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Article ; Online: Response to: Author's reply to: Effect of adjuvant treatment on survival in 2023 FIGO stage IIC endometrial cancer.

Akgor, Utku / Ozgul, Nejat / Ayhan, Ali

2024

Language	English
Publishing date	2024-04-11
Publishing country	Korea (South)
Document type	Letter
ZDB-ID	2478405-9
ISSN	2005-0399 ; 2005-0380
ISSN (online)	2005-0399
ISSN	2005-0380
DOI	10.3802/jgo.2024.35.e92
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Zs.A 6484: Show issues

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Article ; Online: Recurrent mucinous neoplasm arising in cesarean scar: A case report and review of literature.

Gundogdu, Fatma / Orhan, Nazlı / Ozgul, Nejat / Usubutun, Alp

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

2021 Volume 157, Issue 3, Page(s) 564–567

Abstract: Ovarian mucinous tumors are one of the common epithelial tumors in the ovary, but their recurrence is extremely rare. In a 37-year-old female patient who had had five operations in 7 years due to recurrent mucinous neoplasms, a mass extending to the ... ...

Abstract	Ovarian mucinous tumors are one of the common epithelial tumors in the ovary, but their recurrence is extremely rare. In a 37-year-old female patient who had had five operations in 7 years due to recurrent mucinous neoplasms, a mass extending to the umbilicus was recently detected during a routine examination. With this finding the patient underwent cystectomy, total abdominal hysterectomy, and left salpingo-oophorectomy. Two of the five operations were performed during cesarean delivery. In the recent surgical procedure, two cysts were removed. A 20 cm cyst in the pelvic region was diagnosed as a mucinous cystadenoma. The other cyst located in the myometrium was a mucinous cystadenoma with focal borderline change and arose in the previous cesarean scar. The authors present what is believed to be the first case of recurrent mucinous neoplasm arising within a cesarean scar. A review of the literature concerning the topic is also presented.
MeSH term(s)	Adult ; Cicatrix/complications ; Cicatrix/pathology ; Cystadenoma, Mucinous/diagnosis ; Cystadenoma, Mucinous/pathology ; Cystadenoma, Mucinous/surgery ; Cysts ; Female ; Humans ; Ovarian Neoplasms/pathology ; Pregnancy ; Salpingo-oophorectomy
Language	English
Publishing date	2021-09-21
Publishing country	United States
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	80149-5
ISSN	1879-3479 ; 0020-7292
ISSN (online)	1879-3479
ISSN	0020-7292
DOI	10.1002/ijgo.13924
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Zs.A 355: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 183: Show issues

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Article ; Online: The simple right ventricle contraction pressure index: A novel method for echocardiographic assessment of right ventricle dysfunction in acute pulmonary embolism.

Acar, Emrah / Ozgul, Neryan / Izci, Servet

Journal of clinical ultrasound : JCU

2020 Volume 49, Issue 5, Page(s) 466–471

Abstract: Purpose: The simple right ventricular contraction pressure index (sRVCPI) is a new echocardiographic variable for estimating the right ventricular systolic function. Our aim was to investigate the association between the sRVCPI, the pulmonary embolism ... ...

Abstract	Purpose: The simple right ventricular contraction pressure index (sRVCPI) is a new echocardiographic variable for estimating the right ventricular systolic function. Our aim was to investigate the association between the sRVCPI, the pulmonary embolism severity index (PESI), and mortality rate in acute pulmonary embolism (APE). Methods: We included in this study 116 patients diagnosed with APE by pulmonary computed tomography angiography or ventilation/perfusion scintigraphy. They were divided into two groups based on the simplified PESI < or >1. Tricuspid regurgitation velocity and TAPSE were measured and used for sRVCPI calculation. Results: Mortality was higher in patients with a higher sRVCPI (P < .001). In receiver operating characteristic (ROC) curve analysis using a cut-off level of 312.8 mm Hg mm, sRVCPI predicted mortality with a sensitivity of 86.8% and specificity of 69.5% (ROC area under curve: 0.712; 95%CI 0.597-0.882; P < .001). The sRVCPI was lower in the sPESI >1 than in the sPESI <1 group (364.3 ± 31.9 vs 511.6 ± 26.1; P < .001). There was an inverse correlation between sRVCPI and the sPESI score (-0.784; P < .001). Conclusion: The sRVCPI correlated with the sPESI score and was associated with mortality in patients with APE. This easily measurable variable may be used to predict short-term mortality in APE patients.
MeSH term(s)	Acute Disease ; Aged ; Echocardiography ; Humans ; Male ; Middle Aged ; Myocardial Contraction ; Pressure ; Pulmonary Embolism/physiopathology ; ROC Curve ; Ventricular Dysfunction, Right/diagnosis ; Ventricular Dysfunction, Right/physiopathology
Language	English
Publishing date	2020-12-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	189393-2
ISSN	1097-0096 ; 0091-2751
ISSN (online)	1097-0096
ISSN	0091-2751
DOI	10.1002/jcu.22970
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Zs.A 1186: Show issues

