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  1. Book: Regenerative biology of the eye

    Pébay, Alice

    (Stem cell biology and regenerative medicine)

    2014  

    Author's details Alice Pébay ed
    Series title Stem cell biology and regenerative medicine
    Keywords Eye/Diseases/Treatment ; Regenerative medicine ; Stem cells/Therapeutic use
    Subject code 617.7027
    Language English
    Size XII, 309 S. : Ill., graph. Darst., 24 cm
    Publisher Humana Press
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    Note Includes bibliographical references
    HBZ-ID HT018319426
    ISBN 978-1-4939-0786-1 ; 9781493907878 ; 1-4939-0786-7 ; 1493907875
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2014 A 2703 available for loan (reading room) Lesesaal EG

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  2. Book: Sphingosine-1-phosphate

    Pébay, Alice

    methods and protocols

    (Methods in molecular biology ; 874 ; Springer protocols)

    2012  

    Author's details ed. by Alice Pébay
    Series title Methods in molecular biology ; 874
    Springer protocols
    Collection
    Language English
    Size XI, 221 S. : Ill., graph. Darst.
    Publisher Humana Press
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT017222746
    ISBN 978-1-61779-799-6 ; 1-61779-799-5 ; 9781617798009 ; 1617798002
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2012 A 1987 order for loan Magazin

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  3. Book: Sphingosine-1-phosphate

    Pébay, Alice / Turksen, Kursad

    methods and protocols

    (Methods in molecular biology ; 1697 ; Springer protocols)

    2018  

    Author's details edited by Alice Pébay, Kursad Turksen
    Series title Methods in molecular biology ; 1697
    Springer protocols
    Collection
    Keywords Immunohistochemical ; Physiopathology ; Sphingolipids ; S1P ; Bioactive lysophospholipid ; Stem cells
    Subject code 570
    Language English
    Size x, 182 Seiten, Illustrationen, Diagramme, 25.4 cm x 17.8 cm
    Edition Second edition
    Publisher Humana Press
    Publishing place New York, NY
    Publishing country United States
    Document type Book
    HBZ-ID HT019553248
    ISBN 978-1-4939-7412-2 ; 1-4939-7412-2 ; 9781493974139 ; 1493974130
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 7042 -1697- verfügbar in Königswinter Königswinter

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  4. Book: Regenerative biology of the eye

    Pébay, Alice

    (Stem cell biology and regenerative medicine,)

    2014  

    Author's details Alice Pébay, editor
    Series title Stem cell biology and regenerative medicine,
    MeSH term(s) Eye Diseases/surgery ; Ocular Physiological Phenomena ; Stem Cell Transplantation ; Regenerative Medicine/methods
    Language English
    Size xii, 309 pages :, illustrations.
    Document type Book
    ISBN 9781493907861 ; 1493907867 ; 9781493907878 ; 1493907875
    Database Catalogue of the US National Library of Medicine (NLM)

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  5. Article ; Online: Automation of Organoid Cultures: Current Protocols and Applications.

    Louey, Alexandra / Hernández, Damián / Pébay, Alice / Daniszewski, Maciej

    SLAS discovery : advancing life sciences R & D

    2021  Volume 26, Issue 9, Page(s) 1138–1147

    Abstract: Organoids are three-dimensional, functional structures that mimic in vivo organs. They offer new opportunities for the modeling of cancer and infectious and rare hereditary diseases. Furthermore, the advent of organoid biobanks opens new avenues for drug ...

    Abstract Organoids are three-dimensional, functional structures that mimic in vivo organs. They offer new opportunities for the modeling of cancer and infectious and rare hereditary diseases. Furthermore, the advent of organoid biobanks opens new avenues for drug screening in a personalized fashion and holds much promise for personalized regenerative medicine. Thus, there is a need for reproducible, large-scale organoid generation with minimal variability, making manual approaches impracticable. Here, we review the current use of automation in organoid culture and analysis, using cerebral and retinal organoids as illustrations of current applications. An increased demand for automated organoid platforms is anticipated.
    MeSH term(s) Automation/methods ; Drug Discovery/methods ; Humans ; Organoids ; Precision Medicine/methods ; Tissue Culture Techniques/methods ; Tissue Culture Techniques/standards
    Language English
    Publishing date 2021-06-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2885123-7
    ISSN 2472-5560 ; 2472-5552
    ISSN (online) 2472-5560
    ISSN 2472-5552
    DOI 10.1177/24725552211024547
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4911: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Human pluripotent stem cells for the modelling of retinal pigment epithelium homeostasis and disease: A review.

    Hall, Jenna C / Paull, Daniel / Pébay, Alice / Lidgerwood, Grace E

    Clinical & experimental ophthalmology

    2022  Volume 50, Issue 6, Page(s) 667–677

    Abstract: Human pluripotent stem cells (hPSCs), which include induced pluripotent stem cells and embryonic stem cells, are powerful tools for studying human development, physiology and disease, including those affecting the retina. Cells from selected individuals, ...

