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  1. Article: Participation of Single-Nucleotide Variants in

    López-Bielma, María Fernanda / Falfán-Valencia, Ramcés / Abarca-Rojano, Edgar / Pérez-Rubio, Gloria

    Pathogens (Basel, Switzerland)

    2023  Volume 12, Issue 11

    Abstract: Host genetic factors significantly influence susceptibility to SARS-CoV-2 infection and COVID-19 severity. Among these genetic factors are single-nucleotide variants (SNVs). ...

    Abstract Host genetic factors significantly influence susceptibility to SARS-CoV-2 infection and COVID-19 severity. Among these genetic factors are single-nucleotide variants (SNVs).
    Language English
    Publishing date 2023-11-06
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens12111320
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Editorial: Translational research in severe COVID-19 and long-term symptoms post-COVID-19.

    Vicens-Zygmunt, Vanesa / Pérez-Rubio, Gloria / Chavez-Galan, Leslie / Buendia-Roldan, Ivette / Falfán-Valencia, Ramcés

    Frontiers in medicine

    2023  Volume 10, Page(s) 1261211

    Language English
    Publishing date 2023-09-27
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2023.1261211
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Peptidyl Arginine Deiminases in Chronic Diseases: A Focus on Rheumatoid Arthritis and Interstitial Lung Disease.

    Nava-Quiroz, Karol J / López-Flores, Luis A / Pérez-Rubio, Gloria / Rojas-Serrano, Jorge / Falfán-Valencia, Ramcés

    Cells

    2023  Volume 12, Issue 24

    Abstract: Protein citrullination is accomplished by a broad enzyme family named Peptidyl Arginine Deiminases (PADs), which makes this post-translational modification in many proteins that perform physiological and pathologic mechanisms in the body. Due to these ... ...

    Abstract Protein citrullination is accomplished by a broad enzyme family named Peptidyl Arginine Deiminases (PADs), which makes this post-translational modification in many proteins that perform physiological and pathologic mechanisms in the body. Due to these modifications, citrullination has become a significant topic in the study of pathological processes. It has been related to some chronic and autoimmune diseases, including rheumatoid arthritis (RA), interstitial lung diseases (ILD), multiple sclerosis (MS), and certain types of cancer, among others. Antibody production against different targets, including filaggrin, vimentin, and collagen, results in an immune response if they are citrullinated, which triggers a continuous inflammatory process characteristic of autoimmune and certain chronic diseases. PAD coding genes (
    MeSH term(s) Humans ; Protein-Arginine Deiminases/genetics ; Protein-Arginine Deiminases/metabolism ; Arthritis, Rheumatoid ; Lung Diseases, Interstitial/genetics ; Proteins ; Chronic Disease
    Chemical Substances arginine deiminase (EC 3.5.3.6) ; Protein-Arginine Deiminases (EC 3.5.3.15) ; Proteins
    Language English
    Publishing date 2023-12-13
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells12242829
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Association of

    Gutiérrez-Pérez, Ilse Adriana / Buendía-Roldán, Ivette / Zaragoza-García, Oscar / Pérez-Rubio, Gloria / Villafan-Bernal, José Rafael / Chávez-Galán, Leslie / Parra-Rojas, Isela / Hernández-Zenteno, Rafael de Jesús / Fricke-Galindo, Ingrid / Castro-Alarcón, Natividad / Bautista-Becerril, Brandon / Falfán-Valencia, Ramcés / Guzmán-Guzmán, Iris Paola

    Heliyon

    2024  Volume 10, Issue 6, Page(s) e27997

    Abstract: Background: Enzymes of the peptidylarginine deiminase family (PADs) play a relevant role in the pathogenesis of COVID-19. However, the association of single nucleotide polymorphisms (SNPs) in their genes with COVID-19 severity and death is unknown.: ... ...