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Article ; Online: Evaluation of colposcopy after the addition of human papillomavirus testing to the Turkish cervical cancer screening program.

Gunes, Ali Can / Ozgul, Nejat / Turkyılmaz, Murat / Kara, Fatih / Unlu, Fahriye / Ayhan, Ali / Gultekin, Murat

Cancer medicine

2023 Volume 12, Issue 24, Page(s) 21751–21760

Abstract: Objective: To evaluate colposcopy performance following the human papillomavirus (HPV) DNA screening program in Turkey.: Methods: Women aged 30-65 years are screened for cervical cancer every 5 years, with individuals positive for HPV 16 and/or 18 or ...

Abstract	Objective: To evaluate colposcopy performance following the human papillomavirus (HPV) DNA screening program in Turkey. Methods: Women aged 30-65 years are screened for cervical cancer every 5 years, with individuals positive for HPV 16 and/or 18 or other high-risk HPV types with abnormal cytology referred for colposcopy. Both HPV test and cytology are obtained at the same visit. If HPV is negative, cytology will not be assessed. However, if HPV is positive, both cytology and HPV genotyping will be performed. Colposcopy-require was defined as HPV 16/18 positivity or abnormal smear results with any hrHPV positivity, and the remaining patients (normal smear with hrHPV positivity other than HPV 16/18) were grouped as colposcopy non-required. National data on colposcopy outcomes and unnecessary performance rates in February 2018-2019 were evaluated via a questionnaire. Results: A total of 9808 patients were included, divided based on colposcopy requirement: 5751 (58.6%) patients required colposcopy and 4057 (41.4%) did not. Unnecessary colposcopy was performed on 90.1% of the non-required group (3657 of 4057 patients). In the colposcopy-required group, 4455 patients (79.9%) underwent punch biopsy; 3194 (57.1%), endocervical curettage (ECC); and 421 (7.5%), "see and treat" in the non-required group, the results were 2790 (76.3%), 1957 (53.2%), and 211 (5.7%), respectively. A total of 746 cervical intraepithelial neoplasia (CIN)-3 isolates were detected, including 702 using existing screening and triage with 94.1% sensitivity (702/746). Multiple biopsies were taken in 69.8% (n = 3110) of patients from the colposcopy-required group and 63.7% (n = 1777) from the non-required group. The ECC samples included 19 cervical cancers and 212 ≥CIN-3 lesions in the colposcopy-required group, and four cancers and 41 ≥CIN-3 lesions in the non-required group. The proportion of ≥CIN-3 lesions detected by ECC only was 4.7% (35 of 746 ≥CIN-3 lesions). Conclusion: Our results showed high rates of unnecessary colposcopies, and a high percentage of multiple and random punch biopsies and ECC.
MeSH term(s)	Pregnancy ; Humans ; Female ; Uterine Cervical Neoplasms/pathology ; Colposcopy ; Human papillomavirus 16/genetics ; Papillomavirus Infections ; Early Detection of Cancer/methods ; Turkey ; Human papillomavirus 18/genetics ; Uterine Cervical Dysplasia ; Mass Screening/methods ; Papillomaviridae/genetics ; Vaginal Smears/methods
Language	English
Publishing date	2023-11-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	2659751-2
ISSN	2045-7634 ; 2045-7634
ISSN (online)	2045-7634
ISSN	2045-7634
DOI	10.1002/cam4.6740
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Article ; Online: Psychometric Properties and Cutoff Value of the Turkish Overactive Bladder Symptom Score.

Baran, Emine / Gürşen, Ceren / Ozgul, Serap / Çinar, Gamze Nalan / Nakip, Gulbala / Üzelpasaci, Esra / Ozgul, Nejat / Beksaç, Mehmet Sinan / Akbayrak, Türkan

Urogynecology (Philadelphia, Pa.)

