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  1. Article: L2 Acquisition of a Complex Stress Pattern: UG-Constrained Learning Paths in Khalkha Mongolian.

    Özçelik, Öner

    Frontiers in psychology

    2021  Volume 12, Page(s) 627797

    Abstract: This paper examines second language (L2) acquisition of stress in Khalkha Mongolian, which is one of the few Default-to-Opposite Edge stress systems of the world, and as such, demonstrates "conflicting directionality" regarding stress assignment, ... ...

    Abstract This paper examines second language (L2) acquisition of stress in Khalkha Mongolian, which is one of the few Default-to-Opposite Edge stress systems of the world, and as such, demonstrates "conflicting directionality" regarding stress assignment, resulting in the leftmost edge of a word being more prominent in certain words and the rightmost edge in certain others. Given the additional fact that the language exhibits Non-finality effects, and that, unlike English, codas are not moraic, its acquisition presents unique difficulties and challenges for English-speaking learners of the language. Many of these challenges potentially lead these learners to make Universal Grammar (UG)-unconstrained (but cognitively reasonable) assumptions about how the phonology of Mongolian works, especially since the learners do not have all the Mongolian data available to them all at once. The learning scenario here, thus, provides unique opportunities to investigate whether L2 phonologies are constrained by the options made available by UG. The findings of a semi-controlled production experiment indicate that although learners do not necessarily converge on the prosodic representations employed by native speakers of the L2 (i.e., footless intonational prominence, at least for the leftmost/default edge 'stress'), and although certain changes to the grammar are very difficult to implement, such as switching from moraic codas to non-moraic codas, the learners nevertheless demonstrate a stage-like behavior where each step exhibits the parameter settings employed by a natural language, one that is neither like the L2 nor the L1. Conversely, despite the input leading them to do so, learners do not entertain UG-unconstrained prosodic representations, such as End-Rule-
    Language English
    Publishing date 2021-08-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2021.627797
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Evaluating the energy regulatory hormones of nesfatin-1, irisin, adropin and preptin in multiple sclerosis.

    Algul, Sermin / Ozcelik, Oguz

    Multiple sclerosis and related disorders

    2022  Volume 68, Page(s) 104221

    Abstract: Background: Nesfatin-1, irisin, adropin and preptin were originally introduced as energy regulatory hormones. However, the results of studies revealed that these hormones may also have important roles in inflammation, immune function and neurological ... ...

    Abstract Background: Nesfatin-1, irisin, adropin and preptin were originally introduced as energy regulatory hormones. However, the results of studies revealed that these hormones may also have important roles in inflammation, immune function and neurological impairment. Multiple sclerosis (MS) is a chronic autoimmune disease, characterized by progressive inflammation, demyelination, and axonal loss in the central nervous system. We aimed to evaluate nesfatin-1, irisin, adropin and preptin hormones in patients with MS accompanied by inflammation and central nervous system dysfunction.
    Materials and methods: A total of 110 subjects (65 patients with relapsing-remitting MS and 45 healthy individuals as control group) were included in this study. Venous blood samples were collected between 7:30 a.m. and 9:00 a.m. Serum concentrations of all markers were measured by enzyme linked immunoassay methods. The unpaired t-test was used to investigate between-group differences.
    Results: The nesfatin-1, irisin, adropin and preptin levels were found to be significantly lower in the MS group compared to the control group (p < 0.05).
    Conclusion: In the present study, circulating nesfatin-1, irisin, adropin and preptin levels were decreased in patients with MS. However, the pathogenesis of MS and the underlying molecular mechanism of these hormones in MS have still not been elucidated. Further investigations with larger sample sizes and longer periods are required to obtain satisfactory information. In conclusion, the energy regulatory hormones of nesfatin-1, irisin, adropin and preptin may have potential for the development of new therapeutic targets for treatment of inflammatory diseases.
    Language English
    Publishing date 2022-10-08
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2645330-7
    ISSN 2211-0356 ; 2211-0348
    ISSN (online) 2211-0356
    ISSN 2211-0348
    DOI 10.1016/j.msard.2022.104221
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Nitric oxide levels in response to the patients with different stage of diabetes.

    Ozcelik, O / Algul, S

    Cellular and molecular biology (Noisy-le-Grand, France)

    2017  Volume 63, Issue 1, Page(s) 49–52

    Abstract: The association between hyperglycaemia and serum nitric oxide (NO) levels has not yet been fully clarified. Thus, it was aimed to evaluate the concentration of NO metabolites (nitrate, nitrite) in diabetic patients and to find the relationship between ... ...

