LIVIVO - Search results -

Search results

Result 1 - 10 of total 30

Search options

Article ; Online: Plasma metabolomic profile is near-normal in people with HIV on long-term suppressive antiretroviral therapy.

Virseda-Berdices, Ana / Martín-Escolano, Rubén / Berenguer, Juan / González-García, Juan / Brochado-Kith, Oscar / Rojo, David / Fernández-Rodríguez, Amanda / Pérez-Latorre, Leire / Hontañón, Victor / Barbas, Coral / Resino, Salvador / Jiménez-Sousa, María Ángeles

Frontiers in cellular and infection microbiology

2024 Volume 14, Page(s) 1340610

Abstract: Background: Combination antiretroviral therapy (ART) has transformed human immunodeficiency virus (HIV) infection in people with HIV (PWH). However, a chronic state of immune activation and inflammation is maintained despite achieving HIV suppression ... ...

Abstract	Background: Combination antiretroviral therapy (ART) has transformed human immunodeficiency virus (HIV) infection in people with HIV (PWH). However, a chronic state of immune activation and inflammation is maintained despite achieving HIV suppression and satisfactory immunological recovery. We aimed to determine whether the plasma metabolomic profile of PWH on long-term suppressive ART and immunologically recovered approximates the normality by comparison with healthy controls with similar age and gender. Methods: We carried out a cross-sectional study in 17 PWH on long-term ART (HIV-RNA <50 copies/mL, CD4 Results: PCA and PLS-DA analyses found no relevant differences between groups. Adjusted GLM showed 14 significant features (q-value<0.20), of which only three could be identified: lysophosphatidylcholine (LysoPC) (22:6) (q-value=0.148), lysophosphatidylethanolamine (LysoPE) (22:6) (q-value=0.050) and hydroperoxy-octadecatrienoic acid (HpOTrE)/dihydroperoxy-octadecatrienoic acid (DiHOTrE)/epoxy-octadecadienoic acid (EpODE) (q-value=0.136). These significant identified metabolites were directly correlated to plasma inflammatory biomarkers in PWH and negatively correlated in healthy controls. Conclusion: PWH on long-term ART have a metabolomic profile that is almost normal compared to healthy controls. Nevertheless, residual metabolic alterations linked to inflammatory biomarkers persist, which could favor the development of age-related comorbidities among this population.
MeSH term(s)	Humans ; Cross-Sectional Studies ; Metabolomics/methods ; Biomarkers ; Inflammation/metabolism ; HIV Infections
Chemical Substances	Biomarkers
Language	English
Publishing date	2024-03-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2619676-1
ISSN	2235-2988 ; 2235-2988
ISSN (online)	2235-2988
ISSN	2235-2988
DOI	10.3389/fcimb.2024.1340610
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: Bloodstream infections: trends and evolution of incidence and etiology in a 12-year period (2010-2021).

Alonso-Menchén, David / Sánchez-Carrillo, Carlos / Alcalá, Luis / Soriano-Martín, Ana / Cercenado, Emilia / Burillo, Almudena / Serrano-Lobo, Julia / Pérez-Latorre, Leire / Muñoz, Patricia / Bouza, Emilio

Infectious diseases (London, England)

2024 Volume 56, Issue 6, Page(s) 441–450

Abstract: Introduction: The epidemiological evolution of bloodstream infections (BSIs) in the last decade is not clearly defined. Our aim was to analyze the changes in the workload in our institution and to describe the evolution of the incidence and etiology of ... ...