2023

Abstract: Importance: The Overactive Bladder Symptom Score (OABSS) measures all overactive bladder (OAB) symptoms with graded answers, evaluates urgency symptoms, and reveals the subjective bladder control. However, the Turkish version and the cutoff value of the ...

Abstract	Importance: The Overactive Bladder Symptom Score (OABSS) measures all overactive bladder (OAB) symptoms with graded answers, evaluates urgency symptoms, and reveals the subjective bladder control. However, the Turkish version and the cutoff value of the questionnaire have not yet been studied. Objective: The aims of this study were to determine the psychometric properties of the 7-item OABSS and to estimate the cutoff value of the scale. Study design: This was an observational study. The internal consistency (Cronbach α) and test-retest reliability were analyzed, and exploratory factor analysis was performed. For the criterion validity, the correlations between the OABSS, the Overactive Bladder Questionnaire, the Bristol Female Lower Urinary Tract Symptoms questionnaire, and outcomes of a bladder diary were used. The cutoff value of the OABSS was analyzed by the receiver operating characteristics curve analysis. Results: Participants with (n = 49) and without (n = 38) OAB were included. The internal consistency was very strong (Cronbach α = 0.95). The test-retest reliability was very strong (intraclass correlation coefficients = 0.93-0.95, P = 0.001). The percentage of explanation of the total variance was calculated as 78%. There was a strong to very strong correlation between the OABSS and the Overactive Bladder Questionnaire and Bristol Female Lower Urinary Tract Symptoms scores and outcomes of the bladder diary. The cutoff value for the OABSS was determined as 10.5. Conclusions: The Turkish OABSS was found to be a valid and reliable scale to determine OAB symptoms and severity. Those who score more than 10.5 on the questionnaire can be considered as at risk of OAB syndrome.
Language	English
Publishing date	2023-12-28
Publishing country	United States
Document type	Journal Article
ISSN	2771-1897
ISSN (online)	2771-1897
DOI	10.1097/SPV.0000000000001446
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Article: Herlyn-Werner-Wunderlich Syndrome; laparoscopic treatment of obstructing longitudinal vaginal septum in patients with hematocolpos - a different technique for virgin patients

Boyraz, Gökhan / Karalok, Alper / Turan, Taner / Özgül, Nejat

Journal of the Turkish German Gynecological Association

2019 Volume 21, Issue 4, Page(s) 303–304

Abstract: We aimed to define a new laparoscopic treatment approach for patients with hematocolpos and obstructed hemi-vagina due to longitudinal obstructing vaginal septum. This technique is particularly useful for patients who desire to preserve virginity. To the ...

Abstract	We aimed to define a new laparoscopic treatment approach for patients with hematocolpos and obstructed hemi-vagina due to longitudinal obstructing vaginal septum. This technique is particularly useful for patients who desire to preserve virginity. To the best of our knowledge this is the first case reporting laparoscopic resection of vaginal septum with an obstructed hemivagina and hematocolpos.
Language	English
Publishing date	2019-08-27
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	2425806-4
ISSN	1309-0380 ; 1303-9695 ; 1309-0399
ISSN (online)	1309-0380 ; 1303-9695
ISSN	1309-0399
DOI	10.4274/jtgga.galenos.2019.2019.0046
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Article ; Online: Endocervical polyps in high risk human papillomavirus infections.

Kucukyıldız, Irem / Karaca, Mujdegul / Akgor, Utku / Turkyılmaz, Murat / Keskinkılıc, Bekir / Kara, Fatih / Ozgul, Nejat / Gultekin, Murat

Ginekologia polska

2022 Volume 93, Issue 1, Page(s) 7–10

Abstract: Objectives: Human papillomavirus (HPV) positive patients with and without endocervical polyps is compared with respect to HPV genotypes and presence of pre-invasive diseases. To our knowledge, this is the first and largest report in the literature ... ...

