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  1. Article ; Online: Investigation of Granulomatous Inflammations in Terms of Tuberculosis Diagnosis: A 5-Year Multi-center Laboratory Study.

    Öztomurcuk, Derya / Terzi, Özlem / Demirci, Canan / Kılıçaslan, Zeki

    Turkish thoracic journal

    2022  Volume 23, Issue 1, Page(s) 11–16

    Abstract: Objective: Granulomatous inflammation showing "caseification necrosis" is considered pathognomonic for tuberculosis. This study aimed to evaluate patients with granulomatous inflammation and some characteristics to diagnose tuberculosis.: Material and ...

    Abstract Objective: Granulomatous inflammation showing "caseification necrosis" is considered pathognomonic for tuberculosis. This study aimed to evaluate patients with granulomatous inflammation and some characteristics to diagnose tuberculosis.
    Material and methods: This is a cross-sectional descriptive study. The study includes all pathology laboratories in Samsun between the years 2012 and 2017. Pathology reports that contained the term granulomatous were selected between all patient reports of these laboratories. The patient reports were examined by comparing the dispensary records and the presence of a diagnosis of tuberculosis.
    Results: In the 703 pathology reports, it was found that 38% were only granulomatous and 33% were caseous granulomatosis lesions. When the prevalence of tuberculosis according to the presence of microscopic necrosis was observed in granulomatous tissue samples, 85% tuberculosis was found in patients with necrotic granulomatous tissue and 14% tuberculosis was found with non-necrotic lesions. The presence of tuberculosis in necrotic granulomatous tissues was statistically significantly higher (P < .00001).
    Conclusion: As a result, when examining a pathology report for the presence of tuberculosis, the existence of a granulomatous reaction should be considered first. Getting stuck on the definition of caseification necrosis will cause the case to be skipped. An indication of necrosis in the pathologic evaluation will guide the diagnosis of tuberculosis.
    Language English
    Publishing date 2022-02-02
    Publishing country Turkey
    Document type Journal Article
    ISSN 2149-2530
    ISSN (online) 2149-2530
    DOI 10.5152/TurkThoracJ.2022.20314
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Characteristics of tuberculosis-related deaths and risk factors: a retrospective cohort study in Samsun province of Turkey.

    Oruç, Muhammet Ali / Ozdemir, Sule / Oztomurcuk, Derya

    Postgraduate medicine

    2022  Volume 134, Issue 2, Page(s) 217–223

    Abstract: Objectives: Tuberculosis (TB) remains one of the top ten leading causes of death worldwide despite effective therapy. The present study aims to examine the characteristics of TB-related deaths in Samsun Province and to determine the risk factors.: ... ...

    Abstract Objectives: Tuberculosis (TB) remains one of the top ten leading causes of death worldwide despite effective therapy. The present study aims to examine the characteristics of TB-related deaths in Samsun Province and to determine the risk factors.
    Methods: In this retrospective registry-based cohort study, the medical records of patients registered with Samsun Tuberculosis Control Dispensary between 1 January 2018 and 31 December 2019 were retrospectively reviewed. The Cox proportional-hazards model was used to determine the factors associated with the risk of death in patients with TB.
    Results: The treatment outcomes of a total of 382 patients were reviewed. It was found that the treatment was successful in 346 patients (90.6%), and 31 patients (8.1%) died before or during TB therapy. The median survival time of patients who died during the therapy was 1.86 months (95% CI = 0.07-5.17 months), and more than 50% (13/25) of the deaths occurred in the first two months of the treatment. Age above 70 years (HR 15.06 (3.33-67.95)), male gender (HR 2.74 (1.02-7.33)), pulmonary TB (HR 2.92 (1.002-8.52)), multidrug-resistant (MDR) tuberculosis (HR 1.69 (1.22-12.75)), and a delay in the treatment of more than ten days (HR 2.71 (1.22-6.04)) were identified as risk factors associated with mortality in TB patients (p < 0.05).
    Conclusion: The majority of deaths in our cohort occurred within the first two months after starting the treatment. Advanced age, male sex, a new diagnosis of TB, pulmonary TB, MDR-TB, and a treatment delay of more than ten days after diagnosis increased the risk for mortality during antituberculosis treatment.
    MeSH term(s) Aged ; Cohort Studies ; Humans ; Male ; Retrospective Studies ; Risk Factors ; Treatment Outcome ; Tuberculosis/drug therapy ; Tuberculosis/epidemiology ; Tuberculosis, Multidrug-Resistant/drug therapy ; Tuberculosis, Multidrug-Resistant/epidemiology ; Turkey/epidemiology
    Language English
    Publishing date 2022-01-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 410138-8
    ISSN 1941-9260 ; 0032-5481
    ISSN (online) 1941-9260
    ISSN 0032-5481
    DOI 10.1080/00325481.2022.2029106
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Evaluation of effectiveness of pathology reports in active surveillance of tuberculosis.