    Abstract Background: Enzymes of the peptidylarginine deiminase family (PADs) play a relevant role in the pathogenesis of COVID-19. However, the association of single nucleotide polymorphisms (SNPs) in their genes with COVID-19 severity and death is unknown.
    Methodology: We included 1045 patients who were diagnosed with COVID-19 between October 2020 and December 2021. All subjects were genotyped for
    Results: 291 patients presented had severe COVID-19 according to PaO
    Conclusions: Our results suggest that the haplotypic combination of GTACC and some individual genotypes of
    Language English
    Publishing date 2024-03-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e27997
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Genetic variants in

    López-Bielma, María Fernanda / Falfán-Valencia, Ramcés / Fierro-Piña, Aurelio / Abarca-Rojano, Edgar / Córdoba-Lanus, Elizabeth / Fricke-Galindo, Ingrid / Romero-Villaseñor, Priscila / Buendía-Roldán, Ivette / Chávez-Galán, Leslie / Jaime-Capetillo, María Esther / Pérez-Rubio, Gloria

    Heliyon

    2024  Volume 10, Issue 8, Page(s) e29493

    Abstract: Introduction: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of Coronavirus Disease 2019 (COVID-19). The disease has a wide range of clinical manifestations, from asymptomatic to severe. Ancestral contribution, ... ...

    Abstract Introduction: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of Coronavirus Disease 2019 (COVID-19). The disease has a wide range of clinical manifestations, from asymptomatic to severe. Ancestral contribution, sex, immune response, and genetic factors influence the presentation of the disease. The objective of the present study was to validate these genetic variants in patients with severe COVID-19 who died and in survivor patients. Methods: Single nucleotide variants (SNVs) in six genes: ATPase plasma membrane Ca
    Results: In non-related patients with severe COVID-19, carriers of GG genotype (rs2289274) in the
    Conclusions: Unrelated patients with severe COVID-19 that carry the GG genotype (rs2289274) in
    Language English
    Publishing date 2024-04-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e29493
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Serum Levels of IFABP2 and Differences in

    Zaragoza-García, Oscar / Castro-Alarcón, Natividad / Pérez-Rubio, Gloria / Falfán-Valencia, Ramcés / Briceño, Olivia / Navarro-Zarza, José Eduardo / Parra-Rojas, Isela / Tello, Mario / Guzmán-Guzmán, Iris Paola

    International journal of molecular sciences

    2023  Volume 24, Issue 3

    Abstract: Intestinal dysbiosis is related to the physiopathology and clinical manifestation of rheumatoid arthritis (RA) and the response to pharmacologic treatment. The objectives of this study were (1) to analyze the effect of conventional synthetic disease ... ...

    Abstract Intestinal dysbiosis is related to the physiopathology and clinical manifestation of rheumatoid arthritis (RA) and the response to pharmacologic treatment. The objectives of this study were (1) to analyze the effect of conventional synthetic disease modifying anti-rheumatic drugs (csDMARDs) on the abundance of gut microbiota's bacteria; (2) to evaluate the relationship between the differences in microbial abundance with the serum levels of intestinal fatty-acid binding protein 2 (IFABP2), cytokines, and the response phenotype to csDMARDs therapy in RA. A cross-sectional study was conducted on 23 women diagnosed with RA. The abundance of bacteria in gut microbiota was determined with qPCR. The ELISA technique determined serum levels of IFABP2, TNF-α, IL-10, and IL-17A. We found that the accumulated dose of methotrexate or prednisone is negatively associated with the abundance of
    MeSH term(s) Female ; Humans ; Antirheumatic Agents/therapeutic use ; Arthritis, Rheumatoid/drug therapy ; Arthritis, Rheumatoid/genetics ; Arthritis, Rheumatoid/metabolism ; Cross-Sectional Studies ; Gastrointestinal Microbiome/genetics ; Gastrointestinal Microbiome/physiology ; Interleukin-17 ; Pilot Projects ; Porphyromonas gingivalis ; Tumor Necrosis Factor-alpha/therapeutic use ; Lactobacillus ; Intestines/microbiology ; Intestines/physiopathology ; Cell Membrane Permeability
    Chemical Substances Antirheumatic Agents ; Interleukin-17 ; Tumor Necrosis Factor-alpha ; FABP2 protein, human
    Language English
    Publishing date 2023-01-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24031958
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: DMARDs-Gut Microbiota Feedback: Implications in the Response to Therapy.

