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  1. AU="Pérez Latorre, Leire"
  2. AU=Vardhan Seshu
  3. AU="OJ Baker"
  4. AU="Dalton, R C"
  5. AU="Mrozikiewicz-Rakowska, Beata"
  6. AU="Penkert, Judith"
  7. AU="Mak, Susanna"
  8. AU="Karkoszka, Henryk"
  9. AU="Burton, Jeffrey H"
  10. AU="Frederique Pitel"
  11. AU="Pierce, Aimee"
  12. AU="Luque-Ballesteros, Laura"
  13. AU="Dondi, Francesco"
  14. AU="McLachlan, Alex"
  15. AU="Krizova, Ludmila"
  16. AU="Balog, Attila"
  17. AU="Faerber, Karin"
  18. AU="Prettner, Klaus"
  19. AU="Ambrožová, I."
  20. AU="William, Doreen"
  21. AU="Gutiérrez-Sánchez, A M"
  22. AU="Bohan, Dana"
  23. AU="Spracklen, D."
  24. AU="Lobo, Brian C"
  25. AU=Zhuang Jianjian AU=Zhuang Jianjian
  26. AU=Pathanki Adithya M
  27. AU="Armando Vilchis-Ordoñez"
  28. AU="Zhongfu Lu"
  29. AU="Lo, Hong-Yip"
  30. AU="Ziman Xiong"
  31. AU="Oakes, Allison H"
  32. AU="Ma, Shaotong"
  33. AU="Zang, Lili"
  34. AU="Adams Brian D"
  35. AU="Maria Papaioannou"
  36. AU="Kollia, Georgia"
  37. AU="Auxiette, Catherine"
  38. AU="Guzmán, Luis"
  39. AU="Alipour, Elnaz"
  40. AU="Queiroz, Dayanna Joyce Marques"
  41. AU="Ramamurthy, Santosh"
  42. AU="Xueying Huang"
  43. AU="Cromwell, Howard C"
  44. AU="Spence, John C H"
  45. AU="Chapinal, Libertad"
  46. AU=Rohaim Mohammed A AU=Rohaim Mohammed A
  47. AU=Hempel Cornelius

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  1. Artikel ; Online: Plasma metabolomic profile is near-normal in people with HIV on long-term suppressive antiretroviral therapy.

    Virseda-Berdices, Ana / Martín-Escolano, Rubén / Berenguer, Juan / González-García, Juan / Brochado-Kith, Oscar / Rojo, David / Fernández-Rodríguez, Amanda / Pérez-Latorre, Leire / Hontañón, Victor / Barbas, Coral / Resino, Salvador / Jiménez-Sousa, María Ángeles

    Frontiers in cellular and infection microbiology

    2024  Band 14, Seite(n) 1340610

    Abstract: Background: Combination antiretroviral therapy (ART) has transformed human immunodeficiency virus (HIV) infection in people with HIV (PWH). However, a chronic state of immune activation and inflammation is maintained despite achieving HIV suppression ... ...

    Abstract Background: Combination antiretroviral therapy (ART) has transformed human immunodeficiency virus (HIV) infection in people with HIV (PWH). However, a chronic state of immune activation and inflammation is maintained despite achieving HIV suppression and satisfactory immunological recovery. We aimed to determine whether the plasma metabolomic profile of PWH on long-term suppressive ART and immunologically recovered approximates the normality by comparison with healthy controls with similar age and gender.
    Methods: We carried out a cross-sectional study in 17 PWH on long-term ART (HIV-RNA <50 copies/mL, CD4
    Results: PCA and PLS-DA analyses found no relevant differences between groups. Adjusted GLM showed 14 significant features (q-value<0.20), of which only three could be identified: lysophosphatidylcholine (LysoPC) (22:6) (q-value=0.148), lysophosphatidylethanolamine (LysoPE) (22:6) (q-value=0.050) and hydroperoxy-octadecatrienoic acid (HpOTrE)/dihydroperoxy-octadecatrienoic acid (DiHOTrE)/epoxy-octadecadienoic acid (EpODE) (q-value=0.136). These significant identified metabolites were directly correlated to plasma inflammatory biomarkers in PWH and negatively correlated in healthy controls.
    Conclusion: PWH on long-term ART have a metabolomic profile that is almost normal compared to healthy controls. Nevertheless, residual metabolic alterations linked to inflammatory biomarkers persist, which could favor the development of age-related comorbidities among this population.
    Mesh-Begriff(e) Humans ; Cross-Sectional Studies ; Metabolomics/methods ; Biomarkers ; Inflammation/metabolism ; HIV Infections
    Chemische Substanzen Biomarkers
    Sprache Englisch
    Erscheinungsdatum 2024-03-14
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2024.1340610
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Bloodstream infections: trends and evolution of incidence and etiology in a 12-year period (2010-2021).