Abstract	Objectives: Human papillomavirus (HPV) positive patients with and without endocervical polyps is compared with respect to HPV genotypes and presence of pre-invasive diseases. To our knowledge, this is the first and largest report in the literature examining the endocervical polyps in HPV positive cases. Material and methods: Clinicopathological data for the first one million screening patients (n = 1060 992) from around the entire country during 2015 and 2016 were targeted for this research. Colposcopy, colposcopic surgical diagnostic procedures and final pathology results of 3499 patients with high-risk (HR) HPV-positive were obtained from reference colposcopy centers. Patients with endocervical polyps (n = 243 [6.9 %]) were accepted as experimental arm while patients without any endocervical polyp (n = 3256 [93.1%]) were regarded as the control group. Age, HPV genotype, Pap smear abnormality, and final pathological results were compared between two groups using Student's t-test and cross-tabulation chi-square test. Results: The incidence of endocervical polyp was found to be 6.9 % in HR HPV-positive women. The most common HPV genotypes observed in both groups were HPV 16 or 18. Abnormal cytology reports (≥ ASC-US) were not significantly different between both groups. However, with respect to final pathological diagnosis, patients with endocervical polyp had significantly lower numbers of pre-invasive diseases (31.3% vs 44.2%; p < 0.10). Conclusions: Endocervical polyps may be more common in patients with HR HPV infections. HPV 18 is observed significantly more, in the HR HPV positive endocervical polyp group. Patients with endocervical polyps do not have increased risk for preinvasive cervical diseases.
MeSH term(s)	Humans ; Female ; Pregnancy ; Human Papillomavirus Viruses ; Papillomavirus Infections/complications ; Papillomavirus Infections/diagnosis ; Papillomavirus Infections/epidemiology ; Uterine Cervical Neoplasms/diagnosis ; Uterine Cervical Neoplasms/epidemiology ; Uterine Cervical Neoplasms/pathology ; Colposcopy ; Papanicolaou Test ; Papillomaviridae/genetics
Language	English
Publishing date	2022-01-24
Publishing country	Poland
Document type	Journal Article
ZDB-ID	130894-4
ISSN	2543-6767 ; 0017-0011
ISSN (online)	2543-6767
ISSN	0017-0011
DOI	10.5603/GP.a2021.0207
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Zs.B 118: Show issues

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Article ; Online: Tumor apelin immunoreactivity is correlated with body mass index in ovarian high grade serous carcinoma.

Unal, I / Khiavi, I R / Tasar, G E / Goksuluk, D / Boyraz, G / Ozgul, N / Usubutun, A / Yuruker, S / Zeybek, N D

Biotechnic & histochemistry : official publication of the Biological Stain Commission

2019 Volume 95, Issue 1, Page(s) 27–36

Abstract: Ovarian cancer has a high mortality rate. Serous carcinoma is the most common subtype and can be detected by distant or lymph node metastasis in advanced stages. Apelin, an adipokine associated with obesity, and its receptor, APJ, participate in ... ...

Abstract	Ovarian cancer has a high mortality rate. Serous carcinoma is the most common subtype and can be detected by distant or lymph node metastasis in advanced stages. Apelin, an adipokine associated with obesity, and its receptor, APJ, participate in lymphatic invasion. Angiogenesis also can affect lymph node involvement in serous ovarian carcinomas. We investigated apelin/APJ receptor immunoreactivity in stages III and IV ovarian cancer with or without lymph node involvement and correlated the results with body mass index (BMI) to determine whether the potential relation of the two affects the outcome of the cancer. We investigated 30 patients diagnosed between 2014 and 2016 with high grade serous ovarian cancer. Tumor:stroma ratio, indirect immunoperoxidase method, H-score and MATLAB analysis were performed. In obese and pre-obese patients, tumor apelin immunoreactivity was stronger than for patients with normal BMI. Tumor:stroma ratio was correlated with survival and lymph node involvement. Strong apelin and moderate APJ immunoreactivity was detected in both lymph node negative and positive patients. BMI was related to both survival outcome and apelin immunoreactivity. BMI, adipokines such as apelin, and the stromal compartment play critical roles in advanced stage serous carcinomas.
MeSH term(s)	Adult ; Aged ; Apelin/genetics ; Apelin/metabolism ; Body Mass Index ; Carcinoma/classification ; Carcinoma/metabolism ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Middle Aged ; Ovarian Neoplasms/classification ; Ovarian Neoplasms/metabolism
Chemical Substances	APLN protein, human ; Apelin
Language	English
Publishing date	2019-07-02
Publishing country	England
Document type	Journal Article
ZDB-ID	1069349-x
ISSN	1473-7760 ; 1052-0295
ISSN (online)	1473-7760
ISSN	1052-0295
DOI	10.1080/10520295.2019.1627419
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Article: Synchronous Ovarian and Endometrial Endometrioid Adenocarcinoma Presenting with Nonbacterial Thrombotic Endocarditis and Pulmonary Thromboembolism: Adenocarcinoma with Thrombotic Events.