    Zaragoza-García, Oscar / Castro-Alarcón, Natividad / Pérez-Rubio, Gloria / Guzmán-Guzmán, Iris Paola

    Biomolecules

    2020  Volume 10, Issue 11

    Abstract: Due to its immunomodulatory effects and the limitation in the radiological damage progression, disease-modifying antirheumatic drugs (DMARDs) work as first-line rheumatoid arthritis (RA) treatment. In recent years, numerous research projects have ... ...

    Abstract Due to its immunomodulatory effects and the limitation in the radiological damage progression, disease-modifying antirheumatic drugs (DMARDs) work as first-line rheumatoid arthritis (RA) treatment. In recent years, numerous research projects have suggested that the metabolism of DMARDs could have a role in gut dysbiosis, which indicates that the microbiota variability could modify the employment of direct and indirect mechanisms in the response to treatment. The main objective of this review was to understand the gut microbiota bacterial variability in patients with RA, pre and post-treatment with DMARDs, and to identify the possible mechanisms through which microbiota can regulate the response to pharmacological therapy.
    MeSH term(s) Antirheumatic Agents/therapeutic use ; Arthritis, Rheumatoid/drug therapy ; Gastrointestinal Microbiome/drug effects ; Humans
    Chemical Substances Antirheumatic Agents
    Language English
    Publishing date 2020-10-24
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom10111479
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Characterization of the lung microbiome and inflammatory cytokine levels in women exposed to environmental risk factors: A pilot study.

    Morales-González, Fernando / Lira-Lucio, Juan A / Falfán-Valencia, Ramcés / Márquez-García, José E / Abarca-Rojano, Edgar / Ramírez-Venegas, Alejandra / Sansores, Raúl H / García-Gómez, Leonor / Hernández-Pérez, Andrea / Pérez-Rubio, Gloria

    Immunity, inflammation and disease

    2023  Volume 11, Issue 4, Page(s) e825

    Abstract: Introduction: Lung microbiome dysbiosis affects the immune system balance and promotes lung inflammation. We aimed to characterize and compare the lung bacteriome composition and the cytokine profile in women with normal lung function exposed to risk ... ...

    Abstract Introduction: Lung microbiome dysbiosis affects the immune system balance and promotes lung inflammation. We aimed to characterize and compare the lung bacteriome composition and the cytokine profile in women with normal lung function exposed to risk factors for chronic lung diseases (tobacco smoking and biomass-burning smoke exposure).
    Methods: We included women with biomass-burning smoke exposure (BE, n = 11) and current smokers women (TS, n = 10). The bacteriome composition was performed in induced sputum, sequencing the 16 rRNA gene. Cytokine levels were measured using enzyme-linked immunosorbent assay multiplex assay in the supernatant of induced sputum. For quantitative variables, we used medians and minimum and maxim values. For the amplicon sequence variants (ASV) differential abundance testing between groups.
    Results: At the taxa level, the phylum Proteobacteria was found in a higher proportion in the TS group concerning BE (p = .045); however, after the false discovery rate adjustment, this difference was not retained (p = .288). We found a higher concentration of IL-1β in the TS group than in the BE group (248.6 vs. 177.9 pg/mL, p = .010). Women with high biomass-burning smoke exposure in an hour per day had a positive correlation with the abundance of Bacteroidota (ρ = 0.71, p = .014) and Fusobacteriota (ρ = 0.73, p = .011). FEV1/FVC had a positive correlation with an abundance of Bacteroidota, Proteobacteria, and Fusobacteria (ρ = 0.74, p = .009, ρ = 0.85, p = .001, and ρ = 0.83, p = .001, respectively). In tobacco smoking, women had a positive correlation (ρ = 0.77, p = .009) between cigarettes per day and Firmicutes' abundance.
    Conclusion: Compared to biomass-burning smoke-exposed women, current smokers have poor lung function and high levels of IL-1β in sputum. Women with biomass-burning smoke exposure present an increased abundance of Bacteroidota and Fusobacteriota.
    MeSH term(s) Humans ; Female ; Pilot Projects ; Cytokines ; Lung ; Smoke/adverse effects ; Microbiota
    Chemical Substances Cytokines ; Smoke
    Language English
    Publishing date 2023-04-26
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2740382-8
    ISSN 2050-4527 ; 2050-4527
    ISSN (online) 2050-4527
    ISSN 2050-4527
    DOI 10.1002/iid3.825
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The rs16969968 Tobacco Smoking-Related Single-Nucleotide Variant Is Associated with Clinical Markers in Patients with Severe COVID-19.

