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  1. Article ; Online: Caenorhabditis elegans respond to high-glucose diets through a network of stress-responsive transcription factors.

    Alcántar-Fernández, Jonathan / Navarro, Rosa E / Salazar-Martínez, Ana María / Pérez-Andrade, Martha Elva / Miranda-Ríos, Juan

    PloS one

    2018  Volume 13, Issue 7, Page(s) e0199888

    Abstract: High-glycemic-index diets, as well as a sedentary lifestyle are considered as determinant factors for the development of obesity, type 2 diabetes, and cardiovascular diseases in humans. These diets have been shown to shorten the life span of C. elegans ... ...

    Abstract High-glycemic-index diets, as well as a sedentary lifestyle are considered as determinant factors for the development of obesity, type 2 diabetes, and cardiovascular diseases in humans. These diets have been shown to shorten the life span of C. elegans in a manner that is dependent on insulin signaling, but the participation of other signaling pathways have not been addressed. In this study, we have determined that worms fed with high-glucose diets show alterations in glucose content and uptake, triglyceride content, body size, number of eggs laid, egg-laying defects, and signs of oxidative stress and accelerated aging. Additionally, we analyzed the participation of different key regulators of carbohydrate and lipid metabolism, oxidative stress and longevity such as SKN-1/NRF2, HIF-1/HIF1α, SBP-1/SREBP, CRH-1/CREB, CEP-1/p53, and DAF-16/FOXO, in the reduction of lifespan in glucose-fed worms.
    MeSH term(s) Aging/metabolism ; Animals ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans/growth & development ; Caenorhabditis elegans/metabolism ; Caenorhabditis elegans Proteins/genetics ; Caenorhabditis elegans Proteins/metabolism ; Diet, Carbohydrate Loading/adverse effects ; Glucose/administration & dosage ; Glucose/metabolism ; Oviparity ; Oxidative Stress ; Stress, Physiological ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Triglycerides/metabolism
    Chemical Substances Caenorhabditis elegans Proteins ; Transcription Factors ; Triglycerides ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2018-07-10
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0199888
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: High-glucose diets induce mitochondrial dysfunction in Caenorhabditis elegans.

    Alcántar-Fernández, Jonathan / González-Maciel, Angélica / Reynoso-Robles, Rafael / Pérez Andrade, Martha Elva / Hernández-Vázquez, Alain de J / Velázquez-Arellano, Antonio / Miranda-Ríos, Juan

    PloS one

    2019  Volume 14, Issue 12, Page(s) e0226652

    Abstract: Glucose is an important nutrient that dictates the development, fertility and lifespan of all organisms. In humans, a deficit in its homeostatic control might lead to hyperglucemia and the development of obesity and type 2 diabetes, which show a ... ...

    Abstract Glucose is an important nutrient that dictates the development, fertility and lifespan of all organisms. In humans, a deficit in its homeostatic control might lead to hyperglucemia and the development of obesity and type 2 diabetes, which show a decreased ability to respond to and metabolize glucose. Previously, we have reported that high-glucose diets (HGD) induce alterations in triglyceride content, body size, progeny, and the mRNA accumulation of key regulators of carbohydrate and lipid metabolism, and longevity in Caenorhabditis elegans (PLoS ONE 13(7): e0199888). Herein, we show that increasing amounts of glucose in the diet induce the swelling of both mitochondria in germ and muscle cells. Additionally, HGD alter the enzymatic activities of the different respiratory complexes in an intricate pattern. Finally, we observed a downregulation of ceramide synthases (hyl-1 and hyl-2) and antioxidant genes (gcs-1 and gst-4), while mitophagy genes (pink-1 and dct-1) were upregulated, probably as part of a mitohormetic mechanism in response to glucose toxicity.
    MeSH term(s) Animals ; Caenorhabditis elegans/drug effects ; Caenorhabditis elegans/metabolism ; Diet ; Gene Expression Regulation/drug effects ; Glucose/metabolism ; Glucose/pharmacology ; Longevity/drug effects ; Mitochondria/drug effects ; Mitochondria/pathology ; Mitophagy/drug effects
    Chemical Substances Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2019-12-17
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0226652
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: High-Throughput Profiling of Caenorhabditis elegans Starvation-Responsive microRNAs.

    Garcia-Segura, Laura / Abreu-Goodger, Cei / Hernandez-Mendoza, Armando / Dimitrova Dinkova, Tzvetanka D / Padilla-Noriega, Luis / Perez-Andrade, Martha Elva / Miranda-Rios, Juan

    PloS one

    2015  Volume 10, Issue 11, Page(s) e0142262

    Abstract: MicroRNAs (miRNAs) are non-coding RNAs of ~22 nucleotides in length that regulate gene expression by interfering with the stability and translation of mRNAs. Their expression is regulated during development, under a wide variety of stress conditions and ... ...

    Abstract MicroRNAs (miRNAs) are non-coding RNAs of ~22 nucleotides in length that regulate gene expression by interfering with the stability and translation of mRNAs. Their expression is regulated during development, under a wide variety of stress conditions and in several pathological processes. In nature, animals often face feast or famine conditions. We observed that subjecting early L4 larvae from Caenorhabditis elegans to a 12-hr starvation period produced worms that are thinner and shorter than well-fed animals, with a decreased lipid accumulation, diminished progeny, reduced gonad size, and an increased lifespan. Our objective was to identify which of the 302 known miRNAs of C. elegans changed their expression under starvation conditions as compared to well-fed worms by means of deep sequencing in early L4 larvae. Our results indicate that 13 miRNAs (miR-34-3p, the family of miR-35-3p to miR-41-3p, miR-39-5p, miR-41-5p, miR-240-5p, miR-246-3p and miR-4813-5p) were upregulated, while 2 miRNAs (let-7-3p and miR-85-5p) were downregulated in 12-hr starved vs. well-fed early L4 larvae. Some of the predicted targets of the miRNAs that changed their expression in starvation conditions are involved in metabolic or developmental process. In particular, miRNAs of the miR-35 family were upregulated 6-20 fold upon starvation. Additionally, we showed that the expression of gld-1, important in oogenesis, a validated target of miR-35-3p, was downregulated when the expression of miR-35-3p was upregulated. The expression of another reported target, the cell cycle regulator lin-23, was unchanged during starvation. This study represents a starting point for a more comprehensive understanding of the role of miRNAs during starvation in C. elegans.
    MeSH term(s) Animals ; Caenorhabditis elegans/genetics ; Gene Expression ; Gene Expression Profiling ; High-Throughput Nucleotide Sequencing ; MicroRNAs ; Signal Transduction/genetics ; Starvation/genetics
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2015
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0142262
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Hipertirotropinemia en recién nacidos mexicanos

    Vela-Amieva Marcela / Hernández-Osorio Crescencio / Gamboa-Cardiel Salvador / González-Contreras Claudia R / Pérez-Andrade Martha Elva / Ortiz-Cortés Joel / Aguirre-Vélez Blanca E

    Salud Pública de México, Vol 45, Iss 4, Pp 269-

    2003  Volume 275

    Abstract: OBJETIVO: Comunicar las diferencias encontradas en los niveles de concentración sanguínea de la hormona estimulante de la tiroides y su posible uso como indicador del estado de suficiencia de yodo en una muestra de recién nacidos mexicanos. MATERIAL Y ... ...

    Abstract OBJETIVO: Comunicar las diferencias encontradas en los niveles de concentración sanguínea de la hormona estimulante de la tiroides y su posible uso como indicador del estado de suficiencia de yodo en una muestra de recién nacidos mexicanos. MATERIAL Y MÉTODOS: De septiembre de 1999 a agosto de 2000 se estudiaron 25 427 recién nacidos en unidades asistenciales de la Secretaría de Salud de cinco estados de la República Mexicana. Se analizaron 8 095 muestras de sangre de talón y 17 332 de cordón umbilical. La sangre fue recolectada en papel filtro y procesada mediante ensayo inmunoenzimático. Para el análisis estadístico se emplearon las pruebas U de Mann-Wittney, y de Kruskal-Wallis. RESULTADOS: Se observó que 9.95% de las muestras de talón y 24.27% de las de cordón presentaron hipertirotropinemia (TSH>5 µUI/ml). CONCLUSIONES: El porcentaje de muestras de hipertirotropinemia observado es mayor del esperado para una población con aporte suficiente de yodo. Este hallazgo pudiera deberse a una deficiencia en la ingesta materna de yodo.
    Keywords tamiz neonatal ; tirotropina ; deficiencia de yodo ; hipotiroidismo congénito ; retardo mental ; México ; Public aspects of medicine ; RA1-1270
    Language English
    Publishing date 2003-01-01T00:00:00Z
    Publisher Instituto Nacional de Salud Pública
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Hipertirotropinemia en recién nacidos mexicanos.

    Vela-Amieva, Marcela / Hernández-Osorio, Crescencio / Gamboa-Cardiel, Salvador / González-Contreras, Claudia R / Pérez-Andrade, Martha Elva / Ortiz-Cortés, Joel / Aguirre-Vélez, Blanca E

    Salud publica de Mexico

    2003  Volume 45, Issue 4, Page(s) 269–275

    Abstract: Objective: To assess the differences in the blood concentration levels of the thyroid stimulating hormone and their possible use as an indicator of iodine sufficiency, in a sample of Mexican newborns.: Material and methods: A cross-sectional study ... ...

    Title translation Hyperthyrotropinemia in Mexican newborns.
    Abstract Objective: To assess the differences in the blood concentration levels of the thyroid stimulating hormone and their possible use as an indicator of iodine sufficiency, in a sample of Mexican newborns.
    Material and methods: A cross-sectional study was conducted from September 1999 to August 2000, among 25,427 Mexican newborns in the Ministry of Health clinics from 5 states. A total of 8,095 heel-prick and 17,332 umbilical cord blood samples were analyzed. Blood samples were collected in filter paper and processed by enzyme-linked immunosorbent assay. The Mann-Whitney U test and the Kruskal-Wallis test were used for statistical analyses.
    Results: Hyperthyrotropinemia was found in 9.95% of heel samples and in 24.27% of umbilical cord samples (TSH > 5 microUl/ml).
    Conclusions: The percentage of hyperthyrotropinemia observed in this study was higher than that expected in a population with sufficient iodine intake; these findings could be due to poor maternal iodine intake.
    MeSH term(s) Cross-Sectional Studies ; Female ; Humans ; Hypothyroidism/blood ; Hypothyroidism/diagnosis ; Hypothyroidism/prevention & control ; Infant, Newborn ; Male ; Mexico ; Neonatal Screening ; Thyrotropin/blood ; Thyrotropin/deficiency
    Chemical Substances Thyrotropin (9002-71-5)
    Language Spanish
    Publishing date 2003-11-19
    Publishing country Mexico
    Document type Comparative Study ; English Abstract ; Journal Article ; Multicenter Study
    ZDB-ID 954220-6
    ISSN 0036-3634
    ISSN 0036-3634
    DOI 10.1590/s0036-36342003000400005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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