    Abstract Human pluripotent stem cells (hPSCs), which include induced pluripotent stem cells and embryonic stem cells, are powerful tools for studying human development, physiology and disease, including those affecting the retina. Cells from selected individuals, or specific genetic backgrounds, can be differentiated into distinct cell types allowing the modelling of diseases in a dish for therapeutic development. hPSC-derived retinal cultures have already been used to successfully model retinal pigment epithelium (RPE) degeneration for various retinal diseases including monogenic conditions and complex disease such as age-related macular degeneration. Here, we will review the current knowledge gained in understanding the molecular events involved in retinal disease using hPSC-derived retinal models, in particular RPE models. We will provide examples of various conditions to illustrate the scope of applications associated with the use of hPSC-derived RPE models.
    MeSH term(s) Homeostasis ; Humans ; Induced Pluripotent Stem Cells/metabolism ; Macular Degeneration/metabolism ; Macular Degeneration/therapy ; Pluripotent Stem Cells/metabolism ; Retinal Pigment Epithelium/metabolism
    Language English
    Publishing date 2022-07-11
    Publishing country Australia
    Document type Journal Article ; Review
    ZDB-ID 2014008-3
    ISSN 1442-9071 ; 1442-6404
    ISSN (online) 1442-9071
    ISSN 1442-6404
    DOI 10.1111/ceo.14128
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1064: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Autosomal Dominant Alzheimer's Disease Mutations in Human Microglia Are Not Sufficient to Trigger Amyloid Pathology in WT Mice but Might Affect Pathology in 5XFAD Mice.

    Romero-Molina, Carmen / Neuner, Sarah M / Ryszawiec, Marcelina / Pébay, Alice / Dominantly Inherited Alzheimer Network / Marcora, Edoardo / Goate, Alison

    International journal of molecular sciences

    2024  Volume 25, Issue 5

    Abstract: Several genetic variants that affect microglia function have been identified as risk factors for Alzheimer's Disease (AD), supporting the importance of this cell type in disease progression. However, the effect of autosomal dominant mutations in the ... ...

    Abstract Several genetic variants that affect microglia function have been identified as risk factors for Alzheimer's Disease (AD), supporting the importance of this cell type in disease progression. However, the effect of autosomal dominant mutations in the amyloid precursor protein (
    MeSH term(s) Humans ; Animals ; Mice ; Alzheimer Disease ; Microglia ; Amyloidogenic Proteins ; Amyloid beta-Protein Precursor ; Mutation ; Plaque, Amyloid ; Presenilin-1 ; Amyloid beta-Peptides ; Mice, Transgenic ; Disease Models, Animal
    Chemical Substances Amyloidogenic Proteins ; Amyloid beta-Protein Precursor ; Presenilin-1 ; Amyloid beta-Peptides
    Language English
    Publishing date 2024-02-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25052565
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Organelle mapping in dendrites of human iPSC-derived neurons reveals dynamic functional dendritic Golgi structures.

    Wang, Jingqi / Daniszewski, Maciej / Hao, Marlene M / Hernández, Damián / Pébay, Alice / Gleeson, Paul A / Fourriere, Lou

    Cell reports

    2023  Volume 42, Issue 7, Page(s) 112709

    Abstract: Secretory pathways within dendrites of neurons have been proposed for local transport of newly synthesized proteins. However, little is known about the dynamics of the local secretory system and whether the organelles are transient or stable structures. ... ...

    Abstract Secretory pathways within dendrites of neurons have been proposed for local transport of newly synthesized proteins. However, little is known about the dynamics of the local secretory system and whether the organelles are transient or stable structures. Here, we quantify the spatial and dynamic behavior of dendritic Golgi and endosomes during differentiation of human neurons generated from induced pluripotent stem cells (iPSCs). In early neuronal development, before and during migration, the entire Golgi apparatus transiently translocates from the soma into dendrites. In mature neurons, dynamic Golgi elements, containing cis and trans cisternae, are transported from the soma along dendrites, in an actin-dependent process. Dendritic Golgi outposts are dynamic and display bidirectional movement. Similar structures were observed in cerebral organoids. Using the retention using selective hooks (RUSH) system, Golgi resident proteins are transported efficiently into Golgi outposts from the endoplasmic reticulum. This study reveals dynamic, functional Golgi structures in dendrites and a spatial map for investigating dendrite trafficking in human neurons.
    MeSH term(s) Humans ; Induced Pluripotent Stem Cells ; Dendrites/metabolism ; Neurons/physiology ; Golgi Apparatus/metabolism ; Endoplasmic Reticulum/metabolism
    Language English
    Publishing date 2023-06-30
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2023.112709
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Book ; Online: Regenerative Biology of the Eye

    Pébay, Alice

    (Stem Cell Biology and Regenerative Medicine)

    2014  

    Abstract: This text is a comprehensive look at the current knowledge on stem cell application for vision loss, showcasing different types of stem cells (adult, embryonic, iPSCs) for diseases of the front and the back of the eye. It also highlights data obtained in ...