    Alonso-Menchén, David / Sánchez-Carrillo, Carlos / Alcalá, Luis / Soriano-Martín, Ana / Cercenado, Emilia / Burillo, Almudena / Serrano-Lobo, Julia / Pérez-Latorre, Leire / Muñoz, Patricia / Bouza, Emilio

    Infectious diseases (London, England)

    2024  Band 56, Heft 6, Seite(n) 441–450

    Abstract: Introduction: The epidemiological evolution of bloodstream infections (BSIs) in the last decade is not clearly defined. Our aim was to analyze the changes in the workload in our institution and to describe the evolution of the incidence and etiology of ... ...

    Abstract Introduction: The epidemiological evolution of bloodstream infections (BSIs) in the last decade is not clearly defined. Our aim was to analyze the changes in the workload in our institution and to describe the evolution of the incidence and etiology of BSIs in a 12-year period, including the COVID-19 pandemic.
    Methods: All blood cultures received in the laboratory of a tertiary general hospital between 2010 and 2021 were analyzed. Bloodstream infection episodes refer to each episode of bacteremia or fungemia in each patient. Incidence rates per 1000 admissions and per 100,000 population were calculated.
    Results: No significant changes in the incidence of BSI episodes/1000 admissions were observed (mean, 31.1), while estimated population-based incidences showed declining trends (mean, 182.8/100,000 inhabitants). There was a slight increase in BSI episodes per 1000 admissions caused by Gram-negatives (mean, 16.6/1000 admissions) and
    Conclusions: No clear increase in the incidence of BSI episodes was detected in our center over this period. Gram-negatives are the most frequent etiology, with no clear rise in antimicrobial resistance phenotypes. The COVID-19 pandemic accounted for a small increase in BSI episodes in 2020, probably related to the increase of catheter-related infections.
    Mesh-Begriff(e) Humans ; Incidence ; COVID-19/epidemiology ; Bacteremia/epidemiology ; Bacteremia/microbiology ; Male ; Female ; Aged ; Middle Aged ; Fungemia/epidemiology ; Fungemia/microbiology ; SARS-CoV-2 ; Adult ; Aged, 80 and over ; Tertiary Care Centers/statistics & numerical data ; Retrospective Studies ; Catheter-Related Infections/epidemiology ; Catheter-Related Infections/microbiology
    Sprache Englisch
    Erscheinungsdatum 2024-02-26
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2839775-7
    ISSN 2374-4243 ; 2374-4235
    ISSN (online) 2374-4243
    ISSN 2374-4235
    DOI 10.1080/23744235.2024.2320333
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Corrigendum to "PBMCs gene expression signature of advanced cirrhosis with high risk for clinically significant portal hypertension in HIV/HCV coinfected patients: A cross-control study" [Biomed. Pharmacother. 159 (2023) 114220].

    Salgüero, Sergio / Brochado-Kith, Óscar / Verdices, Ana Virseda / Berenguer, Juan / González-García, Juan / Martínez, Isidoro / Díez, Cristina / Hontañón, Víctor / Pérez-Latorre, Leire / Fernández-Rodríguez, Amanda / Jiménez-Sousa, María Ángeles / Resino, Salvador

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2023  Band 163, Seite(n) 114803

    Sprache Englisch
    Erscheinungsdatum 2023-04-27
    Erscheinungsland France
    Dokumenttyp Published Erratum
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2023.114803
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  4. Artikel ; Online: PBMCs gene expression signature of advanced cirrhosis with high risk for clinically significant portal hypertension in HIV/HCV coinfected patients: A cross-control study.