Abstract	Introduction: The epidemiological evolution of bloodstream infections (BSIs) in the last decade is not clearly defined. Our aim was to analyze the changes in the workload in our institution and to describe the evolution of the incidence and etiology of BSIs in a 12-year period, including the COVID-19 pandemic. Methods: All blood cultures received in the laboratory of a tertiary general hospital between 2010 and 2021 were analyzed. Bloodstream infection episodes refer to each episode of bacteremia or fungemia in each patient. Incidence rates per 1000 admissions and per 100,000 population were calculated. Results: No significant changes in the incidence of BSI episodes/1000 admissions were observed (mean, 31.1), while estimated population-based incidences showed declining trends (mean, 182.8/100,000 inhabitants). There was a slight increase in BSI episodes per 1000 admissions caused by Gram-negatives (mean, 16.6/1000 admissions) and Conclusions: No clear increase in the incidence of BSI episodes was detected in our center over this period. Gram-negatives are the most frequent etiology, with no clear rise in antimicrobial resistance phenotypes. The COVID-19 pandemic accounted for a small increase in BSI episodes in 2020, probably related to the increase of catheter-related infections.
MeSH term(s)	Humans ; Incidence ; COVID-19/epidemiology ; Bacteremia/epidemiology ; Bacteremia/microbiology ; Male ; Female ; Aged ; Middle Aged ; Fungemia/epidemiology ; Fungemia/microbiology ; SARS-CoV-2 ; Adult ; Aged, 80 and over ; Tertiary Care Centers/statistics & numerical data ; Retrospective Studies ; Catheter-Related Infections/epidemiology ; Catheter-Related Infections/microbiology
Language	English
Publishing date	2024-02-26
Publishing country	England
Document type	Journal Article
ZDB-ID	2839775-7
ISSN	2374-4243 ; 2374-4235
ISSN (online)	2374-4243
ISSN	2374-4235
DOI	10.1080/23744235.2024.2320333
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 600: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: PBMCs gene expression signature of advanced cirrhosis with high risk for clinically significant portal hypertension in HIV/HCV coinfected patients: A cross-control study.

Salgüero, Sergio / Brochado-Kith, Óscar / Verdices, Ana Virseda / Berenguer, Juan / González-García, Juan / Martínez, Isidoro / Díez, Cristina / Hontañón, Víctor / Pérez-Latorre, Leire / Fernández-Rodríguez, Amanda / Jiménez-Sousa, María Ángeles / Resino, Salvador

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2023 Volume 159, Page(s) 114220

Abstract: Background: Patients with advanced cirrhosis are at high risk of developing clinically significant portal hypertension (CSPH). We analyzed the gene expression profile of peripheral blood mononuclear cells (PBMCs) from HIV/HCV coinfected patients to ... ...

Abstract	Background: Patients with advanced cirrhosis are at high risk of developing clinically significant portal hypertension (CSPH). We analyzed the gene expression profile of peripheral blood mononuclear cells (PBMCs) from HIV/HCV coinfected patients to identify a gene expression signature of advanced cirrhosis with high risk for CSPH. Methods: We conducted a cross-sectional study on 68 patients. Liver stiffness measurement (LSM) was used to stratify patients into < 12.5 kPa (no cirrhosis, n = 19), 12.5 - 24.9 kPa (cirrhosis, n = 20), and ≥ 25 kPa (advanced cirrhosis with high risk for CSPH, n = 29). Besides, we further evaluated LSM < 25 kPa (n = 39) vs. ≥ 25 kPa (n = 29). Total RNA was extracted from PBMCs, and poly(A) RNA sequencing was performed. Two significant differentially expressed (SDE) transcripts were validated by quantitative PCR in a different cohort (n = 46). Results: We found 60 SDE transcripts between patients with LSM < 12.5 kPa and ≥ 25 kPa. Partial least squares discriminant analysis showed that those 60 SDE transcripts collectively discriminated LSM ≥ 25 kPa, with an area under the receiver operating characteristic curve (AUROC) of 0.84. Eight genes had an AUROC ≥ 0.75 for LSM ≥ 25 kPa: five were positively associated with LSM values (SCAMP1, ABHD17B, GPR146, GTF2A1, and TMEM64), while three were inversely associated (ZFHX2-AS1, MDK, and STAG3L2). We validated the two SDE transcripts with the highest discrimination capacity in a different cohort, finding significant differences between < 25 kPa and ≥ 25 kPa (MDK (p = 0.006) and STAG3L2 (p = 0.021)). Conclusions: A gene expression signature of 60 transcripts was associated with advanced cirrhosis with high risk for CSPH in HIV/HCV coinfected patients.
MeSH term(s)	Humans ; Transcriptome/genetics ; Coinfection/genetics ; Cross-Sectional Studies ; Leukocytes, Mononuclear ; HIV Infections/complications ; HIV Infections/genetics ; HIV Infections/pathology ; Liver Cirrhosis/complications ; Liver Cirrhosis/genetics ; Liver Cirrhosis/pathology ; Hypertension, Portal/genetics ; Hypertension, Portal/pathology ; Hepatitis C/complications ; Hepatitis C/genetics ; Elasticity Imaging Techniques ; Liver/pathology ; Vesicular Transport Proteins
Chemical Substances	SCAMP1 protein, human ; Vesicular Transport Proteins
Language	English
Publishing date	2023-01-09
Publishing country	France
Document type	Journal Article
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2023.114220
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ud II Zs.198: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Corrigendum to "PBMCs gene expression signature of advanced cirrhosis with high risk for clinically significant portal hypertension in HIV/HCV coinfected patients: A cross-control study" [Biomed. Pharmacother. 159 (2023) 114220].