Erturk, N K / Erturk, A / Basaran, D / Ozgul, N

Case reports in obstetrics and gynecology

2015 Volume 2015, Page(s) 825404

Abstract: Introduction. Nonbacterial thrombotic endocarditis (NBTE) is a rare manifestation of hypercoagulability in patients with malignant neoplasms. Case Report. A fifty-six-year-old woman presented to the emergency service; the clinical workup revealed deep ... ...

Abstract	Introduction. Nonbacterial thrombotic endocarditis (NBTE) is a rare manifestation of hypercoagulability in patients with malignant neoplasms. Case Report. A fifty-six-year-old woman presented to the emergency service; the clinical workup revealed deep vein thrombosis in right leg and bilateral massive PTE. As the abdominal sections on the spiral CT revealed a giant pelvic mass of ovarian origin, she was referred to our hospital's gynecologic oncology department. She was scheduled for surgery under enoxaparin. She described numbness on one side of her face. Cranial imaging findings revealed acute ischemic cerebral lesions and transesophageal echocardiogram showed vegetation on the aortic cusp. Under anticoagulation treatment, she underwent hysterectomy with bilateral salpingo-oophorectomy and infracolic omentectomy. After tumor resection, her neurological symptoms dissolved with aggressive anticoagulant treatment. Pathology result was synchronous endometrial and ovarian adenocarcinoma. Discussion. NBTE is a rare condition often associated with advanced malignancies. Peripheral embolism and venous thrombosis are complications that have been associated with NBTE due to hypercoagulable state. These disorders could be resistant to routine anticoagulant treatment. In case of a thrombotic complication due to ovarian malignancy, surgical resection of the primary tumor may increase the effect of anticoagulant treatment.
Language	English
Publishing date	2015-10-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	2627654-9
ISSN	2090-6692 ; 2090-6684
ISSN (online)	2090-6692
ISSN	2090-6684
DOI	10.1155/2015/825404
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Article ; Online: The relationship between the presence of HPV infection and biofilm formation in cervicovaginal smears.

Donmez, Hanife Guler / Sahal, Gulcan / Akgor, Utku / Cagan, Murat / Ozgul, Nejat / Beksac, Mehmet Sinan

Infection

2020 Volume 48, Issue 5, Page(s) 735–740

Abstract: Purpose: To demonstrate and understand the association of HPV infection and biofilm formation.: Methods: The study consisted of cervicovaginal samples of 72 women who were evaluated at the colposcopy unit. Papanicolaou staining was used for ... ...

Abstract	Purpose: To demonstrate and understand the association of HPV infection and biofilm formation. Methods: The study consisted of cervicovaginal samples of 72 women who were evaluated at the colposcopy unit. Papanicolaou staining was used for cytological examination while "Crystal Violet Binding" assay was performed to detect biofilm formation. Results: HPV-DNA was positive in 55.5% (n = 40) of the patients. The biofilm formation rate was statistically significantly higher in the HPV-positive women (45%) compared to HPV-negative women (21.9%) (P < 0.05). There was a statistically significant relationship between the presence of single HPV and "high-risk HPV" types and biofilm formation (P < 0.05). Biofilm formation was found in 80% of women with abnormal smear demonstrating atypical epithelial cells (P < 0.05). Conclusion: Biofilm formation is more frequent at the cervicovaginal microbiota of patients with HPV infection. This finding is especially important in cases with atypical epithelial cells at their cervicovaginal smears.
MeSH term(s)	Adult ; Biofilms ; Cervix Uteri/virology ; Female ; Humans ; Middle Aged ; Papillomaviridae/physiology ; Papillomavirus Infections/physiopathology ; Turkey ; Vagina/virology ; Vaginal Smears ; Young Adult
Language	English
Publishing date	2020-07-04
Publishing country	Germany
Document type	Journal Article
ZDB-ID	185104-4
ISSN	1439-0973 ; 0300-8126 ; 0173-2129
ISSN (online)	1439-0973
ISSN	0300-8126 ; 0173-2129
DOI	10.1007/s15010-020-01478-5
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Zs.A 881: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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