    Abstract The association between hyperglycaemia and serum nitric oxide (NO) levels has not yet been fully clarified. Thus, it was aimed to evaluate the concentration of NO metabolites (nitrate, nitrite) in diabetic patients and to find the relationship between hyperglycaemia and serum NO levels in diabetic and prediabetic patients, and control groups. In this study, 100 subjects were divided into 3 groups: healthy control (n=20), prediabetic (n=40) and diabetic (n=40). Glycemic control was assessed using glycated hemoglobin (HbA1c). Nitrate and nitrite levels were measured using the Griess reagent. NO was obtained from the sum of nitrates and nitrites. The serum NO level was higher in diabetic (53.4±2.0 μM) and prediabetic patients (51.6±1.6 μM) as compared to that in the control (45.6±1.2 μM), (p<0.05). The NO level was not significantly different in diabetic and prediabetic patients. Higher levels of serum glucose, insulin and HOMA-IR may be responsible for the activation of endothelial cells to increase NO levels. This study supports the role of insulin resistance in increased NO levels in both diabetic and prediabetic patients.
    MeSH term(s) Adult ; Case-Control Studies ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/metabolism ; Diabetes Mellitus, Type 2/pathology ; Female ; Glycated Hemoglobin A/analysis ; Humans ; Insulin/blood ; Male ; Nitrates/analysis ; Nitric Oxide/blood ; Nitrites/analysis ; Prediabetic State/blood ; Prediabetic State/metabolism ; Prediabetic State/pathology ; Severity of Illness Index
    Chemical Substances Glycated Hemoglobin A ; Insulin ; Nitrates ; Nitrites ; hemoglobin A1c protein, human ; Nitric Oxide (31C4KY9ESH)
    Language English
    Publishing date 2017-02-22
    Publishing country France
    Document type Journal Article
    ZDB-ID 1161779-2
    ISSN 1165-158X ; 0145-5680
    ISSN (online) 1165-158X
    ISSN 0145-5680
    DOI 10.14715/cmb/2017.63.1.10
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Lignocellulosic Bionanomaterials for Biosensor Applications.

    Durmaz, Ekrem / Sertkaya, Selva / Yilmaz, Hande / Olgun, Cagri / Ozcelik, Orhan / Tozluoglu, Ayhan / Candan, Zeki

    Micromachines

    2023  Volume 14, Issue 7

    Abstract: The rapid population growth, increasing global energy demand, climate change, and excessive use of fossil fuels have adversely affected environmental management and sustainability. Furthermore, the requirements for a safer ecology and environment have ... ...

    Abstract The rapid population growth, increasing global energy demand, climate change, and excessive use of fossil fuels have adversely affected environmental management and sustainability. Furthermore, the requirements for a safer ecology and environment have necessitated the use of renewable materials, thereby solving the problem of sustainability of resources. In this perspective, lignocellulosic biomass is an attractive natural resource because of its abundance, renewability, recyclability, and low cost. The ever-increasing developments in nanotechnology have opened up new vistas in sensor fabrication such as biosensor design for electronics, communication, automobile, optical products, packaging, textile, biomedical, and tissue engineering. Due to their outstanding properties such as biodegradability, biocompatibility, non-toxicity, improved electrical and thermal conductivity, high physical and mechanical properties, high surface area and catalytic activity, lignocellulosic bionanomaterials including nanocellulose and nanolignin emerge as very promising raw materials to be used in the development of high-impact biosensors. In this article, the use of lignocellulosic bionanomaterials in biosensor applications is reviewed and major challenges and opportunities are identified.
    Language English
    Publishing date 2023-07-19
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2620864-7
    ISSN 2072-666X
    ISSN 2072-666X
    DOI 10.3390/mi14071450
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Frequency, risk factors, and impacts on quality of life of the restless legs syndrome and side effects among antidepressant users in a tertiary hospital: an observational cross-sectional study.

    Cetin Erdem, Hatice / Kara, Huseyin / Ozcelik, Ozgen / Donmez, Levent / Eryilmaz, Mehmet / Ozbey, Gul

    International clinical psychopharmacology

    2023  Volume 38, Issue 4, Page(s) 209–215

    Abstract: Restless leg syndrome (RLS) is a common but underestimated sensorimotor disorder that significantly affects the quality of life (QoL) which can be induced by antidepressants. This study aims to investigate the frequency and potential risk factors of RLS ... ...