    Salgüero, Sergio / Brochado-Kith, Óscar / Verdices, Ana Virseda / Berenguer, Juan / González-García, Juan / Martínez, Isidoro / Díez, Cristina / Hontañón, Víctor / Pérez-Latorre, Leire / Fernández-Rodríguez, Amanda / Jiménez-Sousa, María Ángeles / Resino, Salvador

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2023  Band 159, Seite(n) 114220

    Abstract: Background: Patients with advanced cirrhosis are at high risk of developing clinically significant portal hypertension (CSPH). We analyzed the gene expression profile of peripheral blood mononuclear cells (PBMCs) from HIV/HCV coinfected patients to ... ...

    Abstract Background: Patients with advanced cirrhosis are at high risk of developing clinically significant portal hypertension (CSPH). We analyzed the gene expression profile of peripheral blood mononuclear cells (PBMCs) from HIV/HCV coinfected patients to identify a gene expression signature of advanced cirrhosis with high risk for CSPH.
    Methods: We conducted a cross-sectional study on 68 patients. Liver stiffness measurement (LSM) was used to stratify patients into < 12.5 kPa (no cirrhosis, n = 19), 12.5 - 24.9 kPa (cirrhosis, n = 20), and ≥ 25 kPa (advanced cirrhosis with high risk for CSPH, n = 29). Besides, we further evaluated LSM < 25 kPa (n = 39) vs. ≥ 25 kPa (n = 29). Total RNA was extracted from PBMCs, and poly(A) RNA sequencing was performed. Two significant differentially expressed (SDE) transcripts were validated by quantitative PCR in a different cohort (n = 46).
    Results: We found 60 SDE transcripts between patients with LSM < 12.5 kPa and ≥ 25 kPa. Partial least squares discriminant analysis showed that those 60 SDE transcripts collectively discriminated LSM ≥ 25 kPa, with an area under the receiver operating characteristic curve (AUROC) of 0.84. Eight genes had an AUROC ≥ 0.75 for LSM ≥ 25 kPa: five were positively associated with LSM values (SCAMP1, ABHD17B, GPR146, GTF2A1, and TMEM64), while three were inversely associated (ZFHX2-AS1, MDK, and STAG3L2). We validated the two SDE transcripts with the highest discrimination capacity in a different cohort, finding significant differences between < 25 kPa and ≥ 25 kPa (MDK (p = 0.006) and STAG3L2 (p = 0.021)).
    Conclusions: A gene expression signature of 60 transcripts was associated with advanced cirrhosis with high risk for CSPH in HIV/HCV coinfected patients.
    Mesh-Begriff(e) Humans ; Transcriptome/genetics ; Coinfection/genetics ; Cross-Sectional Studies ; Leukocytes, Mononuclear ; HIV Infections/complications ; HIV Infections/genetics ; HIV Infections/pathology ; Liver Cirrhosis/complications ; Liver Cirrhosis/genetics ; Liver Cirrhosis/pathology ; Hypertension, Portal/genetics ; Hypertension, Portal/pathology ; Hepatitis C/complications ; Hepatitis C/genetics ; Elasticity Imaging Techniques ; Liver/pathology ; Vesicular Transport Proteins
    Chemische Substanzen SCAMP1 protein, human ; Vesicular Transport Proteins
    Sprache Englisch
    Erscheinungsdatum 2023-01-09
    Erscheinungsland France
    Dokumenttyp Journal Article
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2023.114220
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Metabolomic changes after DAAs therapy are related to the improvement of cirrhosis and inflammation in HIV/HCV-coinfected patients.

    Virseda-Berdices, Ana / Rojo, David / Martínez, Isidoro / Berenguer, Juan / González-García, Juan / Brochado-Kith, Oscar / Fernández-Rodríguez, Amanda / Díez, Cristina / Hontañon, Víctor / Pérez-Latorre, Leire / Micán, Rafael / Barbas, Coral / Resino, Salvador / Jiménez-Sousa, María Angeles

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2022  Band 147, Seite(n) 112623

    Abstract: Background: A better understanding of the evolution of cirrhosis after hepatitis C virus (HCV) clearance is essential since the reversal of liver injury may not happen. We aimed to assess the evolution of plasma metabolites after direct-acting ... ...

