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Article: Awake Prone Decubitus Positioning in COVID-19 Patients: A Systematic Review and MetaAnalysis.

García, Agustin / Galeiras, Rita / Pertega-Díaz, Sonia

Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures)

2023 Volume 9, Issue 2, Page(s) 73–86

Abstract: To date, recommendations for the implementation of awake prone positioning in patients with hypoxia secondary to SARSCoV2 infection have been extrapolated from prior studies on respiratory distress. Thus, we carried out a systematic review and ... ...

Abstract	To date, recommendations for the implementation of awake prone positioning in patients with hypoxia secondary to SARSCoV2 infection have been extrapolated from prior studies on respiratory distress. Thus, we carried out a systematic review and metaanalysis to evaluate the benefits of pronation on the oxygenation, need for endotracheal intubation (ETI), and mortality of this group of patients. We carried out a systematic search in the PubMed and Embase databases between June 2020 and November 2021. A randomeffects metaanalysis was performed to evaluate the impact of pronation on the ETI and mortality rates. A total of 213 articles were identified, 15 of which were finally included in this review. A significant decrease in the mortality rate was observed in the group of pronated patients (relative risk [RR] = 0.69; 95% confidence interval [CI]: 0.480.99; p = 0.044), but no significant effect was observed on the need for ETI (RR = 0.79; 95% CI: 0.631.00; p = 0.051). However, a subgroup analysis of randomized clinical trials (RCTs) did reveal a significant decrease in the need for this intervention (RR = 0.83; 95% CI: 0.710.97). Prone positioning was found to significantly reduce mortality, also diminishing the need for ETI, although this effect was statistically significant only in the subgroup analysis of RCTs. Patients' response to awake prone positioning could be greater when this procedure is implemented early and in combination with noninvasive mechanical ventilation (NIMV) or highflow nasal cannula (HFNC) therapy.
Language	English
Publishing date	2023-05-08
Publishing country	Poland
Document type	Journal Article
ISSN	2393-1809
ISSN	2393-1809
DOI	10.2478/jccm-2023-0014
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Article ; Online: Effect of depression on health-related quality of life of renal patients according to the modality of renal replacement therapy.

Vázquez, Isabel / Pértega-Díaz, Sonia / García-Becerra, Lorena

Journal of nephrology

2023 Volume 36, Issue 7, Page(s) 2143–2145

MeSH term(s)	Humans ; Quality of Life ; Depression ; Renal Replacement Therapy ; Renal Dialysis/adverse effects ; Kidney ; Kidney Failure, Chronic/therapy
Language	English
Publishing date	2023-05-13
Publishing country	Italy
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	1093991-x
ISSN	1724-6059 ; 1120-3625 ; 1121-8428
ISSN (online)	1724-6059
ISSN	1120-3625 ; 1121-8428
DOI	10.1007/s40620-023-01649-1
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Article: Prediction of bronchopulmonary dysplasia in very preterm infants: competitive risk model nomogram.

Sucasas-Alonso, Andrea / Pértega-Díaz, Sonia / Balboa-Barreiro, Vanesa / García-Muñoz Rodrigo, Fermín / Avila-Alvarez, Alejandro

Frontiers in pediatrics

2024 Volume 12, Page(s) 1335891

Abstract: Objective: To develop predictive clinical models of bronchopulmonary dysplasia (BPD) through competing risk analysis.: Methods: Retrospective observational cohort study, including preterm newborns ≤32 weeks gestational age, conducted between January ... ...

Abstract	Objective: To develop predictive clinical models of bronchopulmonary dysplasia (BPD) through competing risk analysis. Methods: Retrospective observational cohort study, including preterm newborns ≤32 weeks gestational age, conducted between January 1, 2013 and September 30, 2022 in a third-level Neonatal Intensive Care Unit in Spain. A prediction study was carried out using competing risk models, where the event of interest was BPD and the competing event was death. A multivariate competing risk model was developed separately for each postnatal day (days 1, 3, 7 and 14). Nomograms to predict BPD risk were developed from the coefficients of the final models and internally validated. Results: A total of 306 patients were included in the study, of which 73 (23.9%) developed BPD and 29 (9.5%) died. On day 1, the model with the greatest predictive capacity was that including birth weight, days since rupture of membranes, and surfactant requirement (area under the receiver operating characteristic (ROC) curve (AUC), 0.896; 95% CI, 0.792-0.999). On day 3, the final predictive model was based on the variables birth weight, surfactant requirement, and Fraction of Inspired Oxygen (FiO Conclusions: Competing risk analysis allowed accurate prediction of BPD, avoiding the potential bias resulting from the exclusion of deceased newborns or the use of combined outcomes. The resulting models are based on clinical variables measured at bedside during the first 3 days of life, can be easily implemented in clinical practice, and can enable earlier identification of patients at high risk of BPD.
Language	English
Publishing date	2024-02-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711999-3
ISSN	2296-2360
ISSN	2296-2360
DOI	10.3389/fped.2024.1335891
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Article ; Online: Prognostic significance of sentinel lymph node biopsy in elderly with cutaneous melanoma: systematic review and meta-analysis.

Martínez Campayo, Nieves / Paradela de la Morena, Sabela / Pértega-Díaz, Sonia / Tejera Vaquerizo, Antonio / Fonseca, Eduardo

International journal of dermatology

2024

Abstract: Sentinel lymph node biopsy is the most powerful prognostic indicator to date for cutaneous melanoma. Even though elderly patients have a lower incidence of sentinel node involvement, its results are still necessary for access to adjuvant therapies. This ... ...

Abstract	Sentinel lymph node biopsy is the most powerful prognostic indicator to date for cutaneous melanoma. Even though elderly patients have a lower incidence of sentinel node involvement, its results are still necessary for access to adjuvant therapies. This is highly relevant considering that the Western population shows an aging trend, and the incidence of melanoma has grown exponentially over the years, making elderly patients more likely to die from melanoma than younger ones. We performed a systematic review to investigate the prognostic significance of sentinel lymph node biopsy in elderly patients with melanoma. The systematic review was conducted following the PRISMA guidelines and registered in PROSPERO. The authors searched the Cochrane Database, EMBASE, PubMed, and WOS. Eligible studies for the systematic review were clinical trials, observational population studies, clinical or hospital-based cohort studies, and case-control studies. The meta-analysis was conducted using the R software program applying the meta package. Six reports were identified to meet the inclusion criteria. All studies were retrospective, non-randomized cohorts. The results obtained in this systematic review show a statistically significant influence of sentinel lymph node biopsy on disease-specific survival (HR = 2.87; 95% CI: 1.73-4.74) but also suggest that a positive result negatively impacts disease-free survival (HR = 3.41; 95% CI: 0.96-12.11). This meta-analysis shows that a positive sentinel lymph node biopsy does not imply differences in overall survival but significantly influences disease-specific survival and suggests an unfavorable impact on disease-free survival.
Language	English
Publishing date	2024-04-02
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	412254-9
ISSN	1365-4632 ; 0011-9059 ; 1461-1244
ISSN (online)	1365-4632
ISSN	0011-9059 ; 1461-1244
DOI	10.1111/ijd.17092
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Article ; Online: Epidemiology and risk factors for bronchopulmonary dysplasia in preterm infants born at or less than 32 weeks of gestation.

Sucasas Alonso, Andrea / Pértega Diaz, Sonia / Sáez Soto, Rebeca / Avila-Alvarez, Alejandro

Anales de pediatria

2022 Volume 96, Issue 3, Page(s) 242–251

Abstract: Objectives: To describe risk factors of bronchopulmonary dysplasia in very preterm infants in the first weeks of life.: Material and methods: Retrospective cohort study of preterm infants ≤ 32 weeks of gestational age and birth weight ≤ 1500 g. A ... ...

Abstract	Objectives: To describe risk factors of bronchopulmonary dysplasia in very preterm infants in the first weeks of life. Material and methods: Retrospective cohort study of preterm infants ≤ 32 weeks of gestational age and birth weight ≤ 1500 g. A multivariate logistic regression analysis was performed to identify independent risk factors for bronchopulmonary dysplasia in the first weeks of life. Results: A total of 202 newborns were included in the study (mean gestational age 29.5 ± 2.1 weeks), 61.4% never received invasive mechanical ventilation. The incidence of bronchopulmonary dysplasia was 28.7%, and 10.4% of the patients were diagnosed with moderate-severe bronchopulmonary dysplasia. Bronchopulmonary dysplasia was independently associated with gestational age (P < 0.001; OR = 0.44 (95% CI = 0.30-0.65)), the need for mechanical ventilation on the first day of life (P = 0.001; OR = 8.13 ((95% CI = 2.41-27.42)), nosocomial sepsis (P < 0.001; OR = 9.51 ((95% CI = 2.99-30.28)) and FiO Conclusions: Gestational age, mechanical ventilation in the first days of life and nosocomial sepsis are early risk factors for bronchopulmonary dysplasia. The analysis of simple and objective clinical data, allows us to select a group of patients at high risk of bronchopulmonary dysplasia in whom it could be justified to act more aggressively, and shows areas for improvement to prevent its development or reduce its severity.
MeSH term(s)	Bronchopulmonary Dysplasia/epidemiology ; Bronchopulmonary Dysplasia/etiology ; Bronchopulmonary Dysplasia/prevention & control ; Cross Infection ; Female ; Humans ; Infant ; Infant, Newborn ; Infant, Premature ; Retrospective Studies ; Risk Factors ; Sepsis
Language	English
Publishing date	2022-03-04
Publishing country	Spain
Document type	Journal Article
ZDB-ID	2830901-7
ISSN	2341-2879 ; 2341-2879
ISSN (online)	2341-2879
ISSN	2341-2879
DOI	10.1016/j.anpede.2021.03.006
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Article ; Online: Predictors of Intensive Care Unit Stay in Patients with Acute Traumatic Spinal Cord Injury Above T6.

Esmorís-Arijón, Inés / Galeiras, Rita / Ferreiro Velasco, María Elena / Pértega Díaz, Sonia

World neurosurgery

2022 Volume 166, Page(s) e681–e691

Abstract: Objective: The objective of this study was to identify factors associated with the intensive care unit (ICU) length of stay (LOS) of patients with an acute traumatic spinal cord injury above T6.: Methods: We performed a retrospective, observational ... ...

Abstract	Objective: The objective of this study was to identify factors associated with the intensive care unit (ICU) length of stay (LOS) of patients with an acute traumatic spinal cord injury above T6. Methods: We performed a retrospective, observational study of patients admitted to an ICU between 1998 and 2017 (n = 241). The LOS was calculated using a cumulative incidence function, with events of death being considered a competing event. Factors associated with the LOS were analyzed using both a cause-specific Cox proportional hazards regression model and a competing risk model. A multistate approach was also used to analyze the impact of nosocomial infections on the LOS. Results: A total of 211 patients (87.5%) were discharged alive from the ICU (median LOS = 23 days), and 30 (12.4%) died (median LOS = 11 days). In the multivariate analysis after adjusting for variables collected 4 days after the ICU admission, a higher American Spinal Injury Association motor score (subdistribution hazards ratio [sHR] = 1.01), neurological level C5-C8 (HR = 0,64), and lower Sequential Organ Failure Assessment score (sHR = 0.82) and fluid balance (sHR = 0.95) on day 4 were linked to a lower LOS in this unit. In the multivariate analysis, the onset of an infection was significantly associated with a longer LOS when adjusting for variables collected both at ICU admission (adjusted sHR = 0.62; 95% confidence interval = 0.50-0.77) and on day 4 (adjusted hazards ratio = 0.65; 95% confidence interval = 0.52-0.80). Conclusions: After adjusting the data for conventional variables, we identified a lower American Spinal Injury Association motor score, injury level C5-C8, a higher Sequential Organ Failure Assessment score on day 4, a more positive fluid balance on day 4, and the onset of an infection as factors independently associated with a longer ICU LOS.
MeSH term(s)	Humans ; Intensive Care Units ; Length of Stay ; Retrospective Studies ; Spinal Cord Injuries/complications ; Spinal Cord Injuries/therapy ; Spinal Injuries/complications
Language	English
Publishing date	2022-07-22
Publishing country	United States
Document type	Journal Article ; Observational Study
ZDB-ID	2534351-8
ISSN	1878-8769 ; 1878-8750
ISSN (online)	1878-8769
ISSN	1878-8750
DOI	10.1016/j.wneu.2022.07.072
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Article ; Online: Foot health and quality of life in women with breast cancer undergoing chemotherapy: a cross-sectional study.

Veiga-Seijo, Raquel / Pertega-Diaz, Sonia / Perez-Lopez, Maria Eva / Martinez, Lourdes Calvo / Novoa, Silvia Antolin / Gonzalez-Martin, Cristina

Journal of foot and ankle research

2023 Volume 16, Issue 1, Page(s) 52

Abstract: Background: Chemotherapy is one of the most widely used therapies for breast cancer, triggering important repercussions on people's quality of life. However, little research has been undertaken about podiatric adverse effects. This study aimed was to ... ...

Abstract	Background: Chemotherapy is one of the most widely used therapies for breast cancer, triggering important repercussions on people's quality of life. However, little research has been undertaken about podiatric adverse effects. This study aimed was to determine the prevalence of podiatric pathology developed in people with breast cancer who receive chemotherapy. Methods: Observational, descriptive, and cross-sectional study was conducted in the Oncology service of the A Coruña University Hospital (northwest Spain). People with breast cancer and undergoing chemotherapy treatment of legal age (≥ 18), who signed the informed consent (n = 117) were included. Sociodemographic, comorbidity, disease and foot health variables, as well as two self-administered questionnaires (Foot Health Status Questionnaire and Foot Function Index) were studied. The current ethical-legal aspects were followed. Results: Foot health problems were highly prevalent, highlighting nail color changes (59.8%), onychocryptosis (39.7%), xerosis (62.4%), plantar fasciitis (12.8%), and neuropathic symptoms (75.2%). Some foot pain was presented in 77.8% of the sample, predominantly at nail level (15.4%) or sole of the foot and nail (14.5%). Most participants described their foot health as fair or poor (56.4%) and felt limited in walking (65.8%). The lowest score for the Foot Health Status Questionnaire was footwear (30.6(33.5)). Conclusions: Foot health adverse effects represent worrisome problems in women with breast cancer undergoing chemotherapy, due to their high prevalence and negative implications on quality of life. These problems are critical as they may have implications for stopping or reducing chemotherapy. All these results call for the development of more research to contribute to the care and wellbeing of people with cancer who receive treatments such as chemotherapy. Thus, this line of research is a new path to be developed by the podiatry community.
MeSH term(s)	Female ; Humans ; Breast Neoplasms/drug therapy ; Cross-Sectional Studies ; Foot ; Health Status ; Quality of Life ; Adolescent ; Adult
Language	English
Publishing date	2023-08-21
Publishing country	England
Document type	Observational Study ; Journal Article
ZDB-ID	2440706-9
ISSN	1757-1146 ; 1757-1146
ISSN (online)	1757-1146
ISSN	1757-1146
DOI	10.1186/s13047-023-00650-y
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Article ; Online: Demographic transition and hospital admissions in Spanish centenarians, 2004-2020: Geographical variations and sex-related differences.

Piñeiro-Fernández, Juan Carlos / Rabuñal-Rey, Ramón / Maseda, Ana / Romay-Lema, Eva / Suárez-Gil, Roi / Pértega-Díaz, Sonia

Archives of gerontology and geriatrics

2023 Volume 117, Page(s) 105276

Abstract: Background: This study aims to describe the distribution and temporal trends of the centenarian population and their hospital admissions in Spain over the past two decades, focusing on regional and sex-based differences.: Methods: A retrospective ... ...

Abstract	Background: This study aims to describe the distribution and temporal trends of the centenarian population and their hospital admissions in Spain over the past two decades, focusing on regional and sex-based differences. Methods: A retrospective study was conducted using data from the Spanish National Health System's Hospital Discharge Records-Minimum Basic Data Set. The analysis included all hospitalized patients ≥100 years between January 2004 and December 2020. The crude annual centenarian population and admission rates were calculated. Joinpoint regression analysis and cross-correlation analysis were used to identify trends and associations. Results: From 2004 to 2020, the centenarian population in Spain increased by 89.0 %, with a larger increase observed in women (86.6 %) than men (32.9 %). Significant geographic variability was found, with rates from 1.1 to 5.2 × 10,000 inhabitants per year across different regions. Joinpoint analysis identified three trends: a decline from 2004 to 2008, an increase from 2008 to 2015, and a slower increase from 2015 to 2020. Hospital admissions of centenarians increased by 121.5 %, with a larger increase in women than men (212.1% vs 90.7 %); women represented 75.4 % of admissions. The proportion of centenarian admissions to total hospitalizations showed an upward trend until 2015 and then stabilized; it also varied among regions. Conclusion: There was a significant increase in the centenarian population and hospital admissions of centenarians in Spain. There are regional disparities in their distribution, with women representing a larger proportion of centenarians and hospital admissions. Understanding these trends and differences is crucial for implementing interventions that ensure adequate healthcare for centenarians.
MeSH term(s)	Male ; Aged, 80 and over ; Humans ; Female ; Centenarians ; Retrospective Studies ; Hospitalization ; Spain/epidemiology ; Population Dynamics ; Hospitals
Language	English
Publishing date	2023-11-17
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	603162-6
ISSN	1872-6976 ; 0167-4943
ISSN (online)	1872-6976
ISSN	0167-4943
DOI	10.1016/j.archger.2023.105276
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Article ; Online: Metabolic syndrome is not associated with erosive hand osteoarthritis: a cross-sectional study using data from the PROCOAC cohort.

Silva-Díaz, Maite / Pértega-Díaz, Sonia / Balboa-Barreiro, Vanesa / Tilve-Álvarez, Carlos M / Raga-Sivira, Ana / Rego-Pérez, Ignacio / Blanco, Francisco J / Oreiro, Natividad

Scientific reports

2024 Volume 14, Issue 1, Page(s) 5968

Abstract: To delineate the phenotype of erosive hand osteoarthritis (EHOA) in a Spanish population and assess its correlation with metabolic syndrome. We conducted a cross-sectional study using baseline data from the Prospective Cohort of Osteoarthritis from A ... ...

Abstract	To delineate the phenotype of erosive hand osteoarthritis (EHOA) in a Spanish population and assess its correlation with metabolic syndrome. We conducted a cross-sectional study using baseline data from the Prospective Cohort of Osteoarthritis from A Coruña (PROCOAC). Demographic and clinical variables, obtained through questionnaires, clinical examinations, and patient analytics, were compared among individuals with hand OA, with and without EHOA. We performed appropriate univariate and multivariate stepwise regression analyses using SPSS v28. Among 1039 subjects diagnosed with hand OA, 303 exhibited EHOA. Multivariate logistic regression analysis revealed associations with inflamed joints, nodular hand OA, and total AUSCAN. Furthermore, the association with a lower prevalence of knee OA remained significant. The influence of metabolic syndrome (MetS) on EHOA patients was analyzed by including MetS as a covariate in the model. It was observed that MetS does not significantly impact the presence of EHOA, maintaining the effect size of other factors. In conclusion, in the PROCOAC cohort, EHOA is associated with nodular hand OA, inflammatory hand OA, and a higher total AUSCAN. However, EHOA is linked to a lower prevalence of knee OA. Importantly, in our cohort, no relationship was found between EHOA and MetS.
MeSH term(s)	Humans ; Cross-Sectional Studies ; Metabolic Syndrome/complications ; Prospective Studies ; Osteoarthritis/complications ; Hand
Language	English
Publishing date	2024-03-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-55374-1
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Article ; Online: Prevalence and prognostic impact of inhalation injury among burn patients: A systematic review and meta-analysis.

Galeiras, Rita / Seoane-Quiroga, Leticia / Pértega-Díaz, Sonia

The journal of trauma and acute care surgery

2019 Volume 88, Issue 2, Page(s) 330–344

Abstract: Background: The objective of our study was to perform a systematic review and meta-analysis aimed at assessing the prevalence of inhalation injury in burn patients and its prognostic value in relation to in-hospital mortality.: Methods: We searched ... ...

Abstract	Background: The objective of our study was to perform a systematic review and meta-analysis aimed at assessing the prevalence of inhalation injury in burn patients and its prognostic value in relation to in-hospital mortality. Methods: We searched the PubMed and EMBASE databases for noninterventional studies published between 1990 and 2018 investigating in-hospital mortality predictors among burn patients.The primary meta-analysis evaluated the association between inhalation injury and mortality. A secondary meta-analysis determined the global estimate of the prevalence of inhalation injury and the rate of mortality. Random effects models were used, and univariate meta-regressions were used to assess sources of heterogeneity. This study is registered in the PROSPERO database with code CRD42019127356. Findings: Fifty-four studies including a total of 408,157 patients were selected for the analysis. A pooled inhalation prevalence of 15.7% (95% confidence interval, 13.4%-18.3%) was calculated.The summarized odds ratio of in-hospital mortality secondary to an inhalation injury was 3.2 (95% confidence interval, 2.5-4.3). A significantly higher odd of mortality was found among the studies that included all hospitalized burn patients, those that included a lower proportion of male patients, those with a lower mean total body surface area, and those with a lower prevalence of inhalation injury. Conclusion: Despite our study's limitations due to the high risk of bias and the interstudy heterogeneity of some of our analyses, our results revealed a wide range of prevalence rates of inhalation injury and a significant association between this entity and in-hospital mortality in burn patients. However, this association is not significant if adjusted for disease severity. Level of evidence: Systematic review/meta-analysis, level III.
MeSH term(s)	Body Surface Area ; Burns/diagnosis ; Burns/mortality ; Hospital Mortality ; Humans ; Injury Severity Score ; Prevalence ; Prognosis ; Smoke Inhalation Injury/epidemiology ; Survival Analysis
Language	English
Publishing date	2019-11-04
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	2651070-4
ISSN	2163-0763 ; 2163-0755
ISSN (online)	2163-0763
ISSN	2163-0755
DOI	10.1097/TA.0000000000002523
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