    Abstract Restless leg syndrome (RLS) is a common but underestimated sensorimotor disorder that significantly affects the quality of life (QoL) which can be induced by antidepressants. This study aims to investigate the frequency and potential risk factors of RLS and side effects in selective serotonin reuptake inhibitors/serotonin and noradrenaline reuptake inhibitors (SSRI/SNRI) users. This cross-sectional study included 198 outpatients who received SSRI/SNRI for 4-8 weeks. Clinical evaluation was performed using the International Restless Leg Syndrome Study Group rating scale for RLS, Udvalg for Kliniske Undersøgelser side effects rating scale, and a short form 36 (SF-36) questionnaire for QoL. The frequency of RLS was 25%. RLS significantly increased with smoking and habituality. Also, habituality increased neurologic side effects reporting. The use of antipsychotics and calcium channel blockers decreased reporting of autonomic side effects. QoL decreased with RLS, psychiatric, neurologic, autonomic, and other side effects in different domains of SF-36. These findings suggested that SSRI/SNRI use could be associated with a higher risk of RLS, especially in smokers. QoL could be influenced negatively by RLS and all side effects. However, further prospective studies are needed to confirm these associations in large samples.
    MeSH term(s) Humans ; Quality of Life/psychology ; Restless Legs Syndrome/chemically induced ; Restless Legs Syndrome/epidemiology ; Restless Legs Syndrome/complications ; Cross-Sectional Studies ; Serotonin and Noradrenaline Reuptake Inhibitors ; Tertiary Care Centers ; Antidepressive Agents/adverse effects ; Drug-Related Side Effects and Adverse Reactions ; Risk Factors
    Chemical Substances Serotonin and Noradrenaline Reuptake Inhibitors ; Antidepressive Agents
    Language English
    Publishing date 2023-02-27
    Publishing country England
    Document type Observational Study ; Journal Article
    ZDB-ID 632837-4
    ISSN 1473-5857 ; 0268-1315
    ISSN (online) 1473-5857
    ISSN 0268-1315
    DOI 10.1097/YIC.0000000000000466
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The outstanding beneficial roles of irisin disorders.

    Ilcın, Saadet / Algül, Sermın / Ozcelık, Oguz

    Endokrynologia Polska

    2021  Volume 73, Issue 1, Page(s) 149–156

    Abstract: Depression is a widely observed psychiatric disorder that affects a quite large number of people all around the world. A major depressive disorder (MDD) is a multifactorial disease that IS associated with fluctuations in appetite, body weight, and energy ...

    Abstract Depression is a widely observed psychiatric disorder that affects a quite large number of people all around the world. A major depressive disorder (MDD) is a multifactorial disease that IS associated with fluctuations in appetite, body weight, and energy situations in addition to serious mood problems. The aim of this review is to investigate a possible link between energy regulatory hormones of irisin and depressive disorders. Irisin is a hormone that plays a significant role in the regulation of lipid and glucose metabolism in skeletal muscle and adipose tissue. Irisin was also reported to play significant roles in the central nervous system. In the literature there are reports indicating a beneficial antidepressant role of irisin in MDD. It should be emphasised that the antidepressive effects of exercise could be the result of exercise-induced increased hormones of irisin.
    MeSH term(s) Adipose Tissue/metabolism ; Depressive Disorder, Major/metabolism ; Exercise ; Fibronectins ; Humans ; Muscle, Skeletal/metabolism
    Chemical Substances Fibronectins
    Language English
    Publishing date 2021-10-14
    Publishing country Poland
    Document type Journal Article ; Review
    ZDB-ID 419270-9
    ISSN 2299-8306 ; 0423-104X
    ISSN (online) 2299-8306
    ISSN 0423-104X
    DOI 10.5603/EP.a2021.0088
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Evaluation of relationship between aerobic fitness level and range of isocapnic buffering periods during incremental exercise test.

    Algul, S / Ozcelik, O / Yilmaz, B

    Cellular and molecular biology (Noisy-le-Grand, France)

    2017  Volume 63, Issue 3, Page(s) 78–82

    Abstract: The purpose of this study is to examine the relationship between the amount of O2 uptake (VO2) in the range of isocapnic buffering (ICB) periods and aerobic fitness levels of subjects with different exercise tolerance levels. A total of 50 young male ... ...