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2023 Volume 163, Page(s) 114803

Language	English
Publishing date	2023-04-27
Publishing country	France
Document type	Published Erratum
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2023.114803
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ud II Zs.198: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Cervical and Oropharyngeal Lymphogranuloma Venereum: Case Report and Literature Review.

Galeano-Valle, Francisco / Pérez-Latorre, Leire / Díez-Romero, Cristina / Fanciulli, Chiara / Aldamiz-Echeverria-Lois, Teresa / Tejerina-Picado, Francisco

Sexually transmitted diseases

2019 Volume 46, Issue 10, Page(s) 689–692

Abstract: Lymphogranuloma venereum (LGV) is a sexually transmitted infection caused by invasive serovars of Chlamydia trachomatis. There have been only a few case reports of oropharyngeal C. trachomatis infection complicated with cervical LGV. We report a case of ... ...

Abstract	Lymphogranuloma venereum (LGV) is a sexually transmitted infection caused by invasive serovars of Chlamydia trachomatis. There have been only a few case reports of oropharyngeal C. trachomatis infection complicated with cervical LGV. We report a case of a HIV-positive male patient with cervical LGV that presented a poor evolution despite appropriate treatment.
MeSH term(s)	Anti-Bacterial Agents/therapeutic use ; Cervical Atlas/microbiology ; Chlamydia Infections/complications ; Chlamydia Infections/microbiology ; Chlamydia trachomatis ; HIV Infections/complications ; HIV Infections/drug therapy ; HIV Infections/microbiology ; HIV Seropositivity/complications ; HIV Seropositivity/microbiology ; Homosexuality, Male ; Humans ; Lymphogranuloma Venereum/diagnostic imaging ; Lymphogranuloma Venereum/drug therapy ; Male ; Middle Aged ; Oropharynx/microbiology ; Serogroup ; Tomography, X-Ray Computed
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2019-06-27
Publishing country	United States
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	435191-5
ISSN	1537-4521 ; 0148-5717
ISSN (online)	1537-4521
ISSN	0148-5717
DOI	10.1097/OLQ.0000000000001036
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1217: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Metabolomic changes after DAAs therapy are related to the improvement of cirrhosis and inflammation in HIV/HCV-coinfected patients.