    Abstract Background: A better understanding of the evolution of cirrhosis after hepatitis C virus (HCV) clearance is essential since the reversal of liver injury may not happen. We aimed to assess the evolution of plasma metabolites after direct-acting antivirals (DAAs) therapy and their association with liver disease scores in HIV/HCV-coinfected patients with advanced HCV-related cirrhosis.
    Methods: We performed a prospective study in 49 cirrhotic patients who started DAAs therapy. Data and samples were collected at baseline and 36 weeks after SVR. Metabolomics analysis was carried out using gas chromatography-mass spectrometry and liquid chromatography-mass spectrometry. Inflammation-related biomarkers were analyzed using ProcartaPlex Immunoassays.
    Results: At 36 weeks after SVR, patients experienced significant decrease in taurocholic acid, 2,3-butanediol, and LPC(18:0); while several phosphatidylcholines (LPC(16:1), LPC(18:1), LPC(20:4), and PC(16:0/9:0(CHO))/PC(16:0/9:0(COH)), 2-keto-n-caproic acid/2-keto-isocaproic acid and N-methyl alanine increased, compared to baseline. The plasma decrease in taurocholic acid was associated with a reduction in Child-Turcotte-Pugh (CTP) (AMR=3.39; q-value=0.006) and liver stiffness measurement (LSM) (AMR=1.06; q-value<0.001), the plasma increase in LPC(20:4) was related to a reduction in LSM (AMR=0.98; q-value=0.027), and the rise of plasma 2-keto-n-caproic acid/2-keto-isocaproic acid was associated with a reduction in CTP (AMR=0.35; q-value=0.004). Finally, plasma changes in taurocholic acid were directly associated with inflammation-related biomarkers, while changes in LPC(20:4) were inversely associated.
    Conclusions: Plasma metabolomic profile changed after HCV clearance with all oral-DAAs in HIV/HCV-coinfected with advanced HCV-related cirrhosis. Changes in plasma levels of LPC (20: 4), 2-keto-n-caproic acid/2-keto-isocaproic acid, and taurocholic acid were related to improvements in cirrhosis scores and inflammatory status of patients.
    Mesh-Begriff(e) Antiviral Agents/therapeutic use ; Biomarkers/blood ; Female ; HIV Infections ; Hepatitis C ; Humans ; Inflammation/complications ; Inflammation/drug therapy ; Inflammation/pathology ; Liver Cirrhosis/complications ; Liver Cirrhosis/drug therapy ; Liver Cirrhosis/pathology ; Longitudinal Studies ; Male ; Middle Aged ; Phosphatidylcholines/blood ; Severity of Illness Index ; Spain ; Taurocholic Acid/blood
    Chemische Substanzen Antiviral Agents ; Biomarkers ; Phosphatidylcholines ; Taurocholic Acid (5E090O0G3Z)
    Sprache Englisch
    Erscheinungsdatum 2022-01-12
    Erscheinungsland France
    Dokumenttyp Journal Article ; Multicenter Study
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2022.112623
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Cervical and Oropharyngeal Lymphogranuloma Venereum: Case Report and Literature Review.

    Galeano-Valle, Francisco / Pérez-Latorre, Leire / Díez-Romero, Cristina / Fanciulli, Chiara / Aldamiz-Echeverria-Lois, Teresa / Tejerina-Picado, Francisco

    Sexually transmitted diseases

    2019  Band 46, Heft 10, Seite(n) 689–692

    Abstract: Lymphogranuloma venereum (LGV) is a sexually transmitted infection caused by invasive serovars of Chlamydia trachomatis. There have been only a few case reports of oropharyngeal C. trachomatis infection complicated with cervical LGV. We report a case of ... ...

    Abstract Lymphogranuloma venereum (LGV) is a sexually transmitted infection caused by invasive serovars of Chlamydia trachomatis. There have been only a few case reports of oropharyngeal C. trachomatis infection complicated with cervical LGV. We report a case of a HIV-positive male patient with cervical LGV that presented a poor evolution despite appropriate treatment.
    Mesh-Begriff(e) Anti-Bacterial Agents/therapeutic use ; Cervical Atlas/microbiology ; Chlamydia Infections/complications ; Chlamydia Infections/microbiology ; Chlamydia trachomatis ; HIV Infections/complications ; HIV Infections/drug therapy ; HIV Infections/microbiology ; HIV Seropositivity/complications ; HIV Seropositivity/microbiology ; Homosexuality, Male ; Humans ; Lymphogranuloma Venereum/diagnostic imaging ; Lymphogranuloma Venereum/drug therapy ; Male ; Middle Aged ; Oropharynx/microbiology ; Serogroup ; Tomography, X-Ray Computed
    Chemische Substanzen Anti-Bacterial Agents
    Sprache Englisch
    Erscheinungsdatum 2019-06-27
    Erscheinungsland United States
    Dokumenttyp Case Reports ; Journal Article ; Review
    ZDB-ID 435191-5
    ISSN 1537-4521 ; 0148-5717
    ISSN (online) 1537-4521
    ISSN 0148-5717
    DOI 10.1097/OLQ.0000000000001036
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Plasma IP-10 and IL-6 are linked to Child-Pugh B cirrhosis in patients with advanced HCV-related cirrhosis: a cross-sectional study.