    Author's details edited by Alice Pébay
    Series title Stem Cell Biology and Regenerative Medicine
    Abstract This text is a comprehensive look at the current knowledge on stem cell application for vision loss, showcasing different types of stem cells (adult, embryonic, iPSCs) for diseases of the front and the back of the eye. It also highlights data obtained in various models from fish to human, as well as from the bionic eye project for vision regeneration. This volume in the Stem Cell Biology and Regenerative Medicine series is essential reading for stem cell biologists, ophthalmologists, advanced and graduate students, in addition to academics and medical staff who work in these disciplines.

    This volume covers visual regenerative biology from current knowledge through future directions and implications. Fifteen chapters discuss the topic thoroughly, from fundamental aspects of developmental biology of the eye through the potential of stem cells and bionic eyes to improve and restore vision. The book also explores the impact of stem cell treatments and regenerative medicine in society. The economic and public health burdens of blindness are immense, in addition to the psychological and social implications for patients. While current treatments for blindness are limited, regenerative medicine offers exciting prospects for vision improvement or restoration, instilling hope in patients suffering from vision loss. Authoritative and timely, this book is a key resource for scientists working in this expanding and dynamic field
    Keywords Life sciences ; Ophthalmology ; Stem cells ; Medizin / Gesundheit # Augenheilkunde ; Technik / Wissen # Biologie
    Language English
    Size Online-Ressource (XII, 309 p. 32 illus., 26 illus. in color), online resource
    Publisher Springer New York
    Publishing place New York, NY ;s.l
    Document type Book ; Online
    Note Description based upon print version of record
    ISBN 9781493907861 ; 9781493907878 ; 1493907867 ; 1493907875
    DOI 10.1007/978-1-4939-0787-8
    Database Former special subject collection: coastal and deep sea fishing

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  10. Article ; Online: Particulate matter from car exhaust alters function of human iPSC-derived microglia.

    Jäntti, Henna / Jonk, Steffi / Gómez Budia, Mireia / Ohtonen, Sohvi / Fagerlund, Ilkka / Fazaludeen, Mohammad Feroze / Aakko-Saksa, Päivi / Pebay, Alice / Lehtonen, Šárka / Koistinaho, Jari / Kanninen, Katja M / Jalava, Pasi I / Malm, Tarja / Korhonen, Paula

    Particle and fibre toxicology

    2024  Volume 21, Issue 1, Page(s) 6

    Abstract: Background: Air pollution is recognized as an emerging environmental risk factor for neurological diseases. Large-scale epidemiological studies associate traffic-related particulate matter (PM) with impaired cognitive functions and increased incidence ... ...

    Abstract Background: Air pollution is recognized as an emerging environmental risk factor for neurological diseases. Large-scale epidemiological studies associate traffic-related particulate matter (PM) with impaired cognitive functions and increased incidence of neurodegenerative diseases such as Alzheimer's disease. Inhaled components of PM may directly invade the brain via the olfactory route, or act through peripheral system responses resulting in inflammation and oxidative stress in the brain. Microglia are the immune cells of the brain implicated in the progression of neurodegenerative diseases. However, it remains unknown how PM affects live human microglia.
    Results: Here we show that two different PMs derived from exhausts of cars running on EN590 diesel or compressed natural gas (CNG) alter the function of human microglia-like cells in vitro. We exposed human induced pluripotent stem cell (iPSC)-derived microglia-like cells (iMGLs) to traffic related PMs and explored their functional responses. Lower concentrations of PMs ranging between 10 and 100 µg ml
    Conclusions: Our study indicates that traffic-related air pollutants alter the function of human microglia and warrant further studies to determine whether these changes contribute to adverse effects in the brain and on cognition over time. This study demonstrates human iPSC-microglia as a valuable tool to study functional microglial responses to environmental agents.
    MeSH term(s) Humans ; Particulate Matter/toxicity ; Particulate Matter/analysis ; Microglia/chemistry ; Induced Pluripotent Stem Cells/chemistry ; Automobiles ; Reactive Oxygen Species ; Vehicle Emissions/toxicity ; Vehicle Emissions/analysis ; Neurodegenerative Diseases
    Chemical Substances Particulate Matter ; Reactive Oxygen Species ; Vehicle Emissions
    Language English
    Publishing date 2024-02-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2170936-1
    ISSN 1743-8977 ; 1743-8977
    ISSN (online) 1743-8977
    ISSN 1743-8977
    DOI 10.1186/s12989-024-00564-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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