    Abstract The purpose of this study is to examine the relationship between the amount of O2 uptake (VO2) in the range of isocapnic buffering (ICB) periods and aerobic fitness levels of subjects with different exercise tolerance levels. A total of 50 young male subjects (20.8±0.4 years) performed an incremental exercise test using a cycle ergometer to determinetheir anaerobic threshold (AT), respiratory compensation point (RCP) and maximal exercise capacity (Wmax). The ICB period is defined as the region between AT and RCP. Pulmonary gas exchange parameters were measured breath-by-breath using a respiratory gas analyser. The subjects' fitness levels, as indicated by peak O2 uptake to body weight ratios (VO2peak/BW), ranged from 28 ml/min/kg to 58 ml/min/kg, and Wmax capacity to body weight ratio (Wmax/BW) ranged from 1.94 W/min/kg to 3.96 W/min/kg. The VO2 in the range of ICB periodsranged from 101 ml to 793 ml (with an average of 295±157 ml). There was a positive linear correlation between VO2peak/BW, Wmax/BW and range of ICB: R=0.76542 (p<0.0001), and R=0.92135 (p<0.0001), respectively. The results of this study suggest that the range of ICB periods may be related to aerobic fitness. Importantly, aerobic fitness levels should be evaluated and considered important data, in addition toAT, VO2peak/BW and Wmax/BW.
    Language English
    Publishing date 2017-03-31
    Publishing country France
    Document type Journal Article
    ZDB-ID 1161779-2
    ISSN 1165-158X ; 0145-5680
    ISSN (online) 1165-158X
    ISSN 0145-5680
    DOI 10.14715/cmb/2017.63.3.15
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Book ; Online: Tweets Under the Rubble

    Toraman, Cagri / Kucukkaya, Izzet Emre / Ozcelik, Oguzhan / Sahin, Umitcan

    Detection of Messages Calling for Help in Earthquake Disaster

    2023  

    Abstract: The importance of social media is again exposed in the recent tragedy of the 2023 Turkey and Syria earthquake. Many victims who were trapped under the rubble called for help by posting messages in Twitter. We present an interactive tool to provide ... ...

    Abstract The importance of social media is again exposed in the recent tragedy of the 2023 Turkey and Syria earthquake. Many victims who were trapped under the rubble called for help by posting messages in Twitter. We present an interactive tool to provide situational awareness for missing and trapped people, and disaster relief for rescue and donation efforts. The system (i) collects tweets, (ii) classifies the ones calling for help, (iii) extracts important entity tags, and (iv) visualizes them in an interactive map screen. Our initial experiments show that the performance in terms of the F1 score is up to 98.30 for tweet classification, and 84.32 for entity extraction. The demonstration, dataset, and other related files can be accessed at https://github.com/avaapm/deprem
    Keywords Computer Science - Social and Information Networks ; Computer Science - Computation and Language ; Computer Science - Information Retrieval
    Publishing date 2023-02-26
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Effects of curcumin administration on Nesfatin-1 levels in blood, brain and fat tissues of diabetic rats.

    Algul, S / Ozcelik, O / Oto, G / Sarikaya, M / Goceroglu, R T / Embiyaoglu, N M / Caf, F / Öner, S / Akcan, A G

    European review for medical and pharmacological sciences

    2021  Volume 25, Issue 3, Page(s) 1616–1621

    Abstract: Objective: We evaluated the efficacy of curcumin administration on blood glucose levels and its relationship with nesfatin-1 levels in blood brain and adipose tissue of streptozotocin-induced diabetic rats.: Materials and methods: A total of 28 male ... ...