Virseda-Berdices, Ana / Rojo, David / Martínez, Isidoro / Berenguer, Juan / González-García, Juan / Brochado-Kith, Oscar / Fernández-Rodríguez, Amanda / Díez, Cristina / Hontañon, Víctor / Pérez-Latorre, Leire / Micán, Rafael / Barbas, Coral / Resino, Salvador / Jiménez-Sousa, María Angeles

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2022 Volume 147, Page(s) 112623

Abstract: Background: A better understanding of the evolution of cirrhosis after hepatitis C virus (HCV) clearance is essential since the reversal of liver injury may not happen. We aimed to assess the evolution of plasma metabolites after direct-acting ... ...

Abstract	Background: A better understanding of the evolution of cirrhosis after hepatitis C virus (HCV) clearance is essential since the reversal of liver injury may not happen. We aimed to assess the evolution of plasma metabolites after direct-acting antivirals (DAAs) therapy and their association with liver disease scores in HIV/HCV-coinfected patients with advanced HCV-related cirrhosis. Methods: We performed a prospective study in 49 cirrhotic patients who started DAAs therapy. Data and samples were collected at baseline and 36 weeks after SVR. Metabolomics analysis was carried out using gas chromatography-mass spectrometry and liquid chromatography-mass spectrometry. Inflammation-related biomarkers were analyzed using ProcartaPlex Immunoassays. Results: At 36 weeks after SVR, patients experienced significant decrease in taurocholic acid, 2,3-butanediol, and LPC(18:0); while several phosphatidylcholines (LPC(16:1), LPC(18:1), LPC(20:4), and PC(16:0/9:0(CHO))/PC(16:0/9:0(COH)), 2-keto-n-caproic acid/2-keto-isocaproic acid and N-methyl alanine increased, compared to baseline. The plasma decrease in taurocholic acid was associated with a reduction in Child-Turcotte-Pugh (CTP) (AMR=3.39; q-value=0.006) and liver stiffness measurement (LSM) (AMR=1.06; q-value<0.001), the plasma increase in LPC(20:4) was related to a reduction in LSM (AMR=0.98; q-value=0.027), and the rise of plasma 2-keto-n-caproic acid/2-keto-isocaproic acid was associated with a reduction in CTP (AMR=0.35; q-value=0.004). Finally, plasma changes in taurocholic acid were directly associated with inflammation-related biomarkers, while changes in LPC(20:4) were inversely associated. Conclusions: Plasma metabolomic profile changed after HCV clearance with all oral-DAAs in HIV/HCV-coinfected with advanced HCV-related cirrhosis. Changes in plasma levels of LPC (20: 4), 2-keto-n-caproic acid/2-keto-isocaproic acid, and taurocholic acid were related to improvements in cirrhosis scores and inflammatory status of patients.
MeSH term(s)	Antiviral Agents/therapeutic use ; Biomarkers/blood ; Female ; HIV Infections ; Hepatitis C ; Humans ; Inflammation/complications ; Inflammation/drug therapy ; Inflammation/pathology ; Liver Cirrhosis/complications ; Liver Cirrhosis/drug therapy ; Liver Cirrhosis/pathology ; Longitudinal Studies ; Male ; Middle Aged ; Phosphatidylcholines/blood ; Severity of Illness Index ; Spain ; Taurocholic Acid/blood
Chemical Substances	Antiviral Agents ; Biomarkers ; Phosphatidylcholines ; Taurocholic Acid (5E090O0G3Z)
Language	English
Publishing date	2022-01-12
Publishing country	France
Document type	Journal Article ; Multicenter Study
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2022.112623
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ud II Zs.198: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Plasma IP-10 and IL-6 are linked to Child-Pugh B cirrhosis in patients with advanced HCV-related cirrhosis: a cross-sectional study.

Salgüero, Sergio / Medrano, Luz Maria / González-García, Juan / Berenguer, Juan / Montes, María L / Diéz, Cristina / Garcia-Broncano, Pilar / Llop-Herrera, Elba / Pérez-Latorre, Leire / Bellóno, José María / Jiménez-Sousa, María Ángeles / Resino, Salvador

Scientific reports

2020 Volume 10, Issue 1, Page(s) 10384

Abstract: We aimed to evaluate the association of plasma biomarkers linked to inflammation (bacterial translocation, inflammatory response, and endothelial dysfunction), coagulopathy, and angiogenesis with the severity of liver cirrhosis (assessed by the Child- ... ...

