, Tomonari / Tsuji, Noriko / Kiso, Tetsuo / Ozawa, Tohru / Narazaki, Fumie / Kakimoto, Shuichiro

    European journal of pharmacology

    2017  Volume 815, Page(s) 42–48

    Abstract: Although exogenous agonists for cannabinoid (CB) receptors are clinically effective for treating chronic pain, global activation of brain CB receptors causes frequent central nervous system (CNS) side-effects. Fatty acid amide hydrolase (FAAH) is a ... ...

    Abstract Although exogenous agonists for cannabinoid (CB) receptors are clinically effective for treating chronic pain, global activation of brain CB receptors causes frequent central nervous system (CNS) side-effects. Fatty acid amide hydrolase (FAAH) is a primary catabolic enzyme for anandamide (AEA), an endogenous CB. Recently, we discovered a novel FAAH inhibitor, 3-pyridyl 4-(phenylcarbamoyl)piperidine-1-carboxylate (ASP8477). In vitro studies demonstrated that ASP8477 inhibited human FAAH-1, FAAH-1 (P129T) and FAAH-2 activity with IC
    Language English
    Publishing date 2017-11-15
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 80121-5
    ISSN 1879-0712 ; 0014-2999
    ISSN (online) 1879-0712
    ISSN 0014-2999
    DOI 10.1016/j.ejphar.2017.10.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 522: Show issues Location:
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  7. Article: [Pharmacological and clinical profile of gabapentin enacarbil: a novel drug for the treatment of restless legs syndrome].

    Kakimoto, Shuichiro / Ozawa, Tohru / Igarashi, Kiyoshi / Tokuno, Tomoaki / Kaku, Seiji / Seki, Nobuo

    Nihon yakurigaku zasshi. Folia pharmacologica Japonica

    2011  Volume 140, Issue 2, Page(s) 85–92

    MeSH term(s) Animals ; Biological Availability ; Carbamates/adverse effects ; Carbamates/pharmacokinetics ; Carbamates/pharmacology ; Carbamates/therapeutic use ; Clinical Trials as Topic ; Humans ; Prodrugs/adverse effects ; Prodrugs/pharmacokinetics ; Prodrugs/pharmacology ; Prodrugs/therapeutic use ; Rats ; Restless Legs Syndrome/drug therapy ; Restless Legs Syndrome/etiology ; Treatment Outcome ; gamma-Aminobutyric Acid/adverse effects ; gamma-Aminobutyric Acid/analogs & derivatives ; gamma-Aminobutyric Acid/pharmacokinetics ; gamma-Aminobutyric Acid/pharmacology ; gamma-Aminobutyric Acid/therapeutic use
    Chemical Substances 1-(((alpha-isobutanoyloxyethoxy)carbonyl)aminomethyl)-1-cyclohexaneacetic acid ; Carbamates ; Prodrugs ; gamma-Aminobutyric Acid (56-12-2)
    Language Japanese
    Publishing date 2011-03-28
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 1097532-9
    ISSN 1347-8397 ; 0015-5691
    ISSN (online) 1347-8397
    ISSN 0015-5691
    DOI 10.1254/fpj.140.85
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 439: Show issues Location:
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  8. Article ; Online: Systemic administration of 5-HT(2C) receptor agonists attenuates muscular hyperalgesia in reserpine-induced myalgia model.

    Ogino, Shinichi / Nagakura, Yukinori / Tsukamoto, Mina / Watabiki, Tomonari / Ozawa, Tohru / Oe, Tomoya / Shimizu, Yasuaki / Ito, Hiroyuki

    Pharmacology, biochemistry, and behavior

    2013  Volume 108, Page(s) 8–15

    Abstract: Fibromyalgia is a prevalent musculoskeletal disorder characterized by chronic widespread pain that significantly reduces quality of life in patients. Due to the lack of consistently effective treatment, the development of improved therapies for treating ... ...

    Abstract Fibromyalgia is a prevalent musculoskeletal disorder characterized by chronic widespread pain that significantly reduces quality of life in patients. Due to the lack of consistently effective treatment, the development of improved therapies for treating fibromyalgia is necessary. As dysfunction of serotonergic analgesic control appears to be involved in the pathophysiology of fibromyalgia, the present study explored the potential of 5-HT(2C) receptor agonists as novel therapies for treating this disease. Three 5-HT(2C) receptor agonists (lorcaserin, vabicaserin and YM348) that have been suggested to be useful in the treatment of several central nervous system diseases, including obesity and schizophrenia, were used. The effect of systemic administration of these agents on the muscular hyperalgesia that develops in the reserpine-induced myalgia (RIM) rat, a putative animal model of fibromyalgia, was investigated. RIM rats exhibited decreased muscle pressure thresholds. Microdialysis experiments showed that the concentration of serotonin (5-HT) in the spinal cord of RIM rats was significantly lower than that of controls. Lorcaserin (0.3-3 mg/kg p.o.), vabicaserin (0.3-3 mg/kg s.c.) and YM348 (0.03-0.3 mg/kg p.o.) recovered the muscle pressure threshold. The effect of lorcaserin was reversed by the pretreatment with SB242084, a 5-HT(2C) receptor antagonist. Our findings demonstrate that 5-HT(2C) receptors play a critical role in muscular hyperalgesia in RIM rats and suggest that 5-HT(2C) receptor agonists have therapeutic potential for treating chronic pain in patients with fibromyalgia although clinical extrapolation remains to be a future challenge.
    MeSH term(s) Animals ; Hyperalgesia/chemically induced ; Hyperalgesia/drug therapy ; Locomotion/drug effects ; Microdialysis ; Muscle, Skeletal/drug effects ; Muscle, Skeletal/pathology ; Rats ; Rats, Sprague-Dawley ; Receptor, Serotonin, 5-HT2C/drug effects ; Reserpine/administration & dosage ; Serotonin/analysis ; Serotonin Receptor Agonists/administration & dosage ; Serotonin Receptor Agonists/pharmacology ; Serotonin Receptor Agonists/therapeutic use ; Spinal Cord/chemistry ; Spinal Cord/drug effects
    Chemical Substances Receptor, Serotonin, 5-HT2C ; Serotonin Receptor Agonists ; Serotonin (333DO1RDJY) ; Reserpine (8B1QWR724A)
    Language English
    Publishing date 2013-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 191042-5
    ISSN 1873-5177 ; 0091-3057
    ISSN (online) 1873-5177
    ISSN 0091-3057
    DOI 10.1016/j.pbb.2013.04.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1060: Show issues Location:
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  9. Article ; Online: ASP5878, a selective FGFR inhibitor, to treat FGFR3-dependent urothelial cancer with or without chemoresistance.

    Kikuchi, Aya / Suzuki, Tomoyuki / Nakazawa, Taisuke / Iizuka, Masateru / Nakayama, Ayako / Ozawa, Tohru / Kameda, Minoru / Shindoh, Nobuaki / Terasaka, Tadashi / Hirano, Masaaki / Kuromitsu, Sadao

    Cancer science

    2016  Volume 108, Issue 2, Page(s) 236–242

    Abstract: FGF/FGFR gene aberrations such as amplification, mutation and fusion are associated with many types of human cancers including urothelial cancer. FGFR kinase inhibitors are expected to be a targeted therapy for urothelial cancer harboring FGFR3 gene ... ...

    Abstract FGF/FGFR gene aberrations such as amplification, mutation and fusion are associated with many types of human cancers including urothelial cancer. FGFR kinase inhibitors are expected to be a targeted therapy for urothelial cancer harboring FGFR3 gene alternations. ASP5878, a selective inhibitor of FGFR1, 2, 3 and 4 under clinical investigation, selectively inhibited cell proliferation of urothelial cancer cell lines harboring FGFR3 point mutation or fusion (UM-UC-14, RT-112, RT4 and SW 780) among 23 urothelial cancer cell lines. Furthermore, ASP5878 inhibited cell proliferation of adriamycin-resistant UM-UC-14 cell line harboring MDR1 overexpression and gemcitabine-resistant RT-112 cell line. The protein expression of c-MYC, an oncoprotein, in gemcitabine-resistant RT-112 cell line was higher than that in RT-112 parental cell line and ASP5878 decreased the c-MYC expression in both RT-112 parental and gemcitabine-resistant RT-112 cell lines. Once-daily oral administration of ASP5878 exerted potent antitumor activities in UM-UC-14, RT-112 and gemcitabine-resistant RT-112 xenograft models without affecting body weight. These findings suggest that ASP5878 has the potential to be an oral targeted therapy against urothelial cancer harboring FGFR3 fusion or FGFR3 point mutation after the acquisition of gemcitabine- or adriamycin-resistance.
    MeSH term(s) ATP Binding Cassette Transporter, Subfamily B/metabolism ; Antineoplastic Agents/pharmacology ; Body Weight/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; DNA-Binding Proteins/metabolism ; Deoxycytidine/analogs & derivatives ; Deoxycytidine/pharmacology ; Doxorubicin/pharmacology ; Drug Resistance, Neoplasm/drug effects ; Drug Resistance, Neoplasm/genetics ; Gene Fusion ; Humans ; Molecular Targeted Therapy ; Point Mutation ; Pyrazoles/pharmacology ; Pyrimidines/pharmacology ; Receptor, Fibroblast Growth Factor, Type 3/antagonists & inhibitors ; Receptor, Fibroblast Growth Factor, Type 3/genetics ; Transcription Factors/metabolism ; Urologic Neoplasms/drug therapy ; Urologic Neoplasms/genetics ; Urologic Neoplasms/metabolism
    Chemical Substances ABCB1 protein, human ; ASP5878 ; ATP Binding Cassette Transporter, Subfamily B ; Antineoplastic Agents ; DNA-Binding Proteins ; MYCBP protein, human ; Pyrazoles ; Pyrimidines ; Transcription Factors ; Deoxycytidine (0W860991D6) ; Doxorubicin (80168379AG) ; gemcitabine (B76N6SBZ8R) ; FGFR3 protein, human (EC 2.7.10.1) ; Receptor, Fibroblast Growth Factor, Type 3 (EC 2.7.10.1)
    Language English
    Publishing date 2016-11-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 2115647-5
    ISSN 1349-7006 ; 1347-9032
    ISSN (online) 1349-7006
    ISSN 1347-9032
    DOI 10.1111/cas.13124
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Effect of MS-153, a glutamate transporter activator, on the conditioned rewarding effects of morphine, methamphetamine and cocaine in mice.

    Nakagawa, Takayuki / Fujio, Mayumi / Ozawa, Tohru / Minami, Masabumi / Satoh, Masamichi

    Behavioural brain research

    2005  Volume 156, Issue 2, Page(s) 233–239

    Abstract: There is a body of evidence implying the involvement of the glutamatergic system in the conditioned rewarding effects of drugs of abuse. It is recognized that the release of extracellular glutamate from nerve terminals is counterbalanced by the functions ...

    Abstract There is a body of evidence implying the involvement of the glutamatergic system in the conditioned rewarding effects of drugs of abuse. It is recognized that the release of extracellular glutamate from nerve terminals is counterbalanced by the functions of neuronal and glial glutamate transporters. In the present study, we investigated the effects of (R)-(-)-5-methyl-1-nicotinoyl-2-pyrazoline (MS-153), a glutamate transporter activator, on the induction of the conditioned place preference to morphine, methamphetamine and cocaine in mice. In the conditioned place preference paradigm, mice were conditioned with repeated subcutaneous injections of morphine (5 mg/kg), methamphetamine (2 mg/kg) or cocaine (8 mg/kg) in combination with or without MS-153 (3 and 10 mg/kg). Co-administration of MS-153 at a dose of 10 mg/kg, but not 3 mg/kg, significantly attenuated the induction of conditioned place preference to morphine, methamphetamine and cocaine. However, MS-153 itself produced neither conditioned place preference nor aversion. On the other hand, co-administration of MS-153 (10 mg/kg) did not alter the acute locomotor activation elicited by a single injection of morphine, methamphetamine and cocaine. These results suggest that MS-153, a glutamate transporter activator, has an inhibitory effect on the conditioned rewarding effects of morphine, methamphetamine and cocaine without affecting their acute locomotor responses.
    MeSH term(s) Amino Acid Transport System X-AG/metabolism ; Analysis of Variance ; Animals ; Behavior, Animal ; Central Nervous System Stimulants/pharmacology ; Cocaine/pharmacology ; Conditioning, Operant/drug effects ; Dose-Response Relationship, Drug ; Drug Combinations ; Drug Interactions ; Male ; Methamphetamine/pharmacology ; Mice ; Morphine/pharmacology ; Motor Activity/drug effects ; Narcotics/pharmacology ; Nicotinic Acids/pharmacology ; Reward ; Time Factors
    Chemical Substances 5-methyl-1-nicotinoyl-2-pyrazoline ; Amino Acid Transport System X-AG ; Central Nervous System Stimulants ; Drug Combinations ; Narcotics ; Nicotinic Acids ; Methamphetamine (44RAL3456C) ; Morphine (76I7G6D29C) ; Cocaine (I5Y540LHVR)
    Language English
    Publishing date 2005-01-30
    Publishing country Netherlands
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 449927-x
    ISSN 1872-7549 ; 0166-4328
    ISSN (online) 1872-7549
    ISSN 0166-4328
    DOI 10.1016/j.bbr.2004.05.029
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    Zs.A 1599: Show issues Location:
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