    Abstract Objective: We evaluated the efficacy of curcumin administration on blood glucose levels and its relationship with nesfatin-1 levels in blood brain and adipose tissue of streptozotocin-induced diabetic rats.
    Materials and methods: A total of 28 male rats were divided into four groups: control group, type 2 diabetes mellitus (DM) group, control plus curcumin group and type 2DM plus curcumin group. After fifteen days, blood samples were collected from sacrificed rats. Nesftain-1 levels were analysed from blood, brain, and fat tissues of rats in all groups.
    Results: Nesfatin-1 level was found to be significantly lower in blood, brain and fat tissues of type 2 DM rats compared to the control group. A significant decrease in fasting blood glucose levels was observed in the curcumin administration group compared to type 2 DM group. Improvement of fasting blood glucose level was accompanied by improvement of nesfatin-1 levels in blood, brain, and fat tissues.
    Conclusions: As expected, curcumin administration caused significant improvement in fasting blood glucose levels. However, for the first time, we found marked improvements in nesfatin-1 levels in blood, brain, and fat tissues of type 2 DM rats. Thus, considering the crucial role of nesfatin-1 in regulation of glucose metabolism, it is logical to expect an interactive relationship between curcumin and nesfatin-1.
    MeSH term(s) Adipose Tissue/chemistry ; Animals ; Brain ; Curcumin/administration & dosage ; Curcumin/pharmacology ; Diabetes Mellitus, Experimental/blood ; Diabetes Mellitus, Experimental/chemically induced ; Diabetes Mellitus, Experimental/diagnosis ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/chemically induced ; Diabetes Mellitus, Type 2/diagnosis ; Injections, Intraperitoneal ; Male ; Nucleobindins/blood ; Rats ; Rats, Wistar ; Streptozocin
    Chemical Substances Nucb2 protein, rat ; Nucleobindins ; Streptozocin (5W494URQ81) ; Curcumin (IT942ZTH98)
    Language English
    Publishing date 2021-02-24
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 605550-3
    ISSN 2284-0729 ; 1128-3602 ; 0392-291X
    ISSN (online) 2284-0729
    ISSN 1128-3602 ; 0392-291X
    DOI 10.26355/eurrev_202102_24872
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Serum nesfatin-1 levels in patients with different glucose tolerance levels.

    Algul, S / Ozkan, Y / Ozcelik, O

    Physiological research

    2016  Volume 65, Issue 6, Page(s) 979–985

    Abstract: The aim of this study was to compare the levels of nesfatin-1 in healthy subjects with those in prediabetic and diabetic patients who have different glucose tolerance levels. Overall, 100 subjects were divided into 5 groups healthy control (C), impaired ... ...

    Abstract The aim of this study was to compare the levels of nesfatin-1 in healthy subjects with those in prediabetic and diabetic patients who have different glucose tolerance levels. Overall, 100 subjects were divided into 5 groups healthy control (C), impaired fasting glycemia (IFG), impaired glucose tolerance (IGT), metabolic syndrome (MS) and type 2 diabetes mellitus, (Type 2 DM). Glycated hemoglobin (HbA1c) assessed the glycemic control. Homeostasis model assessment of insulin resistance (HOMA-IR) was determined using computer analyses. Nesfatin-1 levels were measured using ELISA method. IFG and IGT (prediabetic groups) from MS and Type 2 DM (diabetic groups) differed significantly in HOMA-IR. The nesfatin-1 levels were lower, although not statistically significant, in IFG (0.937+/-0.03 ng/ml, p=0.07) and IGT (1.039+/-0.06 ng/ml, p=0.5) groups compared to healthy subjects (1.094+/-0.07 ng/ml). However, the nesfatin-1 levels were lower in patients with Type 2 DM (0.867+/-0.02 ng/ml, p=0.007) and MS (0.885+/-0.01 ng/ml, p=0.01) compared to healthy subjects. Nesfatin-1 levels were significantly lower in diabetic patients compared to healthy subjects. This study supports the role of insulin resistance in decreased nesfatin-1 levels in patients with Type 2 DM and MS.
    MeSH term(s) Adult ; Blood Glucose/analysis ; Blood Glucose/metabolism ; Calcium-Binding Proteins/blood ; DNA-Binding Proteins/blood ; Diabetes Mellitus, Type 2/blood ; Female ; Glucose Intolerance/blood ; Glucose Tolerance Test ; Glycated Hemoglobin A/analysis ; Healthy Volunteers ; Humans ; Insulin Resistance ; Male ; Metabolic Syndrome/blood ; Nerve Tissue Proteins/blood ; Nucleobindins ; Prediabetic State/blood
    Chemical Substances Blood Glucose ; Calcium-Binding Proteins ; DNA-Binding Proteins ; Glycated Hemoglobin A ; NUCB2 protein, human ; Nerve Tissue Proteins ; Nucleobindins
    Language English
    Publishing date 2016-08-19
    Publishing country Czech Republic
    Document type Journal Article
    ZDB-ID 1073141-6
    ISSN 1802-9973 ; 0369-9463 ; 0862-8408
    ISSN (online) 1802-9973
    ISSN 0369-9463 ; 0862-8408
    DOI 10.33549/physiolres.933186
    Database MEDical Literature Analysis and Retrieval System OnLINE

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