    Salgüero, Sergio / Medrano, Luz Maria / González-García, Juan / Berenguer, Juan / Montes, María L / Diéz, Cristina / Garcia-Broncano, Pilar / Llop-Herrera, Elba / Pérez-Latorre, Leire / Bellóno, José María / Jiménez-Sousa, María Ángeles / Resino, Salvador

    Scientific reports

    2020  Band 10, Heft 1, Seite(n) 10384

    Abstract: We aimed to evaluate the association of plasma biomarkers linked to inflammation (bacterial translocation, inflammatory response, and endothelial dysfunction), coagulopathy, and angiogenesis with the severity of liver cirrhosis (assessed by the Child- ... ...

    Abstract We aimed to evaluate the association of plasma biomarkers linked to inflammation (bacterial translocation, inflammatory response, and endothelial dysfunction), coagulopathy, and angiogenesis with the severity of liver cirrhosis (assessed by the Child-Pugh-Turcotte score, CTP) and Child-Pugh B cirrhosis (CTP 7-9) in patients with advanced hepatitis C virus (HCV)-related cirrhosis. We carried out a cross-sectional study in 97 patients with advanced HCV-related cirrhosis (32 HCV-monoinfected and 65 HIV/HCV-coinfected). Plasma biomarkers were measured by ProcartaPlex multiplex immunoassays. The outcome variable was the CTP score and the Child-Pugh B cirrhosis (CTP 7-9). HIV/HCV-coinfected patients and HCV-monoinfected patients with advanced HCV-related cirrhosis had near-equivalent values of plasma biomarkers. Higher values of plasma biomarkers linked to an inflammatory response (IP-10, IL-8, IL-6, and OPG), endothelial dysfunction (sVCAM-1 and sICAM-1), and coagulopathy (D-dimer) were related to higher CTP values. The most significant biomarkers to detect the presence of Child-Pugh B cirrhosis (CTP 7-9) were IP-10 (p-value= 0.008) and IL-6 (p-value=0.002). The AUC-ROC values of IP-10, IL-6, and both biomarkers combined (IP-10+IL-6) were 0.78, 0.88, and 0.96, respectively. In conclusion, HIV infection does not appear to have a significant impact on the analyzed plasma biomarkers in patients with advanced HCV-related cirrhosis. However, plasma biomarkers linked to inflammation (inflammatory response and endothelial dysfunction) were related to the severity of liver cirrhosis (CTP score), mainly IP-10 and IL-6, which discriminated patients with Child-Pugh B concerning Child-Pugh A.
    Mesh-Begriff(e) Aged ; Aged, 80 and over ; Biomarkers/blood ; Chemokine CXCL10/blood ; Cross-Sectional Studies ; Female ; Follow-Up Studies ; Hepacivirus/isolation & purification ; Hepatitis C/complications ; Hepatitis C/virology ; Humans ; Interleukin-6/blood ; Liver Cirrhosis/blood ; Liver Cirrhosis/classification ; Liver Cirrhosis/diagnosis ; Liver Cirrhosis/etiology ; Male ; Middle Aged ; Prognosis ; Prospective Studies
    Chemische Substanzen Biomarkers ; CXCL10 protein, human ; Chemokine CXCL10 ; IL6 protein, human ; Interleukin-6
    Sprache Englisch
    Erscheinungsdatum 2020-06-25
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-020-67159-3
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: HCV Cure With Direct-Acting Antivirals Improves Liver and Immunological Markers in HIV/HCV-Coinfected Patients.