Abstract	We aimed to evaluate the association of plasma biomarkers linked to inflammation (bacterial translocation, inflammatory response, and endothelial dysfunction), coagulopathy, and angiogenesis with the severity of liver cirrhosis (assessed by the Child-Pugh-Turcotte score, CTP) and Child-Pugh B cirrhosis (CTP 7-9) in patients with advanced hepatitis C virus (HCV)-related cirrhosis. We carried out a cross-sectional study in 97 patients with advanced HCV-related cirrhosis (32 HCV-monoinfected and 65 HIV/HCV-coinfected). Plasma biomarkers were measured by ProcartaPlex multiplex immunoassays. The outcome variable was the CTP score and the Child-Pugh B cirrhosis (CTP 7-9). HIV/HCV-coinfected patients and HCV-monoinfected patients with advanced HCV-related cirrhosis had near-equivalent values of plasma biomarkers. Higher values of plasma biomarkers linked to an inflammatory response (IP-10, IL-8, IL-6, and OPG), endothelial dysfunction (sVCAM-1 and sICAM-1), and coagulopathy (D-dimer) were related to higher CTP values. The most significant biomarkers to detect the presence of Child-Pugh B cirrhosis (CTP 7-9) were IP-10 (p-value= 0.008) and IL-6 (p-value=0.002). The AUC-ROC values of IP-10, IL-6, and both biomarkers combined (IP-10+IL-6) were 0.78, 0.88, and 0.96, respectively. In conclusion, HIV infection does not appear to have a significant impact on the analyzed plasma biomarkers in patients with advanced HCV-related cirrhosis. However, plasma biomarkers linked to inflammation (inflammatory response and endothelial dysfunction) were related to the severity of liver cirrhosis (CTP score), mainly IP-10 and IL-6, which discriminated patients with Child-Pugh B concerning Child-Pugh A.
MeSH term(s)	Aged ; Aged, 80 and over ; Biomarkers/blood ; Chemokine CXCL10/blood ; Cross-Sectional Studies ; Female ; Follow-Up Studies ; Hepacivirus/isolation & purification ; Hepatitis C/complications ; Hepatitis C/virology ; Humans ; Interleukin-6/blood ; Liver Cirrhosis/blood ; Liver Cirrhosis/classification ; Liver Cirrhosis/diagnosis ; Liver Cirrhosis/etiology ; Male ; Middle Aged ; Prognosis ; Prospective Studies
Chemical Substances	Biomarkers ; CXCL10 protein, human ; Chemokine CXCL10 ; IL6 protein, human ; Interleukin-6
Language	English
Publishing date	2020-06-25
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-020-67159-3
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: HCV Cure With Direct-Acting Antivirals Improves Liver and Immunological Markers in HIV/HCV-Coinfected Patients.

Brochado-Kith, Óscar / Martínez, Isidoro / Berenguer, Juan / González-García, Juan / Salgüero, Sergio / Sepúlveda-Crespo, Daniel / Díez, Cristina / Hontañón, Víctor / Ibañez-Samaniego, Luis / Pérez-Latorre, Leire / Fernández-Rodríguez, Amanda / Ángeles Jiménez-Sousa, María / Resino, Salvador

Frontiers in immunology

2021 Volume 12, Page(s) 723196

Abstract: Hepatitis C virus (HCV) cure after all-oral direct-acting antiviral (DAA) therapy greatly improves the liver and immune system. We aimed to assess the impact of this HCV clearance on immune system-related markers in plasma and the gene expression profile ...