    Valencia-Pérez Rea, Daniela / Falfán-Valencia, Ramcés / Fricke-Galindo, Ingrid / Buendía-Roldán, Ivette / Chávez-Galán, Leslie / Nava-Quiroz, Karol J / Alanis-Ponce, Jesús / Pérez-Rubio, Gloria

    International journal of molecular sciences

    2023  Volume 24, Issue 12

    Abstract: Tobacco smoking is the leading risk factor for many respiratory diseases. Several genes are associated with nicotine addiction, such ... ...

    Abstract Tobacco smoking is the leading risk factor for many respiratory diseases. Several genes are associated with nicotine addiction, such as
    MeSH term(s) Humans ; C-Reactive Protein/genetics ; Receptors, Nicotinic/genetics ; Polymorphism, Single Nucleotide ; COVID-19/genetics ; Tobacco Smoking ; Biomarkers ; Fibrinogen/genetics ; Nucleotides ; Genetic Predisposition to Disease ; ADAM Proteins/genetics
    Chemical Substances C-Reactive Protein (9007-41-4) ; Receptors, Nicotinic ; Biomarkers ; Fibrinogen (9001-32-5) ; Nucleotides ; ADAM33 protein, human (EC 3.4.24.-) ; ADAM Proteins (EC 3.4.24.-)
    Language English
    Publishing date 2023-06-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24129811
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Clinical risk factors in patients with interstitial lung disease associated with anti-MDA5 autoantibodies.

    Ramos-Martinez, Espiridión / Rodríguez-Vega, Eric A / Rivera-Matias, Pedro A / Falfán-Valencia, Ramcés / Pérez-Rubio, Gloria / Mejia, Mayra / González-Pérez, Montserrat I / Buendia-Roldán, Ivette / Mateos-Toledo, Heidegger N / Serrano, Jorge Rojas

    Medicina clinica

    2023  Volume 161, Issue 12, Page(s) 515–522

    Abstract: Introduction: The anti-MDA5-associated autoimmune disease represents a poorly understood entity. The study's objectives were to describe a cohort of interstitial lung disease (ILD) patients who were positive for anti-MDA5 autoantibody and identify ... ...

    Abstract Introduction: The anti-MDA5-associated autoimmune disease represents a poorly understood entity. The study's objectives were to describe a cohort of interstitial lung disease (ILD) patients who were positive for anti-MDA5 autoantibody and identify clinical risk factors associated with survival.
    Methods: This single-center cohort study included ILD patients positive for anti-MDA5 autoantibody. Baseline clinical features were registered, and survival analysis was performed to identify risk factors associated with worse survival.
    Results: Fifty-three ILD-MDA5 positive patients were included; twelve died during follow-up due to rapidly progressive interstitial lung disease (RP-ILD). Dermatological signs of anti-MDA5 (Gottron papules, Gottron sign, palmar papules, V-neck sign, facial dermatomyositis rashes, and skin ulcers) were strongly associated with death secondary to RP-ILD (HR: 3.7, 95% CI: 1.02-13.35). Patients with dermatological signs were younger, had higher anti-MDA5 autoantibodies titers, more frequent inflammatory patterns in HRCT evaluation, and less fibrosis extent in HRCT.
    Conclusion: Dermatological manifestation in ILD patients to anti-MDA5 autoantibodies are associated with RP-ILD and short-term fatal outcomes. Dermatological signs may identify a subgroup of ILD-positive to anti-MDA5 patients with a high risk of RP-ILD.
    MeSH term(s) Humans ; Autoantibodies ; Cohort Studies ; Interferon-Induced Helicase, IFIH1 ; Lung Diseases, Interstitial/etiology ; Lung Diseases, Interstitial/complications ; Risk Factors ; Retrospective Studies
    Chemical Substances Autoantibodies ; Interferon-Induced Helicase, IFIH1 (EC 3.6.4.13)
    Language Spanish
    Publishing date 2023-08-09
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 411607-0
    ISSN 1578-8989 ; 0025-7753
    ISSN (online) 1578-8989
    ISSN 0025-7753
    DOI 10.1016/j.medcli.2023.07.013
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