    Brochado-Kith, Óscar / Martínez, Isidoro / Berenguer, Juan / González-García, Juan / Salgüero, Sergio / Sepúlveda-Crespo, Daniel / Díez, Cristina / Hontañón, Víctor / Ibañez-Samaniego, Luis / Pérez-Latorre, Leire / Fernández-Rodríguez, Amanda / Ángeles Jiménez-Sousa, María / Resino, Salvador

    Frontiers in immunology

    2021  Band 12, Seite(n) 723196

    Abstract: Hepatitis C virus (HCV) cure after all-oral direct-acting antiviral (DAA) therapy greatly improves the liver and immune system. We aimed to assess the impact of this HCV clearance on immune system-related markers in plasma and the gene expression profile ...

    Abstract Hepatitis C virus (HCV) cure after all-oral direct-acting antiviral (DAA) therapy greatly improves the liver and immune system. We aimed to assess the impact of this HCV clearance on immune system-related markers in plasma and the gene expression profile in human immunodeficiency virus (HIV)/HCV-coinfected patients with advanced cirrhosis. We performed a prospective study on 33 HIV/HCV-coinfected patients at baseline and 36 weeks after the sustained virological response. Gene expression was evaluated by RNA-seq analysis on peripheral blood mononuclear cells (PBMCs) and plasma biomarkers by multiplex immunoassays. We found a decrease in plasma biomarkers (PD1, PDL1, CXCL10, CXCL8, IL12p70, IL10, and TGFβ) and liver disease markers (stiffness measurement (LSM), hepatic venous pressure gradient (HVPG), and transaminases, among others). Furthermore, decreased plasma levels of CXCL8, CXCL10, IL10, and PD1 were associated with reduced LSM values. We also found two upregulated (
    Mesh-Begriff(e) Aged ; Antiviral Agents/therapeutic use ; Biomarkers/blood ; Chemokines/blood ; Coinfection/drug therapy ; Female ; Gene Expression ; HIV Infections/drug therapy ; Hepacivirus/genetics ; Hepatitis C/complications ; Hepatitis C/drug therapy ; Hepatitis C/virology ; Humans ; Interferons/blood ; Liver Cirrhosis/blood ; Liver Cirrhosis/diagnosis ; Liver Cirrhosis/etiology ; Liver Function Tests ; Male ; Middle Aged ; Prospective Studies ; Sustained Virologic Response
    Chemische Substanzen Antiviral Agents ; Biomarkers ; Chemokines ; Interferons (9008-11-1)
    Sprache Englisch
    Erscheinungsdatum 2021-08-23
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.723196
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: Blood microbiome is associated with changes in portal hypertension after successful direct-acting antiviral therapy in patients with HCV-related cirrhosis.

    Virseda-Berdices, Ana / Brochado-Kith, Oscar / Díez, Cristina / Hontañon, Victor / Berenguer, Juan / González-García, Juan / Rojo, David / Fernández-Rodríguez, Amanda / Ibañez-Samaniego, Luis / Llop-Herrera, Elba / Olveira, Antonio / Perez-Latorre, Leire / Barbas, Coral / Rava, Marta / Resino, Salvador / Jiménez-Sousa, María Angeles

    The Journal of antimicrobial chemotherapy

    2021  Band 77, Heft 3, Seite(n) 719–726

    Abstract: Background: Patients with a significant decrease in hepatic venous pressure gradient (HVPG) have a considerable reduction of liver complications and higher survival after HCV eradication.: Objectives: To evaluate the association between the baseline ... ...

    Abstract Background: Patients with a significant decrease in hepatic venous pressure gradient (HVPG) have a considerable reduction of liver complications and higher survival after HCV eradication.
    Objectives: To evaluate the association between the baseline blood microbiome and the changes in HVPG after successful direct-acting antiviral (DAA) therapy in patients with HCV-related cirrhosis.
    Methods: We performed a prospective study in 32 cirrhotic patients (21 HIV positive) with clinically significant portal hypertension (HVPG ≥10 mmHg). Patients were assessed at baseline and 48 weeks after HCV treatment completion. The clinical endpoint was a decrease in HVPG of ≥20% or HVPG <12 mmHg at the end of follow-up. Bacterial 16S ribosomal DNA was sequenced using MiSeq Illumina technology, inflammatory plasma biomarkers were investigated using ProcartaPlex immunoassays and the metabolome was investigated using GC-MS.
    Results: During the follow-up, 47% of patients reached the clinical endpoint. At baseline, those patients had a higher relative abundance of Corynebacteriales and Diplorickettsiales order, Diplorickettsiaceae family, Corynebacterium and Aquicella genus and Undibacterium parvum species organisms and a lower relative abundance of Oceanospirillales and Rhodospirillales order, Halomonadaceae family and Massilia genus organisms compared with those who did not achieve the clinical endpoint according to the LEfSe algorithm. Corynebacteriales and Massilia were consistently found within the 10 bacterial taxa with the highest differential abundance between groups. Additionally, the relative abundance of the Corynebacteriales order was inversely correlated with IFN-γ, IL-17A and TNF-α levels and the Massilia genus with glycerol and lauric acid.
    Conclusions: Baseline-specific bacterial taxa are related to an HVPG decrease in patients with HCV-related cirrhosis after successful DAA therapy.
    Mesh-Begriff(e) Antiviral Agents/therapeutic use ; Hepatitis C, Chronic/complications ; Hepatitis C, Chronic/drug therapy ; Humans ; Hypertension, Portal/drug therapy ; Hypertension, Portal/etiology ; Liver Cirrhosis/complications ; Microbiota ; Prospective Studies
    Chemische Substanzen Antiviral Agents
    Sprache Englisch
    Erscheinungsdatum 2021-11-30
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 191709-2
    ISSN 1460-2091 ; 0305-7453
    ISSN (online) 1460-2091
    ISSN 0305-7453
    DOI 10.1093/jac/dkab444
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: HIV/HBV coinfection: temporal trends and patient characteristics, Spain, 2002 to 2018.

    Pérez-Latorre, Leire / Berenguer, Juan / Micán, Rafael / Montero, Marta / Cifuentes, Carmen / Puig, Teresa / Sanz, José / Ferrero, Oscar L / De La Fuente, Belén / Rodríguez, Carmen / Reus, Sergio / Hernández-Quero, José / Gaspar, Gabriel / Pérez-Martínez, Laura / García, Coral / Force, Luis / Veloso, Sergio / De Miguel, Marta / Jarrín, Inmaculada /
    González-García, Juan

    Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin

    2022  Band 26, Heft 25

    Abstract: BackgroundRecent and reliable estimates on the prevalence of coinfection with human immunodeficiency virus (HIV) and hepatitis B virus (HBV) in Europe are lacking.AimLeveraged on a study designed to assess HIV/HCV coinfection prevalence, we assessed the ... ...

    Abstract BackgroundRecent and reliable estimates on the prevalence of coinfection with human immunodeficiency virus (HIV) and hepatitis B virus (HBV) in Europe are lacking.AimLeveraged on a study designed to assess HIV/HCV coinfection prevalence, we assessed the prevalence of HIV/HBV coinfection in Spain in 2018 and compared the results with five similar studies performed since 2002.MethodsThis cross-sectional prevalence study was carried out in 43 centres, and patients were selected using simple random sampling. The reference population comprised 40,322 patients and the sample size were 1,690 patients.ResultsThe prevalence of HIV/HBV coinfection in Spain at the end of 2018 was 3.2%. The prevalence in 2002, 2009, 2015, 2016 and 2017 was 4.9%, 3.4%, 3%, 3.9% and 3%, respectively. Among the HIV/HBV-coinfected patients identified in 2018, 16.7% had cirrhosis according to transient elastography and 26.3% tested positive for antibodies against hepatitis D virus. All HIV/HBV-coinfected patients were receiving drugs with activity against HBV, and 97% of those tested for HBV DNA had an HBV DNA load < 80 IU/mL.ConclusionsThe prevalence of HIV/HBV coinfection in Spain remained stable at around 3% for a decade. Our data could facilitate the design of national programmes to control HBV infection and help identify areas of patient management that need improvement.
    Mesh-Begriff(e) Coinfection/epidemiology ; Cross-Sectional Studies ; Europe ; HIV Infections/epidemiology ; Hepatitis B/epidemiology ; Hepatitis B virus ; Humans ; Prevalence ; Spain/epidemiology
    Sprache Englisch
    Erscheinungsdatum 2022-09-14
    Erscheinungsland Sweden
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1338803-4
    ISSN 1560-7917 ; 1025-496X
    ISSN (online) 1560-7917
    ISSN 1025-496X
    DOI 10.2807/1560-7917.ES.2021.26.25.2000236
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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