Abstract	Hepatitis C virus (HCV) cure after all-oral direct-acting antiviral (DAA) therapy greatly improves the liver and immune system. We aimed to assess the impact of this HCV clearance on immune system-related markers in plasma and the gene expression profile in human immunodeficiency virus (HIV)/HCV-coinfected patients with advanced cirrhosis. We performed a prospective study on 33 HIV/HCV-coinfected patients at baseline and 36 weeks after the sustained virological response. Gene expression was evaluated by RNA-seq analysis on peripheral blood mononuclear cells (PBMCs) and plasma biomarkers by multiplex immunoassays. We found a decrease in plasma biomarkers (PD1, PDL1, CXCL10, CXCL8, IL12p70, IL10, and TGFβ) and liver disease markers (stiffness measurement (LSM), hepatic venous pressure gradient (HVPG), and transaminases, among others). Furthermore, decreased plasma levels of CXCL8, CXCL10, IL10, and PD1 were associated with reduced LSM values. We also found two upregulated (
MeSH term(s)	Aged ; Antiviral Agents/therapeutic use ; Biomarkers/blood ; Chemokines/blood ; Coinfection/drug therapy ; Female ; Gene Expression ; HIV Infections/drug therapy ; Hepacivirus/genetics ; Hepatitis C/complications ; Hepatitis C/drug therapy ; Hepatitis C/virology ; Humans ; Interferons/blood ; Liver Cirrhosis/blood ; Liver Cirrhosis/diagnosis ; Liver Cirrhosis/etiology ; Liver Function Tests ; Male ; Middle Aged ; Prospective Studies ; Sustained Virologic Response
Chemical Substances	Antiviral Agents ; Biomarkers ; Chemokines ; Interferons (9008-11-1)
Language	English
Publishing date	2021-08-23
Publishing country	Switzerland
Document type	Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2021.723196
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Blood microbiome is associated with changes in portal hypertension after successful direct-acting antiviral therapy in patients with HCV-related cirrhosis.

Virseda-Berdices, Ana / Brochado-Kith, Oscar / Díez, Cristina / Hontañon, Victor / Berenguer, Juan / González-García, Juan / Rojo, David / Fernández-Rodríguez, Amanda / Ibañez-Samaniego, Luis / Llop-Herrera, Elba / Olveira, Antonio / Perez-Latorre, Leire / Barbas, Coral / Rava, Marta / Resino, Salvador / Jiménez-Sousa, María Angeles

The Journal of antimicrobial chemotherapy

2021 Volume 77, Issue 3, Page(s) 719–726

Abstract: Background: Patients with a significant decrease in hepatic venous pressure gradient (HVPG) have a considerable reduction of liver complications and higher survival after HCV eradication.: Objectives: To evaluate the association between the baseline ... ...

Abstract	Background: Patients with a significant decrease in hepatic venous pressure gradient (HVPG) have a considerable reduction of liver complications and higher survival after HCV eradication. Objectives: To evaluate the association between the baseline blood microbiome and the changes in HVPG after successful direct-acting antiviral (DAA) therapy in patients with HCV-related cirrhosis. Methods: We performed a prospective study in 32 cirrhotic patients (21 HIV positive) with clinically significant portal hypertension (HVPG ≥10 mmHg). Patients were assessed at baseline and 48 weeks after HCV treatment completion. The clinical endpoint was a decrease in HVPG of ≥20% or HVPG <12 mmHg at the end of follow-up. Bacterial 16S ribosomal DNA was sequenced using MiSeq Illumina technology, inflammatory plasma biomarkers were investigated using ProcartaPlex immunoassays and the metabolome was investigated using GC-MS. Results: During the follow-up, 47% of patients reached the clinical endpoint. At baseline, those patients had a higher relative abundance of Corynebacteriales and Diplorickettsiales order, Diplorickettsiaceae family, Corynebacterium and Aquicella genus and Undibacterium parvum species organisms and a lower relative abundance of Oceanospirillales and Rhodospirillales order, Halomonadaceae family and Massilia genus organisms compared with those who did not achieve the clinical endpoint according to the LEfSe algorithm. Corynebacteriales and Massilia were consistently found within the 10 bacterial taxa with the highest differential abundance between groups. Additionally, the relative abundance of the Corynebacteriales order was inversely correlated with IFN-γ, IL-17A and TNF-α levels and the Massilia genus with glycerol and lauric acid. Conclusions: Baseline-specific bacterial taxa are related to an HVPG decrease in patients with HCV-related cirrhosis after successful DAA therapy.
MeSH term(s)	Antiviral Agents/therapeutic use ; Hepatitis C, Chronic/complications ; Hepatitis C, Chronic/drug therapy ; Humans ; Hypertension, Portal/drug therapy ; Hypertension, Portal/etiology ; Liver Cirrhosis/complications ; Microbiota ; Prospective Studies
Chemical Substances	Antiviral Agents
Language	English
Publishing date	2021-11-30
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	191709-2
ISSN	1460-2091 ; 0305-7453
ISSN (online)	1460-2091
ISSN	0305-7453
DOI	10.1093/jac/dkab444
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1197: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 124: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: SARS-COV-2 Infection in People Living with HIV: Experience from a Tertiary Hospital in Madrid.