    Terzi, Özlem / Öztomurcuk, Derya / Gün, Seda / Kiliçaslan, Zeki

    Central European journal of public health

    2021  Volume 29, Issue 2, Page(s) 96–101

    Abstract: Objective: Despite advancing technology, national TB surveillance systems are still inadequate in terms of patient detection around the world. It was aimed to investigate suspicious cases detected by active surveillance method in pathology laboratories ... ...

    Abstract Objective: Despite advancing technology, national TB surveillance systems are still inadequate in terms of patient detection around the world. It was aimed to investigate suspicious cases detected by active surveillance method in pathology laboratories and to evaluate the effectiveness of this method in terms of finding new TB cases.
    Methods: This is a descriptive cross-sectional study. It was administrated in Samsun, Turkey, between January 2012-December 2017. Within the scope of active surveillance, pathology laboratories were regularly visited and reported cases with granulomatous inflammation were assessed. The obtained patient list was compared with the records of the Electronic Tuberculosis Management System (ETMS). Patients who were not included in these records were invited to the dispensary and evaluated for TB. They were also referred to the relevant hospitals for diagnosis if necessary. Frequency values and descriptive statistics were calculated using SPSS method.
    Results: It was found that 35.6% of 703 patients with the diagnosis of granulomatous inflammation were previously diagnosed, treated or currently undergoing treatment in the ETMS registry. As a result of the assessment of remaining 453 cases, 46 patients (10.1%) were newly diagnosed with TB. Newly diagnosed TB patients were reported, and their treatment started.
    Conclusion: As a result, active surveillance method conducted in pathology laboratories are used to detect unknown or late reported TB cases and allows to start treatment without further delay.
    MeSH term(s) Cross-Sectional Studies ; Humans ; Tuberculosis/drug therapy ; Tuberculosis/epidemiology ; Turkey/epidemiology ; Watchful Waiting
    Language English
    Publishing date 2021-07-10
    Publishing country Czech Republic
    Document type Journal Article
    ZDB-ID 1176053-9
    ISSN 1803-1048 ; 1210-7778 ; 0022-1732
    ISSN (online) 1803-1048
    ISSN 1210-7778 ; 0022-1732
    DOI 10.21101/cejph.a6124
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Regional success on screening and chemoprophylaxis in contacts of patients with pulmonary tuberculosis in Turkey: a dispensary experience in 2016-2017.

    Dundar, Cihad / Oztomurcuk, Derya / Terzi, Ozlem

    Transactions of the Royal Society of Tropical Medicine and Hygiene

    2019  Volume 113, Issue 6, Page(s) 351–355

    Abstract: Background: Turkey has a national tuberculosis (TB) control program that follows the standards set by the World Health Organization's (WHO) global TB control program.: Methods: In this record-based retrospective study, contact screening and ... ...

    Abstract Background: Turkey has a national tuberculosis (TB) control program that follows the standards set by the World Health Organization's (WHO) global TB control program.
    Methods: In this record-based retrospective study, contact screening and chemoprophylaxis of 469 TB contacts registered at the Samsun Tuberculosis Dispensary in 2016-2017 were assessed.
    Results: On average, patients with pulmonary TB each had four contacts. Chemoprophylaxis was administered in 233 of the contacts for the following reasons: having close contact with an active TB patient (187 [80%]), being <15 y of age and tuberculin skin test (TST) positive (12 [5%]), detection of latent TB infection (27 [12%]) or not having been treated for TB before in conjunction with the discovery via radiography of a sequel lesion (7 [3%]). The remaining 236 contacts were not given chemoprophylaxis: 203 (86%) were TST negative, 10 (4%) rejected chemoprophylaxis and 23 (10%) refused to participate in an examination. Chemoprophylaxis was given to 30% of contacts in the first week and to 75% of contacts in the first month. The treatment completion rate was 80%, while the rate of chemoprophylaxis abandonment was 19.5% for males and 21.2% for females.
    Conclusions: The Samsun TB dispensary is successfully implementing the WHO's End TB strategy and has achieved higher treatment completion rates than other countries.
    MeSH term(s) Adolescent ; Adult ; Aged ; Antitubercular Agents/therapeutic use ; Chemoprevention/methods ; Child ; Child, Preschool ; Contact Tracing/methods ; Female ; Humans ; Infant ; Male ; Mass Screening/methods ; Middle Aged ; Retrospective Studies ; Tuberculin Test ; Tuberculosis/diagnosis ; Tuberculosis, Pulmonary/diagnosis ; Tuberculosis, Pulmonary/prevention & control ; Turkey ; Young Adult
    Chemical Substances Antitubercular Agents
    Language English
    Publishing date 2019-03-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 441375-1
    ISSN 1878-3503 ; 0035-9203
    ISSN (online) 1878-3503
    ISSN 0035-9203
    DOI 10.1093/trstmh/trz008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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