González Guembe, Maria / Tisner Pensado, Yago / Tejerina Picado, Francisco / Diez, Cristina / Pérez Latorre, Leire / Fanciulli, Chiara / Parras Vázquez, Francisco / López Bernaldo de Quirós, Juan Carlos / Berenguer, Juan / Padilla Ortega, Belen / Machado, Marina / Valerio Minero, Maricela / Muñoz Garcia, Patricia / Bouza Santiago, Emilio / Galar, Alicia / Catalan, Pilar / Alonso, Roberto / Bellón, Jose M / Aldámiz-Echevarría Lois, Teresa

AIDS research and human retroviruses

2022 Volume 38, Issue 5, Page(s) 394–398

Abstract: Since SAR-COV-2 infection emerged and spread worldwide, little is known about its impact on people living with human immunodeficiency virus (HIV). We performed a single-center retrospective study to describe the potential particularities and risk factors ...

Abstract	Since SAR-COV-2 infection emerged and spread worldwide, little is known about its impact on people living with human immunodeficiency virus (HIV). We performed a single-center retrospective study to describe the potential particularities and risk factors for respiratory failure (RF) in that population. This single-center retrospective study included patients infected with HIV, whose current follow-up is run in this center, above18 years of age, with diagnosis of SARS-CoV-2 infection between March 5, 2020 and April 15, 2021. We collected data regarding HIV immunological and virological status, main epidemiological characteristics, as well as those conditions considered to potentially influence in SARS-CoV-2 evolution; and clinical, microbiological, radiological, respiratory status, and survival concerning coronavirus disease 2019 (COVID-19). We compared all that, for patients with and without RF and performed a logistic regression for suspected risk factors for RF. One hundred seventy-seven HIV patients were diagnosed from COVID-19 (mean age 53.8 years, 81.3% male). At diagnosis, 95.5% were receiving ART and 91.3% had undetectable viral load, with median CD4 count of 569 cells/μL. One hundred thirty-eight patients (78.4%) had symptoms, 44 (25%) developed RF and 53 (31%) developed bilateral pneumonia. The most commonly used treatments were: steroids (26.7%) and hydroxychloroquine (13.1%). When comparing patients with and without RF, we found statistically significant differences for 20 of the analyzed variables such as age (
MeSH term(s)	COVID-19/epidemiology ; Female ; HIV Infections/complications ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; Humans ; Male ; Middle Aged ; Retrospective Studies ; SARS-CoV-2 ; Tertiary Care Centers
Language	English
Publishing date	2022-01-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	639130-8
ISSN	1931-8405 ; 0889-2229
ISSN (online)	1931-8405
ISSN	0889-2229
DOI	10.1089/AID.2021.0159
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 1928: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

To top

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito